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The map label for this gene is ydgF [H]

Identifier: 116494534

GI number: 116494534

Start: 1016132

End: 1017520

Strand: Direct

Name: ydgF [H]

Synonym: LSEI_1031

Alternate gene names: 116494534

Gene position: 1016132-1017520 (Clockwise)

Preceding gene: 116494533

Following gene: 116494535

Centisome position: 35.1

GC content: 46.22

Gene sequence:

>1389_bases
ATGCAAGCCAAGAAAGATGACAAGCCCGAACTAGCGCGTCACTTGAAAAGCCGACACGTGCAACTGATTGCGATTGGCGG
AACGATTGGGACAGGCCTTTTTCTAGGATCTGGTCAATCCATCCACACCGCTGGGCCTTCCATCTTACTAGCTTATCTCA
TCACAGGTGGGATTTGTTTTCTAATTATGCGGGCATTGGGTGAACTGCTAATGTCCGATGTGAATTCACATACGTTTATT
GATTTTATTAGCCAATATATGGGAAAAGATGCTGGTTGGGTGACTGGCTGGACCTACTGGATTTGTTGGGTGGCGGTCGC
CATGGCCGAAGTGACAGCGATCGGTCTCTACATTCGATTCTGGTTGCCAGGAGTTCCTCAATGGCTGCCGGGCCTGATTG
CACTGGCAGTGTTGCTGCTAATGAATCTGGTTAGCGTTGGGCTGTTTGGTGAGGCGGAGTTCTGGTTTGCCTTGATTAAG
ATCGTGGCCATTATTGGGTTAATTGCGCTCGGCGTCTTTATGCTGTTTGTGCACTATAAAACGCCTGTTGGCTATGCCAG
CCTAAGCAACCTCGTTAATGACGGTGGCTTTTTTCCAAAAGGAATGAGCGGTTTTCTAATGTCGCTGCAAATGGTGGTGT
TTAGTTTCGTCGGGATCGAAATGGTCGGGTTGACTGCTAGTGAAACCAAAGATCCGCATAAAGTGATTCCAGAAGCGATC
AATGAGATTCCGATGCGGATTTTACTGTTTTACATTGGCGCATTGTTTGTCATTATGTGCATCTACCCATGGCGCGATGT
GTCACCCGTTAATAGTCCTTTTGTCGAGGTTTTTCGTAATGTCGGGATTCCAGCCGCCGCCGACATTATTAATTTTGTGG
TGTTGACAGCGGCAGCTTCTGCCTGCAATTCATCTATTTTCAGCACTGGCAGATTACTCTTCTCACTGACATTAACTGGT
AAAAGCAAGTCCGCGTGTTGGACTGCTAAACTGTCTCGGCGACAAGTGCCAGCGCGGGCCATTATGATTTCAACAGGAGC
CATTGCTGTGGCTGTCATTTTGAACCTTTTTTTACCGGAGTCTGTTTTCGCACTGGTTTCAAGTGTTGCTACAATCAGCT
TTTTATTTGTTTGGGGCATGATTGTCCTCGCTCACTTGCGCTATAAGAAACAACATCCGCGCGGAACGGATTTTCCAATG
CCATTTTATCCTTATTCAAATTATCTTATTTTAGCGTTTTTAGGGCTGACTGCTGTGATTATGATTTTTGATCGGGCAAT
GCTGTCCGCATTGATCTTTGCGGTTATCTGGATTGCAACGTTATTCACCTTGCGCCGATTGCACGCTGATCATAAAGCTC
ACGAAGACAAAACAAAAGACGGTATTTAA

Upstream 100 bases:

>100_bases
CTGATACGATTCAAAGAGCTGGGATATTTCTGCATTTGCAAAGACAGAACCTGTTATGTCCTGATTTTTTTCGGGTTAAC
ACGTTTATAGGAGGATGAGC

Downstream 100 bases:

>100_bases
TCTGATTGAGTGAGCACTCGCTTCAATAACGGGAAAGATACTTGAGGACTCATATAAAAGTAAAAATAATTTTGAGTGTT
CACTCAAAATTATTTATTTT

Product: gamma-aminobutyrate permease related permease

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQAKKDDKPELARHLKSRHVQLIAIGGTIGTGLFLGSGQSIHTAGPSILLAYLITGGICFLIMRALGELLMSDVNSHTFI
DFISQYMGKDAGWVTGWTYWICWVAVAMAEVTAIGLYIRFWLPGVPQWLPGLIALAVLLLMNLVSVGLFGEAEFWFALIK
IVAIIGLIALGVFMLFVHYKTPVGYASLSNLVNDGGFFPKGMSGFLMSLQMVVFSFVGIEMVGLTASETKDPHKVIPEAI
NEIPMRILLFYIGALFVIMCIYPWRDVSPVNSPFVEVFRNVGIPAAADIINFVVLTAAASACNSSIFSTGRLLFSLTLTG
KSKSACWTAKLSRRQVPARAIMISTGAIAVAVILNLFLPESVFALVSSVATISFLFVWGMIVLAHLRYKKQHPRGTDFPM
PFYPYSNYLILAFLGLTAVIMIFDRAMLSALIFAVIWIATLFTLRRLHADHKAHEDKTKDGI

Sequences:

>Translated_462_residues
MQAKKDDKPELARHLKSRHVQLIAIGGTIGTGLFLGSGQSIHTAGPSILLAYLITGGICFLIMRALGELLMSDVNSHTFI
DFISQYMGKDAGWVTGWTYWICWVAVAMAEVTAIGLYIRFWLPGVPQWLPGLIALAVLLLMNLVSVGLFGEAEFWFALIK
IVAIIGLIALGVFMLFVHYKTPVGYASLSNLVNDGGFFPKGMSGFLMSLQMVVFSFVGIEMVGLTASETKDPHKVIPEAI
NEIPMRILLFYIGALFVIMCIYPWRDVSPVNSPFVEVFRNVGIPAAADIINFVVLTAAASACNSSIFSTGRLLFSLTLTG
KSKSACWTAKLSRRQVPARAIMISTGAIAVAVILNLFLPESVFALVSSVATISFLFVWGMIVLAHLRYKKQHPRGTDFPM
PFYPYSNYLILAFLGLTAVIMIFDRAMLSALIFAVIWIATLFTLRRLHADHKAHEDKTKDGI
>Mature_462_residues
MQAKKDDKPELARHLKSRHVQLIAIGGTIGTGLFLGSGQSIHTAGPSILLAYLITGGICFLIMRALGELLMSDVNSHTFI
DFISQYMGKDAGWVTGWTYWICWVAVAMAEVTAIGLYIRFWLPGVPQWLPGLIALAVLLLMNLVSVGLFGEAEFWFALIK
IVAIIGLIALGVFMLFVHYKTPVGYASLSNLVNDGGFFPKGMSGFLMSLQMVVFSFVGIEMVGLTASETKDPHKVIPEAI
NEIPMRILLFYIGALFVIMCIYPWRDVSPVNSPFVEVFRNVGIPAAADIINFVVLTAAASACNSSIFSTGRLLFSLTLTG
KSKSACWTAKLSRRQVPARAIMISTGAIAVAVILNLFLPESVFALVSSVATISFLFVWGMIVLAHLRYKKQHPRGTDFPM
PFYPYSNYLILAFLGLTAVIMIFDRAMLSALIFAVIWIATLFTLRRLHADHKAHEDKTKDGI

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=426, Percent_Identity=23.7089201877934, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790653, Length=447, Percent_Identity=47.6510067114094, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1786789, Length=450, Percent_Identity=43.7777777777778, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=444, Percent_Identity=40.990990990991, Blast_Score=355, Evalue=3e-99,
Organism=Escherichia coli, GI48994972, Length=462, Percent_Identity=41.3419913419913, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1786602, Length=388, Percent_Identity=44.3298969072165, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI87081915, Length=468, Percent_Identity=38.2478632478632, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI87081708, Length=465, Percent_Identity=34.1935483870968, Blast_Score=268, Evalue=5e-73,
Organism=Escherichia coli, GI1789017, Length=431, Percent_Identity=34.8027842227378, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI1788480, Length=402, Percent_Identity=35.0746268656716, Blast_Score=243, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6324061, Length=453, Percent_Identity=31.5673289183223, Blast_Score=196, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=404, Percent_Identity=31.9306930693069, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=30.7692307692308, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=454, Percent_Identity=30.8370044052863, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322892, Length=441, Percent_Identity=30.1587301587302, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6324059, Length=480, Percent_Identity=28.9583333333333, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=430, Percent_Identity=28.6046511627907, Blast_Score=155, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324553, Length=390, Percent_Identity=30.5128205128205, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6321629, Length=428, Percent_Identity=25.2336448598131, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6322967, Length=397, Percent_Identity=27.455919395466, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6319824, Length=395, Percent_Identity=27.0886075949367, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=25.1231527093596, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=26.4197530864197, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319542, Length=400, Percent_Identity=26.5, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=361, Percent_Identity=26.0387811634349, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320251, Length=406, Percent_Identity=26.1083743842365, Blast_Score=127, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6324981, Length=397, Percent_Identity=27.9596977329975, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320364, Length=504, Percent_Identity=24.6031746031746, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666159, Length=344, Percent_Identity=22.9651162790698, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI221512776, Length=344, Percent_Identity=22.9651162790698, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50741; Mature: 50741

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAKKDDKPELARHLKSRHVQLIAIGGTIGTGLFLGSGQSIHTAGPSILLAYLITGGICF
CCCCCCCCHHHHHHHHHCCEEEEEECCCHHCCEEECCCCEECCCCHHHHHHHHHHHHHHH
LIMRALGELLMSDVNSHTFIDFISQYMGKDAGWVTGWTYWICWVAVAMAEVTAIGLYIRF
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPGVPQWLPGLIALAVLLLMNLVSVGLFGEAEFWFALIKIVAIIGLIALGVFMLFVHYK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPVGYASLSNLVNDGGFFPKGMSGFLMSLQMVVFSFVGIEMVGLTASETKDPHKVIPEAI
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHH
NEIPMRILLFYIGALFVIMCIYPWRDVSPVNSPFVEVFRNVGIPAAADIINFVVLTAAAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ACNSSIFSTGRLLFSLTLTGKSKSACWTAKLSRRQVPARAIMISTGAIAVAVILNLFLPE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHEEEECHHHHHHHHHHHHHHH
SVFALVSSVATISFLFVWGMIVLAHLRYKKQHPRGTDFPMPFYPYSNYLILAFLGLTAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MIFDRAMLSALIFAVIWIATLFTLRRLHADHKAHEDKTKDGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQAKKDDKPELARHLKSRHVQLIAIGGTIGTGLFLGSGQSIHTAGPSILLAYLITGGICF
CCCCCCCCHHHHHHHHHCCEEEEEECCCHHCCEEECCCCEECCCCHHHHHHHHHHHHHHH
LIMRALGELLMSDVNSHTFIDFISQYMGKDAGWVTGWTYWICWVAVAMAEVTAIGLYIRF
HHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPGVPQWLPGLIALAVLLLMNLVSVGLFGEAEFWFALIKIVAIIGLIALGVFMLFVHYK
HCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPVGYASLSNLVNDGGFFPKGMSGFLMSLQMVVFSFVGIEMVGLTASETKDPHKVIPEAI
CCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCHHHHHHHHH
NEIPMRILLFYIGALFVIMCIYPWRDVSPVNSPFVEVFRNVGIPAAADIINFVVLTAAAS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ACNSSIFSTGRLLFSLTLTGKSKSACWTAKLSRRQVPARAIMISTGAIAVAVILNLFLPE
HHHHHHHHCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHEEEECHHHHHHHHHHHHHHH
SVFALVSSVATISFLFVWGMIVLAHLRYKKQHPRGTDFPMPFYPYSNYLILAFLGLTAVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
MIFDRAMLSALIFAVIWIATLFTLRRLHADHKAHEDKTKDGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]