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The map label for this gene is mtlR [H]

Identifier: 116493892

GI number: 116493892

Start: 324411

End: 326507

Strand: Direct

Name: mtlR [H]

Synonym: LSEI_0324

Alternate gene names: 116493892

Gene position: 324411-326507 (Clockwise)

Preceding gene: 116493891

Following gene: 116493893

Centisome position: 11.2

GC content: 44.49

Gene sequence:

>2097_bases
ATGCGAGAAAGATTGACGAATCTTCTGCGAACATTGTTGGACAGTTCGGCAAGTTCTTTATCTGATTTAGGCAAGCAATT
CAACGTCACGACAAAGACGATTCGAAATGAGATTCAGGTTTTAAATGAAGTTTTGGCGGAGAAAAGCTTGCCCTTATTCG
ATATCAAAAGAGGTGTCGCCTACAATCATATTTCAACGCAACAGCGGCATTCGCTGTCTGACGTCCTTGATTTTGACAGC
ATCAGTCAAGGCGCTTTAACCCCTGAGCAACGCGCTGTGTATCTCTTATTGGATTTGCTTCAAGCCACCCAACCGGTTTA
TCTCGTCGATGAACAAGAAAAGATGCAGATTAGTAAAAGCTCAATGGATTCTGATCTCCGCAACTTGCGGGCTGATCTAG
CAAAATACAATCTAACACTCACGACCAGCCCAAAGTTAGGCGCACAGATTGAAGGCAACGAGCGATCAATTCGAACGATG
TTTGGGGATGTCCTAACACGGCAACATGCTTTGGTCACCTTGATTGCCCAGCAATTAATCGCCAGCGGGATGTATGTCGA
CAAGATGAAGGAAGTCTTTACCAAACAAGATGTGACCTATATCCGGGACTTACTACGCCGTTGTTTTCCAAAAGGGGCCT
TGGCCGCCAACGACATGTACAGCCAGCAAGTGACCGTGTTACTCATTATCTGGTTACACCGTGTTCGCAGCGGGCACTAT
GTCAAAGATGATGAAACTGCCGTTGATCTCAATAAGGAAAATGCCAAGTTTCTCAATGAACTCATTCAGCATTATGCCTT
ACAAATTGATGTTGCCAGCGAGTTAGGTTATGTCGGTTTTCTGATCAACAGTTTTAATCGCCGCGGTGCGATTGATCTTG
ACGACTGGGTCAAGGCCCAGATTTTCAGCGTTGCGCTCATTGATCATATGGAAACTGAAATTGGCTTTCCATTTTCTAAA
AACGAAAAGCTTTTCGAAGAGCTATATAACCATATGACCGCTTTGTTCAAGCGCTTGTCACAGCACGTCAAAGTGGTTAA
TCCGCTGAGAAAGACCATTCAGCAGGGCTATGGGCCGATCTATGACGCGATTGATCGTTTCTTCAAGACGGGACGCTATC
AGCTGACCATGTCTGATGATGAGAAGGCATTTCTGGCGATGTATTTCTCAGCGACACAAGCTGAGGATCGCCAGCGCCAA
GACTATCAGTATCAAGCCGCAGTTGTCTGCAACTTCGGCACGGCGACGGGCAGAGTGTTGGCAGCCAAACTGGAGGAACG
GTTTAACATTGATGTTCTTGCCGTTTTGAGCACGTCTGAAGTTGGCATTCTCCGCAAATTACCGGTCAGCTTAGTTTTCA
AAACAGTCGACATGCCAATCGATAAAATCCCGAGTTTGAAGGTTAATCCCATTCCTTCAGAAGTTGATTTGACCCGAGTT
GCAGCGTTTTTGAAGAAACACACAACGTTAACTAAGTACGAAGGCCGTACGTTAGATCCAACAAGACTATTTCGCACAGT
TCTGGATGTGCTGAAAACCCATCAGGTGACAGTTGATAAACGACTATTAGCTGATCTGCAAGCAGCATTCAAGGAGAACC
ATGTCGAAATTAATGAAAGGGAGGTTCAGCCTATGTTGAAAGATTTAATCAACGATCACCAGATCCAGCTTCAACAGAAA
GCTGATGATTGGGAAGATGCGATCCGTATTTCAGCAAAACCATTGCTTGACGAGGATTACATTACCAAAAATTATATCCA
AGCAATGATTGATTCAGTTAAGAAATTCGGTCCGTATATTGTCATTGGACCTGCCATCGCGCTAGCCCATGCACGGCCAG
AGGATGGGACAAAGAAGCTTGGCGTGACGATCACAACGTTGGCAAAACCAATCAACTTTGGCAATCCAGACAATGATCCC
GTGAAGATCATCTTTTGTCTGGCCGCGATCGATAATTATTCGCATCTCAATGTCATGAAAGCCATTGTCCAACTCATCAA
TGATCAGCAAAAAGTTGATCAGCTGGCGCAACAAACAGATATTCAAACCTTTAAAAACATTTTATTCAACGAGAAAACGT
CAAAGGAGACGATTTAA

Upstream 100 bases:

>100_bases
GATGAGCAAGGTGTACTTCGTTTCCCAAGTTAAGGAAAAAGGTTCTACTTTTCGACATGTAAGCGCTTGCTTAGTATAGA
AGCTGTAAGGAGGCAAAGCA

Downstream 100 bases:

>100_bases
ATGACCAGGAAATTAACGATTTACTTCATCTGTGGTGCCGGCCTAGGCTCTTCCTTAGCTTGCCAGATGACTGCAGAAGA
TGTTTTAAACCGTTTGGGAT

Product: transcriptional antiterminator and PTS system component IIA

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MRERLTNLLRTLLDSSASSLSDLGKQFNVTTKTIRNEIQVLNEVLAEKSLPLFDIKRGVAYNHISTQQRHSLSDVLDFDS
ISQGALTPEQRAVYLLLDLLQATQPVYLVDEQEKMQISKSSMDSDLRNLRADLAKYNLTLTTSPKLGAQIEGNERSIRTM
FGDVLTRQHALVTLIAQQLIASGMYVDKMKEVFTKQDVTYIRDLLRRCFPKGALAANDMYSQQVTVLLIIWLHRVRSGHY
VKDDETAVDLNKENAKFLNELIQHYALQIDVASELGYVGFLINSFNRRGAIDLDDWVKAQIFSVALIDHMETEIGFPFSK
NEKLFEELYNHMTALFKRLSQHVKVVNPLRKTIQQGYGPIYDAIDRFFKTGRYQLTMSDDEKAFLAMYFSATQAEDRQRQ
DYQYQAAVVCNFGTATGRVLAAKLEERFNIDVLAVLSTSEVGILRKLPVSLVFKTVDMPIDKIPSLKVNPIPSEVDLTRV
AAFLKKHTTLTKYEGRTLDPTRLFRTVLDVLKTHQVTVDKRLLADLQAAFKENHVEINEREVQPMLKDLINDHQIQLQQK
ADDWEDAIRISAKPLLDEDYITKNYIQAMIDSVKKFGPYIVIGPAIALAHARPEDGTKKLGVTITTLAKPINFGNPDNDP
VKIIFCLAAIDNYSHLNVMKAIVQLINDQQKVDQLAQQTDIQTFKNILFNEKTSKETI

Sequences:

>Translated_698_residues
MRERLTNLLRTLLDSSASSLSDLGKQFNVTTKTIRNEIQVLNEVLAEKSLPLFDIKRGVAYNHISTQQRHSLSDVLDFDS
ISQGALTPEQRAVYLLLDLLQATQPVYLVDEQEKMQISKSSMDSDLRNLRADLAKYNLTLTTSPKLGAQIEGNERSIRTM
FGDVLTRQHALVTLIAQQLIASGMYVDKMKEVFTKQDVTYIRDLLRRCFPKGALAANDMYSQQVTVLLIIWLHRVRSGHY
VKDDETAVDLNKENAKFLNELIQHYALQIDVASELGYVGFLINSFNRRGAIDLDDWVKAQIFSVALIDHMETEIGFPFSK
NEKLFEELYNHMTALFKRLSQHVKVVNPLRKTIQQGYGPIYDAIDRFFKTGRYQLTMSDDEKAFLAMYFSATQAEDRQRQ
DYQYQAAVVCNFGTATGRVLAAKLEERFNIDVLAVLSTSEVGILRKLPVSLVFKTVDMPIDKIPSLKVNPIPSEVDLTRV
AAFLKKHTTLTKYEGRTLDPTRLFRTVLDVLKTHQVTVDKRLLADLQAAFKENHVEINEREVQPMLKDLINDHQIQLQQK
ADDWEDAIRISAKPLLDEDYITKNYIQAMIDSVKKFGPYIVIGPAIALAHARPEDGTKKLGVTITTLAKPINFGNPDNDP
VKIIFCLAAIDNYSHLNVMKAIVQLINDQQKVDQLAQQTDIQTFKNILFNEKTSKETI
>Mature_698_residues
MRERLTNLLRTLLDSSASSLSDLGKQFNVTTKTIRNEIQVLNEVLAEKSLPLFDIKRGVAYNHISTQQRHSLSDVLDFDS
ISQGALTPEQRAVYLLLDLLQATQPVYLVDEQEKMQISKSSMDSDLRNLRADLAKYNLTLTTSPKLGAQIEGNERSIRTM
FGDVLTRQHALVTLIAQQLIASGMYVDKMKEVFTKQDVTYIRDLLRRCFPKGALAANDMYSQQVTVLLIIWLHRVRSGHY
VKDDETAVDLNKENAKFLNELIQHYALQIDVASELGYVGFLINSFNRRGAIDLDDWVKAQIFSVALIDHMETEIGFPFSK
NEKLFEELYNHMTALFKRLSQHVKVVNPLRKTIQQGYGPIYDAIDRFFKTGRYQLTMSDDEKAFLAMYFSATQAEDRQRQ
DYQYQAAVVCNFGTATGRVLAAKLEERFNIDVLAVLSTSEVGILRKLPVSLVFKTVDMPIDKIPSLKVNPIPSEVDLTRV
AAFLKKHTTLTKYEGRTLDPTRLFRTVLDVLKTHQVTVDKRLLADLQAAFKENHVEINEREVQPMLKDLINDHQIQLQQK
ADDWEDAIRISAKPLLDEDYITKNYIQAMIDSVKKFGPYIVIGPAIALAHARPEDGTKKLGVTITTLAKPINFGNPDNDP
VKIIFCLAAIDNYSHLNVMKAIVQLINDQQKVDQLAQQTDIQTFKNILFNEKTSKETI

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: COG1762

COG function: function code GT; Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI2367359, Length=128, Percent_Identity=41.40625, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1790755, Length=125, Percent_Identity=39.2, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1789302, Length=117, Percent_Identity=41.025641025641, Blast_Score=96, Evalue=9e-21,
Organism=Escherichia coli, GI1790027, Length=167, Percent_Identity=28.1437125748503, Blast_Score=66, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 79406; Mature: 79406

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS51094 PTS_EIIA_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRERLTNLLRTLLDSSASSLSDLGKQFNVTTKTIRNEIQVLNEVLAEKSLPLFDIKRGVA
CHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCE
YNHISTQQRHSLSDVLDFDSISQGALTPEQRAVYLLLDLLQATQPVYLVDEQEKMQISKS
ECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
SMDSDLRNLRADLAKYNLTLTTSPKLGAQIEGNERSIRTMFGDVLTRQHALVTLIAQQLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGMYVDKMKEVFTKQDVTYIRDLLRRCFPKGALAANDMYSQQVTVLLIIWLHRVRSGHY
HCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VKDDETAVDLNKENAKFLNELIQHYALQIDVASELGYVGFLINSFNRRGAIDLDDWVKAQ
CCCCCCEECCCCHHHHHHHHHHHHHHEEEEHHHHCCHHHHHHHCCCCCCCCCHHHHHHHH
IFSVALIDHMETEIGFPFSKNEKLFEELYNHMTALFKRLSQHVKVVNPLRKTIQQGYGPI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YDAIDRFFKTGRYQLTMSDDEKAFLAMYFSATQAEDRQRQDYQYQAAVVCNFGTATGRVL
HHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHH
AAKLEERFNIDVLAVLSTSEVGILRKLPVSLVFKTVDMPIDKIPSLKVNPIPSEVDLTRV
HHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHH
AAFLKKHTTLTKYEGRTLDPTRLFRTVLDVLKTHQVTVDKRLLADLQAAFKENHVEINER
HHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EVQPMLKDLINDHQIQLQQKADDWEDAIRISAKPLLDEDYITKNYIQAMIDSVKKFGPYI
HHHHHHHHHCCCHHEEHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
VIGPAIALAHARPEDGTKKLGVTITTLAKPINFGNPDNDPVKIIFCLAAIDNYSHLNVMK
EEECHHHHHCCCCCCCCHHHCEEHHHHHCCCCCCCCCCCHHEEEEEEHHHCCCHHHHHHH
AIVQLINDQQKVDQLAQQTDIQTFKNILFNEKTSKETI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MRERLTNLLRTLLDSSASSLSDLGKQFNVTTKTIRNEIQVLNEVLAEKSLPLFDIKRGVA
CHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCE
YNHISTQQRHSLSDVLDFDSISQGALTPEQRAVYLLLDLLQATQPVYLVDEQEKMQISKS
ECCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
SMDSDLRNLRADLAKYNLTLTTSPKLGAQIEGNERSIRTMFGDVLTRQHALVTLIAQQLI
HHHHHHHHHHHHHHHCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
ASGMYVDKMKEVFTKQDVTYIRDLLRRCFPKGALAANDMYSQQVTVLLIIWLHRVRSGHY
HCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
VKDDETAVDLNKENAKFLNELIQHYALQIDVASELGYVGFLINSFNRRGAIDLDDWVKAQ
CCCCCCEECCCCHHHHHHHHHHHHHHEEEEHHHHCCHHHHHHHCCCCCCCCCHHHHHHHH
IFSVALIDHMETEIGFPFSKNEKLFEELYNHMTALFKRLSQHVKVVNPLRKTIQQGYGPI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
YDAIDRFFKTGRYQLTMSDDEKAFLAMYFSATQAEDRQRQDYQYQAAVVCNFGTATGRVL
HHHHHHHHHCCCEEEEECCCCCEEHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHH
AAKLEERFNIDVLAVLSTSEVGILRKLPVSLVFKTVDMPIDKIPSLKVNPIPSEVDLTRV
HHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHH
AAFLKKHTTLTKYEGRTLDPTRLFRTVLDVLKTHQVTVDKRLLADLQAAFKENHVEINER
HHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
EVQPMLKDLINDHQIQLQQKADDWEDAIRISAKPLLDEDYITKNYIQAMIDSVKKFGPYI
HHHHHHHHHCCCHHEEHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCEE
VIGPAIALAHARPEDGTKKLGVTITTLAKPINFGNPDNDPVKIIFCLAAIDNYSHLNVMK
EEECHHHHHCCCCCCCCHHHCEEHHHHHCCCCCCCCCCCHHEEEEEEHHHCCCHHHHHHH
AIVQLINDQQKVDQLAQQTDIQTFKNILFNEKTSKETI
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]