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The map label for this gene is galK [H]

Identifier: 116491927

GI number: 116491927

Start: 124389

End: 125561

Strand: Direct

Name: galK [H]

Synonym: PEPE_0113

Alternate gene names: 116491927

Gene position: 124389-125561 (Clockwise)

Preceding gene: 116491926

Following gene: 116491928

Centisome position: 6.79

GC content: 43.82

Gene sequence:

>1173_bases
ATGAACATCGATAAAACTACAATTTCAAATAAGTTTAAAGAAGTTTTTCATACAGATGTGTACGAAGTCTATTTTTCACC
CGGTCGCATTAATTTAATCGGAGAACACACCGATTACAATGGAGGTCATGTCTTTCCATGCGCCATCAGTTTAGGGACGT
ACGGCGGATATCGACGCCGAACGGATGGACTGGTAAGAATGTATTCTGGTAATTTTCCAGAGGTAGGAGTGTTGGAGTTT
GATGTAAACCACCTCGATTTTGAACCGCAATACCAGTGGAGCAATTATCTTCGAGGAATGATGCGCGAAATTCGGGATTT
AGCCCATGCGGACTACGATCATGGGTTTGAACTCTACCTAGAAGGCGATTTGCCAGATGGCGCTGGATTATCGTCATCGG
CTTCGATTGAAATGTTGATGGGTACCATTCTTAGTAGCGAATTTAATTTTAAAGTCGACCCCGTAGTCATGGCGAAGGCG
GGACAAAGGGTGGAGAACAATTATATTGGGGTAAATTCAGGCATCATGGACCAATTTGCGGTCAAAATGGGGAAACGCAA
CGAAGCAATCTTCCTAGATGCCAATACCATGGAATACGAGTACTCACCGTTGGACTTAGGAAAGCATATCGTATTAATCA
TGAATACCAATAAGCCGCATACGTTAGCTAATTCGGAGTACAATACGCGACGCGCGGAATGTGAACAAGCCTTAGATTGT
CTGAAGCGAAAACTCAACATCAGCACGCTAGGAGACCTCTCCAACCCTGCCTTTGACCAATACACCTATTTGATTCGAGA
CGAAACTTTAATCAAACGGGCTCGGCATGCGGTCTTTGAAAATCAACGTACGATGGATGCCAAAAAAGCATTAGATAACG
GCGATTTGAAACTATTTGGTCGTTTAATCAATGCTTCCCATATCTCACTTCAATATGACTATGAAGTGAGTGTTCCAGAA
CTAGACCTGTTAGTCAGTGAAGCTTGGGAACATGACGGGGTACTCGGCGCGCGGATGATTGGTGGCGGATTTGGTGGCTG
TGCGATTGCTTTGGTTGAACAGGATCAAGTAGCCGATTTAATCGAAAAAGTGGGTGCTAAGTACCAAGCTCAATTTGGTT
ATGCCGCTGATTTCTACGAAGCCAAAGTGGTCGATGGACCACATAAAATTTAA

Upstream 100 bases:

>100_bases
TGAACAAATTCTTGGAGAACAAACGCCAATCGACTGGAGCACCCGTTAATCCACCCGTCGTTCAAAATCTTTCATTCGGA
AACTAATTATGGAGGCTGAA

Downstream 100 bases:

>100_bases
GTAAAAAAACATGAAATGAGAACCGCAATAACTCATTTCGTGGTTTTTTTACTTTCTATCATCAAAATGCCATGTTCTAA
CTAAAATATAATAAAAAAGA

Product: galactokinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNIDKTTISNKFKEVFHTDVYEVYFSPGRINLIGEHTDYNGGHVFPCAISLGTYGGYRRRTDGLVRMYSGNFPEVGVLEF
DVNHLDFEPQYQWSNYLRGMMREIRDLAHADYDHGFELYLEGDLPDGAGLSSSASIEMLMGTILSSEFNFKVDPVVMAKA
GQRVENNYIGVNSGIMDQFAVKMGKRNEAIFLDANTMEYEYSPLDLGKHIVLIMNTNKPHTLANSEYNTRRAECEQALDC
LKRKLNISTLGDLSNPAFDQYTYLIRDETLIKRARHAVFENQRTMDAKKALDNGDLKLFGRLINASHISLQYDYEVSVPE
LDLLVSEAWEHDGVLGARMIGGGFGGCAIALVEQDQVADLIEKVGAKYQAQFGYAADFYEAKVVDGPHKI

Sequences:

>Translated_390_residues
MNIDKTTISNKFKEVFHTDVYEVYFSPGRINLIGEHTDYNGGHVFPCAISLGTYGGYRRRTDGLVRMYSGNFPEVGVLEF
DVNHLDFEPQYQWSNYLRGMMREIRDLAHADYDHGFELYLEGDLPDGAGLSSSASIEMLMGTILSSEFNFKVDPVVMAKA
GQRVENNYIGVNSGIMDQFAVKMGKRNEAIFLDANTMEYEYSPLDLGKHIVLIMNTNKPHTLANSEYNTRRAECEQALDC
LKRKLNISTLGDLSNPAFDQYTYLIRDETLIKRARHAVFENQRTMDAKKALDNGDLKLFGRLINASHISLQYDYEVSVPE
LDLLVSEAWEHDGVLGARMIGGGFGGCAIALVEQDQVADLIEKVGAKYQAQFGYAADFYEAKVVDGPHKI
>Mature_390_residues
MNIDKTTISNKFKEVFHTDVYEVYFSPGRINLIGEHTDYNGGHVFPCAISLGTYGGYRRRTDGLVRMYSGNFPEVGVLEF
DVNHLDFEPQYQWSNYLRGMMREIRDLAHADYDHGFELYLEGDLPDGAGLSSSASIEMLMGTILSSEFNFKVDPVVMAKA
GQRVENNYIGVNSGIMDQFAVKMGKRNEAIFLDANTMEYEYSPLDLGKHIVLIMNTNKPHTLANSEYNTRRAECEQALDC
LKRKLNISTLGDLSNPAFDQYTYLIRDETLIKRARHAVFENQRTMDAKKALDNGDLKLFGRLINASHISLQYDYEVSVPE
LDLLVSEAWEHDGVLGARMIGGGFGGCAIALVEQDQVADLIEKVGAKYQAQFGYAADFYEAKVVDGPHKI

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=380, Percent_Identity=37.1052631578947, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI48527957, Length=412, Percent_Identity=24.2718446601942, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI4503897, Length=412, Percent_Identity=24.2718446601942, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786972, Length=384, Percent_Identity=36.71875, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71989053, Length=401, Percent_Identity=26.1845386533666, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320212, Length=264, Percent_Identity=24.6212121212121, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319494, Length=271, Percent_Identity=26.9372693726937, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24661292, Length=417, Percent_Identity=25.1798561151079, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21355577, Length=417, Percent_Identity=25.1798561151079, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24661285, Length=417, Percent_Identity=25.1798561151079, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 43874; Mature: 43874

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00106 GALACTOKINASE ; PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIDKTTISNKFKEVFHTDVYEVYFSPGRINLIGEHTDYNGGHVFPCAISLGTYGGYRRR
CCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCC
TDGLVRMYSGNFPEVGVLEFDVNHLDFEPQYQWSNYLRGMMREIRDLAHADYDHGFELYL
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
EGDLPDGAGLSSSASIEMLMGTILSSEFNFKVDPVVMAKAGQRVENNYIGVNSGIMDQFA
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEECCCCHHCCCEEECCCCHHHHHH
VKMGKRNEAIFLDANTMEYEYSPLDLGKHIVLIMNTNKPHTLANSEYNTRRAECEQALDC
HHHCCCCCEEEEECCCCEEECCCCCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHH
LKRKLNISTLGDLSNPAFDQYTYLIRDETLIKRARHAVFENQRTMDAKKALDNGDLKLFG
HHHHCCCCCCCCCCCCCHHHEEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
RLINASHISLQYDYEVSVPELDLLVSEAWEHDGVLGARMIGGGFGGCAIALVEQDQVADL
HHHCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEHEECCCCCCEEEEEECHHHHHHH
IEKVGAKYQAQFGYAADFYEAKVVDGPHKI
HHHHCCCEEECCCCEECCEEEEECCCCCCC
>Mature Secondary Structure
MNIDKTTISNKFKEVFHTDVYEVYFSPGRINLIGEHTDYNGGHVFPCAISLGTYGGYRRR
CCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEEECCCCCCCCEEEEEEEEECCCCCCCCC
TDGLVRMYSGNFPEVGVLEFDVNHLDFEPQYQWSNYLRGMMREIRDLAHADYDHGFELYL
CCCEEEEECCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
EGDLPDGAGLSSSASIEMLMGTILSSEFNFKVDPVVMAKAGQRVENNYIGVNSGIMDQFA
ECCCCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEECCCCHHCCCEEECCCCHHHHHH
VKMGKRNEAIFLDANTMEYEYSPLDLGKHIVLIMNTNKPHTLANSEYNTRRAECEQALDC
HHHCCCCCEEEEECCCCEEECCCCCCCCEEEEEEECCCCCEECCCCCCCHHHHHHHHHHH
LKRKLNISTLGDLSNPAFDQYTYLIRDETLIKRARHAVFENQRTMDAKKALDNGDLKLFG
HHHHCCCCCCCCCCCCCHHHEEEEEECHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHH
RLINASHISLQYDYEVSVPELDLLVSEAWEHDGVLGARMIGGGFGGCAIALVEQDQVADL
HHHCCEEEEEEEEEEECCCHHHHHHHHHHCCCCCEEEHEECCCCCCEEEEEECHHHHHHH
IEKVGAKYQAQFGYAADFYEAKVVDGPHKI
HHHHCCCEEECCCCEECCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12566566 [H]