BacMap

Definition	Pediococcus pentosaceus ATCC 25745, complete genome.
Accession	NC_008525
Length	1,832,387

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The map label for this gene is gmk [H]

Identifier: 116492592

GI number: 116492592

Start: 830254

End: 830868

Strand: Direct

Name: gmk [H]

Synonym: PEPE_0825

Alternate gene names: 116492592

Gene position: 830254-830868 (Clockwise)

Preceding gene: 116492590

Following gene: 116492593

Centisome position: 45.31

GC content: 36.59

Gene sequence:

>615_bases
ATGGCTAGAAGAGGAATGTTGATTGTTCTATCTGGCCCTTCCGGTGTTGGTAAGGGAACGGTTAGAAAGGCAATCTTTGA
TCAAGGCGGTAATGATTTTCAGTATTCAATTTCAATGACAACTAGAAAGCCTAGAAAAGGTGAAGTTGATGGTGAAGATT
ACTACTTTGTCTCTAAAGAAGAATTTGAGAAAAATATCAAAGAAGGCCAAATGCTGGAGTATGCCCAGTATGTAGATAAT
TACTATGGCACACCATTAAAGTATGTTAATCAAACTCTAGATTCAGGACGAGATGTTTTCCTAGAAATCGAAGTGAACGG
TGCTCGTCAAGTTCGTGAAAAAATGCCAGACGGGGTATTTTTATTCTTGACTCCACCAGATTTGATGGAATTAAAACAAC
GTATTATCAATCGCGGGACTGAAGACATGGATACGATTAATAAACGAATGGAAAAAGCAGTTGACGAAATCAAGACGATG
CGTGATTATGATTATGCAGTCGTTAACGATAAGATTGAAAATGCGGTTGAAGAAATTAAAAATATTATCAAGGGTGAACA
TCTTCGAGTAACCAGAGTTTATCCTGAATATCAAGAAATGTTAGGAGAATTATAA

Upstream 100 bases:

>100_bases
TTATTAACATGGTACTTTAATTTTCAAGTCAATTGTGGTTGAAAAATATAATAAAAAAGTGCAAAATAGAAGTTACATAT
ATATTTTGAGGAGTTTGTTC

Downstream 100 bases:

>100_bases
GATGATTTTATATCCTTCAGTAGATGATTTACTAGAACGTGTTGATTCCAGATATTCATTGATTATGCTTGCTAGCAAGC
GTGCACACCAATTGGATGAG

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MARRGMLIVLSGPSGVGKGTVRKAIFDQGGNDFQYSISMTTRKPRKGEVDGEDYYFVSKEEFEKNIKEGQMLEYAQYVDN
YYGTPLKYVNQTLDSGRDVFLEIEVNGARQVREKMPDGVFLFLTPPDLMELKQRIINRGTEDMDTINKRMEKAVDEIKTM
RDYDYAVVNDKIENAVEEIKNIIKGEHLRVTRVYPEYQEMLGEL

Sequences:

>Translated_204_residues
MARRGMLIVLSGPSGVGKGTVRKAIFDQGGNDFQYSISMTTRKPRKGEVDGEDYYFVSKEEFEKNIKEGQMLEYAQYVDN
YYGTPLKYVNQTLDSGRDVFLEIEVNGARQVREKMPDGVFLFLTPPDLMELKQRIINRGTEDMDTINKRMEKAVDEIKTM
RDYDYAVVNDKIENAVEEIKNIIKGEHLRVTRVYPEYQEMLGEL
>Mature_203_residues
ARRGMLIVLSGPSGVGKGTVRKAIFDQGGNDFQYSISMTTRKPRKGEVDGEDYYFVSKEEFEKNIKEGQMLEYAQYVDNY
YGTPLKYVNQTLDSGRDVFLEIEVNGARQVREKMPDGVFLFLTPPDLMELKQRIINRGTEDMDTINKRMEKAVDEIKTMR
DYDYAVVNDKIENAVEEIKNIIKGEHLRVTRVYPEYQEMLGEL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=189, Percent_Identity=32.2751322751323, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI4504221, Length=189, Percent_Identity=32.2751322751323, Blast_Score=123, Evalue=1e-28,
Organism=Homo sapiens, GI226874831, Length=189, Percent_Identity=32.2751322751323, Blast_Score=122, Evalue=2e-28,
Organism=Homo sapiens, GI38570142, Length=190, Percent_Identity=27.3684210526316, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI14780902, Length=193, Percent_Identity=27.979274611399, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI262118259, Length=175, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI4505237, Length=175, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI262118263, Length=175, Percent_Identity=28.5714285714286, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI262118255, Length=175, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=4e-18,
Organism=Homo sapiens, GI21361598, Length=193, Percent_Identity=30.0518134715026, Blast_Score=88, Evalue=5e-18,
Organism=Homo sapiens, GI186700627, Length=179, Percent_Identity=25.6983240223464, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI186972120, Length=179, Percent_Identity=25.6983240223464, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI186700629, Length=179, Percent_Identity=25.6983240223464, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI119943108, Length=181, Percent_Identity=28.7292817679558, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI261862237, Length=184, Percent_Identity=28.2608695652174, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI119943106, Length=182, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI52630447, Length=187, Percent_Identity=23.5294117647059, Blast_Score=71, Evalue=6e-13,
Organism=Homo sapiens, GI192447426, Length=181, Percent_Identity=24.8618784530387, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI218156340, Length=159, Percent_Identity=32.7044025157233, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI91199538, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI218156338, Length=184, Percent_Identity=29.8913043478261, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI148539628, Length=182, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI148539578, Length=182, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI218156270, Length=184, Percent_Identity=28.804347826087, Blast_Score=68, Evalue=5e-12,
Organism=Homo sapiens, GI21536464, Length=187, Percent_Identity=22.9946524064171, Blast_Score=68, Evalue=6e-12,
Organism=Homo sapiens, GI4557529, Length=181, Percent_Identity=24.8618784530387, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI111154074, Length=98, Percent_Identity=29.5918367346939, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=202, Percent_Identity=41.0891089108911, Blast_Score=170, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=35.9116022099448, Blast_Score=127, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=35.9116022099448, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI71988048, Length=202, Percent_Identity=28.7128712871287, Blast_Score=95, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71988041, Length=202, Percent_Identity=28.7128712871287, Blast_Score=93, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17556244, Length=124, Percent_Identity=34.6774193548387, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17557440, Length=184, Percent_Identity=25.5434782608696, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71984092, Length=132, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=41.5300546448087, Blast_Score=148, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=36.3128491620112, Blast_Score=118, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161077626, Length=180, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45554481, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24640542, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI85724806, Length=180, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007136, Length=180, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330162, Length=184, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221330164, Length=184, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221330166, Length=184, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI85816106, Length=132, Percent_Identity=31.0606060606061, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45551002, Length=128, Percent_Identity=31.25, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI85816281, Length=132, Percent_Identity=31.0606060606061, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362230, Length=182, Percent_Identity=24.7252747252747, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648808, Length=182, Percent_Identity=24.7252747252747, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI161078487, Length=182, Percent_Identity=24.7252747252747, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI161078485, Length=182, Percent_Identity=24.7252747252747, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24648810, Length=182, Percent_Identity=24.7252747252747, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281362232, Length=182, Percent_Identity=24.7252747252747, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI161077752, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554791, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45554813, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281360700, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641282, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554818, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI161077754, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554804, Length=156, Percent_Identity=32.6923076923077, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641280, Length=156, Percent_Identity=32.6923076923077, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23605; Mature: 23474

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRGMLIVLSGPSGVGKGTVRKAIFDQGGNDFQYSISMTTRKPRKGEVDGEDYYFVSKE
CCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEECHH
EFEKNIKEGQMLEYAQYVDNYYGTPLKYVNQTLDSGRDVFLEIEVNGARQVREKMPDGVF
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEE
LFLTPPDLMELKQRIINRGTEDMDTINKRMEKAVDEIKTMRDYDYAVVNDKIENAVEEIK
EEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NIIKGEHLRVTRVYPEYQEMLGEL
HHHCCCCEEEEEECHHHHHHHCCC
>Mature Secondary Structure 
ARRGMLIVLSGPSGVGKGTVRKAIFDQGGNDFQYSISMTTRKPRKGEVDGEDYYFVSKE
CCCCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCEEEECHH
EFEKNIKEGQMLEYAQYVDNYYGTPLKYVNQTLDSGRDVFLEIEVNGARQVREKMPDGVF
HHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEEEEEEECCHHHHHHHCCCCEE
LFLTPPDLMELKQRIINRGTEDMDTINKRMEKAVDEIKTMRDYDYAVVNDKIENAVEEIK
EEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
NIIKGEHLRVTRVYPEYQEMLGEL
HHHCCCCEEEEEECHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA