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The map label for this gene is zwf [H]

Identifier: 116493015

GI number: 116493015

Start: 1254098

End: 1255585

Strand: Reverse

Name: zwf [H]

Synonym: PEPE_1267

Alternate gene names: 116493015

Gene position: 1255585-1254098 (Counterclockwise)

Preceding gene: 116493016

Following gene: 116493014

Centisome position: 68.52

GC content: 37.5

Gene sequence:

>1488_bases
ATGAATCAAAAGGCTTTATTTATTATTTTTGGCGGAACAGGCGACTTAGCTTATCGAAAATTATATCCGGCGTTATTTAA
TTTATACGAAAAAGGATATTTAAAAGAGGATTTTGCTGTAATTGGTACAGCACGCCGTCCGTGGTCTAACGATCACTACC
ATGAAGTAGTTATGAGTGCAATTGAAGACGCAGGCCGTGATTCTGGTCGGACTAACGATGACCTACCTCGCAAATTTGCA
AGCCATTTCTACTATCAATCACATAATGTTGATGATGTCGATCATTATGTAGCTTTACGTAAATTAGCAGATGAATTGGA
TGAAAAGTATGATCTTCAAGGAAATCGTATTTTTTATTTAGCAATGGCACCAAGATTCTTTGGAACAATTGCCGGCCATC
TGAAAGATCAAGCTTTACTTACAAAGGGAAATGGTTTTAACCGATTAATTATCGAAAAACCCTTCGGACGTGACTATCCC
AGTGCTAAAGAATTGAACGATTCAATTTCGGGTTCCTTTAAAGAAGAACAGATTTTTAGAATTGATCATTATTTAGGTAA
GGAACCGATCCAGTCAATTGCTGGATTACGGTTTGGGAACGCATTGTTCAACTCGCTTTGGAATAAAGAACATATTGATA
ACATTCAGATTACCCTATCTGAATCACTTGGTGTCGAAGAACGGGCTGGATACTATGAAACAGCTGGGGCAATGCGGGAT
ATGGTCCAAAATCATATTATGCAAATTGTTTCGTTACTTACAATGGAACGGCCAGATGTTTTTGATTCAGAACATTTACG
TGACAAGAAAATTGAAGCTTTGGAAAATATCCAAATGTATACCAAAGAAGAAGCTAAAAAATATTTCATTCGTGGCCAAT
ACGGTGCAGATGAGGCTAATACACAACTTGGATACCGAGATGAAGAAGGTACGGATAATCAATCAACTGTTGAAACTTTC
GTTGCCGGTAAATTAATTACACATAATCCGTCATTAGATGGTGTACCAGTTTATATTCGTACTGGGAAACGATTAACTAA
AAAATCAACTCAGATTAACATTGTATTTAAAAATGATGATCAAAACATTTTTGCTAAAGACGCGTCAGAAAAATTAAAGA
CCAATGTTTTGACTATGCATATTGAACCTGATCAAGGGTTTACACTAGAATTTAATACAAAGACTGGAAACCAAGGTTAC
AACCTTTCCCCAGTTCATTTACGTTATCGTAAGACAGCCACTGAAAAGGCTCAAATTCCAGATGCTTACGAAGGTTTGAT
TCGCGATGCTTTAATGGGAAATAAGACTAATTTTGCACATTGGCATGAAGTTAGCCAAGCATGGAAGATTATGGATGTAG
TCCGCGAGGCTTGGGATGAAGAAGAACCCGCATTTCCAAACTATGCAAGTGGTAGTATGGGACCTGAAGCAGCTATGCAA
CTTCTAGCTGATGATGGACGTAAATGGGTTTTTAATCCACGCAGCTAA

Upstream 100 bases:

>100_bases
TAGACCGCGAATTTTAATTCGTGGGTCTTTTTTTTCTTGTTTGAAGTTTTAAAATGGTAGATAATTAATCTATATGAAAA
GCGAAAGCGGGGTTATAAAA

Downstream 100 bases:

>100_bases
TAATGGAAACAGAAGTTTTAACTCCGATCAACATTGATGATTCTCGTAAGATAATTCATGTTGATATGGACGCCTTTTAT
GCTTCAATTGAGATGCGAGA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MNQKALFIIFGGTGDLAYRKLYPALFNLYEKGYLKEDFAVIGTARRPWSNDHYHEVVMSAIEDAGRDSGRTNDDLPRKFA
SHFYYQSHNVDDVDHYVALRKLADELDEKYDLQGNRIFYLAMAPRFFGTIAGHLKDQALLTKGNGFNRLIIEKPFGRDYP
SAKELNDSISGSFKEEQIFRIDHYLGKEPIQSIAGLRFGNALFNSLWNKEHIDNIQITLSESLGVEERAGYYETAGAMRD
MVQNHIMQIVSLLTMERPDVFDSEHLRDKKIEALENIQMYTKEEAKKYFIRGQYGADEANTQLGYRDEEGTDNQSTVETF
VAGKLITHNPSLDGVPVYIRTGKRLTKKSTQINIVFKNDDQNIFAKDASEKLKTNVLTMHIEPDQGFTLEFNTKTGNQGY
NLSPVHLRYRKTATEKAQIPDAYEGLIRDALMGNKTNFAHWHEVSQAWKIMDVVREAWDEEEPAFPNYASGSMGPEAAMQ
LLADDGRKWVFNPRS

Sequences:

>Translated_495_residues
MNQKALFIIFGGTGDLAYRKLYPALFNLYEKGYLKEDFAVIGTARRPWSNDHYHEVVMSAIEDAGRDSGRTNDDLPRKFA
SHFYYQSHNVDDVDHYVALRKLADELDEKYDLQGNRIFYLAMAPRFFGTIAGHLKDQALLTKGNGFNRLIIEKPFGRDYP
SAKELNDSISGSFKEEQIFRIDHYLGKEPIQSIAGLRFGNALFNSLWNKEHIDNIQITLSESLGVEERAGYYETAGAMRD
MVQNHIMQIVSLLTMERPDVFDSEHLRDKKIEALENIQMYTKEEAKKYFIRGQYGADEANTQLGYRDEEGTDNQSTVETF
VAGKLITHNPSLDGVPVYIRTGKRLTKKSTQINIVFKNDDQNIFAKDASEKLKTNVLTMHIEPDQGFTLEFNTKTGNQGY
NLSPVHLRYRKTATEKAQIPDAYEGLIRDALMGNKTNFAHWHEVSQAWKIMDVVREAWDEEEPAFPNYASGSMGPEAAMQ
LLADDGRKWVFNPRS
>Mature_495_residues
MNQKALFIIFGGTGDLAYRKLYPALFNLYEKGYLKEDFAVIGTARRPWSNDHYHEVVMSAIEDAGRDSGRTNDDLPRKFA
SHFYYQSHNVDDVDHYVALRKLADELDEKYDLQGNRIFYLAMAPRFFGTIAGHLKDQALLTKGNGFNRLIIEKPFGRDYP
SAKELNDSISGSFKEEQIFRIDHYLGKEPIQSIAGLRFGNALFNSLWNKEHIDNIQITLSESLGVEERAGYYETAGAMRD
MVQNHIMQIVSLLTMERPDVFDSEHLRDKKIEALENIQMYTKEEAKKYFIRGQYGADEANTQLGYRDEEGTDNQSTVETF
VAGKLITHNPSLDGVPVYIRTGKRLTKKSTQINIVFKNDDQNIFAKDASEKLKTNVLTMHIEPDQGFTLEFNTKTGNQGY
NLSPVHLRYRKTATEKAQIPDAYEGLIRDALMGNKTNFAHWHEVSQAWKIMDVVREAWDEEEPAFPNYASGSMGPEAAMQ
LLADDGRKWVFNPRS

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=500, Percent_Identity=31.6, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI108773793, Length=500, Percent_Identity=31.6, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI52145310, Length=367, Percent_Identity=28.0653950953678, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1788158, Length=493, Percent_Identity=34.4827586206897, Blast_Score=311, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17538218, Length=498, Percent_Identity=32.1285140562249, Blast_Score=274, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6324088, Length=478, Percent_Identity=33.6820083682008, Blast_Score=288, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=31.5352697095436, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=31.5352697095436, Blast_Score=259, Evalue=4e-69,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=26.8595041322314, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56610; Mature: 56610

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKALFIIFGGTGDLAYRKLYPALFNLYEKGYLKEDFAVIGTARRPWSNDHYHEVVMSA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHH
IEDAGRDSGRTNDDLPRKFASHFYYQSHNVDDVDHYVALRKLADELDEKYDLQGNRIFYL
HHHCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
AMAPRFFGTIAGHLKDQALLTKGNGFNRLIIEKPFGRDYPSAKELNDSISGSFKEEQIFR
EECHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCCHHHHCHHHCCCCCHHHHHH
IDHYLGKEPIQSIAGLRFGNALFNSLWNKEHIDNIQITLSESLGVEERAGYYETAGAMRD
HHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHH
MVQNHIMQIVSLLTMERPDVFDSEHLRDKKIEALENIQMYTKEEAKKYFIRGQYGADEAN
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
TQLGYRDEEGTDNQSTVETFVAGKLITHNPSLDGVPVYIRTGKRLTKKSTQINIVFKNDD
CCCCCCCCCCCCCHHHHHHHHHCEEEECCCCCCCEEEEEECCCHHHCCCCEEEEEEECCC
QNIFAKDASEKLKTNVLTMHIEPDQGFTLEFNTKTGNQGYNLSPVHLRYRKTATEKAQIP
CCEECCCHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHCCCC
DAYEGLIRDALMGNKTNFAHWHEVSQAWKIMDVVREAWDEEEPAFPNYASGSMGPEAAMQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LLADDGRKWVFNPRS
HHHCCCCEEECCCCC
>Mature Secondary Structure
MNQKALFIIFGGTGDLAYRKLYPALFNLYEKGYLKEDFAVIGTARRPWSNDHYHEVVMSA
CCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCCCCCHHHHHHHHH
IEDAGRDSGRTNDDLPRKFASHFYYQSHNVDDVDHYVALRKLADELDEKYDLQGNRIFYL
HHHCCCCCCCCCCHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
AMAPRFFGTIAGHLKDQALLTKGNGFNRLIIEKPFGRDYPSAKELNDSISGSFKEEQIFR
EECHHHHHHHHHHHCCCEEEECCCCCCEEEEECCCCCCCCCHHHHCHHHCCCCCHHHHHH
IDHYLGKEPIQSIAGLRFGNALFNSLWNKEHIDNIQITLSESLGVEERAGYYETAGAMRD
HHHHHCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHCCHHHHHHHHHH
MVQNHIMQIVSLLTMERPDVFDSEHLRDKKIEALENIQMYTKEEAKKYFIRGQYGADEAN
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCC
TQLGYRDEEGTDNQSTVETFVAGKLITHNPSLDGVPVYIRTGKRLTKKSTQINIVFKNDD
CCCCCCCCCCCCCHHHHHHHHHCEEEECCCCCCCEEEEEECCCHHHCCCCEEEEEEECCC
QNIFAKDASEKLKTNVLTMHIEPDQGFTLEFNTKTGNQGYNLSPVHLRYRKTATEKAQIP
CCEECCCHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCEEEEEECCCCHHCCCC
DAYEGLIRDALMGNKTNFAHWHEVSQAWKIMDVVREAWDEEEPAFPNYASGSMGPEAAMQ
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHH
LLADDGRKWVFNPRS
HHHCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11463916; 9466257; 9533725 [H]