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The map label for this gene is pcp

Identifier: 116493777

GI number: 116493777

Start: 202633

End: 203280

Strand: Direct

Name: pcp

Synonym: LSEI_0206

Alternate gene names: 116493777

Gene position: 202633-203280 (Clockwise)

Preceding gene: 116493776

Following gene: 116493778

Centisome position: 7.0

GC content: 47.22

Gene sequence:

>648_bases
ATGAAAATTCTTGTTACCGGATTTGATCCCTTTGGCGACGATAAAATTAATCCTGCGATTGAAGCCGTGAAACGTTTGCC
GGATGAAATTGCTGGGGCACAAATCGTTAAATTGGAAATTCCGACAAAGTTTAATGTTTCAGCCGATGTCGTTAAAGATG
CTATTGCCAAAGAAAAGCCTGACTATGTGTTGAGCATTGGTCAGGCTGGTGGCCGGTTTGAACTCACGCCGGAGCGAGTT
GCGATTAACTTGGATGACGGTCGGATTCAAGATAATGCCGGGTATCAGCCACTTAATCACACGATTCATGGCGATGGCGA
GAATGCCTACTTTACCCAGTTACCGATTAAGGCCATGGCCAAAGCCATTCGGGAAGCTGGTGTTCCGGCAGCAGTCTCCA
ACACAGCAGGCACTTACGTCTGCAACCACATTTTTTATCAGGTACAGTATATGCGGGATAAGATGTTTCCCGATATTAAG
GCCGGCTTCATGCATATTCCATTTTTGCCGGAACAGGTTGTCACTCGTCCGGAAACACCAGCGTTGTCATTGGATGATGA
TGTTTTAGGCATCACTGCCGCTATCAGGGCCATCGTCTCCCGTGACGGCAAAGGCGATATCGAAACGATTGAAGGCAAGA
ATCACTAG

Upstream 100 bases:

>100_bases
ACTTGGTGTTATCAAACAGCAGGCGCCAATTGCGATACTATTGTTGATCATTCAAATCGGTCTCATGTACTTCTTGGCAT
TTTAGAAAGGAAATCTTCTC

Downstream 100 bases:

>100_bases
ATAGTTGTGGATCATTTTTTATTTGAACTGCCGCAGACCGCATGACGGGTGTGCGGCTTTTTGAGTGGGCTAGAATGCTT
GCTGGCCGGTATTTAAAGAA

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase; Pyroglutamyl-peptidase I; PGP-I; Pyrase

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDGENAYFTQLPIKAMAKAIREAGVPAAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIRAIVSRDGKGDIETIEGKNH

Sequences:

>Translated_215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDGENAYFTQLPIKAMAKAIREAGVPAAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIRAIVSRDGKGDIETIEGKNH
>Mature_215_residues
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKPDYVLSIGQAGGRFELTPERV
AINLDDGRIQDNAGYQPLNHTIHGDGENAYFTQLPIKAMAKAIREAGVPAAVSNTAGTYVCNHIFYQVQYMRDKMFPDIK
AGFMHIPFLPEQVVTRPETPALSLDDDVLGITAAIRAIVSRDGKGDIETIEGKNH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PCP_LACC3 (Q03CK3)

Other databases:

- EMBL:   CP000423
- RefSeq:   YP_805511.1
- ProteinModelPortal:   Q03CK3
- SMR:   Q03CK3
- STRING:   Q03CK3
- MEROPS:   C15.001
- GeneID:   4420293
- GenomeReviews:   CP000423_GR
- KEGG:   lca:LSEI_0206
- eggNOG:   COG2039
- HOGENOM:   HBG360405
- OMA:   NTAGTYV
- ProtClustDB:   PRK13197
- BioCyc:   LCAS321967:LSEI_0206-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00417
- InterPro:   IPR000816
- InterPro:   IPR016125
- Gene3D:   G3DSA:3.40.630.20
- PANTHER:   PTHR23402
- PIRSF:   PIRSF015592
- PRINTS:   PR00706
- TIGRFAMs:   TIGR00504

Pfam domain/function: PF01470 Peptidase_C15; SSF53182 Peptidase_C15-like

EC number: =3.4.19.3

Molecular weight: Translated: 23472; Mature: 23472

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS01334 PYRASE_CYS; PS01333 PYRASE_GLU

Important sites: ACT_SITE 78-78 ACT_SITE 141-141 ACT_SITE 165-165

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKP
CEEEEECCCCCCCCCCCHHHHHHHHCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DYVLSIGQAGGRFELTPERVAINLDDGRIQDNAGYQPLNHTIHGDGENAYFTQLPIKAMA
CEEEEECCCCCEEEECHHHEEEECCCCEEECCCCCCCCCCCEECCCCCEEEEECCHHHHH
KAIREAGVPAAVSNTAGTYVCNHIFYQVQYMRDKMFPDIKAGFMHIPFLPEQVVTRPETP
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEECCCCCHHHHCCCCCC
ALSLDDDVLGITAAIRAIVSRDGKGDIETIEGKNH
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCC
>Mature Secondary Structure
MKILVTGFDPFGDDKINPAIEAVKRLPDEIAGAQIVKLEIPTKFNVSADVVKDAIAKEKP
CEEEEECCCCCCCCCCCHHHHHHHHCHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHCCC
DYVLSIGQAGGRFELTPERVAINLDDGRIQDNAGYQPLNHTIHGDGENAYFTQLPIKAMA
CEEEEECCCCCEEEECHHHEEEECCCCEEECCCCCCCCCCCEECCCCCEEEEECCHHHHH
KAIREAGVPAAVSNTAGTYVCNHIFYQVQYMRDKMFPDIKAGFMHIPFLPEQVVTRPETP
HHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCHHCCEEECCCCCHHHHCCCCCC
ALSLDDDVLGITAAIRAIVSRDGKGDIETIEGKNH
CCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA