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The map label for this gene is alr

Identifier: 116493287

GI number: 116493287

Start: 1527638

End: 1528762

Strand: Reverse

Name: alr

Synonym: PEPE_1559

Alternate gene names: 116493287

Gene position: 1528762-1527638 (Counterclockwise)

Preceding gene: 116493288

Following gene: 116493286

Centisome position: 83.43

GC content: 38.76

Gene sequence:

>1125_bases
ATGGTTGTAGGGATACATCGTCCCAGCAAGCTAGTTATTAATGCTGAGGCAATTAGAAATAATGTAAAAAATGAGATTAG
TCGATTAGATGGACACAGTGAATTATTTGCCGTGGTTAAGGCTAATGGCTATGGACATGGAATTGTAGAAACAGCCCAAT
TTACGAAACAAGCTGGGGCAACTGGTTTTTGTGTTGCTATCTTAGACGAAGCGTTGGCTTTGCGAGATGCTGGGCTAACA
GAAACTATCCTAGTTTTAGGAATTACAGATGTTAAATATGCTAAATTAGCTGCTGAAAATGATATCTCGTTAACGGTGGG
TGATCAAGCATGGCTAGATGAAGCTACGCAAATTCTAAATCAAAAGCCGCTGAAAGTTCATTTAGGTATTGATACAGGAA
TGGGACGGATTGGTTTTCAAGATGGAGCTTCTTTTAAGAAAGCGGCCGATTATCTTGAACAAAGTCAACAGTTCAATTTT
GAAGGTGTGTTTACACATTTTGCAACAGCAGATGAAAAGGATACGACTTATTTCAATTTACAGGTGGAACGTTTTAACCA
TTTCATCAGCCAATTAACTCGACGTCCACGTTATGTGCATGTTTCTAATACTGCTACCAGCTTGTGGCATGCAGCTTGCA
ATGGTAATATGATTCGTTTTGGAGTCGGCATTTATGGGATGAATCCTTCTGGAAAAACACTGGAAAGTCCTTTTGATTTA
CAGCCAGCTATGAGTCTGGAGTCTGAACTATCTTTTTCTAAACTAGTGCAAAAAGGCCGTTCAATTAGTTATGGAGCGAC
TTATACAGCTGAAGAAGATGAATGGATTGGGACGATCCCGATTGGTTATGCAGATGGTTATGAACGTCGTTTACAAGGAT
TCCATGTTTTGATTGATGGTCAATTTTGCGAAATAGTAGGACGAATTTGTATGGATCAAATGATGGTTCGCTTACCAAAG
TCATATCCTGTGGGAACTAAAGTAATTTTAGCGGGAAAATCAGGCGAAAAATCAATTACCATGACAGACATTGCCGAATA
TGCTGGGACCATTAATTATGAAATCACATGTGGATTCACACAACGTTTACCACGAATCTATACTGAAAATGGTGTAGTAA
ATTAA

Upstream 100 bases:

>100_bases
AAGATTGTTAAACATCCGTTTAGTGGAACCGTACATGTGTCAATTTCCCATTCTGACCACCATGTTGTAACACAGGTAAT
TTTAGAGGGGGATAATTGAA

Downstream 100 bases:

>100_bases
TGTATTGAATGCTAAAATAATGTTAATAATTAAATAGTACAGGAGAGCAATCTAATGAGTATTCAACCAAAAGATATGTC
AATTGAGAAAGAGACTTACT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MVVGIHRPSKLVINAEAIRNNVKNEISRLDGHSELFAVVKANGYGHGIVETAQFTKQAGATGFCVAILDEALALRDAGLT
ETILVLGITDVKYAKLAAENDISLTVGDQAWLDEATQILNQKPLKVHLGIDTGMGRIGFQDGASFKKAADYLEQSQQFNF
EGVFTHFATADEKDTTYFNLQVERFNHFISQLTRRPRYVHVSNTATSLWHAACNGNMIRFGVGIYGMNPSGKTLESPFDL
QPAMSLESELSFSKLVQKGRSISYGATYTAEEDEWIGTIPIGYADGYERRLQGFHVLIDGQFCEIVGRICMDQMMVRLPK
SYPVGTKVILAGKSGEKSITMTDIAEYAGTINYEITCGFTQRLPRIYTENGVVN

Sequences:

>Translated_374_residues
MVVGIHRPSKLVINAEAIRNNVKNEISRLDGHSELFAVVKANGYGHGIVETAQFTKQAGATGFCVAILDEALALRDAGLT
ETILVLGITDVKYAKLAAENDISLTVGDQAWLDEATQILNQKPLKVHLGIDTGMGRIGFQDGASFKKAADYLEQSQQFNF
EGVFTHFATADEKDTTYFNLQVERFNHFISQLTRRPRYVHVSNTATSLWHAACNGNMIRFGVGIYGMNPSGKTLESPFDL
QPAMSLESELSFSKLVQKGRSISYGATYTAEEDEWIGTIPIGYADGYERRLQGFHVLIDGQFCEIVGRICMDQMMVRLPK
SYPVGTKVILAGKSGEKSITMTDIAEYAGTINYEITCGFTQRLPRIYTENGVVN
>Mature_374_residues
MVVGIHRPSKLVINAEAIRNNVKNEISRLDGHSELFAVVKANGYGHGIVETAQFTKQAGATGFCVAILDEALALRDAGLT
ETILVLGITDVKYAKLAAENDISLTVGDQAWLDEATQILNQKPLKVHLGIDTGMGRIGFQDGASFKKAADYLEQSQQFNF
EGVFTHFATADEKDTTYFNLQVERFNHFISQLTRRPRYVHVSNTATSLWHAACNGNMIRFGVGIYGMNPSGKTLESPFDL
QPAMSLESELSFSKLVQKGRSISYGATYTAEEDEWIGTIPIGYADGYERRLQGFHVLIDGQFCEIVGRICMDQMMVRLPK
SYPVGTKVILAGKSGEKSITMTDIAEYAGTINYEITCGFTQRLPRIYTENGVVN

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=368, Percent_Identity=30.9782608695652, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790487, Length=377, Percent_Identity=32.0954907161804, Blast_Score=154, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_PEDPA (Q03DZ2)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_805022.1
- ProteinModelPortal:   Q03DZ2
- SMR:   Q03DZ2
- STRING:   Q03DZ2
- GeneID:   4417191
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_1559
- NMPDR:   fig|278197.10.peg.1368
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   DEYCRVG
- PhylomeDB:   Q03DZ2
- ProtClustDB:   CLSK821195
- BioCyc:   PPEN278197:PEPE_1559-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 41263; Mature: 41263

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 40-40 ACT_SITE 264-264

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVGIHRPSKLVINAEAIRNNVKNEISRLDGHSELFAVVKANGYGHGIVETAQFTKQAGA
CEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
TGFCVAILDEALALRDAGLTETILVLGITDVKYAKLAAENDISLTVGDQAWLDEATQILN
CEEHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCCCCCEEEECCHHHHHHHHHHHC
QKPLKVHLGIDTGMGRIGFQDGASFKKAADYLEQSQQFNFEGVFTHFATADEKDTTYFNL
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEE
QVERFNHFISQLTRRPRYVHVSNTATSLWHAACNGNMIRFGVGIYGMNPSGKTLESPFDL
EHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCC
QPAMSLESELSFSKLVQKGRSISYGATYTAEEDEWIGTIPIGYADGYERRLQGFHVLIDG
CCCHHHHHCCCHHHHHHCCCCEECCEEEECCCCCEEEEEECCCCCCHHHHCCCEEEEECC
QFCEIVGRICMDQMMVRLPKSYPVGTKVILAGKSGEKSITMTDIAEYAGTINYEITCGFT
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEHHHHHHHCCEEEEEEEECHH
QRLPRIYTENGVVN
HHCCHHCCCCCCCC
>Mature Secondary Structure
MVVGIHRPSKLVINAEAIRNNVKNEISRLDGHSELFAVVKANGYGHGIVETAQFTKQAGA
CEEECCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCC
TGFCVAILDEALALRDAGLTETILVLGITDVKYAKLAAENDISLTVGDQAWLDEATQILN
CEEHHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHCCCCCCEEEECCHHHHHHHHHHHC
QKPLKVHLGIDTGMGRIGFQDGASFKKAADYLEQSQQFNFEGVFTHFATADEKDTTYFNL
CCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCEEEEE
QVERFNHFISQLTRRPRYVHVSNTATSLWHAACNGNMIRFGVGIYGMNPSGKTLESPFDL
EHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCCCCC
QPAMSLESELSFSKLVQKGRSISYGATYTAEEDEWIGTIPIGYADGYERRLQGFHVLIDG
CCCHHHHHCCCHHHHHHCCCCEECCEEEECCCCCEEEEEECCCCCCHHHHCCCEEEEECC
QFCEIVGRICMDQMMVRLPKSYPVGTKVILAGKSGEKSITMTDIAEYAGTINYEITCGFT
HHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEHHHHHHHCCEEEEEEEECHH
QRLPRIYTENGVVN
HHCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA