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The map label for this gene is nox [H]

Identifier: 116493757

GI number: 116493757

Start: 189160

End: 190515

Strand: Direct

Name: nox [H]

Synonym: LSEI_0186

Alternate gene names: 116493757

Gene position: 189160-190515 (Clockwise)

Preceding gene: 116493755

Following gene: 116493758

Centisome position: 6.53

GC content: 46.68

Gene sequence:

>1356_bases
ATGAAAGTTGTCGTTGTGGGCTGTACGCATGCAGGAACTGCGGCAGTGCGCGAACTGTTGATGAAGCACCCAGAGACAGA
AGTGGATGTCTTTGAACGGCGGGAAGACATCTCCTTTCTTTCTTGCGGCATCGCGTTATACCTTGAAGGTACCGTTGGCC
GATTGGAAGATATGTTTTATGCTACGCCAGCTTCTTTAGAGGCGCTGGGGCCGCATGTTCACGTTCATCTCAAACATGAT
GTTTTAAGCATTGATGCCGCTGATCATCGGATTTTGGCCGAAAATCTTAAAACGGGCAACCAACAACATTATCAATATGA
TAAATTAGTCATGGCGACAGGTAGTTATCCTGTTGTTCCGCCGATTTCAGGTGTCAGTATTCCGCGGGTGCTGATGTGTA
AAAACTACGATGATGCTCGGCGAATCAAAGAAAGTGCCAAGGATGCTGAGCATATTGCGATTGTTGGTGGCGGGTATATT
GGTGTCGAACTGGCGGAAGCCTATAGCCGCAACCATAAACAGGTAACGTTAATTAATGGTGTTTCGCCTTTACTTAGTCA
TTATGTTGACTTACCACTTAGTCATGAAATCAGTGAGGCCCTGACAACACGTGGGGTTGAGTTGAAAGCCAACACAGTTG
CCAAGCATTTTGATAGTGATGATCAGCATGTTTTTATTCAAACAGATAAAGGCGAAATACAGGCAGATTTGGCGGTGGTT
TGTGTCGGGTTCCGGCCGATGACCGAGTTGCTGATCGGCCAAGTTGATATGAATCCTGATGGGTCCATTCACGTGAATGA
TTATATGCAGACCAGCAATCCGGATATTTTTGCAGCTGGTGATGCGGTCGCCGTCCATTTCAATCCCACTGGTAAGGACG
CTTATGCGCCTTTGGCCACCAATGCTGTGCGCCAAGGGATGATGGCTGGCGCTAACTTGTTTAAACCAACGATTAAATAT
ATGGGAACGCAAGCCACAAGCGCGCTAAAGTTGTACGATCATAACTTAGGTGTGACGGGTTTGACGCTTGCTCACGCCAA
GCGCAATCACCTGTCGGCTGCCAGTGTCACGATGACGGATGATTTTCGACCGCCATTCATGCCGGACACCGTCAAAATTA
CGATGGTGCTCGTCTATGATACTGATGATCGCCGGATTCTGGGTGCCCAGTTTTATAGTCAATATGATATTGTAAATGCA
GCTAATCTCATTTCTGTGATGATCCAAAATCGTAACACGATTGATCAGCTGGCTTATGTCGACATGCTGTTCAATCCGAA
TTATGATAAACCGTGGCATTATTTGAATCTGTTAGGGCAATTGGCTGTGACGCAAGCAGATAATACGACGGCGTAG

Upstream 100 bases:

>100_bases
ACTTGTAAGCGCCAGAAAGCGGTTAGCGACATGCTTTAGGTTTAGCCATTTTCGTGTCATAATGTCATTATTGACAATCT
TGAAAGGAAGGCAGATGCTG

Downstream 100 bases:

