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The map label for this gene is map [H]

Identifier: 116494589

GI number: 116494589

Start: 1073095

End: 1073919

Strand: Direct

Name: map [H]

Synonym: LSEI_1088

Alternate gene names: 116494589

Gene position: 1073095-1073919 (Clockwise)

Preceding gene: 116494587

Following gene: 116494590

Centisome position: 37.06

GC content: 48.85

Gene sequence:

>825_bases
TTGATCACGATCAAATCAGCACGAGAAATTAAAGGCATGGCAAAGTCCGGTGCCATTTTGGCAGGTATGCACCTTGGCCT
GCGTGATATTATCAAACCAGGTATCTCAAGCTGGGAAATTGAAAAGTTCGCCAAAGAATTCTTTGAATCTCATGGCGCCA
AGGCCGAACAAGTCGGTTTTGAAGGTTATAAGTATGTGACTTGTGTCAGCATCAACGATGAAGTTGCGCATGCGGTTCCG
CGTAAGGGCCTGAAACTCAAAGATGGCGATGTTGTCAGTGTTGACACGGTTGTCAGCTGGAATGGCTACTTCAGCGATTC
TTGCTGGACGTACGGCGTTGGCAAGGTGTCAGAAGCTGACCAGAAGCTGATGGACGTTACCAAAAAGTCCCTTTACTTAG
GGATTGATGAAGCACTTGTTGGCAATCGGATCGGTGACATTGGCGCTGCTATTCAGACTTACACCGAAGATGATAACGGC
TACGGCGATGTCCGTGAGCTTATTGGCCACGGCATTCAGCCAACCATGCACGAAAGTCCTAATGTGCCGCATTATGGCGT
GCCAGGTCATGGTTTACGACTAAAAGCCGGCATGACCATTACGATCGAGCCGATGATCACTGAAGGTACTTGGAAGATCA
AGGGCAAGCAAGTCCCAGGCGATACTTGGGAATACTACGTCACTGCTGACGGCAGCAAGTGTGCCCAGTACGAGCACACG
CTGGTCATCACAGATAACGGCCCGAAGATTTTGACTTCTCAAGGCGATGCCATTGACGAGAAGTACAAGTTAACCGAGGC
CGATCTTAAAACACTTCCTGAATAA

Upstream 100 bases:

>100_bases
CACCGACACTGTTTAACCAACCATTCTCAGACTTCTGTTGTTTATCCCTGATTAATGCTACACTAATTGCGAGCTAAACT
TGTATTGGAGGCAGAAAAGC

Downstream 100 bases:

>100_bases
TAGCGGCCAACGCGATCATTCAGAAACAATAGGGTACAAAAAAACGGGGTGGCGACGATGATTGCTCACCCCGTTTTGTA
TGTGAGCGCGAATCAGCCCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MITIKSAREIKGMAKSGAILAGMHLGLRDIIKPGISSWEIEKFAKEFFESHGAKAEQVGFEGYKYVTCVSINDEVAHAVP
RKGLKLKDGDVVSVDTVVSWNGYFSDSCWTYGVGKVSEADQKLMDVTKKSLYLGIDEALVGNRIGDIGAAIQTYTEDDNG
YGDVRELIGHGIQPTMHESPNVPHYGVPGHGLRLKAGMTITIEPMITEGTWKIKGKQVPGDTWEYYVTADGSKCAQYEHT
LVITDNGPKILTSQGDAIDEKYKLTEADLKTLPE

Sequences:

>Translated_274_residues
MITIKSAREIKGMAKSGAILAGMHLGLRDIIKPGISSWEIEKFAKEFFESHGAKAEQVGFEGYKYVTCVSINDEVAHAVP
RKGLKLKDGDVVSVDTVVSWNGYFSDSCWTYGVGKVSEADQKLMDVTKKSLYLGIDEALVGNRIGDIGAAIQTYTEDDNG
YGDVRELIGHGIQPTMHESPNVPHYGVPGHGLRLKAGMTITIEPMITEGTWKIKGKQVPGDTWEYYVTADGSKCAQYEHT
LVITDNGPKILTSQGDAIDEKYKLTEADLKTLPE
>Mature_274_residues
MITIKSAREIKGMAKSGAILAGMHLGLRDIIKPGISSWEIEKFAKEFFESHGAKAEQVGFEGYKYVTCVSINDEVAHAVP
RKGLKLKDGDVVSVDTVVSWNGYFSDSCWTYGVGKVSEADQKLMDVTKKSLYLGIDEALVGNRIGDIGAAIQTYTEDDNG
YGDVRELIGHGIQPTMHESPNVPHYGVPGHGLRLKAGMTITIEPMITEGTWKIKGKQVPGDTWEYYVTADGSKCAQYEHT
LVITDNGPKILTSQGDAIDEKYKLTEADLKTLPE

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=256, Percent_Identity=33.59375, Blast_Score=141, Evalue=5e-34,
Organism=Homo sapiens, GI40385867, Length=255, Percent_Identity=32.156862745098, Blast_Score=127, Evalue=8e-30,
Organism=Escherichia coli, GI1786364, Length=257, Percent_Identity=38.1322957198444, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71996291, Length=226, Percent_Identity=34.9557522123894, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=32.0158102766798, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24583427, Length=251, Percent_Identity=33.0677290836653, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21355531, Length=256, Percent_Identity=31.640625, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29974; Mature: 29974

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIKSAREIKGMAKSGAILAGMHLGLRDIIKPGISSWEIEKFAKEFFESHGAKAEQVGF
CEEECCHHHHHHHHHCCCEEEEHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCC
EGYKYVTCVSINDEVAHAVPRKGLKLKDGDVVSVDTVVSWNGYFSDSCWTYGVGKVSEAD
CCEEEEEEEECCHHHHHHHCCCCCEECCCCEEEEEEEEEECCEECCCCEEECCCCCCHHH
QKLMDVTKKSLYLGIDEALVGNRIGDIGAAIQTYTEDDNGYGDVRELIGHGIQPTMHESP
HHHHHHHHHHHEECCHHHHHCCCCHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCCC
NVPHYGVPGHGLRLKAGMTITIEPMITEGTWKIKGKQVPGDTWEYYVTADGSKCAQYEHT
CCCCCCCCCCCEEEECCCEEEEEEEEECCEEEEECCCCCCCCEEEEEEECCCCCCCEEEE
LVITDNGPKILTSQGDAIDEKYKLTEADLKTLPE
EEEECCCCEEEECCCCCCCHHHEECHHHHHHCCC
>Mature Secondary Structure
MITIKSAREIKGMAKSGAILAGMHLGLRDIIKPGISSWEIEKFAKEFFESHGAKAEQVGF
CEEECCHHHHHHHHHCCCEEEEHHCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHCCC
EGYKYVTCVSINDEVAHAVPRKGLKLKDGDVVSVDTVVSWNGYFSDSCWTYGVGKVSEAD
CCEEEEEEEECCHHHHHHHCCCCCEECCCCEEEEEEEEEECCEECCCCEEECCCCCCHHH
QKLMDVTKKSLYLGIDEALVGNRIGDIGAAIQTYTEDDNGYGDVRELIGHGIQPTMHESP
HHHHHHHHHHHEECCHHHHHCCCCHHHHHHHEEEECCCCCCHHHHHHHHCCCCCCCCCCC
NVPHYGVPGHGLRLKAGMTITIEPMITEGTWKIKGKQVPGDTWEYYVTADGSKCAQYEHT
CCCCCCCCCCCEEEECCCEEEEEEEEECCEEEEECCCCCCCCEEEEEEECCCCCCCEEEE
LVITDNGPKILTSQGDAIDEKYKLTEADLKTLPE
EEEECCCCEEEECCCCCCCHHHEECHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]