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The map label for this gene is dnaC [H]

Identifier: 116491830

GI number: 116491830

Start: 12874

End: 14271

Strand: Direct

Name: dnaC [H]

Synonym: PEPE_0012

Alternate gene names: 116491830

Gene position: 12874-14271 (Clockwise)

Preceding gene: 116491829

Following gene: 116491831

Centisome position: 0.7

GC content: 40.99

Gene sequence:

>1398_bases
ATGGACAACGGTATTTTAGAAAATCAAACGCCTCCGCAAAACATTGAGGCCGAAAAGGCGGTTTTGGGAGCTGTTTTCTT
AAGTTCAGATGCATTGATTGACGCGATGGAATACGTCACGGCGGAAGATTTTTATAAACACGCTCATCAAGTTATTTTTA
AAGTGATGGTTGATTTGAACGATGCGGATGAAGCCATTGACGCATTGACAGTCAACAATGCACTTGAAGAACATAATCAA
ATCGAAGATGCCGGTGGAATTACTTACATTGCTGAATTGGCAGGATCAGTTCCAACCGCAGCCAATGTCGGCTACTACGC
TAAGATTGTTCAAGAAAAATCTTTATTACGAAAATTAATTAAGACAGCAACAGCGATTGCTACAAAAGGTTACACCCAAG
ATGACGATGTGGCTAATATCTTGGACGAAGCTGAACGTGAAATCATGGATGTTGCTGAAAACCGTAATCAAACGGGTTTT
AAGCCAATTGCAGATGTTTTAACAACTTCAATGGAAGAAATTGATCGTCTTTATCAAAATGACGATGAGATTACCGGATT
ACCAACCGGATTTAAAGAGTTAGATAAAATTACTACTGGATTACATGCAGATGAATTAATTATTCTTGCAGCGCGTCCAG
CTGTCGGTAAGACTGCGTTTGCGTTAAATATTGCGCAAAATGTGGGTACTAAGACTGACAAATCAGTGGCTATTTTCAGT
TTGGAAATGGGAGCTGAACAGCTGGTAAATCGTATGTTATGTGCGGAAGGAAGTATTGATGCAAATCATTTAAGAACCGG
TCAGCTAAATGAAGAAGAATGGCAAAATTTAGTGGTGGCGATGGGTTCTTTAGCTAAGGCAAGTATCTATATCGATGATA
CTCCGGGAATTAAAATGTCGGAGATTCGTGCAAAATGTCGTCGTCTAGCTAAAGAGCAAGGAAACCTTGGCTTAGTTGTG
GTAGATTACTTGCAGCTAATTGAAGGTTCTGGAGAAAATCGTCAGCAAGAAGTTTCAGCTATTTCACGACAACTTAAAAA
ACTCGCCAAGGAACTAGGCGTACCGGTCATTGCGCTTTCACAGCTTTCACGTGGAGTGGAACAACGCCAAGATAAGCGCC
CGGTAATGTCTGATATCCGTGAATCTGGTTCAATTGAACAGGATGCGGATATTGTAGCGTTCCTATACCGTGATGATTAT
TATGAACGGGAAGATGGCAATGAAGACGCAGATCGAGACCAAGATCCACGGGATGAAGAAGATCAAAATGTTGGTCCCGT
TGAAGTTATCATTGAAAAAAACCGTAGTGGGGCTCGTGGTACGGTAAATCTGTTGTTTATTAAGTCGTACAATAAATTTT
CTTCGTTAGCTTATATGCCTGAAGCGGGAGCGCATTAG

Upstream 100 bases:

>100_bases
GTTACACCAAAAGGTAACAGCAACGATTCGGGTGCATGTAGCTGAGCAATAGGATTACTAAGGCTCTCAACTCAGAGTCT
AATTCGTACGGGAGAGTAAC

Downstream 100 bases:

>100_bases
GTATTTGAAAAATGAGATTCATTATTTTCAAGACTGGTTTAAGACTTTTTAGTCTAAATCAGTCTTTTATTATAAAAATT
AGGGGAGGAATTATGCGCGA

Product: primary replicative DNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MDNGILENQTPPQNIEAEKAVLGAVFLSSDALIDAMEYVTAEDFYKHAHQVIFKVMVDLNDADEAIDALTVNNALEEHNQ
IEDAGGITYIAELAGSVPTAANVGYYAKIVQEKSLLRKLIKTATAIATKGYTQDDDVANILDEAEREIMDVAENRNQTGF
KPIADVLTTSMEEIDRLYQNDDEITGLPTGFKELDKITTGLHADELIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFS
LEMGAEQLVNRMLCAEGSIDANHLRTGQLNEEEWQNLVVAMGSLAKASIYIDDTPGIKMSEIRAKCRRLAKEQGNLGLVV
VDYLQLIEGSGENRQQEVSAISRQLKKLAKELGVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDY
YEREDGNEDADRDQDPRDEEDQNVGPVEVIIEKNRSGARGTVNLLFIKSYNKFSSLAYMPEAGAH

Sequences:

>Translated_465_residues
MDNGILENQTPPQNIEAEKAVLGAVFLSSDALIDAMEYVTAEDFYKHAHQVIFKVMVDLNDADEAIDALTVNNALEEHNQ
IEDAGGITYIAELAGSVPTAANVGYYAKIVQEKSLLRKLIKTATAIATKGYTQDDDVANILDEAEREIMDVAENRNQTGF
KPIADVLTTSMEEIDRLYQNDDEITGLPTGFKELDKITTGLHADELIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFS
LEMGAEQLVNRMLCAEGSIDANHLRTGQLNEEEWQNLVVAMGSLAKASIYIDDTPGIKMSEIRAKCRRLAKEQGNLGLVV
VDYLQLIEGSGENRQQEVSAISRQLKKLAKELGVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDY
YEREDGNEDADRDQDPRDEEDQNVGPVEVIIEKNRSGARGTVNLLFIKSYNKFSSLAYMPEAGAH
>Mature_465_residues
MDNGILENQTPPQNIEAEKAVLGAVFLSSDALIDAMEYVTAEDFYKHAHQVIFKVMVDLNDADEAIDALTVNNALEEHNQ
IEDAGGITYIAELAGSVPTAANVGYYAKIVQEKSLLRKLIKTATAIATKGYTQDDDVANILDEAEREIMDVAENRNQTGF
KPIADVLTTSMEEIDRLYQNDDEITGLPTGFKELDKITTGLHADELIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFS
LEMGAEQLVNRMLCAEGSIDANHLRTGQLNEEEWQNLVVAMGSLAKASIYIDDTPGIKMSEIRAKCRRLAKEQGNLGLVV
VDYLQLIEGSGENRQQEVSAISRQLKKLAKELGVPVIALSQLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDY
YEREDGNEDADRDQDPRDEEDQNVGPVEVIIEKNRSGARGTVNLLFIKSYNKFSSLAYMPEAGAH

Specific function: Participates In Initiation And Elongation During Chromosome Replication; It Exhibits DNA-Dependent ATPase Activity And Contains Distinct Active Sites For ATP Binding, DNA Binding, And Interaction With DNAc Protein, Primase, And Other Prepriming Proteins.

COG id: COG0305

COG function: function code L; Replicative DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SF4 helicase domain [H]

Homologues:

Organism=Escherichia coli, GI1790486, Length=456, Percent_Identity=43.859649122807, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR007692
- InterPro:   IPR007694
- InterPro:   IPR007693
- InterPro:   IPR016136 [H]

Pfam domain/function: PF00772 DnaB; PF03796 DnaB_C [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 51229; Mature: 51229

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNGILENQTPPQNIEAEKAVLGAVFLSSDALIDAMEYVTAEDFYKHAHQVIFKVMVDLN
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DADEAIDALTVNNALEEHNQIEDAGGITYIAELAGSVPTAANVGYYAKIVQEKSLLRKLI
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
KTATAIATKGYTQDDDVANILDEAEREIMDVAENRNQTGFKPIADVLTTSMEEIDRLYQN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
DDEITGLPTGFKELDKITTGLHADELIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFS
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCCEEEEE
LEMGAEQLVNRMLCAEGSIDANHLRTGQLNEEEWQNLVVAMGSLAKASIYIDDTPGIKMS
ECCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHH
EIRAKCRRLAKEQGNLGLVVVDYLQLIEGSGENRQQEVSAISRQLKKLAKELGVPVIALS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
QLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDYYEREDGNEDADRDQDPRDEE
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DQNVGPVEVIIEKNRSGARGTVNLLFIKSYNKFSSLAYMPEAGAH
CCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHHEEECCCCCCC
>Mature Secondary Structure
MDNGILENQTPPQNIEAEKAVLGAVFLSSDALIDAMEYVTAEDFYKHAHQVIFKVMVDLN
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DADEAIDALTVNNALEEHNQIEDAGGITYIAELAGSVPTAANVGYYAKIVQEKSLLRKLI
CHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
KTATAIATKGYTQDDDVANILDEAEREIMDVAENRNQTGFKPIADVLTTSMEEIDRLYQN
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
DDEITGLPTGFKELDKITTGLHADELIILAARPAVGKTAFALNIAQNVGTKTDKSVAIFS
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHEEHHHHCCCCCCCCEEEEE
LEMGAEQLVNRMLCAEGSIDANHLRTGQLNEEEWQNLVVAMGSLAKASIYIDDTPGIKMS
ECCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEECCCCCCHH
EIRAKCRRLAKEQGNLGLVVVDYLQLIEGSGENRQQEVSAISRQLKKLAKELGVPVIALS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
QLSRGVEQRQDKRPVMSDIRESGSIEQDADIVAFLYRDDYYEREDGNEDADRDQDPRDEE
HHHHHHHHHHCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCC
DQNVGPVEVIIEKNRSGARGTVNLLFIKSYNKFSSLAYMPEAGAH
CCCCCCEEEEEECCCCCCCCEEEEEEEECCCCHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 1312531 [H]