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The map label for this gene is phoP [H]

Identifier: 116332664

GI number: 116332664

Start: 278362

End: 279087

Strand: Direct

Name: phoP [H]

Synonym: LBJ_4245

Alternate gene names: 116332664

Gene position: 278362-279087 (Clockwise)

Preceding gene: 116332662

Following gene: 116332667

Centisome position: 92.86

GC content: 42.29

Gene sequence:

>726_bases
ATGAAAACAATTTTAGTCATAGAAGACGATCCGGACATCGGAAATTTAATCCGTAAATCTTTGGATTCGGCGCACTACTC
GACCACTCTGCAAACGAGCGGAGAAGAAGGTCTCAAATTCTACAAAGCAAATCATCCAGACATGGTTATCTTAGATCTTT
CTCTTCCGGACATAGACGGAATCGAAGTTTGTAGAACCGTTAGACGGAACGACGAAAATACTCCCATTTTTATCGTAACG
GCAAGAAACGAAGAGATCGACAGAATTATGGGACTTGAATTGGGAGCGGATGATTACATTACGAAACCTTTTTCCGTTCG
AGAACTGAAAACTAGAGTAGACGTATTTTTCCGCAGATGGGATAAAAAAGCGGGAATTAAACCGAACGTCGGTGCAAGCG
GCGAAATCATTCGAGGCGCTTTGAAGATCGACCCGGTCCGAAGAAGGGTCACTCTTAAAGATAATATCGTAAATATTTCT
AGAAAAGAATTCGATATTCTGCAACTTATGGCCGCTTCACCCGGAAAAGTTTTTTCCAGAGAAATGATCCTGGAAGCGGT
TTGGGGAATGGAATGGGACGGTTTCGAAAGAATGATCGATTCTCATGTAAAAAGAATTCGTTCCAAACTGGAAAAAAATT
CGGCTCAGCCCGAATGGATTGAAACGATCTGGGGAATCGGTTATCGATTCACGGACAATTACGACAACATCGTAATCCCG
GATTAG

Upstream 100 bases:

>100_bases
ACATGGCGAATAAAAAAAATTCCTTTATTAACATTTCATCGGTTTTATCTGTTGCAGATAAGGTAAATTTACCCTCTAAT
TCTCTTACGGGAGCCTGGTA

Downstream 100 bases:

>100_bases
GTTTGATTTTTTAACTTCGCCCCCGAAAGCCCGGTGTCCCCCGGGCTTTTTTATTTATAGCACATCCCAAAACCTGCGGA
AACGATCCTTAAAAAGCGGC

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDGIEVCRTVRRNDENTPIFIVT
ARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRWDKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNIS
RKEFDILQLMAASPGKVFSREMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIP
D

Sequences:

>Translated_241_residues
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDGIEVCRTVRRNDENTPIFIVT
ARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRWDKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNIS
RKEFDILQLMAASPGKVFSREMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIP
D
>Mature_241_residues
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDGIEVCRTVRRNDENTPIFIVT
ARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRWDKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNIS
RKEFDILQLMAASPGKVFSREMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIP
D

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=38.7234042553192, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=33.9130434782609, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=33.7719298245614, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=33.7777777777778, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=34.3478260869565, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786599, Length=236, Percent_Identity=33.0508474576271, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=32.6086956521739, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=30.3418803418803, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=32.6086956521739, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=32.8947368421053, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=30.3418803418803, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=29.1845493562232, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=28.9473684210526, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=29.5154185022026, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=29.2452830188679, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=195, Percent_Identity=25.1282051282051, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27712; Mature: 27712

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDG
CCEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCH
IEVCRTVRRNDENTPIFIVTARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRW
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHH
DKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNISRKEFDILQLMAASPGKVFSR
HHCCCCCCCCCCCCHHEEEHEEECHHHHEEEECCCEEECCHHHHHHHHHHHCCCCHHHHH
EMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIP
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCEEEEC
D
C
>Mature Secondary Structure
MKTILVIEDDPDIGNLIRKSLDSAHYSTTLQTSGEEGLKFYKANHPDMVILDLSLPDIDG
CCEEEEEECCCCHHHHHHHHHHHHHHEEEEECCCCCCCEEEECCCCCEEEEEECCCCCCH
IEVCRTVRRNDENTPIFIVTARNEEIDRIMGLELGADDYITKPFSVRELKTRVDVFFRRW
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHCCEECCCCCCCCCCHHHHHHHHHHHHHHHH
DKKAGIKPNVGASGEIIRGALKIDPVRRRVTLKDNIVNISRKEFDILQLMAASPGKVFSR
HHCCCCCCCCCCCCHHEEEHEEECHHHHEEEECCCEEECCHHHHHHHHHHHCCCCHHHHH
EMILEAVWGMEWDGFERMIDSHVKRIRSKLEKNSAQPEWIETIWGIGYRFTDNYDNIVIP
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEEECCCCEEEEC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]