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The map label for this gene is hprK

Identifier: 116494452

GI number: 116494452

Start: 923412

End: 924371

Strand: Direct

Name: hprK

Synonym: LSEI_0945

Alternate gene names: 116494452

Gene position: 923412-924371 (Clockwise)

Preceding gene: 116494451

Following gene: 116494453

Centisome position: 31.89

GC content: 48.65

Gene sequence:

>960_bases
ATGGCAGACAGCGTGACAGTGCGGCAGTTGGTTAAGGCAACCAAGCTCGAGGTATACAGCGGCGAGGAGTATCTTGATCA
GCGGCAAGTCGTTTTGAGTGATATTTCGCGTCCCGGCTTGGAACTGACTGGCTATTTTAATTACTATCCACATGAACGGA
TTCAATTGTTCGGTCGAACGGAAATTTCATTTGCGCGAAACATGTCATCCGAAGAACGTTTATTGATTTTAAAGCGCATG
GCAACTGAAGATACCCCAGCATTTTTGGTATCGAGGGGGTTGGAGGCGCCGGCAGAAATGATCACCGCAGCGACAGCGGC
TCATATTCCTGTTTTGGGATCGCGTTTGCCGACGACGCGTTTGTCGAGTCTGATTACCGAGTATTTGGATAGTCAGCTGG
CGGAGAGGCGCAGTATGCATGGGGTGCTAGTCGATATTTATGGGCTCGGGGTGCTGATTACCGGCGATTCTGGTGTCGGC
AAATCCGAAACAGCGTTGGAATTGGTTCAGCGTGGGCATCGCTTGATTGCCGATGATCGGGTTGATGTTTATCAACAGGA
TGAACAAACCATTGTCGGGGCTGCACCGCCGATTCTTTCGCATCTGCTGGAAATTCGTGGCTTGGGCATTATCGATGTCA
TGAATCTTTTCGGTGCTGGCGCTGTTCGTGAAGATACTACTATTTCATTAATCGTCCATCTCGAGAATTGGACACCAGAC
AAAACCTTTGATCGGCTTGGTTCTGGGGAACAGACACAATTAATTTTTGACGTGCCAGTGCCAAAAATCACAGTGCCAGT
TAAGGTCGGGCGTAACTTGGCCATCATCATTGAAGTCGCGGCCATGAACTTCCGCGCCAAGTCAATGGGCTATGACGCCA
CCAAGACATTTGAAAAAAATCTTAATCATCTGATCGAGCATAATGAAGAAACCGACCAGAACAGTTCGGGGGACAAATAA

Upstream 100 bases:

>100_bases
CAATGTGAATGACCTTTTGCGAATGTTTCAACCTGCTGACCATAAGGGGAATCGACTTATGGTAAAATAGAGCAAATATG
GCGAAAGAAAGGTGGACTTC

Downstream 100 bases:

>100_bases
CTTGTTATTAGCACTTAATCCGATCGCTTTTCAATTAGGCGGTCTGGAAGTTCATTGGTACGGTATCATTATTGCCAGTG
CCGTTCTAATTGCGGTTTAT

Product: HPr kinase/phosphorylase

Products: NA

Alternate protein names: HPrK/P; HPr(Ser) kinase/phosphorylase

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRM
ATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVG
KSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPD
KTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK

Sequences:

>Translated_319_residues
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRM
ATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVG
KSETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPD
KTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK
>Mature_318_residues
ADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRTEISFARNMSSEERLLILKRMA
TEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTRLSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGK
SETALELVQRGHRLIADDRVDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPDK
TFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKNLNHLIEHNEETDQNSSGDK

Specific function: Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-pr

COG id: COG1493

COG function: function code T; Serine kinase of the HPr protein, regulates carbohydrate metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPrK/P family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRK_LACC3 (Q03AM8)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_806186.1
- ProteinModelPortal:   Q03AM8
- SMR:   Q03AM8
- STRING:   Q03AM8
- GeneID:   4419342
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0945
- eggNOG:   COG1493
- HOGENOM:   HBG566466
- OMA:   IHGVLVD
- ProtClustDB:   PRK05428
- BioCyc:   LCAS321967:LSEI_0945-MONOMER
- HAMAP:   MF_01249
- InterPro:   IPR003755
- InterPro:   IPR011104
- InterPro:   IPR011126
- TIGRFAMs:   TIGR00679

Pfam domain/function: PF07475 Hpr_kinase_C; PF02603 Hpr_kinase_N

EC number: NA

Molecular weight: Translated: 35349; Mature: 35218

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: ACT_SITE 140-140 ACT_SITE 161-161 ACT_SITE 179-179 ACT_SITE 245-245

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRT
CCCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEEEECCC
EISFARNMSSEERLLILKRMATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTR
HHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHH
LSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDR
HHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEECCCC
VDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPD
CHHHCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
KTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKN
HHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCEEHHHCCCCHHHHHHHH
LNHLIEHNEETDQNSSGDK
HHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
ADSVTVRQLVKATKLEVYSGEEYLDQRQVVLSDISRPGLELTGYFNYYPHERIQLFGRT
CCCHHHHHHHHHHHHEEECCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHEEEECCC
EISFARNMSSEERLLILKRMATEDTPAFLVSRGLEAPAEMITAATAAHIPVLGSRLPTTR
HHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCHHCCCCCHHH
LSSLITEYLDSQLAERRSMHGVLVDIYGLGVLITGDSGVGKSETALELVQRGHRLIADDR
HHHHHHHHHHHHHHHHHHHCCEEEEEECCEEEEECCCCCCCHHHHHHHHHCCCEEECCCC
VDVYQQDEQTIVGAAPPILSHLLEIRGLGIIDVMNLFGAGAVREDTTISLIVHLENWTPD
CHHHCCCCCEEECCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCCC
KTFDRLGSGEQTQLIFDVPVPKITVPVKVGRNLAIIIEVAAMNFRAKSMGYDATKTFEKN
HHHHHCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEEEECCCEEHHHCCCCHHHHHHHH
LNHLIEHNEETDQNSSGDK
HHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA