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The map label for this gene is ntdR [H]

Identifier: 116493964

GI number: 116493964

Start: 402154

End: 403161

Strand: Direct

Name: ntdR [H]

Synonym: LSEI_0400

Alternate gene names: 116493964

Gene position: 402154-403161 (Clockwise)

Preceding gene: 116493960

Following gene: 116493965

Centisome position: 13.89

GC content: 47.62

Gene sequence:

>1008_bases
ATGGCAACGATTTCAGAAGTGGCAAAGTTAGCCGGGGTTTCGGTTTCAACGGTATCACGGATCATTAACCACAAACCACA
TGTTTCACCGCGCAAAGCGGCCCTGGTTGCCGATGCCATGGCGAAGTTGGGTTACACACCGCTTCAAGCTGCTCGACAAA
TGCGTGGTTCTGGCTCACAGACGATTGCCGTGACGGTTCCTTACATTACGAACCCGTTTTTTTCAGAACTCGTTGCAGCG
ATTGAACGCACTGCCGATGAGCGATCCTATAAGACAGTCATTGTGCAAACATTCGGTCAGAAAAGTCACGAACTGAATGC
CTTGGAATTTCTCAAGACGAACCAGGTTGATGCTGTGATTATGTGCGCAATTGAGAATGACTGGGATTTGATTAAGCAGT
ATCGGCAATACGGTTTGATTGGTATTTGTAATGAATACGTTGCCGATCCTGAGGTTTTGATGGTGCGTGCCGATCAGGAA
GGCGGTATGTATGCGGGTACTAAATATCTCTTGAATCGTGGTTATCGCAAGCTAGCATTTTGCACCGGGCAGCAAGCTAT
TCGATACAATGACAAACTTGAAGATTTGAATAGTGATCGTTATCGTGGCTATCTTCGGGCATTGCGTGAATTCGACTTGG
AGCCAGCGGTGGAATGGCAGTTTACAGATGTTGGAACCATTGCTGATGGTCAAGATGTTCTTCAGCGCATCATGGTCATG
AAGCATCGTCCTGATGCTGTGATCGCCGGCTCGGATCAAGCAGCCGCTGGCATGATTGCTGAAGCGCAGACCATGCAATT
GAAGGTGCCTGAAGAACTTGCTGTTCTTGGCTTTGATGATCAACCGCTGAGTCAGGTGGTTGCGCGGCCGTTAACAACCA
TTCATCAACCAGTACATGAGATCGGTGATCGTATTGCTAATATGGTCGCTGATGACTTGGAAGAAAAAACGGTTGAAGCC
AGACAAGTCGTTTTACCGCTTTCTGTTGTTGTTCGTCAGTCGGTTTAA

Upstream 100 bases:

>100_bases
TTGGCTTGTTTTTGAAATCGATACCAAAAAAGCGTTGACAAGAAATCTGAAAGCGCTATATTATTCATGTAATCAAGGAG
ATGCGGAGGAGCGGTGAAAA

Downstream 100 bases:

>100_bases
TCTTTTTTGAGAAAAATTGGTATCAATACCAAAAATATGGAGGAAATTAATATGACAGTCGTATTAGCACGAGTAGATCA
ACGTTTAGTTCATGGCATCG

Product: sugar metabolism regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MATISEVAKLAGVSVSTVSRIINHKPHVSPRKAALVADAMAKLGYTPLQAARQMRGSGSQTIAVTVPYITNPFFSELVAA
IERTADERSYKTVIVQTFGQKSHELNALEFLKTNQVDAVIMCAIENDWDLIKQYRQYGLIGICNEYVADPEVLMVRADQE
GGMYAGTKYLLNRGYRKLAFCTGQQAIRYNDKLEDLNSDRYRGYLRALREFDLEPAVEWQFTDVGTIADGQDVLQRIMVM
KHRPDAVIAGSDQAAAGMIAEAQTMQLKVPEELAVLGFDDQPLSQVVARPLTTIHQPVHEIGDRIANMVADDLEEKTVEA
RQVVLPLSVVVRQSV

Sequences:

>Translated_335_residues
MATISEVAKLAGVSVSTVSRIINHKPHVSPRKAALVADAMAKLGYTPLQAARQMRGSGSQTIAVTVPYITNPFFSELVAA
IERTADERSYKTVIVQTFGQKSHELNALEFLKTNQVDAVIMCAIENDWDLIKQYRQYGLIGICNEYVADPEVLMVRADQE
GGMYAGTKYLLNRGYRKLAFCTGQQAIRYNDKLEDLNSDRYRGYLRALREFDLEPAVEWQFTDVGTIADGQDVLQRIMVM
KHRPDAVIAGSDQAAAGMIAEAQTMQLKVPEELAVLGFDDQPLSQVVARPLTTIHQPVHEIGDRIANMVADDLEEKTVEA
RQVVLPLSVVVRQSV
>Mature_334_residues
ATISEVAKLAGVSVSTVSRIINHKPHVSPRKAALVADAMAKLGYTPLQAARQMRGSGSQTIAVTVPYITNPFFSELVAAI
ERTADERSYKTVIVQTFGQKSHELNALEFLKTNQVDAVIMCAIENDWDLIKQYRQYGLIGICNEYVADPEVLMVRADQEG
GMYAGTKYLLNRGYRKLAFCTGQQAIRYNDKLEDLNSDRYRGYLRALREFDLEPAVEWQFTDVGTIADGQDVLQRIMVMK
HRPDAVIAGSDQAAAGMIAEAQTMQLKVPEELAVLGFDDQPLSQVVARPLTTIHQPVHEIGDRIANMVADDLEEKTVEAR
QVVLPLSVVVRQSV

Specific function: Positively regulates the ntdABC operon and negatively regulates its own transcription. Binds to NTD to induce ntdABC transcription [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790194, Length=338, Percent_Identity=31.0650887573964, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790369, Length=336, Percent_Identity=29.7619047619048, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=27.3529411764706, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1788474, Length=300, Percent_Identity=28, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789202, Length=301, Percent_Identity=28.2392026578073, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787580, Length=317, Percent_Identity=26.813880126183, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI1789068, Length=307, Percent_Identity=25.4071661237785, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786540, Length=345, Percent_Identity=26.6666666666667, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI48994940, Length=300, Percent_Identity=23.6666666666667, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790715, Length=324, Percent_Identity=23.1481481481481, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787906, Length=342, Percent_Identity=23.3918128654971, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786268, Length=320, Percent_Identity=22.1875, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37169; Mature: 37038

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATISEVAKLAGVSVSTVSRIINHKPHVSPRKAALVADAMAKLGYTPLQAARQMRGSGSQ
CCCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TIAVTVPYITNPFFSELVAAIERTADERSYKTVIVQTFGQKSHELNALEFLKTNQVDAVI
EEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHEEEHHCCCCCCCHHHHHHHCCCCCEEE
MCAIENDWDLIKQYRQYGLIGICNEYVADPEVLMVRADQEGGMYAGTKYLLNRGYRKLAF
EEEECCCHHHHHHHHHCCCCEEHHHHCCCCEEEEEEECCCCCEEHHHHHHHHCCCHHEEE
CTGQQAIRYNDKLEDLNSDRYRGYLRALREFDLEPAVEWQFTDVGTIADGQDVLQRIMVM
ECCCHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
KHRPDAVIAGSDQAAAGMIAEAQTMQLKVPEELAVLGFDDQPLSQVVARPLTTIHQPVHE
HCCCCEEEECCCCHHHHHHHHHHEEEEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
IGDRIANMVADDLEEKTVEARQVVLPLSVVVRQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ATISEVAKLAGVSVSTVSRIINHKPHVSPRKAALVADAMAKLGYTPLQAARQMRGSGSQ
CCHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCC
TIAVTVPYITNPFFSELVAAIERTADERSYKTVIVQTFGQKSHELNALEFLKTNQVDAVI
EEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHEEEHHCCCCCCCHHHHHHHCCCCCEEE
MCAIENDWDLIKQYRQYGLIGICNEYVADPEVLMVRADQEGGMYAGTKYLLNRGYRKLAF
EEEECCCHHHHHHHHHCCCCEEHHHHCCCCEEEEEEECCCCCEEHHHHHHHHCCCHHEEE
CTGQQAIRYNDKLEDLNSDRYRGYLRALREFDLEPAVEWQFTDVGTIADGQDVLQRIMVM
ECCCHHHHCCCHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHH
KHRPDAVIAGSDQAAAGMIAEAQTMQLKVPEELAVLGFDDQPLSQVVARPLTTIHQPVHE
HCCCCEEEECCCCHHHHHHHHHHEEEEECCHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
IGDRIANMVADDLEEKTVEARQVVLPLSVVVRQSV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]