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The map label for this gene is nhaK [H]

Identifier: 116492167

GI number: 116492167

Start: 409013

End: 410989

Strand: Reverse

Name: nhaK [H]

Synonym: PEPE_0364

Alternate gene names: 116492167

Gene position: 410989-409013 (Counterclockwise)

Preceding gene: 116492168

Following gene: 116492165

Centisome position: 22.43

GC content: 37.23

Gene sequence:

>1977_bases
ATGTCCATTGTATTTTTCGTTTTGATTTTAATCATCGCCACCGTTTTTTCAAACGCATTAGATACTAAAATCAAATTTTT
ACCACGGGCTATTATTCAAATTATGATGGGGTTAGCACTTTCTTTCATCCCCAATTTTAATCATTTCAATCTTAACCCTG
AAGTTTTCATGCTAGCAATTATTGCGCCGCTTATGTTTTACGACGGGATGAACACTAACATTGTCAAACTTAAACGTACT
CTGAGTAATACCTTTTCTCTAGCCATTGGACTAGCCGTTGTCACGATTATTCTAGTTGGTTACTTAGGATATGCTTTATT
ACCTCATATTCCGATTGCCCTTGCCTTTGCTTTAGCCGCTATTATTACCCCTACCGATGCGGTTGCAGTGTCATCCGTGA
CCGAAAATCTAGATCTTCCTAATGAGGCCATGCTGAGTCTCAAAAATGAGTCTTTGTTTAACGATGCAAGTGGAATCGTA
ATGTTTGATTTAGCTTTAACTGCCTTTCATACGGGACATTTTTCTCCGGTTCTAAGTATTTTTAATTACCTATATGTCTT
CTTTGGTGGCTTAATTGTCGGCTGGATTGTCGGTTGGCTTTTTGTTCGCTTACAATTACTCTTAATTGAAACCGATATTG
ATAACCCCAACATTATTGTCCCCATCAACTTCATTAAGCCTTTTGCTATCTACCTTCTGGCTGAAATGTTTGATACTTCC
GGAATTTTGGCTGTGGTAGCAGCTGGATTGATTCAAAGTACTCAAGCTCAATCCCTGCGTCTTACTTCAACCAAAACTCA
AATGGTGTCTAAAACCACCTACGAAATTTTTACTAACTTAATGAACGGTTTCGTTTTTATTCTTCTAGGAGTTTCATTTC
CAACCGTCATCTACGATATTACCAATGAAGGCCGCCAGGTTTCTTCGCTAGGTTATCTCATTTTGGTTGGTATCATTTTG
TACATCGTCATGATTATCATTCGCTACCTATGGGTTACTTTAAAACTAGCCAACATCCGTATCCGGCCAGCCGATAAAGT
ACTTAATCATTTTTTAATTGCTATTAATGGTATTCATGGGACTATTACCCTATCGATGGCCTTTTCTATTCCAATTGTAT
TACATGGTAAGATTTTTCCATTTCGCAATGATATTATTTTCATCGCGGCAACCGTCATCATTCTCAGCTTACTCGTGCCA
AGTATTATCTTACCGTTGATGTTACCAGCCAAATCTTATTCCTACAGTTTAGAAGATATTAGCACCTACCGCCAAAAAAT
GATTGAATACGCCATTAAACGCGTCCATGATGCCGATGAAGATCCAGTCGAAACGCAGGCGGTGATTGCTACTTTAAGAA
GCCAACAGTCTATCTTACAACGTCCTAAACGAAACGCTACTTACAAAATTTTACAGAAATGTTTTAATTTAGAAGAGAAA
CTACTTCAAGAGATGGTGGATAATGGTGAAATTAGCGTTAAACAACAAACTTTTTACGAAAGAATGTCATTGTTCCAAAG
TTTCCAACTCCATCAATCGTTTATCCAGCACTTCATGTATCGAGCACGTTTTTACTTTATTAAATTAAGCCATCGTTTCA
AACGACGCATTAAACGGGTAGATCCTTTGGTGGTTACCAAAAAATTCAATAATGCTCGAGACGAATTAGCTCAAGTAGAA
AATGAAATATCGCCTCAGATTTTTGCTTATCTCAAAGAACATCTAAACGCAGACAATCGAGCAGAAATCCACTGGATTGA
AGAGTACTATCGTGAACGCCATCGTCGTTTTCAAAATAACACTCGTGCTAACGAAATTCAGGAAGAACTTTTTATTAACG
CCTTCCAAAATGAATATAACTTTATTCAAGAACAATTAGGAAAGAAAAATATTTCTCGTGAACTGGCCAGTTTGCTATAT
GAACAGGTCTCCAATGACGAGTGGGTTTATATGCAAAATGATAGTATTTACGCATAA

Upstream 100 bases:

>100_bases
CTAAAAATTAATATCCTCTATACCAAAGCCACAAAAATCGATTTTTTTGTGGCTTTTTGGTACGCTTGGTTTAGAGAAAC
CAAAAAAGGAGTCGTTGTGC

Downstream 100 bases:

>100_bases
AAAACTATGATAACAAGTCACCTTGCACTGCTTAGTGTCAGAGACAACCTGCTACCATAGTTTTTTTAATCCATATATTT
ATCTAAAAATTTTTCAACTG

Product: NhaP-type Na+/H+ and K+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 657

Protein sequence:

>658_residues
MSIVFFVLILIIATVFSNALDTKIKFLPRAIIQIMMGLALSFIPNFNHFNLNPEVFMLAIIAPLMFYDGMNTNIVKLKRT
LSNTFSLAIGLAVVTIILVGYLGYALLPHIPIALAFALAAIITPTDAVAVSSVTENLDLPNEAMLSLKNESLFNDASGIV
MFDLALTAFHTGHFSPVLSIFNYLYVFFGGLIVGWIVGWLFVRLQLLLIETDIDNPNIIVPINFIKPFAIYLLAEMFDTS
GILAVVAAGLIQSTQAQSLRLTSTKTQMVSKTTYEIFTNLMNGFVFILLGVSFPTVIYDITNEGRQVSSLGYLILVGIIL
YIVMIIIRYLWVTLKLANIRIRPADKVLNHFLIAINGIHGTITLSMAFSIPIVLHGKIFPFRNDIIFIAATVIILSLLVP
SIILPLMLPAKSYSYSLEDISTYRQKMIEYAIKRVHDADEDPVETQAVIATLRSQQSILQRPKRNATYKILQKCFNLEEK
LLQEMVDNGEISVKQQTFYERMSLFQSFQLHQSFIQHFMYRARFYFIKLSHRFKRRIKRVDPLVVTKKFNNARDELAQVE
NEISPQIFAYLKEHLNADNRAEIHWIEEYYRERHRRFQNNTRANEIQEELFINAFQNEYNFIQEQLGKKNISRELASLLY
EQVSNDEWVYMQNDSIYA

Sequences:

>Translated_658_residues
MSIVFFVLILIIATVFSNALDTKIKFLPRAIIQIMMGLALSFIPNFNHFNLNPEVFMLAIIAPLMFYDGMNTNIVKLKRT
LSNTFSLAIGLAVVTIILVGYLGYALLPHIPIALAFALAAIITPTDAVAVSSVTENLDLPNEAMLSLKNESLFNDASGIV
MFDLALTAFHTGHFSPVLSIFNYLYVFFGGLIVGWIVGWLFVRLQLLLIETDIDNPNIIVPINFIKPFAIYLLAEMFDTS
GILAVVAAGLIQSTQAQSLRLTSTKTQMVSKTTYEIFTNLMNGFVFILLGVSFPTVIYDITNEGRQVSSLGYLILVGIIL
YIVMIIIRYLWVTLKLANIRIRPADKVLNHFLIAINGIHGTITLSMAFSIPIVLHGKIFPFRNDIIFIAATVIILSLLVP
SIILPLMLPAKSYSYSLEDISTYRQKMIEYAIKRVHDADEDPVETQAVIATLRSQQSILQRPKRNATYKILQKCFNLEEK
LLQEMVDNGEISVKQQTFYERMSLFQSFQLHQSFIQHFMYRARFYFIKLSHRFKRRIKRVDPLVVTKKFNNARDELAQVE
NEISPQIFAYLKEHLNADNRAEIHWIEEYYRERHRRFQNNTRANEIQEELFINAFQNEYNFIQEQLGKKNISRELASLLY
EQVSNDEWVYMQNDSIYA
>Mature_657_residues
SIVFFVLILIIATVFSNALDTKIKFLPRAIIQIMMGLALSFIPNFNHFNLNPEVFMLAIIAPLMFYDGMNTNIVKLKRTL
SNTFSLAIGLAVVTIILVGYLGYALLPHIPIALAFALAAIITPTDAVAVSSVTENLDLPNEAMLSLKNESLFNDASGIVM
FDLALTAFHTGHFSPVLSIFNYLYVFFGGLIVGWIVGWLFVRLQLLLIETDIDNPNIIVPINFIKPFAIYLLAEMFDTSG
ILAVVAAGLIQSTQAQSLRLTSTKTQMVSKTTYEIFTNLMNGFVFILLGVSFPTVIYDITNEGRQVSSLGYLILVGIILY
IVMIIIRYLWVTLKLANIRIRPADKVLNHFLIAINGIHGTITLSMAFSIPIVLHGKIFPFRNDIIFIAATVIILSLLVPS
IILPLMLPAKSYSYSLEDISTYRQKMIEYAIKRVHDADEDPVETQAVIATLRSQQSILQRPKRNATYKILQKCFNLEEKL
LQEMVDNGEISVKQQTFYERMSLFQSFQLHQSFIQHFMYRARFYFIKLSHRFKRRIKRVDPLVVTKKFNNARDELAQVEN
EISPQIFAYLKEHLNADNRAEIHWIEEYYRERHRRFQNNTRANEIQEELFINAFQNEYNFIQEQLGKKNISRELASLLYE
QVSNDEWVYMQNDSIYA

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790501, Length=457, Percent_Identity=32.6039387308534, Blast_Score=201, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71992107, Length=328, Percent_Identity=23.4756097560976, Blast_Score=72, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25147678, Length=312, Percent_Identity=25, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71992101, Length=328, Percent_Identity=23.4756097560976, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980847, Length=379, Percent_Identity=22.6912928759894, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 75348; Mature: 75216

Theoretical pI: Translated: 8.30; Mature: 8.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIVFFVLILIIATVFSNALDTKIKFLPRAIIQIMMGLALSFIPNFNHFNLNPEVFMLAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IAPLMFYDGMNTNIVKLKRTLSNTFSLAIGLAVVTIILVGYLGYALLPHIPIALAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITPTDAVAVSSVTENLDLPNEAMLSLKNESLFNDASGIVMFDLALTAFHTGHFSPVLSI
HHCCCHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FNYLYVFFGGLIVGWIVGWLFVRLQLLLIETDIDNPNIIVPINFIKPFAIYLLAEMFDTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECHHHHHHHHHHHHHHCCC
GILAVVAAGLIQSTQAQSLRLTSTKTQMVSKTTYEIFTNLMNGFVFILLGVSFPTVIYDI
CHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEC
TNEGRQVSSLGYLILVGIILYIVMIIIRYLWVTLKLANIRIRPADKVLNHFLIAINGIHG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHEECCCE
TITLSMAFSIPIVLHGKIFPFRNDIIFIAATVIILSLLVPSIILPLMLPAKSYSYSLEDI
EEEEEEEECCCEEEECEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
STYRQKMIEYAIKRVHDADEDPVETQAVIATLRSQQSILQRPKRNATYKILQKCFNLEEK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHH
LLQEMVDNGEISVKQQTFYERMSLFQSFQLHQSFIQHFMYRARFYFIKLSHRFKRRIKRV
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVVTKKFNNARDELAQVENEISPQIFAYLKEHLNADNRAEIHWIEEYYRERHRRFQNN
CCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
TRANEIQEELFINAFQNEYNFIQEQLGKKNISRELASLLYEQVSNDEWVYMQNDSIYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
>Mature Secondary Structure 
SIVFFVLILIIATVFSNALDTKIKFLPRAIIQIMMGLALSFIPNFNHFNLNPEVFMLAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
IAPLMFYDGMNTNIVKLKRTLSNTFSLAIGLAVVTIILVGYLGYALLPHIPIALAFALAA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IITPTDAVAVSSVTENLDLPNEAMLSLKNESLFNDASGIVMFDLALTAFHTGHFSPVLSI
HHCCCHHHHHHHHHHCCCCCCHHHHHHCCHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHH
FNYLYVFFGGLIVGWIVGWLFVRLQLLLIETDIDNPNIIVPINFIKPFAIYLLAEMFDTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECHHHHHHHHHHHHHHCCC
GILAVVAAGLIQSTQAQSLRLTSTKTQMVSKTTYEIFTNLMNGFVFILLGVSFPTVIYDI
CHHHHHHHHHHHHCCHHHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHEEEEC
TNEGRQVSSLGYLILVGIILYIVMIIIRYLWVTLKLANIRIRPADKVLNHFLIAINGIHG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHEECCCE
TITLSMAFSIPIVLHGKIFPFRNDIIFIAATVIILSLLVPSIILPLMLPAKSYSYSLEDI
EEEEEEEECCCEEEECEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
STYRQKMIEYAIKRVHDADEDPVETQAVIATLRSQQSILQRPKRNATYKILQKCFNLEEK
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHHH
LLQEMVDNGEISVKQQTFYERMSLFQSFQLHQSFIQHFMYRARFYFIKLSHRFKRRIKRV
HHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DPLVVTKKFNNARDELAQVENEISPQIFAYLKEHLNADNRAEIHWIEEYYRERHRRFQNN
CCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCC
TRANEIQEELFINAFQNEYNFIQEQLGKKNISRELASLLYEQVSNDEWVYMQNDSIYA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA