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The map label for this gene is recS [H]

Identifier: 116494862

GI number: 116494862

Start: 1363879

End: 1365288

Strand: Direct

Name: recS [H]

Synonym: LSEI_1376

Alternate gene names: 116494862

Gene position: 1363879-1365288 (Clockwise)

Preceding gene: 116494861

Following gene: 116494863

Centisome position: 47.11

GC content: 48.51

Gene sequence:

>1410_bases
GTGTCACAACTTGAAGCACAACTTCAACAACATTTTGGCTTTCAAGAATTTCGACCTGGACAAAAGGCTTTGATCCAATC
GGTGTTGGATGGACATGACACGCTGGGAATTTTACCTACTGGCAGCGGGAAATCACTCTGTTATCAATTGCCGACTTTGA
TCAGTAACAAGCCAAGTTTAATTGTTGAACCGCTCATTGCCTTGATGAATGATCAAGTTGGTCGTTTGCAAGCAGCTGGA
GAAAAACGGGTCATTGCCTTGTCAGCGCAAATGCCACCGGTTGCTTTTACCCAAATTCTCAAACGATTGGCAAGTTACCA
CTATATTTTTGTCTCACCAGAAATTTTACAACGCGTTGATGTGCTCATGGCGCTCAAACGACTGGCCCTAGGCTTATTTG
TGGTAGATGAAGCGCATTGTATCTCACAGTGGGGGCCAGATTTTCGACCTGCTTATTTGCAGCTGGGACAAGTTCGCCAA
CAATTGCAAGCAGATGCGATTCTTGCCTTAACCGCAACCGCACCGGAACCCGTTCGCCGTGACATTGTCCAACATCTAAG
CATGCAATCGCCAGCAATTTTGGCTGGGTCAGTCGATCGACCAAATATTTTCCTTGGCGTTGAGACCGGCTTAACAGATA
AGGAAAAGGCTTTAAGACTGGATCAGTTATTGCACGAGGTGGTGGGGCCAACGATCATTTATAGTGCTACCCGAGCCGCG
TGTGAGACGTTAGCGATACGATTGCAAAAAGCCGGCCATGCTGCGGCCTTTTATCATGCTGGGTTGGATCGGCACCAACG
CGATCTAATCCAGCGACAGTTTCAATCGGATCAGTTGCAGATTATCTGTGCGACGAGTGCGTTTGGCATGGGGATCGATA
AGGCAAATGTACGGTTCGTCGTGCATACCTATGTGCCGGAATCGCTTGAAGCTTATTATCAGGCAATCGGACGAGCCGGC
CGTGATGGCAAGCAGAGTCTAGCGGCGCTTTTGGTGACCGATCATGATGTTCAGCACGGCGCTATTTTGGCGGGGATGTT
GCCAGATGCGGCATTGATTCGGCTCATCTATGCGCATCCTGAGGCGTATCGCACTTTTGACGATCCGCAGATCAACCTGA
TCGAAGCGTATGTAGACGCTGGCTTTTCGGTAGAGGCTACGCAGCAGCAATTACAGCACAGACTAACTGAGAAACAGGCT
AGTTTCGCAGCGATGGCGGCTTTTGTTAATGAATCAGAATGCCGTCGTGCTGTTCTGCTGCAACATTTTGATTCGCCAAT
TGAACCGCATACGGCTTTGTGCTGTGGTGAGATCACCACTACGATATTGCGCCAACTACAGCCTGAAGTGCCGCAAGAAC
AACCAAAATTAGCTTCTTGGCAGGCAGTATTTCACCAAATCTTTAGATAA

Upstream 100 bases:

>100_bases
CAAATCTACGATCATCAGGCATTGTTGGCAGCCATTCCTGGAAGTACTTTTTTTCAGATTCGACTGTTCCAGATTCTAAG
TTTTCAAGGGAGGTGGCCGC

Downstream 100 bases:

>100_bases
CCGACGCCCTGACGCTGGTCAATATGATACAATAAGCGCAGTAGTGAGGGGGATCGTGATGGCGGAAAAAGATGAACACC
AACATGACAATGAGGATCAC

Product: superfamily II DNA helicase

Products: NA

Alternate protein names: Recombination protein S [H]

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSQLEAQLQQHFGFQEFRPGQKALIQSVLDGHDTLGILPTGSGKSLCYQLPTLISNKPSLIVEPLIALMNDQVGRLQAAG
EKRVIALSAQMPPVAFTQILKRLASYHYIFVSPEILQRVDVLMALKRLALGLFVVDEAHCISQWGPDFRPAYLQLGQVRQ
QLQADAILALTATAPEPVRRDIVQHLSMQSPAILAGSVDRPNIFLGVETGLTDKEKALRLDQLLHEVVGPTIIYSATRAA
CETLAIRLQKAGHAAAFYHAGLDRHQRDLIQRQFQSDQLQIICATSAFGMGIDKANVRFVVHTYVPESLEAYYQAIGRAG
RDGKQSLAALLVTDHDVQHGAILAGMLPDAALIRLIYAHPEAYRTFDDPQINLIEAYVDAGFSVEATQQQLQHRLTEKQA
SFAAMAAFVNESECRRAVLLQHFDSPIEPHTALCCGEITTTILRQLQPEVPQEQPKLASWQAVFHQIFR

Sequences:

>Translated_469_residues
MSQLEAQLQQHFGFQEFRPGQKALIQSVLDGHDTLGILPTGSGKSLCYQLPTLISNKPSLIVEPLIALMNDQVGRLQAAG
EKRVIALSAQMPPVAFTQILKRLASYHYIFVSPEILQRVDVLMALKRLALGLFVVDEAHCISQWGPDFRPAYLQLGQVRQ
QLQADAILALTATAPEPVRRDIVQHLSMQSPAILAGSVDRPNIFLGVETGLTDKEKALRLDQLLHEVVGPTIIYSATRAA
CETLAIRLQKAGHAAAFYHAGLDRHQRDLIQRQFQSDQLQIICATSAFGMGIDKANVRFVVHTYVPESLEAYYQAIGRAG
RDGKQSLAALLVTDHDVQHGAILAGMLPDAALIRLIYAHPEAYRTFDDPQINLIEAYVDAGFSVEATQQQLQHRLTEKQA
SFAAMAAFVNESECRRAVLLQHFDSPIEPHTALCCGEITTTILRQLQPEVPQEQPKLASWQAVFHQIFR
>Mature_468_residues
SQLEAQLQQHFGFQEFRPGQKALIQSVLDGHDTLGILPTGSGKSLCYQLPTLISNKPSLIVEPLIALMNDQVGRLQAAGE
KRVIALSAQMPPVAFTQILKRLASYHYIFVSPEILQRVDVLMALKRLALGLFVVDEAHCISQWGPDFRPAYLQLGQVRQQ
LQADAILALTATAPEPVRRDIVQHLSMQSPAILAGSVDRPNIFLGVETGLTDKEKALRLDQLLHEVVGPTIIYSATRAAC
ETLAIRLQKAGHAAAFYHAGLDRHQRDLIQRQFQSDQLQIICATSAFGMGIDKANVRFVVHTYVPESLEAYYQAIGRAGR
DGKQSLAALLVTDHDVQHGAILAGMLPDAALIRLIYAHPEAYRTFDDPQINLIEAYVDAGFSVEATQQQLQHRLTEKQAS
FAAMAAFVNESECRRAVLLQHFDSPIEPHTALCCGEITTTILRQLQPEVPQEQPKLASWQAVFHQIFR

Specific function: Probable DNA helicase. Required in synaptic and/or post- synaptic stages of recombination. Probably has overlapping function with recQ (AC O34748). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI169218196, Length=424, Percent_Identity=35.1415094339623, Blast_Score=235, Evalue=7e-62,
Organism=Homo sapiens, GI110735439, Length=429, Percent_Identity=34.7319347319347, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI4557365, Length=343, Percent_Identity=39.067055393586, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI51242943, Length=354, Percent_Identity=38.9830508474576, Blast_Score=225, Evalue=7e-59,
Organism=Homo sapiens, GI51242947, Length=354, Percent_Identity=38.9830508474576, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI148612816, Length=354, Percent_Identity=38.9830508474576, Blast_Score=222, Evalue=7e-58,
Organism=Homo sapiens, GI14591902, Length=434, Percent_Identity=30.6451612903226, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI14591904, Length=434, Percent_Identity=30.6451612903226, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI284005309, Length=342, Percent_Identity=37.1345029239766, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI148613856, Length=376, Percent_Identity=26.3297872340426, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI38201710, Length=376, Percent_Identity=26.3297872340426, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4758138, Length=351, Percent_Identity=25.9259259259259, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI222352149, Length=367, Percent_Identity=25.0681198910082, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI41327771, Length=177, Percent_Identity=29.9435028248588, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI7661920, Length=346, Percent_Identity=20.8092485549133, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI48994977, Length=421, Percent_Identity=41.8052256532066, Blast_Score=280, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI32564293, Length=340, Percent_Identity=38.5294117647059, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI25145561, Length=350, Percent_Identity=39.7142857142857, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI71987997, Length=328, Percent_Identity=37.8048780487805, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71987993, Length=328, Percent_Identity=37.8048780487805, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17552866, Length=324, Percent_Identity=36.7283950617284, Blast_Score=197, Evalue=9e-51,
Organism=Caenorhabditis elegans, GI71987143, Length=343, Percent_Identity=24.4897959183673, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533224, Length=366, Percent_Identity=24.8633879781421, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17537549, Length=353, Percent_Identity=21.8130311614731, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71995724, Length=350, Percent_Identity=22, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507121, Length=350, Percent_Identity=21.7142857142857, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323844, Length=346, Percent_Identity=37.5722543352601, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324217, Length=348, Percent_Identity=25.8620689655172, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320041, Length=339, Percent_Identity=25.3687315634218, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321856, Length=351, Percent_Identity=24.5014245014245, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24646066, Length=337, Percent_Identity=37.3887240356083, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24664226, Length=362, Percent_Identity=37.5690607734807, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24664230, Length=366, Percent_Identity=36.8852459016393, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI62472181, Length=366, Percent_Identity=36.8852459016393, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21358123, Length=346, Percent_Identity=34.971098265896, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24642151, Length=385, Percent_Identity=26.4935064935065, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574962, Length=348, Percent_Identity=25.8620689655172, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24584994, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR002464
- InterPro:   IPR004589
- InterPro:   IPR001650
- InterPro:   IPR014021 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51952; Mature: 51821

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLEAQLQQHFGFQEFRPGQKALIQSVLDGHDTLGILPTGSGKSLCYQLPTLISNKPSL
CCHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHH
IVEPLIALMNDQVGRLQAAGEKRVIALSAQMPPVAFTQILKRLASYHYIFVSPEILQRVD
HHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEECHHHHHHHH
VLMALKRLALGLFVVDEAHCISQWGPDFRPAYLQLGQVRQQLQADAILALTATAPEPVRR
HHHHHHHHHHHHHEECHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
DIVQHLSMQSPAILAGSVDRPNIFLGVETGLTDKEKALRLDQLLHEVVGPTIIYSATRAA
HHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
CETLAIRLQKAGHAAAFYHAGLDRHQRDLIQRQFQSDQLQIICATSAFGMGIDKANVRFV
HHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCCCEEEE
VHTYVPESLEAYYQAIGRAGRDGKQSLAALLVTDHDVQHGAILAGMLPDAALIRLIYAHP
EEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHHHCC
EAYRTFDDPQINLIEAYVDAGFSVEATQQQLQHRLTEKQASFAAMAAFVNESECRRAVLL
HHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QHFDSPIEPHTALCCGEITTTILRQLQPEVPQEQPKLASWQAVFHQIFR
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SQLEAQLQQHFGFQEFRPGQKALIQSVLDGHDTLGILPTGSGKSLCYQLPTLISNKPSL
CHHHHHHHHHCCHHHCCCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCHH
IVEPLIALMNDQVGRLQAAGEKRVIALSAQMPPVAFTQILKRLASYHYIFVSPEILQRVD
HHHHHHHHHCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCEEEEECHHHHHHHH
VLMALKRLALGLFVVDEAHCISQWGPDFRPAYLQLGQVRQQLQADAILALTATAPEPVRR
HHHHHHHHHHHHHEECHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHH
DIVQHLSMQSPAILAGSVDRPNIFLGVETGLTDKEKALRLDQLLHEVVGPTIIYSATRAA
HHHHHHCCCCCCEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHH
CETLAIRLQKAGHAAAFYHAGLDRHQRDLIQRQFQSDQLQIICATSAFGMGIDKANVRFV
HHHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEEEEECHHCCCCCCCCEEEE
VHTYVPESLEAYYQAIGRAGRDGKQSLAALLVTDHDVQHGAILAGMLPDAALIRLIYAHP
EEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHHHHCC
EAYRTFDDPQINLIEAYVDAGFSVEATQQQLQHRLTEKQASFAAMAAFVNESECRRAVLL
HHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
QHFDSPIEPHTALCCGEITTTILRQLQPEVPQEQPKLASWQAVFHQIFR
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8760912; 9384377; 9642195 [H]