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The map label for this gene is clpE [H]

Identifier: 116492401

GI number: 116492401

Start: 662216

End: 664282

Strand: Reverse

Name: clpE [H]

Synonym: PEPE_0607

Alternate gene names: 116492401

Gene position: 664282-662216 (Counterclockwise)

Preceding gene: 116492410

Following gene: 116492392

Centisome position: 36.25

GC content: 42.28

Gene sequence:

>2067_bases
ATGGCACAAGATCCATTTGGATTTGGAAACTTAGATGACATCTTCCGTGCGATGCAAGGCGGCAATATGGGACAACCCGA
AAACCTCTATGGACAACAAGTTCCCCCTACTCAACCAGGTGGTGGAAATGGTTCAGGTGGTAATCCTAACAACCGTGGCA
ACGGCGGATCACTTTTAAGTCAGTATGGCTTGAACCTAACTGATTTAGCTAAACAAGGTAAGATTGATCCCGTGATTGGT
CGTGACAGCGAAATTGAACGGGTCATTGAAATTCTAAACCGTCGTACTAAAAATAACCCAGTTTTAATTGGTGAAGCTGG
GGTTGGTAAAACTGCTGTCGTAGAAGGATTGGCTCAGCGGATTGTGGAAGGTTCTGTTCCTCAAAAGCTAGTTAATAAAC
AAATCGTGCGTTTGGACGTAGTTTCTCTAGTTCAAGGTACTGGAATTCGTGGTCAATTCGAACAACGTATGCAACAACTA
ATGAAAGAAGTTCAAGCTAACAAAGACATGGTCGTCTTCATCGATGAAATCCATGAAATTGTTGGCGCTGGTAATGCTGA
AGGCGGCATGGATGCTGGTAACGTTCTTAAACCAGCCCTTGCCCGAGGCGACTTCCAATTAGTCGGTGCTACAACGCTTA
AAGAATTCCGGGACATTGAAAAGGATGCGGCCCTTGCCCGTCGTTTACAACCAGTACAAGTCGATGAACCTAGTGAAGAA
GAAGCTATTAAGATTCTAAAAGGAATTCAAAAGAAATACGAAGATTATCATCATGTTCACTACACGGATGATGCAATCGA
AGCAGCCGTAAAATTATCAAAACGCTACATTCAAGATCGCTTCCTTCCTGATAAGGCCATCGACCTCCTTGATGAAGCTG
GTTCTAAGAAGAATCTAACGATTAACATCGCTGATCCAGAAACCATTCAAAAGAAGATTGATGAAGCGGAAGCTCAAAAG
AAAGCTGCCCTTCAATCAGAAGATTACGAAAAAGCAGCTTACTACCGTGATCAAGTTTCTAAGCTTGAAAAGAACAAAGA
TGGTGCAACAAGTAGCGAAGAACAACCAACGGTCACTGAAGAAGATATGGAAAAGATTATCGAAACTAAGACTGACATTC
CAGTTGGTGACTTGCAAAAGCAGGAACAAGAACAACTTCAAAATCTTTCAGAAAACTTGAAAGATCACGTCATTGGACAA
AATGAAGCTGTCGATAAGATTTCTCGGGCCATTCGTCGTAACCGGATTGGTTTAAACGGAACTGGTCGTCCGATTGGTTC
CTTCCTCTTCGTCGGTCCTACCGGAGTTGGTAAGACTGAGTTAGCTAAGCAACTTGCGCAACAATTGTTTGGTTCTAAGG
ATTCTATGATTCGCTTTGATATGAGTGAGTACATGGAGCCTCATTCAATATCAAAATTAATCGGTTCGCCTCCAGGGTAC
GTTGGTTACGAAGAAGCGGGTCAATTAACTGAACAAGTTCGTCGTCATCCATACAGCTTAGTTCTCCTAGATGAAGTGGA
AAAAGCTCACCCAGATGTCATGCATATGTTCTTGCAAATCTTGGATGATGGTCGTCTAACTGATTCACAAGGTCGGACAG
TAAGCTTCAAAGATACCATCATTATTATGACTTCTAATGCCGGAACTGGTGACGTACAAGCTGATGTTGGTTTTGGAGCA
GCTGCTCAAGGTAAGACCCACTCCGTCCTTGACAAACTGGGAAATTACTTCAAGCCTGAATTCTTGAACCGTTTTGACGA
CATTGTTGAGTTCCAAGCCTTAACTAAGGAAAACTTAATGCAAATTGTCGACTTAATGATTGCAGACGTTAATAGCATGT
TGGCAACCCAAGGACTACACGTTGATGTAACCAAACCAGTTGAAGAACGCTTAGTTGATTTAGGCTACAATCCTAAGATG
GGTGCTCGCCCATTGCGTCGGGTAATTCAAGAACAAATTGAAGATCGCATCGCGGACTTTTATCTTGACCATCCAGCAGA
AAAGCAACTAAACGCTAAGATTAAAGATGATCAAATTGAAATTACTGGTGCTCCTAAAAAAGATTAA

Upstream 100 bases:

>100_bases
CGTGAATGGTCAACGTACAGAAGTTAATCTGTGTCAGAATTGCTATCAACTTTTAAAAAATCAACGAAATAATAACATTA
ATAGAAACGGAGGTGCTCGT

Downstream 100 bases:

>100_bases
ATAATAAAAAGAGGTTAGGTAAACCAATTATGGTTTACCTAACCTCTTCTTTTTTTATCCGCGATAACCAATTGCCATAC
CAATAATTAGAATTACTAGT

Product: ATP-binding subunit of Clp protease and DnaK/DnaJ chaperones

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 688; Mature: 687

Protein sequence:

>688_residues
MAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIG
RDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQL
MKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEE
EAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQK
KAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQ
NEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGY
VGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGA
AAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKM
GARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD

Sequences:

>Translated_688_residues
MAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIG
RDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQL
MKEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEE
EAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQK
KAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQ
NEAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGY
VGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGA
AAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKM
GARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD
>Mature_687_residues
AQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLSQYGLNLTDLAKQGKIDPVIGR
DSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQRIVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLM
KEVQANKDMVVFIDEIHEIVGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEEE
AIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLTINIADPETIQKKIDEAEAQKK
AALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTEEDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQN
EAVDKISRAIRRNRIGLNGTGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGYV
GYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTIIIMTSNAGTGDVQADVGFGAA
AQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLMQIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMG
ARPLRRVIQEQIEDRIADFYLDHPAEKQLNAKIKDDQIEITGAPKKD

Specific function: Could be necessary for degrading proteins generated by certain types of stress [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=303, Percent_Identity=37.6237623762376, Blast_Score=193, Evalue=4e-49,
Organism=Escherichia coli, GI1788943, Length=672, Percent_Identity=46.2797619047619, Blast_Score=574, Evalue=1e-165,
Organism=Escherichia coli, GI1787109, Length=637, Percent_Identity=41.1302982731554, Blast_Score=491, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6320464, Length=679, Percent_Identity=43.8880706921944, Blast_Score=555, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6323002, Length=364, Percent_Identity=38.1868131868132, Blast_Score=241, Evalue=2e-64,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR001943
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76106; Mature: 75975

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50151 UVR ; PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLS
CCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQR
HHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
IVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEI
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEE
HCCCCCCCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
EAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLT
HHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEE
INIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTE
EEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQNEAVDKISRAIRRNRIGLNG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
TGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGY
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCHHHHHHHHCCCCCC
VGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTI
CCHHHHHHHHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEECCEE
IIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLM
EEEECCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADF
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLDHPAEKQLNAKIKDDQIEITGAPKKD
HHCCCHHHHHCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
AQDPFGFGNLDDIFRAMQGGNMGQPENLYGQQVPPTQPGGGNGSGGNPNNRGNGGSLLS
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHH
QYGLNLTDLAKQGKIDPVIGRDSEIERVIEILNRRTKNNPVLIGEAGVGKTAVVEGLAQR
HHCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHH
IVEGSVPQKLVNKQIVRLDVVSLVQGTGIRGQFEQRMQQLMKEVQANKDMVVFIDEIHEI
HHCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
VGAGNAEGGMDAGNVLKPALARGDFQLVGATTLKEFRDIEKDAALARRLQPVQVDEPSEE
HCCCCCCCCCCCCHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
EAIKILKGIQKKYEDYHHVHYTDDAIEAAVKLSKRYIQDRFLPDKAIDLLDEAGSKKNLT
HHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEE
INIADPETIQKKIDEAEAQKKAALQSEDYEKAAYYRDQVSKLEKNKDGATSSEEQPTVTE
EEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCH
EDMEKIIETKTDIPVGDLQKQEQEQLQNLSENLKDHVIGQNEAVDKISRAIRRNRIGLNG
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCC
TGRPIGSFLFVGPTGVGKTELAKQLAQQLFGSKDSMIRFDMSEYMEPHSISKLIGSPPGY
CCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHCCHHHHHHHHCCCCCC
VGYEEAGQLTEQVRRHPYSLVLLDEVEKAHPDVMHMFLQILDDGRLTDSQGRTVSFKDTI
CCHHHHHHHHHHHHHCCCEEEEHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCEEEECCEE
IIMTSNAGTGDVQADVGFGAAAQGKTHSVLDKLGNYFKPEFLNRFDDIVEFQALTKENLM
EEEECCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QIVDLMIADVNSMLATQGLHVDVTKPVEERLVDLGYNPKMGARPLRRVIQEQIEDRIADF
HHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
YLDHPAEKQLNAKIKDDQIEITGAPKKD
HHCCCHHHHHCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]