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The map label for this gene is dltA [H]

Identifier: 116493318

GI number: 116493318

Start: 1559073

End: 1560599

Strand: Reverse

Name: dltA [H]

Synonym: PEPE_1590

Alternate gene names: 116493318

Gene position: 1560599-1559073 (Counterclockwise)

Preceding gene: 116493319

Following gene: 116493317

Centisome position: 85.17

GC content: 37.33

Gene sequence:

>1527_bases
ATGGGGAAAGTAATTAACGTGATTGAGCAAATTGATTCAATCGCAGTTAAACATCCAGATTGGATTGCTTATGATTATCT
AGGTACTAAGAACACATATGGAGAATTAAAAGCTTATTCAGATAGCTTAGCTGCATATATTTTAACGCAAGGGTTGGAAG
AAGATGCGCCAATTATGGTTTATGGTGCTCAAACCTTTGATATGATTGCAGCTTTTTTAGGGGTTGTAAAAAGTGGACAC
GCTTATGTCCCAATTGATCGCCACTCACCAGCAGAACGATTAACAATGATTAATGAAATTGCTAATCCTGGGATGTGTAT
CGCGGTTGAAGATTTGCCTGTAAATTTGGGTGATCTACCAGTTCTAGAAGGACAAGAATTAAACGATGTTTTTAATGCAA
ATAAAAATGTAACACCTAATAGTTTCGTCACTAAAGATGATAATTATTATATTATTTTCACGTCTGGGACAACTGGTAAG
CCTAAGGGAGTACAAATCAGTCACAATAATCTTTTAAGTTTTGTGAATTGGGAAATTGGCAATCTAGGTTTACCTGAACG
TCCAGTGACGTTATCACAGCCACCTTACTCATTTGACCTATCCGTAATGGATTTATATCCCACATTAGTTATGGGTGGAA
CAATCAAAGCGGTGCCCAAGCAAGTTACGGATGATTTCAAAAAATTATTTGAAATATTACCCACTTTGGGCTTAAATGTG
TGGGTTTCAACACCATCCTTCATGGATATCTGTTTGTTGCAACCGACTTTTGATGCAGAACATCTACCAGCATTGAGCCG
ATTCTTGTTCTGTGGTGAAGAATTAACACACGCTACTGCGCAAGCTCTTAAACTACGTTTTCCAGATGCAAAAATCTTTA
ATACGTACGGGCCTACAGAAGCGACCGTCGCAGTTAGTGCAATCGAAATTACAGATGAGGTACTTAAACAATATGATCGT
CTACCAATTGGATATTTAAAAGAAGATACTCTGGGATTTATCCTTGATGATAATGGAAGAATGGCCAATGCTGGTGCTGA
AGGAGAATTAGTTCTATCAGGACCAAGTGTTTCCAAAGGTTATCTCAATAATCCGGAAAAAACGGACGAAGCCTTTTTTG
AATATGAAGGTCAACGTGCCTATAAAACTGGTGATTTAGTTAAGATTGATGATACTGGAATGCTTTATTATCATGGACGG
ACTGATTTCCAAATTAAACTGCATGGTTACCGAATCGAACTTGAAGAGGTTAACCATTACTTAAATAACGATCCATTAAT
TCAGGCTGGAGTGGCAGTTCCTAAATATGGGAAAGACCAAAAGGTGGCTCAATTAGTGGCCTATGTTGTTCCTGAAAAAA
ATGAGTTCGATTCTCAAATTCAATTAACAGTTGCGATTAAAGATAGTTTGAAGGATAACATGATGGAATATGCTGTTCCA
AATCGCTTTGTATTTGTTGAAAGTTTACCGCAAACGGCCAACGGAAAAATCGATATTAAATCTGTTATTGCTGAGGTTAA
TGCCTAA

Upstream 100 bases:

>100_bases
TTTGCAGTTTTAGTCGTCTTGTTGTACTTGTACGATTACAGCGGAATGACTGGCGGAACATTTATCTATAACGAATTTTA
AACGGGGGATTTAATTAATT

Downstream 100 bases:

>100_bases
TGCTTTCATTAACACCATATGAAAATCCAATGTATTTTGGCATGCTAGCTGTGGCATTTATTCCCATTGTTGTAGGAATC
CTTTGGGGCAAGAGATTTCG

Product: D-alanine-activating enzyme

Products: NA

Alternate protein names: D-alanine-D-alanyl carrier protein ligase; DCL; D-alanine-activating enzyme; DAE [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MGKVINVIEQIDSIAVKHPDWIAYDYLGTKNTYGELKAYSDSLAAYILTQGLEEDAPIMVYGAQTFDMIAAFLGVVKSGH
AYVPIDRHSPAERLTMINEIANPGMCIAVEDLPVNLGDLPVLEGQELNDVFNANKNVTPNSFVTKDDNYYIIFTSGTTGK
PKGVQISHNNLLSFVNWEIGNLGLPERPVTLSQPPYSFDLSVMDLYPTLVMGGTIKAVPKQVTDDFKKLFEILPTLGLNV
WVSTPSFMDICLLQPTFDAEHLPALSRFLFCGEELTHATAQALKLRFPDAKIFNTYGPTEATVAVSAIEITDEVLKQYDR
LPIGYLKEDTLGFILDDNGRMANAGAEGELVLSGPSVSKGYLNNPEKTDEAFFEYEGQRAYKTGDLVKIDDTGMLYYHGR
TDFQIKLHGYRIELEEVNHYLNNDPLIQAGVAVPKYGKDQKVAQLVAYVVPEKNEFDSQIQLTVAIKDSLKDNMMEYAVP
NRFVFVESLPQTANGKIDIKSVIAEVNA

Sequences:

>Translated_508_residues
MGKVINVIEQIDSIAVKHPDWIAYDYLGTKNTYGELKAYSDSLAAYILTQGLEEDAPIMVYGAQTFDMIAAFLGVVKSGH
AYVPIDRHSPAERLTMINEIANPGMCIAVEDLPVNLGDLPVLEGQELNDVFNANKNVTPNSFVTKDDNYYIIFTSGTTGK
PKGVQISHNNLLSFVNWEIGNLGLPERPVTLSQPPYSFDLSVMDLYPTLVMGGTIKAVPKQVTDDFKKLFEILPTLGLNV
WVSTPSFMDICLLQPTFDAEHLPALSRFLFCGEELTHATAQALKLRFPDAKIFNTYGPTEATVAVSAIEITDEVLKQYDR
LPIGYLKEDTLGFILDDNGRMANAGAEGELVLSGPSVSKGYLNNPEKTDEAFFEYEGQRAYKTGDLVKIDDTGMLYYHGR
TDFQIKLHGYRIELEEVNHYLNNDPLIQAGVAVPKYGKDQKVAQLVAYVVPEKNEFDSQIQLTVAIKDSLKDNMMEYAVP
NRFVFVESLPQTANGKIDIKSVIAEVNA
>Mature_507_residues
GKVINVIEQIDSIAVKHPDWIAYDYLGTKNTYGELKAYSDSLAAYILTQGLEEDAPIMVYGAQTFDMIAAFLGVVKSGHA
YVPIDRHSPAERLTMINEIANPGMCIAVEDLPVNLGDLPVLEGQELNDVFNANKNVTPNSFVTKDDNYYIIFTSGTTGKP
KGVQISHNNLLSFVNWEIGNLGLPERPVTLSQPPYSFDLSVMDLYPTLVMGGTIKAVPKQVTDDFKKLFEILPTLGLNVW
VSTPSFMDICLLQPTFDAEHLPALSRFLFCGEELTHATAQALKLRFPDAKIFNTYGPTEATVAVSAIEITDEVLKQYDRL
PIGYLKEDTLGFILDDNGRMANAGAEGELVLSGPSVSKGYLNNPEKTDEAFFEYEGQRAYKTGDLVKIDDTGMLYYHGRT
DFQIKLHGYRIELEEVNHYLNNDPLIQAGVAVPKYGKDQKVAQLVAYVVPEKNEFDSQIQLTVAIKDSLKDNMMEYAVPN
RFVFVESLPQTANGKIDIKSVIAEVNA

Specific function: Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp [H]

COG id: COG1020

COG function: function code Q; Non-ribosomal peptide synthetase modules and related proteins

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. DltA subfamily [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=392, Percent_Identity=27.8061224489796, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI187761343, Length=392, Percent_Identity=27.8061224489796, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI156151445, Length=366, Percent_Identity=26.5027322404372, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI38505220, Length=379, Percent_Identity=25.5936675461741, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI115511026, Length=398, Percent_Identity=25.3768844221106, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI122937307, Length=370, Percent_Identity=26.4864864864865, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI58082049, Length=365, Percent_Identity=24.9315068493151, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI157311624, Length=365, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI157311622, Length=365, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1786801, Length=503, Percent_Identity=28.0318091451292, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI145693145, Length=505, Percent_Identity=25.1485148514851, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786810, Length=500, Percent_Identity=23.4, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788107, Length=550, Percent_Identity=22, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=483, Percent_Identity=25.0517598343685, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17556356, Length=477, Percent_Identity=26.2054507337526, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI32563687, Length=476, Percent_Identity=22.8991596638655, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17550940, Length=377, Percent_Identity=23.8726790450928, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=374, Percent_Identity=25.668449197861, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=396, Percent_Identity=24.2424242424242, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=385, Percent_Identity=23.8961038961039, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71985884, Length=328, Percent_Identity=26.219512195122, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17560308, Length=535, Percent_Identity=24.4859813084112, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6319591, Length=554, Percent_Identity=25.0902527075812, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319699, Length=402, Percent_Identity=28.3582089552239, Blast_Score=92, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24648676, Length=454, Percent_Identity=27.7533039647577, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI21355181, Length=389, Percent_Identity=26.2210796915167, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18859661, Length=367, Percent_Identity=26.9754768392371, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR010072 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.1.1.13 [H]

Molecular weight: Translated: 56324; Mature: 56192

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKVINVIEQIDSIAVKHPDWIAYDYLGTKNTYGELKAYSDSLAAYILTQGLEEDAPIMV
CCHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
YGAQTFDMIAAFLGVVKSGHAYVPIDRHSPAERLTMINEIANPGMCIAVEDLPVNLGDLP
ECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
VLEGQELNDVFNANKNVTPNSFVTKDDNYYIIFTSGTTGKPKGVQISHNNLLSFVNWEIG
CCCCCCHHHHHCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEECC
NLGLPERPVTLSQPPYSFDLSVMDLYPTLVMGGTIKAVPKQVTDDFKKLFEILPTLGLNV
CCCCCCCCEECCCCCCEECEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
WVSTPSFMDICLLQPTFDAEHLPALSRFLFCGEELTHATAQALKLRFPDAKIFNTYGPTE
EECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCEEEECCCCCC
ATVAVSAIEITDEVLKQYDRLPIGYLKEDTLGFILDDNGRMANAGAEGELVLSGPSVSKG
CEEEEEEHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCEECCCCCCEEEEECCCCCCC
YLNNPEKTDEAFFEYEGQRAYKTGDLVKIDDTGMLYYHGRTDFQIKLHGYRIELEEVNHY
CCCCCCCCCHHHHEECCCEEECCCCEEEECCCEEEEEECCCEEEEEEEEEEEEHHHHHHH
LNNDPLIQAGVAVPKYGKDQKVAQLVAYVVPEKNEFDSQIQLTVAIKDSLKDNMMEYAVP
HCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHHCCC
NRFVFVESLPQTANGKIDIKSVIAEVNA
CEEEEEECCCCCCCCCEEHHHHHHHCCC
>Mature Secondary Structure 
GKVINVIEQIDSIAVKHPDWIAYDYLGTKNTYGELKAYSDSLAAYILTQGLEEDAPIMV
CHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEE
YGAQTFDMIAAFLGVVKSGHAYVPIDRHSPAERLTMINEIANPGMCIAVEDLPVNLGDLP
ECCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCC
VLEGQELNDVFNANKNVTPNSFVTKDDNYYIIFTSGTTGKPKGVQISHNNLLSFVNWEIG
CCCCCCHHHHHCCCCCCCCCCEEECCCCEEEEEECCCCCCCCCEEEECCCEEEEEEEECC
NLGLPERPVTLSQPPYSFDLSVMDLYPTLVMGGTIKAVPKQVTDDFKKLFEILPTLGLNV
CCCCCCCCEECCCCCCEECEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
WVSTPSFMDICLLQPTFDAEHLPALSRFLFCGEELTHATAQALKLRFPDAKIFNTYGPTE
EECCCCCEEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHEEECCCCEEEECCCCCC
ATVAVSAIEITDEVLKQYDRLPIGYLKEDTLGFILDDNGRMANAGAEGELVLSGPSVSKG
CEEEEEEHHHHHHHHHHHCCCCCCEECCCCEEEEECCCCCEECCCCCCEEEEECCCCCCC
YLNNPEKTDEAFFEYEGQRAYKTGDLVKIDDTGMLYYHGRTDFQIKLHGYRIELEEVNHY
CCCCCCCCCHHHHEECCCEEECCCCEEEECCCEEEEEECCCEEEEEEEEEEEEHHHHHHH
LNNDPLIQAGVAVPKYGKDQKVAQLVAYVVPEKNEFDSQIQLTVAIKDSLKDNMMEYAVP
HCCCCEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEEEEEHHHHHHHHHHCCC
NRFVFVESLPQTANGKIDIKSVIAEVNA
CEEEEEECCCCCCCCCEEHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]