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The map label for this gene is xerC

Identifier: 116494889

GI number: 116494889

Start: 1391015

End: 1391911

Strand: Direct

Name: xerC

Synonym: LSEI_1403

Alternate gene names: 116494889

Gene position: 1391015-1391911 (Clockwise)

Preceding gene: 116494888

Following gene: 116494890

Centisome position: 48.04

GC content: 43.03

Gene sequence:

>897_bases
ATGAAGCCAATTGCAGCGTTTCAAGAGTATCTTGAAGTTGAACGGCAGTATTCACCGGAAACAGTGACGGCTTATTTGAG
TGATCTTCAAGAATTTCAGGCGTTTCTCAAGGCCAACGGCGGGTTTACTGACTTTCGGCATGTGGATGATTTAGACGTTC
AAACTTATTTGACTGATCTTAACAAACAGGATTTGGCACGGACATCGATTGCCCGAAAAATCAGTAGTTTGCGAAGCTTT
TACCGTTATTTGACACGAATTGATGTCGTCAAACGCAACCCATTTGAGCTGGTTGAATTAAAAAAGCAGCATCATCATTT
ACCACAATTTTTCTATGAAGCCGAGATTCAGGAACTGTTCAAGACAGTTGCTGGCAAAACCCCGCTGGATCAACGTAATC
GCGCTTTGTTGGAAGTTTTGTATGGCACCGGTATTCGAGTTTCCGAGTGTGCCAAACTGACATTGAATCAGGTCGATTTC
AATACGGCATTACTGTTGATTCATGGTAAAGGCAACAAAGATAGGTATGTGCCCTTTGGACAGTACGCTCAGCAAGCACT
ACGAACTTATTTAAAAGATGGCCGACAAGTCTTGATGGCTAAAAGTCAGGCACAGCATCGATATGTATTCGTGAACCAGT
ATGGGCGTCCGATTACCTCGCGTGGCATTGAATATATTTTGGATCAGCTCATCAAGCAGACGACGCTGACAGCTAACATT
CATCCCCACATGCTGCGGCATAGTTTTGCAACCCATATGCTGGATCATGGTGCTGACCTGCGAACTGTTCAAGAGCTACT
GGGTCATGCAAGTTTATCAACCACACAAATCTACACGCATGTCACCATGGCACATTTAAAAAATGAGTATATGAAATATT
ATCCGAAGCATAATTAA

Upstream 100 bases:

>100_bases
GGGATTTTTTCATTGGTATTTCGGCGGCTTGATGGTGTTGATGCACTGAAAGCGTCAACAATGGCTGCATTTTATGTTAA
TGTATTATCGGAGGGATTCA

Downstream 100 bases:

>100_bases
GACTAAAGCATGATGCAAAAGCAGTCTGAGTTTTTTAAGCTAAGAACATTGGCGATAACAGATTAATCGCTACTTTAGCT
GTTTTTATCCGACGAGATAC

Product: integrase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDFRHVDDLDVQTYLTDLNKQDLARTSIARKISSLRSF
YRYLTRIDVVKRNPFELVELKKQHHHLPQFFYEAEIQELFKTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDF
NTALLLIHGKGNKDRYVPFGQYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGRPITSRGIEYILDQLIKQTTLTANI
HPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHVTMAHLKNEYMKYYPKHN

Sequences:

>Translated_298_residues
MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDFRHVDDLDVQTYLTDLNKQDLARTSIARKISSLRSF
YRYLTRIDVVKRNPFELVELKKQHHHLPQFFYEAEIQELFKTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDF
NTALLLIHGKGNKDRYVPFGQYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGRPITSRGIEYILDQLIKQTTLTANI
HPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHVTMAHLKNEYMKYYPKHN
>Mature_298_residues
MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDFRHVDDLDVQTYLTDLNKQDLARTSIARKISSLRSF
YRYLTRIDVVKRNPFELVELKKQHHHLPQFFYEAEIQELFKTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDF
NTALLLIHGKGNKDRYVPFGQYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGRPITSRGIEYILDQLIKQTTLTANI
HPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHVTMAHLKNEYMKYYPKHN

Specific function: Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The xerC-xerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell div

COG id: COG4974

COG function: function code L; Site-specific recombinase XerD

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family. XerC subfamily

Homologues:

Organism=Escherichia coli, GI1790244, Length=287, Percent_Identity=36.2369337979094, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1789261, Length=298, Percent_Identity=35.9060402684564, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790767, Length=173, Percent_Identity=29.4797687861272, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XERC_LACC3 (Q039E1)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806623.1
- ProteinModelPortal:   Q039E1
- SMR:   Q039E1
- STRING:   Q039E1
- GeneID:   4419744
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1403
- eggNOG:   COG4974
- HOGENOM:   HBG727654
- OMA:   GIRYCLT
- PhylomeDB:   Q039E1
- ProtClustDB:   CLSK770889
- BioCyc:   LCAS321967:LSEI_1403-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01808
- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104
- InterPro:   IPR010998
- InterPro:   IPR023109
- InterPro:   IPR004107
- InterPro:   IPR011931
- Gene3D:   G3DSA:1.10.150.130
- Gene3D:   G3DSA:1.10.443.10
- TIGRFAMs:   TIGR02224

Pfam domain/function: PF02899 Phage_integr_N; PF00589 Phage_integrase; SSF56349 DNA_brk_join_enz; SSF47823 L_intgrse_like_N

EC number: NA

Molecular weight: Translated: 34684; Mature: 34684

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: ACT_SITE 146-146 ACT_SITE 170-170 ACT_SITE 243-243 ACT_SITE 246-246 ACT_SITE 269-269 ACT_SITE 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDFRHVDDLDVQTYLTDL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHC
NKQDLARTSIARKISSLRSFYRYLTRIDVVKRNPFELVELKKQHHHLPQFFYEAEIQELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDFNTALLLIHGKGNKDRYVPFG
HHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
QYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGRPITSRGIEYILDQLIKQTTLTANI
HHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
HPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHVTMAHLKNEYMKYYPKHN
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKPIAAFQEYLEVERQYSPETVTAYLSDLQEFQAFLKANGGFTDFRHVDDLDVQTYLTDL
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHC
NKQDLARTSIARKISSLRSFYRYLTRIDVVKRNPFELVELKKQHHHLPQFFYEAEIQELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KTVAGKTPLDQRNRALLEVLYGTGIRVSECAKLTLNQVDFNTALLLIHGKGNKDRYVPFG
HHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHH
QYAQQALRTYLKDGRQVLMAKSQAQHRYVFVNQYGRPITSRGIEYILDQLIKQTTLTANI
HHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCC
HPHMLRHSFATHMLDHGADLRTVQELLGHASLSTTQIYTHVTMAHLKNEYMKYYPKHN
CHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA