Click here to switch to the map view.

The map label for this gene is mraY

Identifier: 116494761

GI number: 116494761

Start: 1248227

End: 1249192

Strand: Direct

Name: mraY

Synonym: LSEI_1270

Alternate gene names: 116494761

Gene position: 1248227-1249192 (Clockwise)

Preceding gene: 116494760

Following gene: 116494762

Centisome position: 43.11

GC content: 45.03

Gene sequence:

>966_bases
ATGCAACTTGCTCAGATGCTCATCCCGATGGTTTCGGCATTTGCAATTACCATTATGTTCATGCCATTGTTCATCGGCTA
CATGCGTTACAAAAAAGAAGGTCAGGTGATTCGCGAAGAGGGTCCAAGCTGGCACGAGAAAAAGTCAGGAACACCGACTA
TGGGTGGTTTGATTTTTATTGCTGCGATCATTGTGTCGGCCATTTGGGTCGGTATTTGGCAGCATCAACTGACGCTCAGT
GTCTGGGTCTCCTTGTTTATTTTGGTGCTCTATGGACTGCTTGGCTTCTATGACGATTTTGAGAAACTGGTTCATCATCG
CAATGAAGGACTTAAGGCATGGCAAAAGCTAGCCGGTCAGATTCTCGGTGCGATTATTTTCCTAATCGCTTATTTCCATG
AAGGCTTTGATCACACGCTATGGGTGCCAATTATCGGCAATGTCAGTGCCGCTTGGTTCTACGTTCTTTTTGTCATTGTT
TGGTTGGTAGGCTTCAGTAATGCTGTTAATTTGACGGACGGCTTGGATGGCTTGGTTGCCGGTCAAACAACAATTTCATT
TGGCACTTACGCGATTATCGCGGCACATGACGGTCGGACTGATGTTTTGATCGTTTGTTTGGTGACGATCGGTGCCATGC
TTGGTTTCTTGATGTTCAATCACAAACCTGCTCAGATTTTTATGGGTGATCTTGGATCATTAGCGCTGGGTGGCATGTTG
GCAGTGGTTGCTATCTTGCTGCACCGCGAATGGTCATTGTTGTTGATTGGGATTATTTATGTCACCGAAACAGCCAGCGT
GATTTTGCAGGTGGGTTCTTTTAAGTTAACCGGCAAAAGAATCTTTCTCATGTCACCTATTCATCACCATTTTGAAATGA
AGGGCTGGTCTGAGTGGCAAATTGATCTGACGTTCTGGTTGGTCGGGCTAATTGGCAGTGGCATCTATTTAGCATTTTTT
CTTTAA

Upstream 100 bases:

>100_bases
GTGATGGTTTTGTGACCCAGCAAAGTATCGCTGCAGGCACATTGTTAGGCGATACTAGCGGGACCATTAAATTTAAACAA
CAATAGAATTGGGGATAGTC

Downstream 100 bases:

>100_bases
AAATAAGGCATAAGCAAAGAAGGATAAATCGTGAAGAATATTTCGGATTATCGCAATAAAAAAGTGCTTGTTTTGGGATT
AGCGAAAAGTGGCGTGAATG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MQLAQMLIPMVSAFAITIMFMPLFIGYMRYKKEGQVIREEGPSWHEKKSGTPTMGGLIFIAAIIVSAIWVGIWQHQLTLS
VWVSLFILVLYGLLGFYDDFEKLVHHRNEGLKAWQKLAGQILGAIIFLIAYFHEGFDHTLWVPIIGNVSAAWFYVLFVIV
WLVGFSNAVNLTDGLDGLVAGQTTISFGTYAIIAAHDGRTDVLIVCLVTIGAMLGFLMFNHKPAQIFMGDLGSLALGGML
AVVAILLHREWSLLLIGIIYVTETASVILQVGSFKLTGKRIFLMSPIHHHFEMKGWSEWQIDLTFWLVGLIGSGIYLAFF
L

Sequences:

>Translated_321_residues
MQLAQMLIPMVSAFAITIMFMPLFIGYMRYKKEGQVIREEGPSWHEKKSGTPTMGGLIFIAAIIVSAIWVGIWQHQLTLS
VWVSLFILVLYGLLGFYDDFEKLVHHRNEGLKAWQKLAGQILGAIIFLIAYFHEGFDHTLWVPIIGNVSAAWFYVLFVIV
WLVGFSNAVNLTDGLDGLVAGQTTISFGTYAIIAAHDGRTDVLIVCLVTIGAMLGFLMFNHKPAQIFMGDLGSLALGGML
AVVAILLHREWSLLLIGIIYVTETASVILQVGSFKLTGKRIFLMSPIHHHFEMKGWSEWQIDLTFWLVGLIGSGIYLAFF
L
>Mature_321_residues
MQLAQMLIPMVSAFAITIMFMPLFIGYMRYKKEGQVIREEGPSWHEKKSGTPTMGGLIFIAAIIVSAIWVGIWQHQLTLS
VWVSLFILVLYGLLGFYDDFEKLVHHRNEGLKAWQKLAGQILGAIIFLIAYFHEGFDHTLWVPIIGNVSAAWFYVLFVIV
WLVGFSNAVNLTDGLDGLVAGQTTISFGTYAIIAAHDGRTDVLIVCLVTIGAMLGFLMFNHKPAQIFMGDLGSLALGGML
AVVAILLHREWSLLLIGIIYVTETASVILQVGSFKLTGKRIFLMSPIHHHFEMKGWSEWQIDLTFWLVGLIGSGIYLAFF
L

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=327, Percent_Identity=40.9785932721713, Blast_Score=220, Evalue=9e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_LACC3 (Q039R9)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806495.1
- STRING:   Q039R9
- GeneID:   4419566
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_1270
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q039R9
- ProtClustDB:   PRK00108
- BioCyc:   LCAS321967:LSEI_1270-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 35827; Mature: 35827

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x150c0954)-; HASH(0x15981e0c)-; HASH(0x15993970)-; HASH(0x15993700)-; HASH(0x15993898)-; HASH(0x15993988)-; HASH(0x13084d18)-; HASH(0x12eec890)-; HASH(0x13084cb8)-; HASH(0x1598498c)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLAQMLIPMVSAFAITIMFMPLFIGYMRYKKEGQVIREEGPSWHEKKSGTPTMGGLIFI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHH
AAIIVSAIWVGIWQHQLTLSVWVSLFILVLYGLLGFYDDFEKLVHHRNEGLKAWQKLAGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILGAIIFLIAYFHEGFDHTLWVPIIGNVSAAWFYVLFVIVWLVGFSNAVNLTDGLDGLVA
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHC
GQTTISFGTYAIIAAHDGRTDVLIVCLVTIGAMLGFLMFNHKPAQIFMGDLGSLALGGML
CCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHH
AVVAILLHREWSLLLIGIIYVTETASVILQVGSFKLTGKRIFLMSPIHHHFEMKGWSEWQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCHHHHHCCCCCCCEE
IDLTFWLVGLIGSGIYLAFFL
HHHHHHHHHHHHCHHHHHEEH
>Mature Secondary Structure
MQLAQMLIPMVSAFAITIMFMPLFIGYMRYKKEGQVIREEGPSWHEKKSGTPTMGGLIFI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCHHHHHHH
AAIIVSAIWVGIWQHQLTLSVWVSLFILVLYGLLGFYDDFEKLVHHRNEGLKAWQKLAGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ILGAIIFLIAYFHEGFDHTLWVPIIGNVSAAWFYVLFVIVWLVGFSNAVNLTDGLDGLVA
HHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHC
GQTTISFGTYAIIAAHDGRTDVLIVCLVTIGAMLGFLMFNHKPAQIFMGDLGSLALGGML
CCEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHH
AVVAILLHREWSLLLIGIIYVTETASVILQVGSFKLTGKRIFLMSPIHHHFEMKGWSEWQ
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEECCHHHHHCCCCCCCEE
IDLTFWLVGLIGSGIYLAFFL
HHHHHHHHHHHHCHHHHHEEH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA