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The map label for this gene is ifcA [H]

Identifier: 116493890

GI number: 116493890

Start: 322613

End: 324139

Strand: Direct

Name: ifcA [H]

Synonym: LSEI_0322

Alternate gene names: 116493890

Gene position: 322613-324139 (Clockwise)

Preceding gene: 116493889

Following gene: 116493891

Centisome position: 11.14

GC content: 50.69

Gene sequence:

>1527_bases
TTGAAAAAGTGGGTTAAAATCGCAGGGCTGTTGGCGCTGATGAGTGTAGTGCTGGTTGGTTGCAGTAGCGGGGCGAGTTC
AAAGTCGAGTTCGTCAAGTTCAAAAGCAAACAAAGCAGCTAGCAGCAAGGTCACTAGCGGGGCTTCACAGCAGGCCTACA
CAGATCCGAAAACGATGAAGGGCAAGTATGACATCGTGATTGTCGGTGCTGGTGGTGCCGGGATGACAGCTGCCATCGAG
GCGAAGCAGCAAGGGATGAATCCCGTCATTCTTGAAAAAATGCCCGTTGCTGGCGGGAATACGCTGAAAGCCTCTAGCGG
TATGAATGCCAGTCAGACGAAAGTTGAAGCTGCCCAAGGGGTTAAGGACAGCAATGATCAGTTCTATGAAGAAACGCTAA
AAGGTGGCGGCGGGACGAATGACAAAGCACTGCTGCGCTATTTTGTCGACAACTCAGCCAGCGCCATTGACTGGCTTGAT
TCGATTGGGATTAAGCTGGACAAATTGACGATTTCCGGTGGGATGTCGGTCAAGCGCACGCATCGGCCACACGATGGTTC
AGCCGTTGGCGGTTATCTCGTTGATGGGCTCGTGAAAGAAGTCAAAAAAGAAAAGATTCCGCTGTTTGTGAACTCAGATG
TTACCAAGTTGAATGAAACAGATGGTAAAATCAGCGGGGTCACCGTCAAGATCAATCAAGACAAGACGAAAAAAATCGCA
GCCAAGGCCTTGATTGTGACCACTGGCGGTTTCGGGGCAAGTAAGCAAATGATCAAGAAATATCGCCCTGATCTGGCTCA
TTACGTCACCACTAACCAAGCTGGCGCAACCGGTGATGGCATCAAGATGATCGAGAAAGTCGGCGGCTATGCGATCGACA
TGAATAAGATCCAAATTCACCCAACTGTTAACCAAAGCAAGCATATTCTCATTGGTGAAGCGACCCGCGGTGAAGGCGGC
ATTTTAGTTAACCAAAGCGGGAAGCGGTTCTATAACGAAATGAATACCCGTGACAAGGTTTCCGCTGCCATTAACAAGCA
AAAAGGTAAGGATGCTTGGGTCGTGATTGATACAGGCGTCCGCCAACGGTCGAGTGCCATTGACTTTTATATCAAGGACA
AGCTCGGTGTCGAAGGCAAAACCCTTGATGAACTCGCCAAGAAAATGAAGGTGCCAGCGGCCACGTTATCCAAGACGGTT
TCAACTTGGAACGAAGCGGTCACCAACAAAAAGGATGCCGAGTTTGGTCGGACAACTGGGATGGACCATGGCCTCACCAC
CGGCCCATACTATGCTTTCAAAATCGCCCCAGGCATCCATTACACCATGGGTGGCGTGAAGATCAACACCAAGACTGAGG
TGCTGACCAAGAAGCAGCAACCAATCCCAGCACTATACGCAGCCGGTGAAGTCACGGGCGGCCTACACGGCGACAACCGA
ATCGGTGGCAATTCCGTCGCCGATATTGTGATCTTTGGTCGCCAAGCAGGAACGCAGGCGACGGCTTACGTGAAAGCACA
ACAGTAA

Upstream 100 bases:

>100_bases
GATTAACGTTTATATCATCAAACTCAAGGTTAAGTTGAGATGGTTTCGCTACTTTGTTAATCTATTCACGTAGACAACAA
CATAAGGGAGGGACTATGTT

Downstream 100 bases:

>100_bases
CTTGAATGACTTAAAGGCGGTTCTCGTCAGATGAGAATCGCTTTTTTTGATGCGCTGAAAATGGCGATGTCCGCTCAGCC
TCAAAAATTCATATGCCCCA

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: Fe(3+)-induced flavocytochrome C3; Ifc3; Iron(III)-induced flavocytochrome C3 [H]

Number of amino acids: Translated: 508; Mature: 508

Protein sequence:

>508_residues
MKKWVKIAGLLALMSVVLVGCSSGASSKSSSSSSKANKAASSKVTSGASQQAYTDPKTMKGKYDIVIVGAGGAGMTAAIE
AKQQGMNPVILEKMPVAGGNTLKASSGMNASQTKVEAAQGVKDSNDQFYEETLKGGGGTNDKALLRYFVDNSASAIDWLD
SIGIKLDKLTISGGMSVKRTHRPHDGSAVGGYLVDGLVKEVKKEKIPLFVNSDVTKLNETDGKISGVTVKINQDKTKKIA
AKALIVTTGGFGASKQMIKKYRPDLAHYVTTNQAGATGDGIKMIEKVGGYAIDMNKIQIHPTVNQSKHILIGEATRGEGG
ILVNQSGKRFYNEMNTRDKVSAAINKQKGKDAWVVIDTGVRQRSSAIDFYIKDKLGVEGKTLDELAKKMKVPAATLSKTV
STWNEAVTNKKDAEFGRTTGMDHGLTTGPYYAFKIAPGIHYTMGGVKINTKTEVLTKKQQPIPALYAAGEVTGGLHGDNR
IGGNSVADIVIFGRQAGTQATAYVKAQQ

Sequences:

>Translated_508_residues
MKKWVKIAGLLALMSVVLVGCSSGASSKSSSSSSKANKAASSKVTSGASQQAYTDPKTMKGKYDIVIVGAGGAGMTAAIE
AKQQGMNPVILEKMPVAGGNTLKASSGMNASQTKVEAAQGVKDSNDQFYEETLKGGGGTNDKALLRYFVDNSASAIDWLD
SIGIKLDKLTISGGMSVKRTHRPHDGSAVGGYLVDGLVKEVKKEKIPLFVNSDVTKLNETDGKISGVTVKINQDKTKKIA
AKALIVTTGGFGASKQMIKKYRPDLAHYVTTNQAGATGDGIKMIEKVGGYAIDMNKIQIHPTVNQSKHILIGEATRGEGG
ILVNQSGKRFYNEMNTRDKVSAAINKQKGKDAWVVIDTGVRQRSSAIDFYIKDKLGVEGKTLDELAKKMKVPAATLSKTV
STWNEAVTNKKDAEFGRTTGMDHGLTTGPYYAFKIAPGIHYTMGGVKINTKTEVLTKKQQPIPALYAAGEVTGGLHGDNR
IGGNSVADIVIFGRQAGTQATAYVKAQQ
>Mature_508_residues
MKKWVKIAGLLALMSVVLVGCSSGASSKSSSSSSKANKAASSKVTSGASQQAYTDPKTMKGKYDIVIVGAGGAGMTAAIE
AKQQGMNPVILEKMPVAGGNTLKASSGMNASQTKVEAAQGVKDSNDQFYEETLKGGGGTNDKALLRYFVDNSASAIDWLD
SIGIKLDKLTISGGMSVKRTHRPHDGSAVGGYLVDGLVKEVKKEKIPLFVNSDVTKLNETDGKISGVTVKINQDKTKKIA
AKALIVTTGGFGASKQMIKKYRPDLAHYVTTNQAGATGDGIKMIEKVGGYAIDMNKIQIHPTVNQSKHILIGEATRGEGG
ILVNQSGKRFYNEMNTRDKVSAAINKQKGKDAWVVIDTGVRQRSSAIDFYIKDKLGVEGKTLDELAKKMKVPAATLSKTV
STWNEAVTNKKDAEFGRTTGMDHGLTTGPYYAFKIAPGIHYTMGGVKINTKTEVLTKKQQPIPALYAAGEVTGGLHGDNR
IGGNSVADIVIFGRQAGTQATAYVKAQQ

