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The map label for this gene is clpP

Identifier: 116492258

GI number: 116492258

Start: 508621

End: 509214

Strand: Reverse

Name: clpP

Synonym: PEPE_0455

Alternate gene names: 116492258

Gene position: 509214-508621 (Counterclockwise)

Preceding gene: 116492268

Following gene: 116492227

Centisome position: 27.79

GC content: 37.54

Gene sequence:

>594_bases
ATGAACTTGGTCCCAACAGTTATTGAACAATCATCACGTGGTGAACGTGCTTATGATATTTACTCACGACTATTAAAAGA
TCGAATCATCATGCTATCAGGTCCTATTGACGATGATTTAGCAAACTCAATCATCTCTCAACTACTCTTCCTTGATGCAC
AAGACTCAGAAAAGGATATTTACCTATACATCAACTCTCCTGGTGGAGTTGTTACCGCCGGTTTAGCTATTTACGATACC
ATGAACTTCATTAAATCTGATGTTCAAACAATCGTAATGGGAATGGCTGCTTCAATGGCCAGTGTGCTTGCTTCATCTGG
TACAAAGGGTAAACGTTTTGCTCTACCTCATTCAGAAGTTATGATTCATCAACCTTCTGGTGGAGCTCAAGGTCAACAAA
CTGAAATTGAGATTGCTGCAGAACAAATCTTGAAGACTCGTAAAGAATTGAATACGATTTTAGCTGAAAATTCTGGACAA
CCTCTTGAAAAGATTAATATTGATACTGAACGTGATAACTATCTATCAGCTCAAGACGCCGTTGAATACGGTTTGATTGA
TGGTATCATGGAAAAAAATGCTAACTTAAAATAA

Upstream 100 bases:

>100_bases
AGTAAAAATATTTGACCTTTTTTGACCAATGATATAAACTATAGCCATGTTAGTTATTTAACAGGAAATTTTTTACGATA
ATAAAGGAGGTTACTAAGTT

Downstream 100 bases:

>100_bases
TTAGTGGCATAAAAAAGACATCGGAAAAATTCCGATGTCTTTTTTTATTTTCCTAGTGCACTTTTCATCATTTTGTAACG
AAATTCGAAAATTTCTTCGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIDDDLANSIISQLLFLDAQDSEKDIYLYINSPGGVVTAGLAIYDT
MNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPHSEVMIHQPSGGAQGQQTEIEIAAEQILKTRKELNTILAENSGQ
PLEKINIDTERDNYLSAQDAVEYGLIDGIMEKNANLK

Sequences:

>Translated_197_residues
MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIDDDLANSIISQLLFLDAQDSEKDIYLYINSPGGVVTAGLAIYDT
MNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPHSEVMIHQPSGGAQGQQTEIEIAAEQILKTRKELNTILAENSGQ
PLEKINIDTERDNYLSAQDAVEYGLIDGIMEKNANLK
>Mature_197_residues
MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIDDDLANSIISQLLFLDAQDSEKDIYLYINSPGGVVTAGLAIYDT
MNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPHSEVMIHQPSGGAQGQQTEIEIAAEQILKTRKELNTILAENSGQ
PLEKINIDTERDNYLSAQDAVEYGLIDGIMEKNANLK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=54.2105263157895, Blast_Score=226, Evalue=1e-59,
Organism=Escherichia coli, GI1786641, Length=190, Percent_Identity=63.6842105263158, Blast_Score=264, Evalue=4e-72,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=49.2227979274611, Blast_Score=207, Evalue=3e-54,
Organism=Drosophila melanogaster, GI20129427, Length=191, Percent_Identity=50.7853403141361, Blast_Score=218, Evalue=2e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_PEDPA (Q03GX1)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803993.1
- ProteinModelPortal:   Q03GX1
- SMR:   Q03GX1
- STRING:   Q03GX1
- MEROPS:   S14.001
- GeneID:   4418352
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0455
- NMPDR:   fig|278197.10.peg.424
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   SPMEAQD
- ProtClustDB:   PRK00277
- BioCyc:   PPEN278197:PEPE_0455-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 21540; Mature: 21540

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 98-98 ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIDDDLANSIISQLLFLDAQDSEKDI
CCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGVVTAGLAIYDTMNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPHSEV
EEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPSGGAQGQQTEIEIAAEQILKTRKELNTILAENSGQPLEKINIDTERDNYLSAQDA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHH
VEYGLIDGIMEKNANLK
HHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNLVPTVIEQSSRGERAYDIYSRLLKDRIIMLSGPIDDDLANSIISQLLFLDAQDSEKDI
CCCCCHHHHCCCCCCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCEE
YLYINSPGGVVTAGLAIYDTMNFIKSDVQTIVMGMAASMASVLASSGTKGKRFALPHSEV
EEEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCE
MIHQPSGGAQGQQTEIEIAAEQILKTRKELNTILAENSGQPLEKINIDTERDNYLSAQDA
EEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCHHHH
VEYGLIDGIMEKNANLK
HHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA