Click here to switch to the map view.

The map label for this gene is pbuX [H]

Identifier: 116494617

GI number: 116494617

Start: 1102448

End: 1103776

Strand: Direct

Name: pbuX [H]

Synonym: LSEI_1118

Alternate gene names: 116494617

Gene position: 1102448-1103776 (Clockwise)

Preceding gene: 116494616

Following gene: 116494618

Centisome position: 38.08

GC content: 47.93

Gene sequence:

>1329_bases
ATGAAGAATAAAGCGATTTCGAATCCTAAAGCAGCCGCATTGGGACTGCAGCATTTGCTGGCGATGTATTCCGGTTCGGT
GTTAGTACCAATTCTGATTGGTGCTTCGTTGCATTTTACGTCTGAGCAGATGACGTATCTGGTGTCGATTGATATCTTCA
TGTGTGGTATCGCAACGGCTTTGCAAGTATTTGGCAACAAGTATTTTGGGATTAAGCTGCCAGCCGTTTTGGGCTGTGCC
GTCCAAGCGGTGGCGCCTTTGATCATGATTGGCCAGAAGTTTAATTTTCAAACGATGTACGGGGCCATCATTGTTGCTGG
GTTGTTCGTTTTCCTAATCGGCGGTGCTTTTTCAAAGTTGCGTTTCTTGTTCCCGCCGTTGGTGACCGGTTCGTTGATCA
CGGTCATTGGCTTGTCGTTGATTCCGGTTGCTTTTCAAAATCTTGGCGGTGGCTCAACAACGGCCAAGGATTTTGGTAAC
ATGACCAATCTGATGGTCGGGGCCTTCACGGTACTTCTGATCTTAGCGATCAATGTCTGGGGCAAAGGTTTCCTGCATTC
AATCGCGATTTTGGTTGGCTTGATTGCTGGTACGGTGCTTGGCGGTTTTCTTGGGTTGGTTAGTTTTCAGCCGGTGATTG
AGGCAAGCTGGTTCCACGTACCGACGCCATTTTACTTTGGGGTACCGCAGTTTGAGTGGAGCTCGATTGTCACGATGATT
TTAATTTCGATGACATCCATGGTTGAAAGTACTGGCGTTTTCTTCGCGTTAGGGGACATTGTCGGCCGTAAAATTGAAGC
AGACGACCTGAAGCGCGGCTATCGCGCCGAAGGGTTAGCCGTGATGCTTGGCGGGTTGTTCAATACCTTCCCATACACCA
CTTTCTCGCAAAACGTTGGGTTGGTTCAATTGTCAGGGATTAAGACCCGCAAGCCAGTCATTTTTTCCGCGATTTTCTTA
GTGATTCTTGGTTTACTGCCAAAAATTGGCGCTTTAGCCACGATTATTCCAGCACCGGTGCTTGGCGGGGCCATGCTGGT
GATGTTCGGCATGGTGGCTGTGCAAGGCATTCGGATGTTGCAACAGGTTGATTTTGACAATGATAAGAATTTGCTTGTCG
CTGCCATTTCGATCGGTCTGGGACTTGGCGTGACAGTTCAGCCACATATCGTTCAGTTTTTGCCAAAAACAATTCAATTG
CTGTTTGGGTCAGGCATTTTAATGACCAGCTTGAGTGCGGTTTTGCTGAACTGGCTGTTCAATTCGCCACGTCGGACGCA
AGAAATGTCGGTTGATGAAGGCTTGAACGAACGCGATTCAGATAAATAA

Upstream 100 bases:

>100_bases
CAAGTTGCTTGATGAAAAGCACGTTCGCGTCGAATCATTGGCGCGCATCAATGCATTTGAAAATGGTCAGGTCATCTTTG
CGCCGGAGGATTAGCCCACG

Downstream 100 bases:

>100_bases
AGTCAAAGCGAGGAACAGATGTGACGCAATTTATTAGTCCAGGTGCAACGATTGGCATTATCGGCGGCGGTGTAACTGCT
TTTCAAATGGCGAATACGGC

Product: xanthine/uracil permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MKNKAISNPKAAALGLQHLLAMYSGSVLVPILIGASLHFTSEQMTYLVSIDIFMCGIATALQVFGNKYFGIKLPAVLGCA
VQAVAPLIMIGQKFNFQTMYGAIIVAGLFVFLIGGAFSKLRFLFPPLVTGSLITVIGLSLIPVAFQNLGGGSTTAKDFGN
MTNLMVGAFTVLLILAINVWGKGFLHSIAILVGLIAGTVLGGFLGLVSFQPVIEASWFHVPTPFYFGVPQFEWSSIVTMI
LISMTSMVESTGVFFALGDIVGRKIEADDLKRGYRAEGLAVMLGGLFNTFPYTTFSQNVGLVQLSGIKTRKPVIFSAIFL
VILGLLPKIGALATIIPAPVLGGAMLVMFGMVAVQGIRMLQQVDFDNDKNLLVAAISIGLGLGVTVQPHIVQFLPKTIQL
LFGSGILMTSLSAVLLNWLFNSPRRTQEMSVDEGLNERDSDK

Sequences:

>Translated_442_residues
MKNKAISNPKAAALGLQHLLAMYSGSVLVPILIGASLHFTSEQMTYLVSIDIFMCGIATALQVFGNKYFGIKLPAVLGCA
VQAVAPLIMIGQKFNFQTMYGAIIVAGLFVFLIGGAFSKLRFLFPPLVTGSLITVIGLSLIPVAFQNLGGGSTTAKDFGN
MTNLMVGAFTVLLILAINVWGKGFLHSIAILVGLIAGTVLGGFLGLVSFQPVIEASWFHVPTPFYFGVPQFEWSSIVTMI
LISMTSMVESTGVFFALGDIVGRKIEADDLKRGYRAEGLAVMLGGLFNTFPYTTFSQNVGLVQLSGIKTRKPVIFSAIFL
VILGLLPKIGALATIIPAPVLGGAMLVMFGMVAVQGIRMLQQVDFDNDKNLLVAAISIGLGLGVTVQPHIVQFLPKTIQL
LFGSGILMTSLSAVLLNWLFNSPRRTQEMSVDEGLNERDSDK
>Mature_442_residues
MKNKAISNPKAAALGLQHLLAMYSGSVLVPILIGASLHFTSEQMTYLVSIDIFMCGIATALQVFGNKYFGIKLPAVLGCA
VQAVAPLIMIGQKFNFQTMYGAIIVAGLFVFLIGGAFSKLRFLFPPLVTGSLITVIGLSLIPVAFQNLGGGSTTAKDFGN
MTNLMVGAFTVLLILAINVWGKGFLHSIAILVGLIAGTVLGGFLGLVSFQPVIEASWFHVPTPFYFGVPQFEWSSIVTMI
LISMTSMVESTGVFFALGDIVGRKIEADDLKRGYRAEGLAVMLGGLFNTFPYTTFSQNVGLVQLSGIKTRKPVIFSAIFL
VILGLLPKIGALATIIPAPVLGGAMLVMFGMVAVQGIRMLQQVDFDNDKNLLVAAISIGLGLGVTVQPHIVQFLPKTIQL
LFGSGILMTSLSAVLLNWLFNSPRRTQEMSVDEGLNERDSDK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=433, Percent_Identity=24.7113163972286, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI44680143, Length=437, Percent_Identity=24.4851258581236, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI44680148, Length=170, Percent_Identity=31.7647058823529, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI40316845, Length=170, Percent_Identity=31.7647058823529, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI87082181, Length=441, Percent_Identity=40.5895691609977, Blast_Score=314, Evalue=7e-87,
Organism=Escherichia coli, GI1790087, Length=434, Percent_Identity=31.5668202764977, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87082178, Length=431, Percent_Identity=32.2505800464037, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788843, Length=377, Percent_Identity=29.1777188328912, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI87081818, Length=394, Percent_Identity=31.7258883248731, Blast_Score=147, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI17558856, Length=178, Percent_Identity=33.7078651685393, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17541904, Length=173, Percent_Identity=30.0578034682081, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=178, Percent_Identity=25.2808988764045, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17542260, Length=202, Percent_Identity=24.7524752475248, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71993493, Length=202, Percent_Identity=24.2574257425743, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21356175, Length=424, Percent_Identity=25.7075471698113, Blast_Score=98, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 47250; Mature: 47250

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCHHHCCHHCCCCCCCCCC
>Mature Secondary Structure
MKNKAISNPKAAALGLQHLLAMYSGSVLVPILIGASLHFTSEQMTYLVSIDIFMCGIATA
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCEECHHHHEEHHHHHHHHHHHHHH
LQVFGNKYFGIKLPAVLGCAVQAVAPLIMIGQKFNFQTMYGAIIVAGLFVFLIGGAFSKL
HHHHCCCCCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLFPPLVTGSLITVIGLSLIPVAFQNLGGGSTTAKDFGNMTNLMVGAFTVLLILAINVW
HHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
GKGFLHSIAILVGLIAGTVLGGFLGLVSFQPVIEASWFHVPTPFYFGVPQFEWSSIVTMI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCEECCCCCCCCCCCCCHHHHHHHH
LISMTSMVESTGVFFALGDIVGRKIEADDLKRGYRAEGLAVMLGGLFNTFPYTTFSQNVG
HHHHHHHHHHCCHHEEHHHHHCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCCCEECCCCC
LVQLSGIKTRKPVIFSAIFLVILGLLPKIGALATIIPAPVLGGAMLVMFGMVAVQGIRML
EEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQVDFDNDKNLLVAAISIGLGLGVTVQPHIVQFLPKTIQLLFGSGILMTSLSAVLLNWLF
HHCCCCCCCCCEEEEEHHHCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
NSPRRTQEMSVDEGLNERDSDK
CCCCCHHHCCHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]