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The map label for this gene is thiD [H]

Identifier: 116492036

GI number: 116492036

Start: 268227

End: 269036

Strand: Reverse

Name: thiD [H]

Synonym: PEPE_0228

Alternate gene names: 116492036

Gene position: 269036-268227 (Counterclockwise)

Preceding gene: 116492037

Following gene: 116492034

Centisome position: 14.68

GC content: 40.86

Gene sequence:

>810_bases
ATGTCAAATGAATTTCCACAAGCTTTAACTATCGCTGGTTCTGATTCAGATGGAAGTGCTGGAATGGAAGCAGATATGAA
CACATTCCAACGTCGTAACGTTCATGGAATGTGTGTCATGACTGCCTGCGTAGCCGGTAACTCTTACGGTATTCAAGCAA
GCCACGCCCTACCCACCGATTTTGTTGATCAAGAATTTCAATCTCTTGCAGCTGATTTTAAAATCCGTGCTAGTAAAACT
GGCATGCTTGCTGACAGTCCCATGATTGAAACAGTCGTTAAAAACTATCAAAAATTTGATTTTGGACCACTAGTCTTAGA
TCCTGTAATTATTACCAAGCATGGTGCCTTGTTACTTGAAGAAGAAGCTTTCGAAACTTTAAAGCAACAACTCATTCCAT
TGGCAACTGTGATTACTCCTAATTTTTATGAAGCAATCAAACTTACTGGTATTGATATTAAAAATGACGATGATACCATC
CAAGCTGCTCATATCCTACAGGAAATGGGTGCTAAAAATGTGATGTTGAAGGGTTCGCACAAACCGGGTGAACAAACCGA
AGTTCGTGACTTCGTTCTCTTGGAAGATGGCTCCAGTTTTTGGCTTAGTGAACCATACATTGAAACTGACCGGGTTAACG
GTACTGGCGATGTCCTCTCAGCATGTATCACTGCTGAAATCGCTAAGGGAACTGATATTCCAACTGCTATCCGTATTGCT
AAAAAATTTGTTACCGCTGCAATTGCCAACCCAATCGCAGTAGGTCATAAGTATGGACCCGTTAATCATTTAGCGAAATT
CCAAGCTTAA

Upstream 100 bases:

>100_bases
TTTTAAAAATGCCGCTTTGAATCTCCAATCAATTCCATTAAATTAAGTTTCTTAAATTATGGTATCCTTGAATCAACCAT
TTATGAGGAGTGTGAATTTA

Downstream 100 bases:

>100_bases
TCCATTTAAATTAAAAACGCGAAACAAATTTAAGGGTCAAGGCCCGCAACTTGTTTCGCGTTTTTTATATTAGTTTTCCG
TATCTTTTTCAGTAACAGTC

Product: hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSNEFPQALTIAGSDSDGSAGMEADMNTFQRRNVHGMCVMTACVAGNSYGIQASHALPTDFVDQEFQSLAADFKIRASKT
GMLADSPMIETVVKNYQKFDFGPLVLDPVIITKHGALLLEEEAFETLKQQLIPLATVITPNFYEAIKLTGIDIKNDDDTI
QAAHILQEMGAKNVMLKGSHKPGEQTEVRDFVLLEDGSSFWLSEPYIETDRVNGTGDVLSACITAEIAKGTDIPTAIRIA
KKFVTAAIANPIAVGHKYGPVNHLAKFQA

Sequences:

>Translated_269_residues
MSNEFPQALTIAGSDSDGSAGMEADMNTFQRRNVHGMCVMTACVAGNSYGIQASHALPTDFVDQEFQSLAADFKIRASKT
GMLADSPMIETVVKNYQKFDFGPLVLDPVIITKHGALLLEEEAFETLKQQLIPLATVITPNFYEAIKLTGIDIKNDDDTI
QAAHILQEMGAKNVMLKGSHKPGEQTEVRDFVLLEDGSSFWLSEPYIETDRVNGTGDVLSACITAEIAKGTDIPTAIRIA
KKFVTAAIANPIAVGHKYGPVNHLAKFQA
>Mature_268_residues
SNEFPQALTIAGSDSDGSAGMEADMNTFQRRNVHGMCVMTACVAGNSYGIQASHALPTDFVDQEFQSLAADFKIRASKTG
MLADSPMIETVVKNYQKFDFGPLVLDPVIITKHGALLLEEEAFETLKQQLIPLATVITPNFYEAIKLTGIDIKNDDDTIQ
AAHILQEMGAKNVMLKGSHKPGEQTEVRDFVLLEDGSSFWLSEPYIETDRVNGTGDVLSACITAEIAKGTDIPTAIRIAK
KFVTAAIANPIAVGHKYGPVNHLAKFQA

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=263, Percent_Identity=34.2205323193916, Blast_Score=156, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6325378, Length=274, Percent_Identity=26.6423357664234, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=28, Blast_Score=93, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6324997, Length=276, Percent_Identity=28.9855072463768, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 29149; Mature: 29017

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNEFPQALTIAGSDSDGSAGMEADMNTFQRRNVHGMCVMTACVAGNSYGIQASHALPTD
CCCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCHH
FVDQEFQSLAADFKIRASKTGMLADSPMIETVVKNYQKFDFGPLVLDPVIITKHGALLLE
HHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEEH
EEAFETLKQQLIPLATVITPNFYEAIKLTGIDIKNDDDTIQAAHILQEMGAKNVMLKGSH
HHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEECCCCCHHHHHHHHHHCCCCCEEEECCC
KPGEQTEVRDFVLLEDGSSFWLSEPYIETDRVNGTGDVLSACITAEIAKGTDIPTAIRIA
CCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
KKFVTAAIANPIAVGHKYGPVNHLAKFQA
HHHHHHHHHCHHHCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
SNEFPQALTIAGSDSDGSAGMEADMNTFQRRNVHGMCVMTACVAGNSYGIQASHALPTD
CCCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCHH
FVDQEFQSLAADFKIRASKTGMLADSPMIETVVKNYQKFDFGPLVLDPVIITKHGALLLE
HHHHHHHHHHHCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCEEECCEEEECCCCEEEH
EEAFETLKQQLIPLATVITPNFYEAIKLTGIDIKNDDDTIQAAHILQEMGAKNVMLKGSH
HHHHHHHHHHHHHHHHHHCCCHHHEEEEECCEECCCCCHHHHHHHHHHCCCCCEEEECCC
KPGEQTEVRDFVLLEDGSSFWLSEPYIETDRVNGTGDVLSACITAEIAKGTDIPTAIRIA
CCCCCCCCEEEEEEECCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
KKFVTAAIANPIAVGHKYGPVNHLAKFQA
HHHHHHHHHCHHHCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]