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The map label for this gene is dnaX [H]

Identifier: 116493222

GI number: 116493222

Start: 1454199

End: 1455944

Strand: Reverse

Name: dnaX [H]

Synonym: PEPE_1484

Alternate gene names: 116493222

Gene position: 1455944-1454199 (Counterclockwise)

Preceding gene: 116493223

Following gene: 116493221

Centisome position: 79.46

GC content: 38.49

Gene sequence:

>1746_bases
ATGAGTTATCAAGCATTATACCGTGTTTGGCGGCCTCAAAAGTTTGATGATATGGTCGGTCAAGACGTCGTCACGAGGAC
TTTAAAAAATGCATTAATAACTGAGCAGACCAGCCATGCGTATCTATTTACTGGTCCACGAGGAACCGGAAAAACATCGG
CAGCTAAGATTTTTGCTAAGGCGGTTAATTGTCACTATCTTAAAGATGGTGAGCCTTGTAATGAATGTGTGACTTGTAAA
GCGATTACTGAGGGAACCTTAAACGATGTAATCGAAATTGATGCGGCCTCGAATAATGGTGTCGAAGAAATTCGCGATAT
TCGAGATAAGGCAAAGTATGCTCCAACTGAAGCAGACTACAAAGTCTACATTGTTGATGAAGTCCATATGCTATCAACCG
GAGCATTTAATGCGTTGTTGAAAACTTTAGAAGAACCACCAGCTAATGTAATTTTTATTTTAGCAACGACGGAACCTCAA
AAGATTCCATTAACTATTATTTCAAGAACACAACGTTTTGATTTTAAACGAATTACACCAGCTCAAAGTTATGATCGCAT
GGTCTATATTTTGGATCAAAAGGGAATCCAGTACGATCAAAAGGCTTTAGCAATTATCGCCAAGGCTGCTGAAGGTGGGA
TGCGAGATGCGTTAAGTATTTTGGATCAAGTGATCTCATTTGGTAACGAAGAAGTAACTTTAGATAACGCCTTATTAGTT
ACAGGAAGTGTTAACCAAAAACTATTAGATCAGTATTTAACGCAAATTTTTAAGCAAGAAACATCAGCGGCATTAGAAAC
TTTGCATCAAATTTTAGATGAGGGTAAAGATGGACAACGATTAATTGAAGACTTAATTGCTGTCCAAAGAAATTTACTCT
TATACCAAGAAGATCCCCAGTTGGTGCAAGAACAAAGCTTGAATGATCTATCGGAAGCTTTTACTGAAGAAGCAGCTATG
GTGACTGGCGTGGAGCTATATCAGATGATTGATACGTTGAATAGTATTCAACAACAAATGCGCTTCACGACTCACCCAGA
TGTCTATTTGGAAGTTTTGACGATTAAGCTATCACAACGAAAAACTGCGAAAGTTTCCACCGAAGCCCCAACCGGTTCCG
TGGATAACCAAGAAGTGGAGCAGTTACGTTCAGAAGTCAGTCAATTAAAACAAGCAATTCAAAAGCTACAACAAAATGTA
AAAAATACGCCAAGTAATTCACAATCAGCTCAGCCTAAACCTAAGAAAAAAGCGGTAGGGGCTAAACAAGTTAAAACTCC
TGCTAATTTAACCAAGATTTATCCGATCTTGGAAAATGCTACTAAGGCCAGTTTAAATACAATGCAGGAACTCTGGCGCG
ACCTAATGGATATGCTATCTGTTACAGAACGGGCTTTAATGCACGTTTCTAAGCCAGTTGCAGCTAGTAAAGAAGGAGTG
GTCGTAGCGTTCAATTACGACTTTCTGTTTGAAAAGGCCGTCGATAATGAAGTGCTTCGTACTGAACTTCAACAAAATTT
AGCTAAGTTAACTGGTTCCGATTTTAAGGTAGTTTATGTTACAGTTGAAGAGTGGCCAGAGGTGCGGTCAGGTTTCTTAA
ATACTCATCATTTTGATAAGAATCAAGAAAAATCTGAACCAGAGGCATCAGAGCAATCTACACCCAAAGCGGATGAAGAT
AATCAAGCTGTTAAAAAAGCGGTCGAATTATTTGGCTCTGAAAATGTAAATATAAAAAATGATTAA

Upstream 100 bases:

>100_bases
CTCTGGCTTGTGCCTTAAGTTATTGGGTAAATTAACGAACTCTTAGTCCATTGGGCTAAGGGTTCTTTTCTTAAAAAAAG
CAAATATGGAAGGAAATCAA

Downstream 100 bases:

>100_bases
AGGATGGTAATACAAATGCGTGGTGGAATGGGAAACATGCAAAGCATGATGCGTCAAATGCAAAAGATGCAAAAAAAGGT
AACAGAAGAACAAGAAAAAT

Product: DNA polymerase III, gamma/tau subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MSYQALYRVWRPQKFDDMVGQDVVTRTLKNALITEQTSHAYLFTGPRGTGKTSAAKIFAKAVNCHYLKDGEPCNECVTCK
AITEGTLNDVIEIDAASNNGVEEIRDIRDKAKYAPTEADYKVYIVDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPQ
KIPLTIISRTQRFDFKRITPAQSYDRMVYILDQKGIQYDQKALAIIAKAAEGGMRDALSILDQVISFGNEEVTLDNALLV
TGSVNQKLLDQYLTQIFKQETSAALETLHQILDEGKDGQRLIEDLIAVQRNLLLYQEDPQLVQEQSLNDLSEAFTEEAAM
VTGVELYQMIDTLNSIQQQMRFTTHPDVYLEVLTIKLSQRKTAKVSTEAPTGSVDNQEVEQLRSEVSQLKQAIQKLQQNV
KNTPSNSQSAQPKPKKKAVGAKQVKTPANLTKIYPILENATKASLNTMQELWRDLMDMLSVTERALMHVSKPVAASKEGV
VVAFNYDFLFEKAVDNEVLRTELQQNLAKLTGSDFKVVYVTVEEWPEVRSGFLNTHHFDKNQEKSEPEASEQSTPKADED
NQAVKKAVELFGSENVNIKND

Sequences:

>Translated_581_residues
MSYQALYRVWRPQKFDDMVGQDVVTRTLKNALITEQTSHAYLFTGPRGTGKTSAAKIFAKAVNCHYLKDGEPCNECVTCK
AITEGTLNDVIEIDAASNNGVEEIRDIRDKAKYAPTEADYKVYIVDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPQ
KIPLTIISRTQRFDFKRITPAQSYDRMVYILDQKGIQYDQKALAIIAKAAEGGMRDALSILDQVISFGNEEVTLDNALLV
TGSVNQKLLDQYLTQIFKQETSAALETLHQILDEGKDGQRLIEDLIAVQRNLLLYQEDPQLVQEQSLNDLSEAFTEEAAM
VTGVELYQMIDTLNSIQQQMRFTTHPDVYLEVLTIKLSQRKTAKVSTEAPTGSVDNQEVEQLRSEVSQLKQAIQKLQQNV
KNTPSNSQSAQPKPKKKAVGAKQVKTPANLTKIYPILENATKASLNTMQELWRDLMDMLSVTERALMHVSKPVAASKEGV
VVAFNYDFLFEKAVDNEVLRTELQQNLAKLTGSDFKVVYVTVEEWPEVRSGFLNTHHFDKNQEKSEPEASEQSTPKADED
NQAVKKAVELFGSENVNIKND
>Mature_580_residues
SYQALYRVWRPQKFDDMVGQDVVTRTLKNALITEQTSHAYLFTGPRGTGKTSAAKIFAKAVNCHYLKDGEPCNECVTCKA
ITEGTLNDVIEIDAASNNGVEEIRDIRDKAKYAPTEADYKVYIVDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPQK
IPLTIISRTQRFDFKRITPAQSYDRMVYILDQKGIQYDQKALAIIAKAAEGGMRDALSILDQVISFGNEEVTLDNALLVT
GSVNQKLLDQYLTQIFKQETSAALETLHQILDEGKDGQRLIEDLIAVQRNLLLYQEDPQLVQEQSLNDLSEAFTEEAAMV
TGVELYQMIDTLNSIQQQMRFTTHPDVYLEVLTIKLSQRKTAKVSTEAPTGSVDNQEVEQLRSEVSQLKQAIQKLQQNVK
NTPSNSQSAQPKPKKKAVGAKQVKTPANLTKIYPILENATKASLNTMQELWRDLMDMLSVTERALMHVSKPVAASKEGVV
VAFNYDFLFEKAVDNEVLRTELQQNLAKLTGSDFKVVYVTVEEWPEVRSGFLNTHHFDKNQEKSEPEASEQSTPKADEDN
QAVKKAVELFGSENVNIKND

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=257, Percent_Identity=27.2373540856031, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI194306571, Length=257, Percent_Identity=27.2373540856031, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI194306567, Length=257, Percent_Identity=27.2373540856031, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI31563534, Length=335, Percent_Identity=23.2835820895522, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786676, Length=256, Percent_Identity=47.265625, Blast_Score=253, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17541988, Length=282, Percent_Identity=24.468085106383, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=220, Percent_Identity=26.3636363636364, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=224, Percent_Identity=25, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=232, Percent_Identity=25.8620689655172, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324478, Length=238, Percent_Identity=23.5294117647059, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI17647857, Length=333, Percent_Identity=22.2222222222222, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI18859927, Length=258, Percent_Identity=24.4186046511628, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI19921076, Length=307, Percent_Identity=24.7557003257329, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 65152; Mature: 65020

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQALYRVWRPQKFDDMVGQDVVTRTLKNALITEQTSHAYLFTGPRGTGKTSAAKIFAK
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
AVNCHYLKDGEPCNECVTCKAITEGTLNDVIEIDAASNNGVEEIRDIRDKAKYAPTEADY
HHCCEEECCCCCCCHHEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIVDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPQKIPLTIISRTQRFDFKRITP
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHEEHHHHHCCCCCCCC
AQSYDRMVYILDQKGIQYDQKALAIIAKAAEGGMRDALSILDQVISFGNEEVTLDNALLV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCEEEE
TGSVNQKLLDQYLTQIFKQETSAALETLHQILDEGKDGQRLIEDLIAVQRNLLLYQEDPQ
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCHH
LVQEQSLNDLSEAFTEEAAMVTGVELYQMIDTLNSIQQQMRFTTHPDVYLEVLTIKLSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
KTAKVSTEAPTGSVDNQEVEQLRSEVSQLKQAIQKLQQNVKNTPSNSQSAQPKPKKKAVG
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
AKQVKTPANLTKIYPILENATKASLNTMQELWRDLMDMLSVTERALMHVSKPVAASKEGV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVAFNYDFLFEKAVDNEVLRTELQQNLAKLTGSDFKVVYVTVEEWPEVRSGFLNTHHFDK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCHHHHHCCCCCCCCCC
NQEKSEPEASEQSTPKADEDNQAVKKAVELFGSENVNIKND
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SYQALYRVWRPQKFDDMVGQDVVTRTLKNALITEQTSHAYLFTGPRGTGKTSAAKIFAK
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
AVNCHYLKDGEPCNECVTCKAITEGTLNDVIEIDAASNNGVEEIRDIRDKAKYAPTEADY
HHCCEEECCCCCCCHHEEEHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCE
KVYIVDEVHMLSTGAFNALLKTLEEPPANVIFILATTEPQKIPLTIISRTQRFDFKRITP
EEEEEECHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHEEHHHHHCCCCCCCC
AQSYDRMVYILDQKGIQYDQKALAIIAKAAEGGMRDALSILDQVISFGNEEVTLDNALLV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCEEEE
TGSVNQKLLDQYLTQIFKQETSAALETLHQILDEGKDGQRLIEDLIAVQRNLLLYQEDPQ
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEECCCHH
LVQEQSLNDLSEAFTEEAAMVTGVELYQMIDTLNSIQQQMRFTTHPDVYLEVLTIKLSQR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCC
KTAKVSTEAPTGSVDNQEVEQLRSEVSQLKQAIQKLQQNVKNTPSNSQSAQPKPKKKAVG
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCC
AKQVKTPANLTKIYPILENATKASLNTMQELWRDLMDMLSVTERALMHVSKPVAASKEGV
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCE
VVAFNYDFLFEKAVDNEVLRTELQQNLAKLTGSDFKVVYVTVEEWPEVRSGFLNTHHFDK
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEHHHCHHHHHCCCCCCCCCC
NQEKSEPEASEQSTPKADEDNQAVKKAVELFGSENVNIKND
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]