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The map label for this gene is hrcA

Identifier: 116492660

GI number: 116492660

Start: 896346

End: 897386

Strand: Direct

Name: hrcA

Synonym: PEPE_0894

Alternate gene names: 116492660

Gene position: 896346-897386 (Clockwise)

Preceding gene: 116492659

Following gene: 116492661

Centisome position: 48.92

GC content: 37.37

Gene sequence:

>1041_bases
ATGTTAACAGATCGTGAGTTGTTAATTTTAGAGGAGATTGTCCGAGAGTATACTGAGAATGGTCAGCCAATCGGATCAAA
AACGTTGATGAATAATCTTCCAGTAAAAGTGAGTTCGGCAACGATTAGAAATGATATGGCTAAGCTAGAAGAGATGGGTC
TGATTGAAAAGATGCATTCATCTTCTGGAAGAATTCCATCTTTGATGGGATATCGGTATTACGTAGATCATTTGTTAAGC
CCCAAGAAGTTAAATCAAAGTGAGGCTCAACAGATTCAAAAGGGTCTGGGGATGCATTTTAGAGAAGTAGATGACATTGT
TCGAACTTCGGCTGAAATGTTATCAAATTTAACGCATTATACAGCGTTAACGTTAAAACCTGACCAAAAAGATGCGACTT
TAGATGGTTTTCGAATGGTTCCACTTGGTGGGAATCAAGTGATGTTGATTTTGGTTTCTAGTAATGGCGACGTTACTAGT
CAGCAATTTTCGATCCCCCGCGGAATGAATAGTGAGACTGTCGAACGCGTCTTGAGAATTATGAATGATCGCTTGATTGG
CGAAACGCTTGATCAAGTTTATTATCACCTGAAAACAGATATTCCTAAAATTGTTGAGCATTATCTGCATAGTAACGACG
GAATTATTGATATTTTCGAAAATGTAGTTGCGCAGTCTTCACAGGACCGTTACTTCATTGGAGGGAAGTTGAATATCCTT
AATTTCTCCAAGAATGTAGATGTTAGTTCAATTAGAGGGCTTTTGACTCTATTTAATGAGAATGATCAACTTGATGGATT
ACTTGGAAATAATCAGAGTGACTTAGATGTAAAGATTGGCGATGAATTAAGCAATGCTTTACTAAAGGATTTTAGCTTAA
TCACTGCTACTTATGATGTTGGTAGTCGAGGCAAGGGATTAATTGCCATTCTCGGTCCAACTAGTATGCAGTATTCGAAA
ACATTAGGCTTACTTGATACATTTAGAGATCAGTTGTCTAATCGAATGCTCGAATATTATAAGCACCTTGATGATAGTTA
G

Upstream 100 bases:

>100_bases
TGACCAAATTTGACTATAGTTGACATTTCTACAAACCTCTGGTATCTTATTAAGTGTTCTTAGCACTCCAACTTTCTAAG
TGCTAAAAGAGGTGATTTTC

Downstream 100 bases:

>100_bases
GAGGATTGAATTGGCAAAAGAGAAAAAAGAAGAAGTCAAAGAAGAAGAAGTTTCTGAAGCTACTTCAACAGAAGGGTCAA
CAGATGTTGAATCAACTAAT

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MLTDRELLILEEIVREYTENGQPIGSKTLMNNLPVKVSSATIRNDMAKLEEMGLIEKMHSSSGRIPSLMGYRYYVDHLLS
PKKLNQSEAQQIQKGLGMHFREVDDIVRTSAEMLSNLTHYTALTLKPDQKDATLDGFRMVPLGGNQVMLILVSSNGDVTS
QQFSIPRGMNSETVERVLRIMNDRLIGETLDQVYYHLKTDIPKIVEHYLHSNDGIIDIFENVVAQSSQDRYFIGGKLNIL
NFSKNVDVSSIRGLLTLFNENDQLDGLLGNNQSDLDVKIGDELSNALLKDFSLITATYDVGSRGKGLIAILGPTSMQYSK
TLGLLDTFRDQLSNRMLEYYKHLDDS

Sequences:

>Translated_346_residues
MLTDRELLILEEIVREYTENGQPIGSKTLMNNLPVKVSSATIRNDMAKLEEMGLIEKMHSSSGRIPSLMGYRYYVDHLLS
PKKLNQSEAQQIQKGLGMHFREVDDIVRTSAEMLSNLTHYTALTLKPDQKDATLDGFRMVPLGGNQVMLILVSSNGDVTS
QQFSIPRGMNSETVERVLRIMNDRLIGETLDQVYYHLKTDIPKIVEHYLHSNDGIIDIFENVVAQSSQDRYFIGGKLNIL
NFSKNVDVSSIRGLLTLFNENDQLDGLLGNNQSDLDVKIGDELSNALLKDFSLITATYDVGSRGKGLIAILGPTSMQYSK
TLGLLDTFRDQLSNRMLEYYKHLDDS
>Mature_346_residues
MLTDRELLILEEIVREYTENGQPIGSKTLMNNLPVKVSSATIRNDMAKLEEMGLIEKMHSSSGRIPSLMGYRYYVDHLLS
PKKLNQSEAQQIQKGLGMHFREVDDIVRTSAEMLSNLTHYTALTLKPDQKDATLDGFRMVPLGGNQVMLILVSSNGDVTS
QQFSIPRGMNSETVERVLRIMNDRLIGETLDQVYYHLKTDIPKIVEHYLHSNDGIIDIFENVVAQSSQDRYFIGGKLNIL
NFSKNVDVSSIRGLLTLFNENDQLDGLLGNNQSDLDVKIGDELSNALLKDFSLITATYDVGSRGKGLIAILGPTSMQYSK
TLGLLDTFRDQLSNRMLEYYKHLDDS

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_PEDPA (Q03FR9)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804395.1
- ProteinModelPortal:   Q03FR9
- SMR:   Q03FR9
- STRING:   Q03FR9
- GeneID:   4417872
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0894
- NMPDR:   fig|278197.10.peg.796
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   VHYKLRT
- ProtClustDB:   PRK00082
- BioCyc:   PPEN278197:PEPE_0894-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00081
- InterPro:   IPR001034
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA; PF08220 HTH_DeoR

EC number: NA

Molecular weight: Translated: 38929; Mature: 38929

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDRELLILEEIVREYTENGQPIGSKTLMNNLPVKVSSATIRNDMAKLEEMGLIEKMHS
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHC
SSGRIPSLMGYRYYVDHLLSPKKLNQSEAQQIQKGLGMHFREVDDIVRTSAEMLSNLTHY
CCCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TALTLKPDQKDATLDGFRMVPLGGNQVMLILVSSNGDVTSQQFSIPRGMNSETVERVLRI
EEEEECCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCCCHHCCCCCCCCHHHHHHHHHH
MNDRLIGETLDQVYYHLKTDIPKIVEHYLHSNDGIIDIFENVVAQSSQDRYFIGGKLNIL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCEEEEE
NFSKNVDVSSIRGLLTLFNENDQLDGLLGNNQSDLDVKIGDELSNALLKDFSLITATYDV
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHEEEECC
GSRGKGLIAILGPTSMQYSKTLGLLDTFRDQLSNRMLEYYKHLDDS
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLTDRELLILEEIVREYTENGQPIGSKTLMNNLPVKVSSATIRNDMAKLEEMGLIEKMHS
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHC
SSGRIPSLMGYRYYVDHLLSPKKLNQSEAQQIQKGLGMHFREVDDIVRTSAEMLSNLTHY
CCCCCCHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TALTLKPDQKDATLDGFRMVPLGGNQVMLILVSSNGDVTSQQFSIPRGMNSETVERVLRI
EEEEECCCCCCCCCCCEEEEEECCCEEEEEEEECCCCCCCHHCCCCCCCCHHHHHHHHHH
MNDRLIGETLDQVYYHLKTDIPKIVEHYLHSNDGIIDIFENVVAQSSQDRYFIGGKLNIL
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEECCEEEEE
NFSKNVDVSSIRGLLTLFNENDQLDGLLGNNQSDLDVKIGDELSNALLKDFSLITATYDV
ECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHEEEECC
GSRGKGLIAILGPTSMQYSKTLGLLDTFRDQLSNRMLEYYKHLDDS
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA