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The map label for this gene is pox5 [H]

Identifier: 116492409

GI number: 116492409

Start: 678838

End: 680571

Strand: Direct

Name: pox5 [H]

Synonym: PEPE_0639

Alternate gene names: 116492409

Gene position: 678838-680571 (Clockwise)

Preceding gene: 116492408

Following gene: 116492411

Centisome position: 37.05

GC content: 40.2

Gene sequence:

>1734_bases
ATGACTGAAAAAATTAATGCATCTGATGCAATGATTAAAGTTTTGGAATCATGGGGAGTTCATAACGTTTATGGTCTACC
AGGGGGATCTTTTGATTCGACAATGAATGCTTTGTACAATCGGAAAAGCACCATTAATTATGTTCAAGTTCGACATGAAG
AAGTTGGGGCTCTGGCAGCGGTCGGAGAAGCTAAGGTAACTGGTAAACTTGGAGTTACATTTGGATCAGCTGGACCTGGT
GCAGTTCATTTACTTAATGGTTTATATGATGCTAAGCATGATCATATGCCTGTATTAGCCTTGGTCGGACAAGTTCCTAC
AACATTAATGAACACGGACTATTTCCAAGAATTAAATGAAAATCCAATTTTCACCGATGTTGCAGTTTATAATCGAACCG
TAATGACTGCTGAACAAATGCCACACGTCGTCGACGAAGCTATTCGCCAAGCTTACAAATATAGTGGGGTAGCGGTAGTT
ACAATTCCTAAGGATTTAGGTTGGCAACCCATTGAAGATAACTATGTCTCATCAGCTAATCTTTATCAAGCACCAATCTT
ACCTGAACCAGATGTAAAGCAGGTTGACGAAGCGCTTGAAATTTTGAGTAATGCCAAGCATCCAGTGATGTACATCGGGC
AAGGTACAAGAGGAGCTGGATCAGATATTATTGCATTGTCTGAAAAACTGCATATTCCGATTGTTACATCAGCCTTGGCT
AAGGGAATTGTCCCCGACAGTTATAAGGCTAACATGGGATCGGCTGGTCGAGTAGCAACTAAACCAGGGGTAGAAGTTTT
ACAAGCGGCAGATGCTGTAATGTTCGTGGGCTCTGATTTTCCATTCCAGCCTTACTTTGTTGCCCCAGATGCTAAATATA
TCCAAGTAGATATTGATGCAAGTAAATTTGGTAGAAGACATGTTGTAGATTTGGCTATTTTAGCTGACTCCCATAAATTC
CTCAAGGTGATGCTAGAAAAAGCTGAAACTACTGCTGAAAGCAAATGGTATAAGGCAGCATTAGAAAACAAAAAGAATTG
GGAAGAATGGAAGAATTCGTTTGTGGGCCAGCAAGATACACCTTTAAATGTTGAAAATGTTTTTGCGAAGATTAATGCTT
TAGCAACCGATGATGCTATTTTCCAAGTTGATGTTGGTAATGTAACGATCGATGGCATGCGTTTCCTTAAAGCTGATCAA
GCTCAACGATTTACGACCTCAGGTTGGTATGCCACAATGGGTTATGCCTTACCAGCAGCCATTGGAGCACAAGCTGAATA
TCCAGATCGCCAAGTTTGGTCAATTTCAGGCGATGGTGGATATGCCATGGTAATGCAAGATGTCCTAACTCAAGTTAAGT
ATCATATGCCTATCATCAATGTTATATTAACAAATGAAAGCTTAGGCTTTATCGAAGCTGAACAAGATGATAGCAAGCAA
CCACATTCTGGTGTAGATTTGATTGATGCAGATTACGGTACTTCAGCCCAAGCACTGGGGGCAGAAGGATTTGAAGTTCG
GACCTACGACGAACTGGAACAAGCCTTTGAAAAAGCGAAAGATCGTAAAGGCCCCGTGGTAATTGATATTAAGATTACAA
ACTTAAGACCACTTCCTGTTGAACAGCTACTTTTGGATAAAGAAACTCAAGATCCTGAAGCAGTCGAACAATTTGTTAAG
AAGTATCATGCTGAATCATTGATTCCTTTCAGAAAATTATTAGAAGAAGCATAA

Upstream 100 bases:

>100_bases
ATTTAACAAATAATAACGTTTTAGTTTACAAATGTATTGAATAGAACTACAATGAACCTTGTAAAAAACTTACTAAAAAG
AAGTGGAATGAGGGGATTAT

Downstream 100 bases:

>100_bases
TTTAAATGCTAAAAAACGGGCGAAAAAGTCAAAGATTGATTTTTCGTCCGTTTTTATTTGTTTAAGAAATTAATTGATGG
TTATAAAAAATGAAGCCAAA

Product: pyruvate oxidase

Products: NA

Alternate protein names: Pyruvic oxidase; POX [H]

Number of amino acids: Translated: 577; Mature: 576

Protein sequence:

>577_residues
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPG
AVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVV
TIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALA
KGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKF
LKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQ
AQRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQ
PHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDIKITNLRPLPVEQLLLDKETQDPEAVEQFVK
KYHAESLIPFRKLLEEA

Sequences:

>Translated_577_residues
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPG
AVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVV
TIPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALA
KGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKF
LKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQ
AQRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQ
PHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDIKITNLRPLPVEQLLLDKETQDPEAVEQFVK
KYHAESLIPFRKLLEEA
>Mature_576_residues
TEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAAVGEAKVTGKLGVTFGSAGPGA
VHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNENPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVT
IPKDLGWQPIEDNYVSSANLYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALAK
GIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDASKFGRRHVVDLAILADSHKFL
KVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDTPLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQA
QRFTTSGWYATMGYALPAAIGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQP
HSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDIKITNLRPLPVEQLLLDKETQDPEAVEQFVKK
YHAESLIPFRKLLEEA

Specific function: Important for the aerobic growth. Decarboxylates pyruvate in four steps. The energy released is partially stored in acetyl phosphate [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=558, Percent_Identity=25.4480286738351, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI21361361, Length=582, Percent_Identity=23.8831615120275, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1787096, Length=521, Percent_Identity=32.0537428023033, Blast_Score=295, Evalue=5e-81,
Organism=Escherichia coli, GI1790104, Length=542, Percent_Identity=27.859778597786, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI87081685, Length=555, Percent_Identity=27.9279279279279, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1786717, Length=566, Percent_Identity=24.5583038869258, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1788716, Length=558, Percent_Identity=22.2222222222222, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17531299, Length=547, Percent_Identity=24.8628884826325, Blast_Score=148, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17531301, Length=547, Percent_Identity=24.8628884826325, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17542570, Length=558, Percent_Identity=23.2974910394265, Blast_Score=122, Evalue=6e-28,
Organism=Saccharomyces cerevisiae, GI6323755, Length=560, Percent_Identity=25.7142857142857, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320816, Length=539, Percent_Identity=23.747680890538, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI19922626, Length=561, Percent_Identity=25.4901960784314, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014092
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =1.2.3.3 [H]

Molecular weight: Translated: 63410; Mature: 63278

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAA
CCCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHC
VGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNE
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHCCHHHHHCCC
NPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSAN
CCCEEEHHHHCCEEEEHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCC
LYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALA
CEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCEEHHHHHH
KGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDA
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCEEECCCCEEEEEEECH
SKFGRRHVVDLAILADSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDT
HHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
PLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAA
CCCHHHHHHHHHHEECCCEEEEEECCCEEECCHHHHHHHHHHHEECCCCHHHHHHHHHHH
IGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQ
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCC
PHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDIKITNLRPLPV
CCCCCCEEECCCCCCCHHCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
EQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKINASDAMIKVLESWGVHNVYGLPGGSFDSTMNALYNRKSTINYVQVRHEEVGALAA
CCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHC
VGEAKVTGKLGVTFGSAGPGAVHLLNGLYDAKHDHMPVLALVGQVPTTLMNTDYFQELNE
CCCCEEEEEEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHCCHHHHHCCC
NPIFTDVAVYNRTVMTAEQMPHVVDEAIRQAYKYSGVAVVTIPKDLGWQPIEDNYVSSAN
CCCEEEHHHHCCEEEEHHHCHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCC
LYQAPILPEPDVKQVDEALEILSNAKHPVMYIGQGTRGAGSDIIALSEKLHIPIVTSALA
CEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCEEHHHHHH
KGIVPDSYKANMGSAGRVATKPGVEVLQAADAVMFVGSDFPFQPYFVAPDAKYIQVDIDA
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCEEEEECCCCCCCCEEECCCCEEEEEEECH
SKFGRRHVVDLAILADSHKFLKVMLEKAETTAESKWYKAALENKKNWEEWKNSFVGQQDT
HHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
PLNVENVFAKINALATDDAIFQVDVGNVTIDGMRFLKADQAQRFTTSGWYATMGYALPAA
CCCHHHHHHHHHHEECCCEEEEEECCCEEECCHHHHHHHHHHHEECCCCHHHHHHHHHHH
IGAQAEYPDRQVWSISGDGGYAMVMQDVLTQVKYHMPIINVILTNESLGFIEAEQDDSKQ
HCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEECCCCCCCC
PHSGVDLIDADYGTSAQALGAEGFEVRTYDELEQAFEKAKDRKGPVVIDIKITNLRPLPV
CCCCCCEEECCCCCCCHHCCCCCCEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
EQLLLDKETQDPEAVEQFVKKYHAESLIPFRKLLEEA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12566566; 8145244; 8438155 [H]