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The map label for this gene is rnc

Identifier: 116492609

GI number: 116492609

Start: 847745

End: 848443

Strand: Direct

Name: rnc

Synonym: PEPE_0842

Alternate gene names: 116492609

Gene position: 847745-848443 (Clockwise)

Preceding gene: 116492608

Following gene: 116492610

Centisome position: 46.26

GC content: 36.34

Gene sequence:

>699_bases
ATGATAAAAGCCTTAGAAGATGACTTAAGTCAGACGTTTGATATTCATTTTAATAACCATGCGTTGTTAGATGAAGCTTT
TACGCAAGCTTCTTATGTTAATGAACATCCACATCAAGAATTAAAATTTTACGAAAGAATCGAATTTTTAGGAGACGCTG
TTTTACAACTAATTGTCTCTGAATATTTGTTTAAGCGTTATCCTGAAATGCCACAAGGAAAACTAACCCGTTTACGAGCT
GCAATGGTTTGTGAAGCTAGTTTTAGTGATTTTGCCAAAGAATGTCATTTTGACCAATATATTCGTTTAGGTAAAGGAGA
AGAAAAATCCGGCGCTCGCCAGCGCTCATCACTTCTTTGTGATATTTTTGAATCGTTTATTGGTGCTCTTTACCTCGATC
AAGGTCGGGCAGCTGTCGAGCGTTTTGTACGAATCGTCATTTTCCCTAAATTAGACGAAGGCAAATTTGATCACATTATC
GACCATAAATCAGAACTTCAAGAATTACTTCAAAAAAATGGAGACGTTGAAATTGATTATGAATTAGTTTCTGAAGAAGG
ACCTGAAAATGATTTAATCTTTACGGTTAGTGTTACGGCTGATCATAAAAAACTAGCAACTGGAACCGGACATTCCAAAA
AGGTTGCTGAACAAAATGCGGCTAATCAGGCGCTACAACTTTTACGTAGGCCTAAATAG

Upstream 100 bases:

>100_bases
TTAATTTCATATACTAAGAGAACTCGGTGATTAATCTAATTGGTCACCGAGTTATTCTTATGTGCTAAATAAATTAATAG
ATTTGGAAAGGAAGATATTC

Downstream 100 bases:

>100_bases
GTATTTTAAATGAAACTACGCACGATTGAAATCAGTGGGTTTAAATCATTTGCTGATAATACCAAGATTGAATTTAAAGA
TGGTATTACTGGAATTGTTG

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVSEYLFKRYPEMPQGKLTRLRA
AMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLCDIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHII
DHKSELQELLQKNGDVEIDYELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK

Sequences:

>Translated_232_residues
MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVSEYLFKRYPEMPQGKLTRLRA
AMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLCDIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHII
DHKSELQELLQKNGDVEIDYELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK
>Mature_232_residues
MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVSEYLFKRYPEMPQGKLTRLRA
AMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLCDIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHII
DHKSELQELLQKNGDVEIDYELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain

Homologues:

Organism=Homo sapiens, GI155030234, Length=217, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI155030236, Length=217, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1788920, Length=210, Percent_Identity=31.9047619047619, Blast_Score=107, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI193202651, Length=232, Percent_Identity=32.3275862068966, Blast_Score=98, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17506883, Length=232, Percent_Identity=32.3275862068966, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323895, Length=196, Percent_Identity=22.4489795918367, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17137682, Length=225, Percent_Identity=34.2222222222222, Blast_Score=111, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNC_PEDPA (Q03FX0)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804344.1
- ProteinModelPortal:   Q03FX0
- SMR:   Q03FX0
- STRING:   Q03FX0
- GeneID:   4417959
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0842
- NMPDR:   fig|278197.10.peg.746
- eggNOG:   COG0571
- HOGENOM:   HBG744556
- OMA:   ALTHKSF
- ProtClustDB:   PRK00102
- BioCyc:   PPEN278197:PEPE_0842-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00104
- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907
- Gene3D:   G3DSA:3.30.160.20
- Gene3D:   G3DSA:1.10.1520.10
- SMART:   SM00358
- SMART:   SM00535
- TIGRFAMs:   TIGR02191

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3; SSF69065 RNase_III

EC number: =3.1.26.3

Molecular weight: Translated: 26566; Mature: 26566

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50137 DS_RBD; PS00517 RNASE_3_1; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVS
CCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EYLFKRYPEMPQGKLTRLRAAMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLC
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHH
DIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHIIDHKSELQELLQKNGDVEIDY
HHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCHHHHHCCHHHHHHHHHCCCCEEEEE
ELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK
EEECCCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIKALEDDLSQTFDIHFNNHALLDEAFTQASYVNEHPHQELKFYERIEFLGDAVLQLIVS
CCCCHHHHHHHEEEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EYLFKRYPEMPQGKLTRLRAAMVCEASFSDFAKECHFDQYIRLGKGEEKSGARQRSSLLC
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCCHHHHHHHHHH
DIFESFIGALYLDQGRAAVERFVRIVIFPKLDEGKFDHIIDHKSELQELLQKNGDVEIDY
HHHHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCHHHHHCCHHHHHHHHHCCCCEEEEE
ELVSEEGPENDLIFTVSVTADHKKLATGTGHSKKVAEQNAANQALQLLRRPK
EEECCCCCCCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA