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The map label for this gene is yclK [H]

Identifier: 116494544

GI number: 116494544

Start: 1026088

End: 1027563

Strand: Direct

Name: yclK [H]

Synonym: LSEI_1042

Alternate gene names: 116494544

Gene position: 1026088-1027563 (Clockwise)

Preceding gene: 116494543

Following gene: 116494545

Centisome position: 35.44

GC content: 44.31

Gene sequence:

>1476_bases
ATGAAGATGCTTTACCAGCAGCTGATTGGCTTTTTCTCAGTCATTATGGTGACCTTAGTGATTGTCTCGATTCTGTTTAT
TCGGTCTACCACGAACACGGTTTGGGAAAATGGCTTTAAACAGTTAGAGCAATACACGGATGTTTTAAAAAATAATGCGG
TTGATGAAAATACTTACGTCATCAATGCCAGATTTATTCAAAATGCTGAAGAGATTTTAAGCGATCAACACGTGCATTTT
GTTATTTATGATGCCAATAACGTTGCTAAATATCCTGTGTCCCAAAAAGGTCAGATGCCAGCGATCAAGGCAAGCTATTG
GAAAAAGCTAAAGCAAGGGGCGGCTGTTGCCGTCCCGGAGATGATGACGAATCCAATCAGCGGCCATGCACAAAGCATGA
CGATCTATTATCAACCGGTTTTTCTGAGTGAAAAATTACTCTTTGTGATTGCCGCCTTTGCACCAGTTGAGCAAATTCAA
AGTTCACTTAGCAAAACTGAGCATAATTTGCTTATCGCGTTCGTACTGTCAACGCTTGCGGCGTTCATCATCAGTTATTT
CATTGCGTCCTATCAGGTGCGGCGGATTAATCAATTACGGCGCGCAACGCATCAAGTGGCAGAAGGCAATTATGATGTTG
AAGTAAAAATTAAAAGCCGCAGTCATGATGAAGTTGCGGAACTGGCCGATGATTTTCGCGACATGGTGACCTCACTGAAA
GCTAGTCAGCAAGAAATTCAACGGCAGGAAGATCGGCGCCGGCAGTTTATGGCTGATGCGGCTCATGAAATGCGGACCCC
GCTGACAACAATCAATGGCTTACTTGAAGGCTTGGCCTATGATGCCATCCCTGAAGAAAGTAAGGGAAAGAGTATCGAAT
TAATGCGGAACGAAACGAACCGCTTGATTCGGCTTGTCAACGAGAACCTTGATTATGAAAAAATTCGGACAAATCAAATT
TTGCTCAGCAAACAGACGTTTAACGCGCGCACGGATCTTGATAACATCGCGGAACAGCTGGCGCAGAAATCCGAAGAGGC
TGGTGATAAGATCACAATTGATGCCCCAGCAGATCTGCCGACATATGCTGATCATGATCGGTTCGTTCAGATTCTTTTCA
ACATTGTTCAAAATGCGGTCCAATTCACTAAAAATGGTCAAATCACTATAAAAGCAAAAGTGGGGTATCATCAGACTGAA
TTTGCCATTAGCGATACTGGTATTGGTATGTCCAAGGATCAGATGAAGAATATTTGGGAGCGGTATTACAAGGCCGATCC
ATCACGTAAAAACACCAAATATGGTGAGTCCGGTTTGGGCATGGCGATTGTGCATCAGTTAATGGGACAACACGGTGGCA
CCATTCATGTTGACTCGACCCTAGGCAAAGGTACAACCTTTACGTTGACCTTCCCAGATGAAGCGACAGCGCCTAAGCAA
AAGCAGCCAGGAGCCGATCAGCAGACCTCATCATGA

Upstream 100 bases:

>100_bases
ATATTAAAAAACTACGCCAAAAAGTCGAAAAAGTCGGTCCGCAAATTATTCAAACTGTTTGGGGCGTCGGCTACAAGTTT
GATGATTCGGGGCTTGATCG

Downstream 100 bases:

>100_bases
AGAAGAGACAAGTTCAAGCAGCGTCAAGATACACCAGAAAAAGGCCATTAGGACCGTTCGAAATGATCATCACGCTCACG
TGAATTGCCTGATTTTGTTA

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MKMLYQQLIGFFSVIMVTLVIVSILFIRSTTNTVWENGFKQLEQYTDVLKNNAVDENTYVINARFIQNAEEILSDQHVHF
VIYDANNVAKYPVSQKGQMPAIKASYWKKLKQGAAVAVPEMMTNPISGHAQSMTIYYQPVFLSEKLLFVIAAFAPVEQIQ
SSLSKTEHNLLIAFVLSTLAAFIISYFIASYQVRRINQLRRATHQVAEGNYDVEVKIKSRSHDEVAELADDFRDMVTSLK
ASQQEIQRQEDRRRQFMADAAHEMRTPLTTINGLLEGLAYDAIPEESKGKSIELMRNETNRLIRLVNENLDYEKIRTNQI
LLSKQTFNARTDLDNIAEQLAQKSEEAGDKITIDAPADLPTYADHDRFVQILFNIVQNAVQFTKNGQITIKAKVGYHQTE
FAISDTGIGMSKDQMKNIWERYYKADPSRKNTKYGESGLGMAIVHQLMGQHGGTIHVDSTLGKGTTFTLTFPDEATAPKQ
KQPGADQQTSS

Sequences:

>Translated_491_residues
MKMLYQQLIGFFSVIMVTLVIVSILFIRSTTNTVWENGFKQLEQYTDVLKNNAVDENTYVINARFIQNAEEILSDQHVHF
VIYDANNVAKYPVSQKGQMPAIKASYWKKLKQGAAVAVPEMMTNPISGHAQSMTIYYQPVFLSEKLLFVIAAFAPVEQIQ
SSLSKTEHNLLIAFVLSTLAAFIISYFIASYQVRRINQLRRATHQVAEGNYDVEVKIKSRSHDEVAELADDFRDMVTSLK
ASQQEIQRQEDRRRQFMADAAHEMRTPLTTINGLLEGLAYDAIPEESKGKSIELMRNETNRLIRLVNENLDYEKIRTNQI
LLSKQTFNARTDLDNIAEQLAQKSEEAGDKITIDAPADLPTYADHDRFVQILFNIVQNAVQFTKNGQITIKAKVGYHQTE
FAISDTGIGMSKDQMKNIWERYYKADPSRKNTKYGESGLGMAIVHQLMGQHGGTIHVDSTLGKGTTFTLTFPDEATAPKQ
KQPGADQQTSS
>Mature_491_residues
MKMLYQQLIGFFSVIMVTLVIVSILFIRSTTNTVWENGFKQLEQYTDVLKNNAVDENTYVINARFIQNAEEILSDQHVHF
VIYDANNVAKYPVSQKGQMPAIKASYWKKLKQGAAVAVPEMMTNPISGHAQSMTIYYQPVFLSEKLLFVIAAFAPVEQIQ
SSLSKTEHNLLIAFVLSTLAAFIISYFIASYQVRRINQLRRATHQVAEGNYDVEVKIKSRSHDEVAELADDFRDMVTSLK
ASQQEIQRQEDRRRQFMADAAHEMRTPLTTINGLLEGLAYDAIPEESKGKSIELMRNETNRLIRLVNENLDYEKIRTNQI
LLSKQTFNARTDLDNIAEQLAQKSEEAGDKITIDAPADLPTYADHDRFVQILFNIVQNAVQFTKNGQITIKAKVGYHQTE
FAISDTGIGMSKDQMKNIWERYYKADPSRKNTKYGESGLGMAIVHQLMGQHGGTIHVDSTLGKGTTFTLTFPDEATAPKQ
KQPGADQQTSS

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=281, Percent_Identity=28.1138790035587, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1788713, Length=251, Percent_Identity=28.6852589641434, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1788393, Length=290, Percent_Identity=28.2758620689655, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789149, Length=255, Percent_Identity=28.6274509803922, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790436, Length=245, Percent_Identity=31.8367346938775, Blast_Score=112, Evalue=7e-26,
Organism=Escherichia coli, GI48994928, Length=241, Percent_Identity=29.045643153527, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=26.4462809917355, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081816, Length=356, Percent_Identity=23.5955056179775, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=27.9569892473118, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786783, Length=318, Percent_Identity=25.4716981132075, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786912, Length=250, Percent_Identity=26.4, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788549, Length=292, Percent_Identity=26.027397260274, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=339, Percent_Identity=21.2389380530973, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787894, Length=314, Percent_Identity=22.9299363057325, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790861, Length=345, Percent_Identity=23.4782608695652, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1789808, Length=305, Percent_Identity=24.2622950819672, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=333, Percent_Identity=21.9219219219219, Blast_Score=65, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55497; Mature: 55497

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMLYQQLIGFFSVIMVTLVIVSILFIRSTTNTVWENGFKQLEQYTDVLKNNAVDENTYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
INARFIQNAEEILSDQHVHFVIYDANNVAKYPVSQKGQMPAIKASYWKKLKQGAAVAVPE
EEHHHHHCHHHHHCCCCEEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEECHH
MMTNPISGHAQSMTIYYQPVFLSEKLLFVIAAFAPVEQIQSSLSKTEHNLLIAFVLSTLA
HHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFIISYFIASYQVRRINQLRRATHQVAEGNYDVEVKIKSRSHDEVAELADDFRDMVTSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ASQQEIQRQEDRRRQFMADAAHEMRTPLTTINGLLEGLAYDAIPEESKGKSIELMRNETN
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHH
RLIRLVNENLDYEKIRTNQILLSKQTFNARTDLDNIAEQLAQKSEEAGDKITIDAPADLP
HHHHHHHCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
TYADHDRFVQILFNIVQNAVQFTKNGQITIKAKVGYHQTEFAISDTGIGMSKDQMKNIWE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHH
RYYKADPSRKNTKYGESGLGMAIVHQLMGQHGGTIHVDSTLGKGTTFTLTFPDEATAPKQ
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
KQPGADQQTSS
CCCCCCCCCCC
>Mature Secondary Structure
MKMLYQQLIGFFSVIMVTLVIVSILFIRSTTNTVWENGFKQLEQYTDVLKNNAVDENTYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
INARFIQNAEEILSDQHVHFVIYDANNVAKYPVSQKGQMPAIKASYWKKLKQGAAVAVPE
EEHHHHHCHHHHHCCCCEEEEEEECCCCEECCCCCCCCCCCHHHHHHHHHHCCCCEECHH
MMTNPISGHAQSMTIYYQPVFLSEKLLFVIAAFAPVEQIQSSLSKTEHNLLIAFVLSTLA
HHCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFIISYFIASYQVRRINQLRRATHQVAEGNYDVEVKIKSRSHDEVAELADDFRDMVTSLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ASQQEIQRQEDRRRQFMADAAHEMRTPLTTINGLLEGLAYDAIPEESKGKSIELMRNETN
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHH
RLIRLVNENLDYEKIRTNQILLSKQTFNARTDLDNIAEQLAQKSEEAGDKITIDAPADLP
HHHHHHHCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCC
TYADHDRFVQILFNIVQNAVQFTKNGQITIKAKVGYHQTEFAISDTGIGMSKDQMKNIWE
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHH
RYYKADPSRKNTKYGESGLGMAIVHQLMGQHGGTIHVDSTLGKGTTFTLTFPDEATAPKQ
HHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCC
KQPGADQQTSS
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]