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The map label for this gene is mvk [H]

Identifier: 116494593

GI number: 116494593

Start: 1076338

End: 1077411

Strand: Direct

Name: mvk [H]

Synonym: LSEI_1092

Alternate gene names: 116494593

Gene position: 1076338-1077411 (Clockwise)

Preceding gene: 116494590

Following gene: 116494594

Centisome position: 37.18

GC content: 49.26

Gene sequence:

>1074_bases
GTGATAACAGCGCAGGCGCCAGGCAAGCTTTATGTTGCCGGTGAATACGCGGTGGTTGAAACTGGCTTCCCCGCAATCAT
TGTGGCGTTAGATCAATTCGTCACCGTCACGGTTGAGGCAACGAAGCATTTCGGCAGTATCGTGTCCGAGCAGTATCAGG
AAAACTCGCTGTATTGGCAGCGTCAAGGCGACGAGATGGTCTTTGATAATCGGGATAATCCGTTTCATTACATTCTCTCG
GCAATCAAATTGACTGAACAATACGCTCGAGAGTTAGACAAACCGCTCGCGTTATATAAGCTCTATATTGATTCGCAGCT
GGACGCCAAGGATGGGAAGAAGTATGGCCTAGGCAGTTCAGCAGCGGTGACTGTTGCCACCATTAAGGCATTAGCCAAGT
TTTACGACTTGAAAATGTCGAAGGATCAGATCTACAAGCTGGCTGCCATTGCCCATCTAGACGTACAGGGCAATGGCTCT
TTAGGTGACATAGCAGCATCTGTCTATGGGGGATGGATTGCCTACCGTTCGTTTGATAAAGCGTGGTTGGCGGCAGCACG
AAATCAGATGTCACTAGCCGACCTGATTAACACTGACTGGCCGGACTTGTCGATTGAGCTGCTTACAGCTCCGGCTGACA
TGCAATTGCTGGTTGGCTGGACAGGTTCACCAGCTTCAACTTCTCAGTTGGTCGACAAAATTACGCTGGCCAAAGCGAAG
AAGCCACAACTTTACCGTGACTTCTTGACTGCTAGCCGTGAAACCTTAGAAAAATTAATTGATGGGTTCCGCAACCGTTC
GTTGAGCAGTATTCAAGCTGGTATTCGCCGCAACCGTGAGTTGTTGGATGAATTAGCTCATTTCTCGGGGGTTGCGATCC
AAACACCAGCATTGCGTCAGCTTGTTGAACTAGCTGAACAAGCAGGCGGCGCGGCAAAATCTTCAGGTGCCGGTGGCGGT
GATTGCGGGATCGTCTTGATTGATTCTCATCAAGCCATCAAGCCGCTACTTGCGGCTTGGCGCGACCATCATATCGAGCC
TCTGAAATTTAATGTGCATGAAATTAATGATTAA

Upstream 100 bases:

>100_bases
TTTTGTTGGTTTACGTCACTGTGACGTAAGGTCAGCTATACTTACAGTCGGATTCCCTCTGGGGTCCTATATAAATGAAA
AATTGAAGGGTTCTGATTGT

Downstream 100 bases:

>100_bases
AGACAACTCGATTGCTAATGGTGATCGAGTTTTTTATTTTCAGCGATGAAAATGTGAATTCTTTGTTAGAATTCAGGATT
TCCAATACTTTTCGCAAGCG

Product: phosphomevalonate kinase

Products: NA

Alternate protein names: MK [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MITAQAPGKLYVAGEYAVVETGFPAIIVALDQFVTVTVEATKHFGSIVSEQYQENSLYWQRQGDEMVFDNRDNPFHYILS
AIKLTEQYARELDKPLALYKLYIDSQLDAKDGKKYGLGSSAAVTVATIKALAKFYDLKMSKDQIYKLAAIAHLDVQGNGS
LGDIAASVYGGWIAYRSFDKAWLAAARNQMSLADLINTDWPDLSIELLTAPADMQLLVGWTGSPASTSQLVDKITLAKAK
KPQLYRDFLTASRETLEKLIDGFRNRSLSSIQAGIRRNRELLDELAHFSGVAIQTPALRQLVELAEQAGGAAKSSGAGGG
DCGIVLIDSHQAIKPLLAAWRDHHIEPLKFNVHEIND

Sequences:

>Translated_357_residues
MITAQAPGKLYVAGEYAVVETGFPAIIVALDQFVTVTVEATKHFGSIVSEQYQENSLYWQRQGDEMVFDNRDNPFHYILS
AIKLTEQYARELDKPLALYKLYIDSQLDAKDGKKYGLGSSAAVTVATIKALAKFYDLKMSKDQIYKLAAIAHLDVQGNGS
LGDIAASVYGGWIAYRSFDKAWLAAARNQMSLADLINTDWPDLSIELLTAPADMQLLVGWTGSPASTSQLVDKITLAKAK
KPQLYRDFLTASRETLEKLIDGFRNRSLSSIQAGIRRNRELLDELAHFSGVAIQTPALRQLVELAEQAGGAAKSSGAGGG
DCGIVLIDSHQAIKPLLAAWRDHHIEPLKFNVHEIND
>Mature_357_residues
MITAQAPGKLYVAGEYAVVETGFPAIIVALDQFVTVTVEATKHFGSIVSEQYQENSLYWQRQGDEMVFDNRDNPFHYILS
AIKLTEQYARELDKPLALYKLYIDSQLDAKDGKKYGLGSSAAVTVATIKALAKFYDLKMSKDQIYKLAAIAHLDVQGNGS
LGDIAASVYGGWIAYRSFDKAWLAAARNQMSLADLINTDWPDLSIELLTAPADMQLLVGWTGSPASTSQLVDKITLAKAK
KPQLYRDFLTASRETLEKLIDGFRNRSLSSIQAGIRRNRELLDELAHFSGVAIQTPALRQLVELAEQAGGAAKSSGAGGG
DCGIVLIDSHQAIKPLLAAWRDHHIEPLKFNVHEIND

Specific function: Unknown

COG id: COG1577

COG function: function code I; Mevalonate kinase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Mevalonate kinase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006205
- InterPro:   IPR006206
- InterPro:   IPR022937
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.36 [H]

Molecular weight: Translated: 39189; Mature: 39189

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITAQAPGKLYVAGEYAVVETGFPAIIVALDQFVTVTVEATKHFGSIVSEQYQENSLYWQ
CCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCEEEE
RQGDEMVFDNRDNPFHYILSAIKLTEQYARELDKPLALYKLYIDSQLDAKDGKKYGLGSS
ECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHEEECCCCCCCCCCCCCCCCC
AAVTVATIKALAKFYDLKMSKDQIYKLAAIAHLDVQGNGSLGDIAASVYGGWIAYRSFDK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AWLAAARNQMSLADLINTDWPDLSIELLTAPADMQLLVGWTGSPASTSQLVDKITLAKAK
HHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCC
KPQLYRDFLTASRETLEKLIDGFRNRSLSSIQAGIRRNRELLDELAHFSGVAIQTPALRQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECHHHHH
LVELAEQAGGAAKSSGAGGGDCGIVLIDSHQAIKPLLAAWRDHHIEPLKFNVHEIND
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MITAQAPGKLYVAGEYAVVETGFPAIIVALDQFVTVTVEATKHFGSIVSEQYQENSLYWQ
CCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHEEEEEHHHHHHHHHHHHHHHCCCEEEE
RQGDEMVFDNRDNPFHYILSAIKLTEQYARELDKPLALYKLYIDSQLDAKDGKKYGLGSS
ECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHEEECCCCCCCCCCCCCCCCC
AAVTVATIKALAKFYDLKMSKDQIYKLAAIAHLDVQGNGSLGDIAASVYGGWIAYRSFDK
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
AWLAAARNQMSLADLINTDWPDLSIELLTAPADMQLLVGWTGSPASTSQLVDKITLAKAK
HHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCC
KPQLYRDFLTASRETLEKLIDGFRNRSLSSIQAGIRRNRELLDELAHFSGVAIQTPALRQ
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHCCCEEECHHHHH
LVELAEQAGGAAKSSGAGGGDCGIVLIDSHQAIKPLLAAWRDHHIEPLKFNVHEIND
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 10497066 [H]