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The map label for this gene is zosA [H]

Identifier: 116493642

GI number: 116493642

Start: 65748

End: 67604

Strand: Direct

Name: zosA [H]

Synonym: LSEI_0070

Alternate gene names: 116493642

Gene position: 65748-67604 (Clockwise)

Preceding gene: 116493629

Following gene: 116493643

Centisome position: 2.27

GC content: 52.45

Gene sequence:

>1857_bases
ATGCATTTTATTCAGACGCATAAACAAGAAGCGATGATTGCTGGCGGTGTGCTGACAGCAGGCGGTCTGATTTTTAGTCA
GGCATGGGTGCTAGTGTTGGCGAGTTTGGTGGCGGGCTTGCCGATTGCGATCAATGCATTGGCGGCGCTGCGGTATAAGC
AGATTAGTATTGAGTTGCTGGTGACGATTGCCCTGGTTGGCGCGGTGTTGATTGGTGAGCCGGTTGAAAGTGCTGTGGTC
AGTTTTCTATTTTTATTCGGTGACTGGTTAGAGCAGCGCAGTTTGGCGAAGACGCGTTCGGCGATTCAAGGCTTGGCGGC
TGCGGCACCGAAAACCGCGCGGCGACTGGATGGCACCATGATTCCGGTTGGTGACTTGGCGGTTGGTGATCAAGTCCGTG
TACTGGCCGGCGAAACGGTACCAGCTGATGGCAAAGTGATCAGTGGGCAGGCGAATGTTGTTGAAGCCGCGATCACTGGT
GAGCCGGATGCAAAAAGCAAGCAGGCCGACGCAACGGTTTATTCCGGCACGCAGGTGAGTGATGGTACGGTGGCTATTGA
AGTTGAGAAAACCGGCTACAACACGGTTTATCAACAGATCATTGATTTGATTGAAGATGCTCAGGACGCACAGTCACCAG
TCGCCACTTTTATCCAGAAGTTTGCGCGGTGGTATACGCCGCTGGTATTGATCATTGCTTTGCTCGTTGGTTTGATCAGC
CAAAATGTCCGACTAGCCATTACGATTTTGGTATTAGGCTGCCCTGGTGCATTGGTGATTGGCGCCCCCGTCAGCAATGT
TGTCGGCTTAGGCTTTGGCGCGAAGCACGGCATTTTGATCAAAGGCGGGGATGTGGCCACCAAATTGGATCAGATTGACA
CGGTGATGTTTGATAAAACCGGCACCTTAACCCAAGGCAAAATCAGCGTTGCAACGGCACATTATTGGGCGAACGATGAC
GCCAAAGTTGCTGAACTGGTGGCGGCAGTCGAGCAAGCAACAGCGCATCCGTTGGGGCAGGCATTGGTCGCCTACCTAAA
GCCGCAAACAACACCGTCTGTGACCGACGTGAAAGTCACGCGGGGAATTGGCGTGCAGGCGCAAGTAGCTGACCATACCG
TTAGCATTGGGAATCAAAAGAGTCTGACGCAGCCGCTGACTACCGCTCAGCAAGCCGCTATTCAAAACGTAATTAAAAGC
GGTGCTTCGTTGGTCGTGGCGACGATTGACGGCAAACTTGCTGCAGTTTACGGCTTACGCGATCAGTTGCGGACCGATAC
CCCAGGCATGTTGGCGACTCTTCAAGATAACGGTAAAAAGACGGTTGTGCTTTCAGGCGACTCGCAGGCGGCGGTTGAAC
ACATGATGGCGGATTTGCCACTGAGCCAGACCCACGGCGGTTTACTACCAGTCGACAAGGTCACGGCGATCAAGGCAGCG
CAAGCGCATGGTGAAAAGGTGATGTTTGTCGGTGACGGGATCAACGACGGGCCTGCACTGGCGCAAGCAGATGTTGGGGT
AGCCATGGGCTCAGGGATGGATGTGGCCATTGATACTGCTGATGTCATTTTAACCAGCAGTCGCCTGACGAATCTCGGCG
TTCTTTTCGATCTGGCTAAACGGATGGACAACAATATTAAACAGAATCTTGTCATTGCGATCGGAACTGTTGCTTTACTG
TTAAGCGGCTTGCTCATTGGGTTAGTTGATATGGCCAGCGGGATGCTGTTCCACGAAATTTCGATTCTGTTGGTCATCGC
GAATGCCTTACGGTTACGGCACACCCCCCGGAAGTTACAAAACTTGACGACGATCAAGGACGCCGCAGCACAAACTGTTA
ATAATGAAGGTAAATAA

Upstream 100 bases:

>100_bases
CAGTTCCAGAATAATCGTGTGGCAAATCCCTAAAGTTGATCACCGTCAAGGCAGCTTTCTTCATACCTCGGTACACTGGT
CTCAAATGGAGGGATTAGCG

Downstream 100 bases:

>100_bases
ACAAGAAAGGATTTTTAACATGACAAAATTAGTTTATCAATTAGATGGTTTAACCTGCCCAAGTTGCTTGCAGAAAATTG
AAGGCGCATTAGGCCAGCAA

Product: cation transport ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MHFIQTHKQEAMIAGGVLTAGGLIFSQAWVLVLASLVAGLPIAINALAALRYKQISIELLVTIALVGAVLIGEPVESAVV
SFLFLFGDWLEQRSLAKTRSAIQGLAAAAPKTARRLDGTMIPVGDLAVGDQVRVLAGETVPADGKVISGQANVVEAAITG
EPDAKSKQADATVYSGTQVSDGTVAIEVEKTGYNTVYQQIIDLIEDAQDAQSPVATFIQKFARWYTPLVLIIALLVGLIS
QNVRLAITILVLGCPGALVIGAPVSNVVGLGFGAKHGILIKGGDVATKLDQIDTVMFDKTGTLTQGKISVATAHYWANDD
AKVAELVAAVEQATAHPLGQALVAYLKPQTTPSVTDVKVTRGIGVQAQVADHTVSIGNQKSLTQPLTTAQQAAIQNVIKS
GASLVVATIDGKLAAVYGLRDQLRTDTPGMLATLQDNGKKTVVLSGDSQAAVEHMMADLPLSQTHGGLLPVDKVTAIKAA
QAHGEKVMFVGDGINDGPALAQADVGVAMGSGMDVAIDTADVILTSSRLTNLGVLFDLAKRMDNNIKQNLVIAIGTVALL
LSGLLIGLVDMASGMLFHEISILLVIANALRLRHTPRKLQNLTTIKDAAAQTVNNEGK

Sequences:

>Translated_618_residues
MHFIQTHKQEAMIAGGVLTAGGLIFSQAWVLVLASLVAGLPIAINALAALRYKQISIELLVTIALVGAVLIGEPVESAVV
SFLFLFGDWLEQRSLAKTRSAIQGLAAAAPKTARRLDGTMIPVGDLAVGDQVRVLAGETVPADGKVISGQANVVEAAITG
EPDAKSKQADATVYSGTQVSDGTVAIEVEKTGYNTVYQQIIDLIEDAQDAQSPVATFIQKFARWYTPLVLIIALLVGLIS
QNVRLAITILVLGCPGALVIGAPVSNVVGLGFGAKHGILIKGGDVATKLDQIDTVMFDKTGTLTQGKISVATAHYWANDD
AKVAELVAAVEQATAHPLGQALVAYLKPQTTPSVTDVKVTRGIGVQAQVADHTVSIGNQKSLTQPLTTAQQAAIQNVIKS
GASLVVATIDGKLAAVYGLRDQLRTDTPGMLATLQDNGKKTVVLSGDSQAAVEHMMADLPLSQTHGGLLPVDKVTAIKAA
QAHGEKVMFVGDGINDGPALAQADVGVAMGSGMDVAIDTADVILTSSRLTNLGVLFDLAKRMDNNIKQNLVIAIGTVALL
LSGLLIGLVDMASGMLFHEISILLVIANALRLRHTPRKLQNLTTIKDAAAQTVNNEGK
>Mature_618_residues
MHFIQTHKQEAMIAGGVLTAGGLIFSQAWVLVLASLVAGLPIAINALAALRYKQISIELLVTIALVGAVLIGEPVESAVV
SFLFLFGDWLEQRSLAKTRSAIQGLAAAAPKTARRLDGTMIPVGDLAVGDQVRVLAGETVPADGKVISGQANVVEAAITG
EPDAKSKQADATVYSGTQVSDGTVAIEVEKTGYNTVYQQIIDLIEDAQDAQSPVATFIQKFARWYTPLVLIIALLVGLIS
QNVRLAITILVLGCPGALVIGAPVSNVVGLGFGAKHGILIKGGDVATKLDQIDTVMFDKTGTLTQGKISVATAHYWANDD
AKVAELVAAVEQATAHPLGQALVAYLKPQTTPSVTDVKVTRGIGVQAQVADHTVSIGNQKSLTQPLTTAQQAAIQNVIKS
GASLVVATIDGKLAAVYGLRDQLRTDTPGMLATLQDNGKKTVVLSGDSQAAVEHMMADLPLSQTHGGLLPVDKVTAIKAA
QAHGEKVMFVGDGINDGPALAQADVGVAMGSGMDVAIDTADVILTSSRLTNLGVLFDLAKRMDNNIKQNLVIAIGTVALL
LSGLLIGLVDMASGMLFHEISILLVIANALRLRHTPRKLQNLTTIKDAAAQTVNNEGK

Specific function: Couples the hydrolysis of ATP with the transport of zinc into the cell [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=628, Percent_Identity=28.8216560509554, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI55743073, Length=480, Percent_Identity=30.4166666666667, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI115529486, Length=449, Percent_Identity=26.9487750556793, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI83700225, Length=252, Percent_Identity=26.5873015873016, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI153946397, Length=350, Percent_Identity=25.7142857142857, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI237681111, Length=270, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI22748667, Length=246, Percent_Identity=26.0162601626016, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI237681109, Length=262, Percent_Identity=25.9541984732824, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI21361181, Length=262, Percent_Identity=25.9541984732824, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI297374799, Length=258, Percent_Identity=26.7441860465116, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI4502271, Length=246, Percent_Identity=25.609756097561, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1789879, Length=578, Percent_Identity=35.121107266436, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786691, Length=549, Percent_Identity=34.0619307832423, Blast_Score=252, Evalue=5e-68,
Organism=Escherichia coli, GI1786914, Length=532, Percent_Identity=26.8796992481203, Blast_Score=112, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17556548, Length=563, Percent_Identity=26.6429840142096, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17559224, Length=310, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=522, Percent_Identity=27.2030651340996, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319772, Length=631, Percent_Identity=26.6244057052298, Blast_Score=176, Evalue=7e-45,
Organism=Saccharomyces cerevisiae, GI6325221, Length=493, Percent_Identity=22.5152129817444, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321430, Length=526, Percent_Identity=21.8631178707224, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221329854, Length=342, Percent_Identity=26.9005847953216, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI281366676, Length=244, Percent_Identity=27.4590163934426, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648582, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24648576, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553441, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648580, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648578, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI281362164, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553435, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553439, Length=336, Percent_Identity=25, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI45553437, Length=336, Percent_Identity=25, Blast_Score=66, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR000150 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 64415; Mature: 64415

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFIQTHKQEAMIAGGVLTAGGLIFSQAWVLVLASLVAGLPIAINALAALRYKQISIELL
CCCCHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VTIALVGAVLIGEPVESAVVSFLFLFGDWLEQRSLAKTRSAIQGLAAAAPKTARRLDGTM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCE
IPVGDLAVGDQVRVLAGETVPADGKVISGQANVVEAAITGEPDAKSKQADATVYSGTQVS
ECCCCCCCCCCEEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCEEC
DGTVAIEVEKTGYNTVYQQIIDLIEDAQDAQSPVATFIQKFARWYTPLVLIIALLVGLIS
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNVRLAITILVLGCPGALVIGAPVSNVVGLGFGAKHGILIKGGDVATKLDQIDTVMFDKT
CCCEEEEEEEEECCCCCEEECCCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEEECCC
GTLTQGKISVATAHYWANDDAKVAELVAAVEQATAHPLGQALVAYLKPQTTPSVTDVKVT
CCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEE
RGIGVQAQVADHTVSIGNQKSLTQPLTTAQQAAIQNVIKSGASLVVATIDGKLAAVYGLR
CCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCH
DQLRTDTPGMLATLQDNGKKTVVLSGDSQAAVEHMMADLPLSQTHGGLLPVDKVTAIKAA
HHHCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
QAHGEKVMFVGDGINDGPALAQADVGVAMGSGMDVAIDTADVILTSSRLTNLGVLFDLAK
HCCCCEEEEEECCCCCCCCHHHCCCCEEECCCCEEEEECHHHEEEHHHHHHHHHHHHHHH
RMDNNIKQNLVIAIGTVALLLSGLLIGLVDMASGMLFHEISILLVIANALRLRHTPRKLQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NLTTIKDAAAQTVNNEGK
HHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MHFIQTHKQEAMIAGGVLTAGGLIFSQAWVLVLASLVAGLPIAINALAALRYKQISIELL
CCCCHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
VTIALVGAVLIGEPVESAVVSFLFLFGDWLEQRSLAKTRSAIQGLAAAAPKTARRLDGTM
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCE
IPVGDLAVGDQVRVLAGETVPADGKVISGQANVVEAAITGEPDAKSKQADATVYSGTQVS
ECCCCCCCCCCEEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEECCCEEC
DGTVAIEVEKTGYNTVYQQIIDLIEDAQDAQSPVATFIQKFARWYTPLVLIIALLVGLIS
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
QNVRLAITILVLGCPGALVIGAPVSNVVGLGFGAKHGILIKGGDVATKLDQIDTVMFDKT
CCCEEEEEEEEECCCCCEEECCCHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHEEECCC
GTLTQGKISVATAHYWANDDAKVAELVAAVEQATAHPLGQALVAYLKPQTTPSVTDVKVT
CCCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCEEEEE
RGIGVQAQVADHTVSIGNQKSLTQPLTTAQQAAIQNVIKSGASLVVATIDGKLAAVYGLR
CCCCCEEEECCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEECCCH
DQLRTDTPGMLATLQDNGKKTVVLSGDSQAAVEHMMADLPLSQTHGGLLPVDKVTAIKAA
HHHCCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
QAHGEKVMFVGDGINDGPALAQADVGVAMGSGMDVAIDTADVILTSSRLTNLGVLFDLAK
HCCCCEEEEEECCCCCCCCHHHCCCCEEECCCCEEEEECHHHEEEHHHHHHHHHHHHHHH
RMDNNIKQNLVIAIGTVALLLSGLLIGLVDMASGMLFHEISILLVIANALRLRHTPRKLQ
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHH
NLTTIKDAAAQTVNNEGK
HHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]