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The map label for this gene is dnaA

Identifier: 116491819

GI number: 116491819

Start: 50

End: 1390

Strand: Direct

Name: dnaA

Synonym: PEPE_0001

Alternate gene names: 116491819

Gene position: 50-1390 (Clockwise)

Preceding gene: NA

Following gene: 116491820

Centisome position: 0.0

GC content: 39.45

Gene sequence:

>1341_bases
GTGCCTAACTATATTGACCTTTGGAACAACATTAAAAATAGTTTCGAAAAAGACGACTCCATGTCAAAGGCCAGTTTCGG
TGCTTGGGTAGAAACGGCAGAACCCATTTCATTAGAAAACCACATAATGAAGATTAAGGTTCTTTCGAGTCTACATCGAG
ATTACTGGACAAAGCATTTGATCGAGAAGTTTGTCGAATATGCCTACCAGTTCACTGATCAAGACATTACGCCTGAATTC
GTAACGGAAGATGAATTCAAGACGCAGCAGGCGGAAAGGTCCGCTACCTCTAAAAAAGAAACCAAAGCTTCTACTGAAGA
TACCCAACTTAATAGTAGATATACTTTTGATACTTTTGTTATTGGTAGTGGTAACCAAATGGCGCATGCAGCTGCGATGG
CTGTATCAGATGAACCTGGCGTTCTATATAATCCGCTCTTTTTCTATGGAGGAGTGGGACTTGGAAAAACCCATTTAATG
CATGCGATTGGGCATCAGTTATTAGAAAATGATCCCAAAACTCGCGTTAAATATGTAACAAGTGAAGCCTTCACTAACGA
CTTCATTAATTCGATTCAAAAGAATAAGACGGAAGAGTTTCATGAGAAGTATCGTAACGTTGATCTTTTATTAGTAGATG
ATGTGCAGTTTTTTGCGGATAAAGAAGCAACTCAAGAGGAATTTTTCCATACATTTGAGGCCTTGTATAATGCCCAAAAA
CAAATCGTGTTGACATCCGATCGCTTACCAAATGAAATTCCGAAGTTGCAAGAACGTTTGGTATCAAGATTTAAGTGGGG
ACTTTCAATTGATATCACGCCCCCTAATTTAGAAACTCGAATTGCAATCTTGCGGGAGAAGGCTCAAGCAGATAACGTTG
AAATTCCTGACGAAACCTTGGAATACATCGCTAATCGTATTGATTCAAATATTCGTGAGTTAGAGGGGGCGATGGCTCGA
ATCCAGGCTTACGCTAAATTGCAAAACGCAGCGATTACCACCGATTTAGCTTCAGACGCTCTTCGCAGTTTGAATTTCGG
TAGCAACCTTAGCCATATTACGATTCCAATGATTCAAGACAAGGTCGCAAAATATTTCCATGTTACAGTAGCTGACCTTA
AAGGAAAGAAACGGATGAAATCCATCGTTATTCCACGCCAGATTGCGATGTATCTATCCCGTGAATTAACTGAAAGTTCA
TTGCCTAAAATTGGAACAGAATTTGGTGGTAAAGATCATACTACCGTTATTCATTCCTTTGATAAGATCAAAGCTGAACT
AGAAAAAGATGAGGAACTTGCTCGCCAAGTTGGAGATTTAAAAAGTGAGCTAAAACCTTAA

Upstream 100 bases:

>100_bases
GACTGTTATTTAACCCCATTTAGTTATCCACATCCATGTGGATAACTTTATTTTTTTATGTTAAACTTAGTGAGCTAAAA
ATTTTGGAGGAATTGAAAAA

Downstream 100 bases:

>100_bases
ATTGTGGATAAGTGTTAATAACTTCGAAAGTTATCCACAGGTAGTCCACAGGCTAAAAGTTAAATTATGACGGCTAATTT
GAGTTATTAACAGTTCCAAC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPNYIDLWNNIKNSFEKDDSMSKASFGAWVETAEPISLENHIMKIKVLSSLHRDYWTKHLIEKFVEYAYQFTDQDITPEF
VTEDEFKTQQAERSATSKKETKASTEDTQLNSRYTFDTFVIGSGNQMAHAAAMAVSDEPGVLYNPLFFYGGVGLGKTHLM
HAIGHQLLENDPKTRVKYVTSEAFTNDFINSIQKNKTEEFHEKYRNVDLLLVDDVQFFADKEATQEEFFHTFEALYNAQK
QIVLTSDRLPNEIPKLQERLVSRFKWGLSIDITPPNLETRIAILREKAQADNVEIPDETLEYIANRIDSNIRELEGAMAR
IQAYAKLQNAAITTDLASDALRSLNFGSNLSHITIPMIQDKVAKYFHVTVADLKGKKRMKSIVIPRQIAMYLSRELTESS
LPKIGTEFGGKDHTTVIHSFDKIKAELEKDEELARQVGDLKSELKP

Sequences:

>Translated_446_residues
MPNYIDLWNNIKNSFEKDDSMSKASFGAWVETAEPISLENHIMKIKVLSSLHRDYWTKHLIEKFVEYAYQFTDQDITPEF
VTEDEFKTQQAERSATSKKETKASTEDTQLNSRYTFDTFVIGSGNQMAHAAAMAVSDEPGVLYNPLFFYGGVGLGKTHLM
HAIGHQLLENDPKTRVKYVTSEAFTNDFINSIQKNKTEEFHEKYRNVDLLLVDDVQFFADKEATQEEFFHTFEALYNAQK
QIVLTSDRLPNEIPKLQERLVSRFKWGLSIDITPPNLETRIAILREKAQADNVEIPDETLEYIANRIDSNIRELEGAMAR
IQAYAKLQNAAITTDLASDALRSLNFGSNLSHITIPMIQDKVAKYFHVTVADLKGKKRMKSIVIPRQIAMYLSRELTESS
LPKIGTEFGGKDHTTVIHSFDKIKAELEKDEELARQVGDLKSELKP
>Mature_445_residues
PNYIDLWNNIKNSFEKDDSMSKASFGAWVETAEPISLENHIMKIKVLSSLHRDYWTKHLIEKFVEYAYQFTDQDITPEFV
TEDEFKTQQAERSATSKKETKASTEDTQLNSRYTFDTFVIGSGNQMAHAAAMAVSDEPGVLYNPLFFYGGVGLGKTHLMH
AIGHQLLENDPKTRVKYVTSEAFTNDFINSIQKNKTEEFHEKYRNVDLLLVDDVQFFADKEATQEEFFHTFEALYNAQKQ
IVLTSDRLPNEIPKLQERLVSRFKWGLSIDITPPNLETRIAILREKAQADNVEIPDETLEYIANRIDSNIRELEGAMARI
QAYAKLQNAAITTDLASDALRSLNFGSNLSHITIPMIQDKVAKYFHVTVADLKGKKRMKSIVIPRQIAMYLSRELTESSL
PKIGTEFGGKDHTTVIHSFDKIKAELEKDEELARQVGDLKSELKP

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family

Homologues:

Organism=Escherichia coli, GI2367267, Length=372, Percent_Identity=46.7741935483871, Blast_Score=348, Evalue=6e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DNAA_PEDPA (Q03I60)

Other databases:

- EMBL:   CP000422
- RefSeq:   YP_803554.1
- ProteinModelPortal:   Q03I60
- SMR:   Q03I60
- STRING:   Q03I60
- GeneID:   4416998
- GenomeReviews:   CP000422_GR
- KEGG:   ppe:PEPE_0001
- NMPDR:   fig|278197.10.peg.1
- eggNOG:   COG0593
- HOGENOM:   HBG695666
- OMA:   CHTLNAL
- PhylomeDB:   Q03I60
- ProtClustDB:   PRK00149
- BioCyc:   PPEN278197:PEPE_0001-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00377
- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921
- Gene3D:   G3DSA:1.10.1750.10
- PRINTS:   PR00051
- SMART:   SM00382
- SMART:   SM00760
- TIGRFAMs:   TIGR00362

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C; SSF48295 Trp_repress_rep

EC number: NA

Molecular weight: Translated: 50947; Mature: 50816

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNYIDLWNNIKNSFEKDDSMSKASFGAWVETAEPISLENHIMKIKVLSSLHRDYWTKHL
CCCHHHHHHHHHHHHHCCCCHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IEKFVEYAYQFTDQDITPEFVTEDEFKTQQAERSATSKKETKASTEDTQLNSRYTFDTFV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
IGSGNQMAHAAAMAVSDEPGVLYNPLFFYGGVGLGKTHLMHAIGHQLLENDPKTRVKYVT
EECCCCHHHHHHHEECCCCCCEECCHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
SEAFTNDFINSIQKNKTEEFHEKYRNVDLLLVDDVQFFADKEATQEEFFHTFEALYNAQK
HHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHCCCC
QIVLTSDRLPNEIPKLQERLVSRFKWGLSIDITPPNLETRIAILREKAQADNVEIPDETL
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHH
EYIANRIDSNIRELEGAMARIQAYAKLQNAAITTDLASDALRSLNFGSNLSHITIPMIQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
KVAKYFHVTVADLKGKKRMKSIVIPRQIAMYLSRELTESSLPKIGTEFGGKDHTTVIHSF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
DKIKAELEKDEELARQVGDLKSELKP
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PNYIDLWNNIKNSFEKDDSMSKASFGAWVETAEPISLENHIMKIKVLSSLHRDYWTKHL
CCHHHHHHHHHHHHHCCCCHHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IEKFVEYAYQFTDQDITPEFVTEDEFKTQQAERSATSKKETKASTEDTQLNSRYTFDTFV
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEE
IGSGNQMAHAAAMAVSDEPGVLYNPLFFYGGVGLGKTHLMHAIGHQLLENDPKTRVKYVT
EECCCCHHHHHHHEECCCCCCEECCHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHH
SEAFTNDFINSIQKNKTEEFHEKYRNVDLLLVDDVQFFADKEATQEEFFHTFEALYNAQK
HHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEECCHHHHHCCHHHHHHHHHHHHHHHCCCC
QIVLTSDRLPNEIPKLQERLVSRFKWGLSIDITPPNLETRIAILREKAQADNVEIPDETL
EEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCCHHHH
EYIANRIDSNIRELEGAMARIQAYAKLQNAAITTDLASDALRSLNFGSNLSHITIPMIQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
KVAKYFHVTVADLKGKKRMKSIVIPRQIAMYLSRELTESSLPKIGTEFGGKDHTTVIHSF
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHH
DKIKAELEKDEELARQVGDLKSELKP
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA