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The map label for this gene is galM [H]

Identifier: 116492029

GI number: 116492029

Start: 260817

End: 261821

Strand: Reverse

Name: galM [H]

Synonym: PEPE_0221

Alternate gene names: 116492029

Gene position: 261821-260817 (Counterclockwise)

Preceding gene: 116492034

Following gene: 116492028

Centisome position: 14.29

GC content: 39.6

Gene sequence:

>1005_bases
TTGAAGATTAATAAAGAAGAGTTCCAAAACGTAAATTGGTACACGCTTTCTAATGACAACCATGTTTCTGTTACTATCAG
TACCCTAGGGGCTACGGTAGTCGCTGTAAATACCCCTGATAAAAAAGGGAATGTCGAAAATATTGTCTTAGGCTTTGATA
ATCCCCAAACTTATCCAAAGCACAACGATTATTTTGGTGCTTCGGTTGCGCGGGTTGCCGGCCGGATTAAAGATGGTAAG
TGGCGCGATTACCAATTAAATCAAAATGAAGGTCAAAATACTTTACACGGAGGTAATAAGCCTTCACTTAGCTACGTTAA
TTGGAAGAAAATCAGTAAATTTATCCGCCCAGAAGAAGTCGGTTTAGTTCTTAAACGTTTTAGTATTGACGGTGAAAATG
GCTTTCCTGGTGATTTAACCATCGATGCTATTTTCCGTTTAAATAACCGAAATGAATTTTCGATAACTTATATCGGTCAC
GCTTCTAAACAAACCCTCTTCAACCCCACTAATCATATGTACTTTAATCTTAGCGGGGATGCTAAGCGTTCAATTAAGCA
ACATCAAATTGAATTAAAAAGCGATGTAATCGCAGAAGTTGATGCAGAGTTAATTCCCACTGGTAATTTATTAAACGTGG
ATGGCACACCGTATGACTTGCACCATCCAACTTCAATGCAATCCATCCTTGATCAAGTATCAGACGGATTAGACACTGCT
TTCAAAGTTGAACCTAGCATCGAAGCGCCTCAACTTACGCTGGAAGATCCTGAATCTGGTCGTAAGATACGGGTTCAAAC
TTCTGCCAATGCCTTTACCCTCTTTACTACTAATGAGCCACAAGAGCCATTCAAAATTAATGGCAATCAAGATATGGCAG
CCAACATCGGATTAGCAATCGAACCTCAAATGCTTCCCGATGCCATCCACCATTCCGGCTTCGGTAATATCATTATTTCT
CCATCTAAACCGATGATGTATCGGAACGTTTACTATTTAAACTAA

Upstream 100 bases:

>100_bases
ACTTACTTAAAGTAAAACAAAAACATTCATCATAAAGCTAACTGTAATCGGTTTCATTGTGATAAAATCAATTATAAGAA
GACATAGGAGGGATTGTATT

Downstream 100 bases:

>100_bases
CAATTTTTTGAAAAAGGTTCTGTAATCAGCTTATAGTTTGATTGCAGGACCTTTTTATGATAATTTAGGTGAGTTATTAA
TGCACCTCAACACAATTATG

Product: aldose 1-epimerase

Products: NA

Alternate protein names: Galactose mutarotase; Type-1 mutarotase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MKINKEEFQNVNWYTLSNDNHVSVTISTLGATVVAVNTPDKKGNVENIVLGFDNPQTYPKHNDYFGASVARVAGRIKDGK
WRDYQLNQNEGQNTLHGGNKPSLSYVNWKKISKFIRPEEVGLVLKRFSIDGENGFPGDLTIDAIFRLNNRNEFSITYIGH
ASKQTLFNPTNHMYFNLSGDAKRSIKQHQIELKSDVIAEVDAELIPTGNLLNVDGTPYDLHHPTSMQSILDQVSDGLDTA
FKVEPSIEAPQLTLEDPESGRKIRVQTSANAFTLFTTNEPQEPFKINGNQDMAANIGLAIEPQMLPDAIHHSGFGNIIIS
PSKPMMYRNVYYLN

Sequences:

>Translated_334_residues
MKINKEEFQNVNWYTLSNDNHVSVTISTLGATVVAVNTPDKKGNVENIVLGFDNPQTYPKHNDYFGASVARVAGRIKDGK
WRDYQLNQNEGQNTLHGGNKPSLSYVNWKKISKFIRPEEVGLVLKRFSIDGENGFPGDLTIDAIFRLNNRNEFSITYIGH
ASKQTLFNPTNHMYFNLSGDAKRSIKQHQIELKSDVIAEVDAELIPTGNLLNVDGTPYDLHHPTSMQSILDQVSDGLDTA
FKVEPSIEAPQLTLEDPESGRKIRVQTSANAFTLFTTNEPQEPFKINGNQDMAANIGLAIEPQMLPDAIHHSGFGNIIIS
PSKPMMYRNVYYLN
>Mature_334_residues
MKINKEEFQNVNWYTLSNDNHVSVTISTLGATVVAVNTPDKKGNVENIVLGFDNPQTYPKHNDYFGASVARVAGRIKDGK
WRDYQLNQNEGQNTLHGGNKPSLSYVNWKKISKFIRPEEVGLVLKRFSIDGENGFPGDLTIDAIFRLNNRNEFSITYIGH
ASKQTLFNPTNHMYFNLSGDAKRSIKQHQIELKSDVIAEVDAELIPTGNLLNVDGTPYDLHHPTSMQSILDQVSDGLDTA
FKVEPSIEAPQLTLEDPESGRKIRVQTSANAFTLFTTNEPQEPFKINGNQDMAANIGLAIEPQMLPDAIHHSGFGNIIIS
PSKPMMYRNVYYLN

Specific function: Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose [H]

COG id: COG2017

COG function: function code G; Galactose mutarotase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldose epimerase family [H]

Homologues:

Organism=Homo sapiens, GI20270355, Length=308, Percent_Identity=31.1688311688312, Blast_Score=148, Evalue=8e-36,
Organism=Escherichia coli, GI1786971, Length=312, Percent_Identity=29.1666666666667, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17557428, Length=329, Percent_Identity=29.1793313069909, Blast_Score=124, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI115533334, Length=329, Percent_Identity=29.1793313069909, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319493, Length=332, Percent_Identity=26.8072289156627, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322004, Length=331, Percent_Identity=28.3987915407855, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324399, Length=288, Percent_Identity=28.8194444444444, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583720, Length=348, Percent_Identity=32.4712643678161, Blast_Score=160, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24668282, Length=340, Percent_Identity=29.7058823529412, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24659048, Length=341, Percent_Identity=30.2052785923754, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24668278, Length=343, Percent_Identity=28.2798833819242, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24641876, Length=347, Percent_Identity=28.2420749279539, Blast_Score=133, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018052
- InterPro:   IPR013458
- InterPro:   IPR008183
- InterPro:   IPR015443
- InterPro:   IPR011013
- InterPro:   IPR014718 [H]

Pfam domain/function: PF01263 Aldose_epim [H]

EC number: =5.1.3.3 [H]

Molecular weight: Translated: 37365; Mature: 37365

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00545 ALDOSE_1_EPIMERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKINKEEFQNVNWYTLSNDNHVSVTISTLGATVVAVNTPDKKGNVENIVLGFDNPQTYPK
CCCCHHHHCCCCEEEECCCCEEEEEEEECCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
HNDYFGASVARVAGRIKDGKWRDYQLNQNEGQNTLHGGNKPSLSYVNWKKISKFIRPEEV
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHHCCHHHH
GLVLKRFSIDGENGFPGDLTIDAIFRLNNRNEFSITYIGHASKQTLFNPTNHMYFNLSGD
CEEEEEEECCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCEECCCCEEEEEECCH
AKRSIKQHQIELKSDVIAEVDAELIPTGNLLNVDGTPYDLHHPTSMQSILDQVSDGLDTA
HHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCCEECCCCHHHHHHHHHHHCCCCCE
FKVEPSIEAPQLTLEDPESGRKIRVQTSANAFTLFTTNEPQEPFKINGNQDMAANIGLAI
EEECCCCCCCEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEECCCCCEEEECCEEE
EPQMLPDAIHHSGFGNIIISPSKPMMYRNVYYLN
CCCCCHHHHHHCCCCCEEECCCCCEEEEEEEEEC
>Mature Secondary Structure
MKINKEEFQNVNWYTLSNDNHVSVTISTLGATVVAVNTPDKKGNVENIVLGFDNPQTYPK
CCCCHHHHCCCCEEEECCCCEEEEEEEECCEEEEEEECCCCCCCCCEEEEECCCCCCCCC
HNDYFGASVARVAGRIKDGKWRDYQLNQNEGQNTLHGGNKPSLSYVNWKKISKFIRPEEV
CCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECHHHHHHHCCHHHH
GLVLKRFSIDGENGFPGDLTIDAIFRLNNRNEFSITYIGHASKQTLFNPTNHMYFNLSGD
CEEEEEEECCCCCCCCCCEEEEEEEEECCCCEEEEEEEECCCCCCEECCCCEEEEEECCH
AKRSIKQHQIELKSDVIAEVDAELIPTGNLLNVDGTPYDLHHPTSMQSILDQVSDGLDTA
HHHHHHHHHHHHHHHHHHHCCCEEECCCCEEECCCCCEECCCCHHHHHHHHHHHCCCCCE
FKVEPSIEAPQLTLEDPESGRKIRVQTSANAFTLFTTNEPQEPFKINGNQDMAANIGLAI
EEECCCCCCCEEEECCCCCCCEEEEEECCCEEEEEECCCCCCCEEECCCCCEEEECCEEE
EPQMLPDAIHHSGFGNIIISPSKPMMYRNVYYLN
CCCCCHHHHHHCCCCCEEECCCCCEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1694527 [H]