>100_bases
GGGGAAAATTATGAATTCGTGGAATCTTATCGGACTGTTGGCATGGGTGATACTCATCGCCTATTTGATTTTCATCGTCT
GGCACATTCGGCAACGGCAC

Product: NAD(FAD)-dependent dehydrogenase

Products: NA

Alternate protein names: NOXase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKVVVVGCTHAGTAAVRELLMKHPETEVDVFERREDISFLSCGIALYLEGTVGRLEDMFYATPASLEALGPHVHVHLKHD
VLSIDAADHRILAENLKTGNQQHYQYDKLVMATGSYPVVPPISGVSIPRVLMCKNYDDARRIKESAKDAEHIAIVGGGYI
GVELAEAYSRNHKQVTLINGVSPLLSHYVDLPLSHEISEALTTRGVELKANTVAKHFDSDDQHVFIQTDKGEIQADLAVV
CVGFRPMTELLIGQVDMNPDGSIHVNDYMQTSNPDIFAAGDAVAVHFNPTGKDAYAPLATNAVRQGMMAGANLFKPTIKY
MGTQATSALKLYDHNLGVTGLTLAHAKRNHLSAASVTMTDDFRPPFMPDTVKITMVLVYDTDDRRILGAQFYSQYDIVNA
ANLISVMIQNRNTIDQLAYVDMLFNPNYDKPWHYLNLLGQLAVTQADNTTA

Sequences:

>Translated_451_residues
MKVVVVGCTHAGTAAVRELLMKHPETEVDVFERREDISFLSCGIALYLEGTVGRLEDMFYATPASLEALGPHVHVHLKHD
VLSIDAADHRILAENLKTGNQQHYQYDKLVMATGSYPVVPPISGVSIPRVLMCKNYDDARRIKESAKDAEHIAIVGGGYI
GVELAEAYSRNHKQVTLINGVSPLLSHYVDLPLSHEISEALTTRGVELKANTVAKHFDSDDQHVFIQTDKGEIQADLAVV
CVGFRPMTELLIGQVDMNPDGSIHVNDYMQTSNPDIFAAGDAVAVHFNPTGKDAYAPLATNAVRQGMMAGANLFKPTIKY
MGTQATSALKLYDHNLGVTGLTLAHAKRNHLSAASVTMTDDFRPPFMPDTVKITMVLVYDTDDRRILGAQFYSQYDIVNA
ANLISVMIQNRNTIDQLAYVDMLFNPNYDKPWHYLNLLGQLAVTQADNTTA
>Mature_451_residues
MKVVVVGCTHAGTAAVRELLMKHPETEVDVFERREDISFLSCGIALYLEGTVGRLEDMFYATPASLEALGPHVHVHLKHD
VLSIDAADHRILAENLKTGNQQHYQYDKLVMATGSYPVVPPISGVSIPRVLMCKNYDDARRIKESAKDAEHIAIVGGGYI
GVELAEAYSRNHKQVTLINGVSPLLSHYVDLPLSHEISEALTTRGVELKANTVAKHFDSDDQHVFIQTDKGEIQADLAVV
CVGFRPMTELLIGQVDMNPDGSIHVNDYMQTSNPDIFAAGDAVAVHFNPTGKDAYAPLATNAVRQGMMAGANLFKPTIKY
MGTQATSALKLYDHNLGVTGLTLAHAKRNHLSAASVTMTDDFRPPFMPDTVKITMVLVYDTDDRRILGAQFYSQYDIVNA
ANLISVMIQNRNTIDQLAYVDMLFNPNYDKPWHYLNLLGQLAVTQADNTTA

Specific function: Catalyzes the four-electron reduction of molecular oxygen to water [H]

COG id: COG0446

COG function: function code R; Uncharacterized NAD(FAD)-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=247, Percent_Identity=27.9352226720648, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI226437568, Length=215, Percent_Identity=24.1860465116279, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI65787454, Length=215, Percent_Identity=24.1860465116279, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI21389617, Length=215, Percent_Identity=24.1860465116279, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1789065, Length=216, Percent_Identity=31.9444444444444, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789765, Length=327, Percent_Identity=26.2996941896024, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788892, Length=190, Percent_Identity=24.2105263157895, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082354, Length=232, Percent_Identity=26.7241379310345, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358499, Length=195, Percent_Identity=30.2564102564103, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24585130, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 49622; Mature: 49622

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVVVVGCTHAGTAAVRELLMKHPETEVDVFERREDISFLSCGIALYLEGTVGRLEDMFY
CEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECEEEEEECCHHHHHHHHC
ATPASLEALGPHVHVHLKHDVLSIDAADHRILAENLKTGNQQHYQYDKLVMATGSYPVVP
CCCCCHHHCCCEEEEEEECCEEEECCCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCC
PISGVSIPRVLMCKNYDDARRIKESAKDAEHIAIVGGGYIGVELAEAYSRNHKQVTLING
CCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHCCCCCEEEEECC
VSPLLSHYVDLPLSHEISEALTTRGVELKANTVAKHFDSDDQHVFIQTDKGEIQADLAVV
HHHHHHHHHCCCCCHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEEE
CVGFRPMTELLIGQVDMNPDGSIHVNDYMQTSNPDIFAAGDAVAVHFNPTGKDAYAPLAT
EECCCHHHHHHEEEECCCCCCCEEEECCEECCCCCEEEECCEEEEEECCCCCCCCCCHHH
NAVRQGMMAGANLFKPTIKYMGTQATSALKLYDHNLGVTGLTLAHAKRNHLSAASVTMTD
HHHHHHHHHCCHHHHHHHHHCCCCCHHEEEEEECCCCCCEEEEEHHHCCCCCEEEEEEEC
DFRPPFMPDTVKITMVLVYDTDDRRILGAQFYSQYDIVNAANLISVMIQNRNTIDQLAYV
CCCCCCCCCCEEEEEEEEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHEE
DMLFNPNYDKPWHYLNLLGQLAVTQADNTTA
HEEECCCCCCCHHHHHHHHHHHEECCCCCCC
>Mature Secondary Structure
MKVVVVGCTHAGTAAVRELLMKHPETEVDVFERREDISFLSCGIALYLEGTVGRLEDMFY
CEEEEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCEEEECEEEEEECCHHHHHHHHC
ATPASLEALGPHVHVHLKHDVLSIDAADHRILAENLKTGNQQHYQYDKLVMATGSYPVVP
CCCCCHHHCCCEEEEEEECCEEEECCCCCHHHHHHHCCCCCCCEEEEEEEEECCCCCCCC
PISGVSIPRVLMCKNYDDARRIKESAKDAEHIAIVGGGYIGVELAEAYSRNHKQVTLING
CCCCCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEECCEEHHHHHHHHCCCCCEEEEECC
VSPLLSHYVDLPLSHEISEALTTRGVELKANTVAKHFDSDDQHVFIQTDKGEIQADLAVV
HHHHHHHHHCCCCCHHHHHHHHHCCCEEEEHHHHHHCCCCCCEEEEEECCCCEEEEEEEE
CVGFRPMTELLIGQVDMNPDGSIHVNDYMQTSNPDIFAAGDAVAVHFNPTGKDAYAPLAT
EECCCHHHHHHEEEECCCCCCCEEEECCEECCCCCEEEECCEEEEEECCCCCCCCCCHHH
NAVRQGMMAGANLFKPTIKYMGTQATSALKLYDHNLGVTGLTLAHAKRNHLSAASVTMTD
HHHHHHHHHCCHHHHHHHHHCCCCCHHEEEEEECCCCCCEEEEEHHHCCCCCEEEEEEEC
DFRPPFMPDTVKITMVLVYDTDDRRILGAQFYSQYDIVNAANLISVMIQNRNTIDQLAYV
CCCCCCCCCCEEEEEEEEEECCCCEEEHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHEE
DMLFNPNYDKPWHYLNLLGQLAVTQADNTTA
HEEECCCCCCCHHHHHHHHHHHEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1404382; 12663927; 2511195; 8262333 [H]