Specific function: Catalyzes unidirectional fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=484, Percent_Identity=27.4793388429752, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1788928, Length=462, Percent_Identity=28.1385281385281, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1790597, Length=408, Percent_Identity=27.6960784313726, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786942, Length=481, Percent_Identity=25.987525987526, Blast_Score=102, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71986328, Length=439, Percent_Identity=33.2574031890661, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17505833, Length=434, Percent_Identity=27.4193548387097, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17550100, Length=432, Percent_Identity=27.3148148148148, Blast_Score=106, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=459, Percent_Identity=36.8191721132898, Blast_Score=259, Evalue=7e-70,
Organism=Saccharomyces cerevisiae, GI6322511, Length=474, Percent_Identity=33.9662447257384, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322701, Length=494, Percent_Identity=26.5182186234818, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6322416, Length=463, Percent_Identity=26.5658747300216, Blast_Score=105, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17137288, Length=488, Percent_Identity=27.0491803278689, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24655642, Length=488, Percent_Identity=27.0491803278689, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24655647, Length=488, Percent_Identity=27.0491803278689, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24663005, Length=463, Percent_Identity=24.8380129589633, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 53789; Mature: 53789

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKWVKIAGLLALMSVVLVGCSSGASSKSSSSSSKANKAASSKVTSGASQQAYTDPKTMK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCC
GKYDIVIVGAGGAGMTAAIEAKQQGMNPVILEKMPVAGGNTLKASSGMNASQTKVEAAQG
CCEEEEEEECCCCCCEEEEEHHHCCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHCC
VKDSNDQFYEETLKGGGGTNDKALLRYFVDNSASAIDWLDSIGIKLDKLTISGGMSVKRT
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCCEEEC
HRPHDGSAVGGYLVDGLVKEVKKEKIPLFVNSDVTKLNETDGKISGVTVKINQDKTKKIA
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEEEEECCCHHHHHE
AKALIVTTGGFGASKQMIKKYRPDLAHYVTTNQAGATGDGIKMIEKVGGYAIDMNKIQIH
EEEEEEEECCCCHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHHHCCEEEEECEEEEE
PTVNQSKHILIGEATRGEGGILVNQSGKRFYNEMNTRDKVSAAINKQKGKDAWVVIDTGV
ECCCCCCEEEEEECCCCCCCEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCC
RQRSSAIDFYIKDKLGVEGKTLDELAKKMKVPAATLSKTVSTWNEAVTNKKDAEFGRTTG
CCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MDHGLTTGPYYAFKIAPGIHYTMGGVKINTKTEVLTKKQQPIPALYAAGEVTGGLHGDNR
CCCCCCCCCEEEEEECCCCEEEECCEEECCHHHHHHCCCCCCCCEEECCCCCCCCCCCCC
IGGNSVADIVIFGRQAGTQATAYVKAQQ
CCCCCEEEEEEECCCCCCCEEEEEEECC
>Mature Secondary Structure
MKKWVKIAGLLALMSVVLVGCSSGASSKSSSSSSKANKAASSKVTSGASQQAYTDPKTMK
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCC
GKYDIVIVGAGGAGMTAAIEAKQQGMNPVILEKMPVAGGNTLKASSGMNASQTKVEAAQG
CCEEEEEEECCCCCCEEEEEHHHCCCCCEEEEECCCCCCCEEECCCCCCCHHHHHHHHCC
VKDSNDQFYEETLKGGGGTNDKALLRYFVDNSASAIDWLDSIGIKLDKLTISGGMSVKRT
CCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCCEEEC
HRPHDGSAVGGYLVDGLVKEVKKEKIPLFVNSDVTKLNETDGKISGVTVKINQDKTKKIA
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCEEEEEEEEECCCHHHHHE
AKALIVTTGGFGASKQMIKKYRPDLAHYVTTNQAGATGDGIKMIEKVGGYAIDMNKIQIH
EEEEEEEECCCCHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHHHHHCCEEEEECEEEEE
PTVNQSKHILIGEATRGEGGILVNQSGKRFYNEMNTRDKVSAAINKQKGKDAWVVIDTGV
ECCCCCCEEEEEECCCCCCCEEECCCCHHHHHHCCCHHHHHHHHHHCCCCCEEEEEECCC
RQRSSAIDFYIKDKLGVEGKTLDELAKKMKVPAATLSKTVSTWNEAVTNKKDAEFGRTTG
CCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
MDHGLTTGPYYAFKIAPGIHYTMGGVKINTKTEVLTKKQQPIPALYAAGEVTGGLHGDNR
CCCCCCCCCEEEEEECCCCEEEECCEEECCHHHHHHCCCCCCCCEEECCCCCCCCCCCCC
IGGNSVADIVIFGRQAGTQATAYVKAQQ
CCCCCEEEEEEECCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10455032; 10581549 [H]