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The map label for this gene is glcK [H]

Identifier: 116492500

GI number: 116492500

Start: 770647

End: 771609

Strand: Direct

Name: glcK [H]

Synonym: PEPE_0732

Alternate gene names: 116492500

Gene position: 770647-771609 (Clockwise)

Preceding gene: 116492499

Following gene: 116492501

Centisome position: 42.06

GC content: 41.12

Gene sequence:

>963_bases
ATGGAACGTAAATTAATCGGTGTCGATCTTGGTGGAACAACAATTAAGTTTGCTATTTTAACTGAAAATGGCGATGTTCA
ACAAAAATGGAGTGTGGAAACAAATGTTTTAGATGAAGGTTCACACATTGTTCCAGACATTATTGACTCAATCAATCATC
ATCTTGATTTATATAAGATGACTAAGGATCAATTTATTGGAATCGGGATGGGAACACCGGGAACTGTAAACCGCGAAAAT
GGTACAGTAATTGGTGCTTTCAACCTGAACTGGAAAGAAACTCAATACGTTAAGGATGCAATTGAAGATGGTACAGGAAT
CAAGTTTGCCATTGATAACGATGCTAATGTTGCTGGTCTAGGTGAACGTTGGAAGGGTGCTGGAGAAAACGGCGAAGATG
TTTCTTTCGTTACTCTTGGTACCGGTATCGGTGGCGGTTTGATTGCTGGTGGACAATTGCTTCATGGTTTAGCTGGAGCT
GCTGGTGAAATCGGACATGTTACGGTTGATCCTGAAGGTTACCTATGTACATGTGGTAAGCGTGGATGTCTTGAACAATA
TGCCAGTGCTACAGGTGTTGTTCATGTAGCCCGCGACATGGCAGAAGAATTTTCTGGCGATTCAGAACTTAAACGTGAAA
CTGATGACGGACAAGATATTACTTCTAAATTAGTTTTCGACCTTGCAAAGAAGGGTGACGTTTTAGCTCTTCGTGTTGTT
GATCGGGTCTGCAGTCTCTTAGGACTTGCTTTAGGTAACTTGGCTAATACTTTAAACCCTGAAAGCATTGTTATCGGTGG
CGGAGTTTCAGCAGCTGGTGATTTCTTATTAGAACGTGTCCGTAATTATTACGAACAATATGCATTCTCAACTGTTCGTT
CTTCAACCCAATTAAAATTAGCTCGCTTAGGAAATGACGCTGGTGTAATCGGTGCCGCTTCATTAGCTCGTGTATTTGCA
TAA

Upstream 100 bases:

>100_bases
ATAAACCGACCTATGTTAAAGCTCAGTTGGTTTTACGACATGAGCATCATATTGAAGAGGTTAGAGATAACCAACAAAAA
TAATGGAGGGTTTCGAAGTA

Downstream 100 bases:

>100_bases
ATAAAACAAAAATTTTGGAGATGAGAGAAACATGGCTGTTGCTGCTGCAAAATATACAACCGGATTTTGGATAAATACAA
TCGTGATCATCCTTATCATT

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MERKLIGVDLGGTTIKFAILTENGDVQQKWSVETNVLDEGSHIVPDIIDSINHHLDLYKMTKDQFIGIGMGTPGTVNREN
GTVIGAFNLNWKETQYVKDAIEDGTGIKFAIDNDANVAGLGERWKGAGENGEDVSFVTLGTGIGGGLIAGGQLLHGLAGA
AGEIGHVTVDPEGYLCTCGKRGCLEQYASATGVVHVARDMAEEFSGDSELKRETDDGQDITSKLVFDLAKKGDVLALRVV
DRVCSLLGLALGNLANTLNPESIVIGGGVSAAGDFLLERVRNYYEQYAFSTVRSSTQLKLARLGNDAGVIGAASLARVFA

Sequences:

>Translated_320_residues
MERKLIGVDLGGTTIKFAILTENGDVQQKWSVETNVLDEGSHIVPDIIDSINHHLDLYKMTKDQFIGIGMGTPGTVNREN
GTVIGAFNLNWKETQYVKDAIEDGTGIKFAIDNDANVAGLGERWKGAGENGEDVSFVTLGTGIGGGLIAGGQLLHGLAGA
AGEIGHVTVDPEGYLCTCGKRGCLEQYASATGVVHVARDMAEEFSGDSELKRETDDGQDITSKLVFDLAKKGDVLALRVV
DRVCSLLGLALGNLANTLNPESIVIGGGVSAAGDFLLERVRNYYEQYAFSTVRSSTQLKLARLGNDAGVIGAASLARVFA
>Mature_320_residues
MERKLIGVDLGGTTIKFAILTENGDVQQKWSVETNVLDEGSHIVPDIIDSINHHLDLYKMTKDQFIGIGMGTPGTVNREN
GTVIGAFNLNWKETQYVKDAIEDGTGIKFAIDNDANVAGLGERWKGAGENGEDVSFVTLGTGIGGGLIAGGQLLHGLAGA
AGEIGHVTVDPEGYLCTCGKRGCLEQYASATGVVHVARDMAEEFSGDSELKRETDDGQDITSKLVFDLAKKGDVLALRVV
DRVCSLLGLALGNLANTLNPESIVIGGGVSAAGDFLLERVRNYYEQYAFSTVRSSTQLKLARLGNDAGVIGAASLARVFA

Specific function: May Be A Regulator In Specific Sugar Metabolism. May Influence The Rate Of Glucose Uptake Or Glycolysis In Cells In The Rich Medium. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI190014632, Length=276, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI4885285, Length=276, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI298566315, Length=276, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI298566325, Length=276, Percent_Identity=30.4347826086957, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1787878, Length=272, Percent_Identity=29.7794117647059, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786891, Length=301, Percent_Identity=26.2458471760797, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI87082127, Length=222, Percent_Identity=27.4774774774775, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87081733, Length=319, Percent_Identity=28.2131661442006, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1787363, Length=329, Percent_Identity=27.355623100304, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082230, Length=281, Percent_Identity=24.9110320284698, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33834; Mature: 33834

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKLIGVDLGGTTIKFAILTENGDVQQKWSVETNVLDEGSHIVPDIIDSINHHLDLYKM
CCCEEEEEECCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEE
TKDQFIGIGMGTPGTVNRENGTVIGAFNLNWKETQYVKDAIEDGTGIKFAIDNDANVAGL
CCCCEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCEECC
GERWKGAGENGEDVSFVTLGTGIGGGLIAGGQLLHGLAGAAGEIGHVTVDPEGYLCTCGK
CHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCC
RGCLEQYASATGVVHVARDMAEEFSGDSELKRETDDGQDITSKLVFDLAKKGDVLALRVV
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHH
DRVCSLLGLALGNLANTLNPESIVIGGGVSAAGDFLLERVRNYYEQYAFSTVRSSTQLKL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ARLGNDAGVIGAASLARVFA
EECCCCCCCHHHHHHHHHCC
>Mature Secondary Structure
MERKLIGVDLGGTTIKFAILTENGDVQQKWSVETNVLDEGSHIVPDIIDSINHHLDLYKM
CCCEEEEEECCCCEEEEEEEECCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHEEE
TKDQFIGIGMGTPGTVNRENGTVIGAFNLNWKETQYVKDAIEDGTGIKFAIDNDANVAGL
CCCCEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCEECC
GERWKGAGENGEDVSFVTLGTGIGGGLIAGGQLLHGLAGAAGEIGHVTVDPEGYLCTCGK
CHHCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCEEECCC
RGCLEQYASATGVVHVARDMAEEFSGDSELKRETDDGQDITSKLVFDLAKKGDVLALRVV
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEEHHHH
DRVCSLLGLALGNLANTLNPESIVIGGGVSAAGDFLLERVRNYYEQYAFSTVRSSTQLKL
HHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
ARLGNDAGVIGAASLARVFA
EECCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]