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The map label for this gene is folD

Identifier: 116492584

GI number: 116492584

Start: 823250

End: 824101

Strand: Direct

Name: folD

Synonym: PEPE_0817

Alternate gene names: 116492584

Gene position: 823250-824101 (Clockwise)

Preceding gene: 116492583

Following gene: 116492585

Centisome position: 44.93

GC content: 38.97

Gene sequence:

>852_bases
ATGGGCCAAATTATTGATGGAAAAACTTTAGCTGCTGAGATTGATAAACAAACAATGACTGAAGTACAAAAATTGAAAAA
TCAAGGTGTCGAACCACATCTTGTTGTGGTTCTAGTTGGTGAAAATCCAGCAAGTCAAATTTACGTAAGAAATAAAGAAA
AGCGCGCTAATAAGTTAGGCATTAAATCAACGCTAGTTACGATGAATGCCGATATTAGCGAAAATGAATTGCTCCTAAAA
ATCCAAGAATTAAATCAAACCGAAGATGTGAATGCCATTCTGGTCCAAATGCCACTCCCTAAGCATATCGATGCTTTTAA
AGTAACGATGGCCATTGATCCGCGTAAGGATGTTGATGGCTTTCATCCAGTTAACGTGGGGAAACTTTTCGAAGGAAAGA
CGCAACACACGCCCATTGCATGTACACCGCAAGGAATTATGGAGATGTTCCAAAAATATCATATAGATATTCAAGGTAAG
CGTGCAGTAGTGGTGGGACGTAGTTCGATTGTTGGAAAACCAATGGCAGCATTACTATTGAATGCCAACGCAACAGTTAC
ATTGGCTCATAGTTATACTAAAAATTTAGCCGCTCTGACTAAAGAAGCAGATATCTTGGTGGTCGCAACAGGTATTGCCC
ATTTTATTAAAGAAGATCAGGTTAAAGAAGGTGCAGTTGTTATCGACGTTGGTATGGACCGCGATGAAAATGGTAAACTA
ACGGGAGACGTTGATTTCGAGAATGTCGAAAAACATGTTTCATACATCACCCCCGTTCCTAAGGGCGTTGGTCCGATGAC
AATATCAATGTTAATGAAACAAACGGTGAATTTAACTAAATGGAGTATTTAA

Upstream 100 bases:

>100_bases
TGATATTTACAACCATTTTTAATTTGTTTAAGATTTAAAAAGAAAATGCATCTTATGATATGATTTAAGATGGATAAATA
TTTGAAACGGAGGAGTAATA

Downstream 100 bases:

>100_bases
ATGCAAGAAGATAAGTATTTAACGGTCAGTGCACTAACCAATTATATTAAACGAAAATTTGATGCTGATCCGTATTTACA
TCGCGTTTATTTAGTGGGGG

Product: methenyltetrahydrofolate cyclohydrolase

Products: NA

Alternate protein names: Methylenetetrahydrofolate dehydrogenase; Methenyltetrahydrofolate cyclohydrolase

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MGQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLGIKSTLVTMNADISENELLLK
IQELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDGFHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGK
RAVVVGRSSIVGKPMAALLLNANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKL
TGDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI

Sequences:

>Translated_283_residues
MGQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLGIKSTLVTMNADISENELLLK
IQELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDGFHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGK
RAVVVGRSSIVGKPMAALLLNANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKL
TGDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI
>Mature_282_residues
GQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLGIKSTLVTMNADISENELLLKI
QELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDGFHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGKR
AVVVGRSSIVGKPMAALLLNANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKLT
GDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI

Specific function: Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate

COG id: COG0190

COG function: function code H; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Homologues:

Organism=Homo sapiens, GI94721354, Length=289, Percent_Identity=45.6747404844291, Blast_Score=222, Evalue=3e-58,
Organism=Homo sapiens, GI222418558, Length=289, Percent_Identity=44.9826989619377, Blast_Score=221, Evalue=5e-58,
Organism=Homo sapiens, GI222136639, Length=288, Percent_Identity=42.3611111111111, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI36796743, Length=218, Percent_Identity=24.3119266055046, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786741, Length=275, Percent_Identity=49.4545454545455, Blast_Score=256, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17568735, Length=255, Percent_Identity=42.3529411764706, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6319558, Length=278, Percent_Identity=45.3237410071942, Blast_Score=252, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6321643, Length=291, Percent_Identity=39.1752577319588, Blast_Score=216, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322933, Length=324, Percent_Identity=23.7654320987654, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI62472483, Length=285, Percent_Identity=44.2105263157895, Blast_Score=220, Evalue=8e-58,
Organism=Drosophila melanogaster, GI45551871, Length=285, Percent_Identity=44.2105263157895, Blast_Score=220, Evalue=8e-58,
Organism=Drosophila melanogaster, GI24645718, Length=285, Percent_Identity=44.2105263157895, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17137370, Length=285, Percent_Identity=44.2105263157895, Blast_Score=220, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17136818, Length=297, Percent_Identity=44.1077441077441, Blast_Score=216, Evalue=1e-56,
Organism=Drosophila melanogaster, GI17136816, Length=297, Percent_Identity=44.1077441077441, Blast_Score=216, Evalue=1e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLD_PEDPA (Q03FZ5)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_804319.1
- ProteinModelPortal:   Q03FZ5
- SMR:   Q03FZ5
- STRING:   Q03FZ5
- GeneID:   4418003
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0817
- NMPDR:   fig|278197.10.peg.722
- eggNOG:   COG0190
- HOGENOM:   HBG328751
- OMA:   TYVRNKQ
- PhylomeDB:   Q03FZ5
- BioCyc:   PPEN278197:PEPE_0817-MONOMER
- GO:   GO:0005488
- HAMAP:   MF_01576
- InterPro:   IPR016040
- InterPro:   IPR000672
- InterPro:   IPR020630
- InterPro:   IPR020867
- InterPro:   IPR020631
- Gene3D:   G3DSA:3.40.50.720
- PRINTS:   PR00085

Pfam domain/function: PF00763 THF_DHG_CYH; PF02882 THF_DHG_CYH_C

EC number: =1.5.1.5; =3.5.4.9

Molecular weight: Translated: 31040; Mature: 30908

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00766 THF_DHG_CYH_1; PS00767 THF_DHG_CYH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCHHHHHHCC
IKSTLVTMNADISENELLLKIQELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDG
CEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCC
FHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGKRAVVVGRSSIVGKPMAALLL
CCCCCCCHHCCCCCCCCCEEECHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCHHHEEE
NANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKL
CCCCEEEEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCCCE
TGDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI
EECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEECCC
>Mature Secondary Structure 
GQIIDGKTLAAEIDKQTMTEVQKLKNQGVEPHLVVVLVGENPASQIYVRNKEKRANKLG
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEECCHHHHHHCC
IKSTLVTMNADISENELLLKIQELNQTEDVNAILVQMPLPKHIDAFKVTMAIDPRKDVDG
CEEEEEEEECCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCCCCC
FHPVNVGKLFEGKTQHTPIACTPQGIMEMFQKYHIDIQGKRAVVVGRSSIVGKPMAALLL
CCCCCCCHHCCCCCCCCCEEECHHHHHHHHHHHCCEECCCEEEEEECCCCCCCCHHHEEE
NANATVTLAHSYTKNLAALTKEADILVVATGIAHFIKEDQVKEGAVVIDVGMDRDENGKL
CCCCEEEEEEHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCCCEEEEECCCCCCCCCE
TGDVDFENVEKHVSYITPVPKGVGPMTISMLMKQTVNLTKWSI
EECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA