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The map label for this gene is pyrH

Identifier: 116492645

GI number: 116492645

Start: 878276

End: 879001

Strand: Direct

Name: pyrH

Synonym: PEPE_0879

Alternate gene names: 116492645

Gene position: 878276-879001 (Clockwise)

Preceding gene: 116492644

Following gene: 116492646

Centisome position: 47.93

GC content: 40.5

Gene sequence:

>726_bases
ATGTCGGAAGTTAAATACAAGCGAGTAATAATGAAGCTGAGTGGTGAAGCACTTGCTGGAGATAAAGGAACAGGTATTAA
TCCACCAGTAATTCAAAAGGTTGCTGAAGAACTTCGTGACGTGCATGACCTAGGAGTACAAATTGCCATCGTTGTTGGTG
GTGGGAACATGTGGCGTGGAGAAACTGGTGAACAGCTTGGAATGGAACGTGTTCAAGCTGACTATATTGGTATGCTAGGT
ACGGTTATGAATGCTTTAGCACTTCAAGATAGCCTAGAATCACTAGGAGTTCCAACTCGCGTTCAAACTTCCATTGAAAT
GCGTCAAATCGCTGAACCTTACATTCGTCGTAAGGCCGTTCGTCATCTTGAAAAGAATCGCATAGTAATCTTTGCTGCTG
GTACAGGTAGCCCATACTTCTCAACTGATACAACTTCAGCTTTAAGAGCGGCTGAAATTGGGGCGGAAGCAATTTTAATG
GCTAAAAACGGCGTAGATGGTATTTATTCTGCCGATCCAAACGTAGACCCTGATGCAGTTAAATTTGACGAATTAACACA
TATGGATATTATTGATAAAGGACTTAATGTTATGGACACTACTGCAAGTTCACTTTCGATGGAGAATAATATTCCATTAG
TTGTTTTCAACTTAAACCAAGCAGGTAACATTAAAAAGGTTGTTGCAGGTGAAAATATTGGAACAACGGTTAGAGGAGAA
GAATAA

Upstream 100 bases:

>100_bases
TAATTCGCTTTTTTGTAGGATTTTACACGTAATAACAGTGTGGTTTGCCGCATTTTTATGATAGAATTAATGAAGGAAAT
TAAACATAGGAGGCCGTAAT

Downstream 100 bases:

>100_bases
TGGCAAAAAATGAGATAATCCAAAAAGCTGAAGAAAAAATGCAAAAGGCACAGAATGTTTTAGAACGTGATCTAGGTTCA
ATCCGTGCTGGCCGTGCTAA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MSEVKYKRVIMKLSGEALAGDKGTGINPPVIQKVAEELRDVHDLGVQIAIVVGGGNMWRGETGEQLGMERVQADYIGMLG
TVMNALALQDSLESLGVPTRVQTSIEMRQIAEPYIRRKAVRHLEKNRIVIFAAGTGSPYFSTDTTSALRAAEIGAEAILM
AKNGVDGIYSADPNVDPDAVKFDELTHMDIIDKGLNVMDTTASSLSMENNIPLVVFNLNQAGNIKKVVAGENIGTTVRGE
E

Sequences:

>Translated_241_residues
MSEVKYKRVIMKLSGEALAGDKGTGINPPVIQKVAEELRDVHDLGVQIAIVVGGGNMWRGETGEQLGMERVQADYIGMLG
TVMNALALQDSLESLGVPTRVQTSIEMRQIAEPYIRRKAVRHLEKNRIVIFAAGTGSPYFSTDTTSALRAAEIGAEAILM
AKNGVDGIYSADPNVDPDAVKFDELTHMDIIDKGLNVMDTTASSLSMENNIPLVVFNLNQAGNIKKVVAGENIGTTVRGE
E
>Mature_240_residues
SEVKYKRVIMKLSGEALAGDKGTGINPPVIQKVAEELRDVHDLGVQIAIVVGGGNMWRGETGEQLGMERVQADYIGMLGT
VMNALALQDSLESLGVPTRVQTSIEMRQIAEPYIRRKAVRHLEKNRIVIFAAGTGSPYFSTDTTSALRAAEIGAEAILMA
KNGVDGIYSADPNVDPDAVKFDELTHMDIIDKGLNVMDTTASSLSMENNIPLVVFNLNQAGNIKKVVAGENIGTTVRGEE

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=232, Percent_Identity=41.8103448275862, Blast_Score=213, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_PEDPA (Q03FT4)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804380.1
- ProteinModelPortal:   Q03FT4
- SMR:   Q03FT4
- STRING:   Q03FT4
- GeneID:   4417839
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0879
- NMPDR:   fig|278197.10.peg.781
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   PPEN278197:PEPE_0879-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 25957; Mature: 25826

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: BINDING 54-54 BINDING 55-55 BINDING 59-59 BINDING 74-74 BINDING 163-163 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVKYKRVIMKLSGEALAGDKGTGINPPVIQKVAEELRDVHDLGVQIAIVVGGGNMWRG
CCCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCC
ETGEQLGMERVQADYIGMLGTVMNALALQDSLESLGVPTRVQTSIEMRQIAEPYIRRKAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RHLEKNRIVIFAAGTGSPYFSTDTTSALRAAEIGAEAILMAKNGVDGIYSADPNVDPDAV
HHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCE
KFDELTHMDIIDKGLNVMDTTASSLSMENNIPLVVFNLNQAGNIKKVVAGENIGTTVRGE
EHHHHHHHHHHHCCCCEECCCHHHHEECCCCCEEEEECCCCCCEEEEEECCCCCCCCCCC
E
C
>Mature Secondary Structure 
SEVKYKRVIMKLSGEALAGDKGTGINPPVIQKVAEELRDVHDLGVQIAIVVGGGNMWRG
CCHHHHHHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCC
ETGEQLGMERVQADYIGMLGTVMNALALQDSLESLGVPTRVQTSIEMRQIAEPYIRRKAV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
RHLEKNRIVIFAAGTGSPYFSTDTTSALRAAEIGAEAILMAKNGVDGIYSADPNVDPDAV
HHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCEECCCCCCCCCCE
KFDELTHMDIIDKGLNVMDTTASSLSMENNIPLVVFNLNQAGNIKKVVAGENIGTTVRGE
EHHHHHHHHHHHCCCCEECCCHHHHEECCCCCEEEEECCCCCCEEEEEECCCCCCCCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA