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The map label for this gene is hemH

Identifier: 116332464

GI number: 116332464

Start: 20091

End: 21191

Strand: Reverse

Name: hemH

Synonym: LBJ_4018

Alternate gene names: 116332464

Gene position: 21191-20091 (Counterclockwise)

Preceding gene: 116332465

Following gene: 116332453

Centisome position: 7.07

GC content: 41.14

Gene sequence:

>1101_bases
CTGAAAAACAGAATTTTATTAATCAATCTAGGCGGTCCGCGGGATACATCGGAAATCGAAAAATTTCTGATCGACCTTTT
TGAAGATCCTCTTGTTTTCGATCTTCCTCTTCCTGAATGGATCAGAAAACCTCTAGGAAAATGGGTCGCAAAAAAAAGGG
CCCCCAAAGTCGCTCAAACCTACAAGTCAATGGGCTTTGGAGGTGGTTCCCCTCTTGTTTCAGAAACTTCTAAACAGGCG
AACGCAATCGCAAAAGCCCTCGAAAAAATTACGGGAGAAAAATGGGAAGGCAACATCACCATGACCTGCGGCTATCCCGA
TATTAGAAAACTAAACCGAGATTTTCTTGTTCCTACAAAACAAAATATTCTACTTCCTTTATATCCACACTTCTCCAGAT
CCACCGTTTTAAGCACGGCTAAACTCGTGGAACAAACGACAAAATTCTGTCCCGTAAGTTACGAAGGTTGGGTCGCACCA
TTCCATTCTTCACAAGTCTATTTAGAATCGATTCGGGATCTTATTTTGGACTTTTTTCAAAACAGACTGAACCGGAAAGA
TTTTTTACACTCCGATTCTTTTCAAGGTGTGTCGAATTGGGAAACGATCGACTTGATCTTCAGCGCTCACGGTATACCGA
TCCGTTTGATCGAAAAAGGAGACCGATACAGGGAAGAAATCAATTCCAATGTCGAAAATTTAAAACGACTTCTTTATGAA
AAAGGATTTCAAGGAAAATGTCATACGTCCTTTCAAAGTAGGGTAGGGCCTTCGAAATGGACGGAGCCAAATACGATTAC
GATGCTCGAGCAATTAGGAAAGAACGGAGTCAAAAGAGTCGCCGTATATCCGATCAGTTTCGTAAGCGATCACTTGGAAA
CTTTGGAAGAGATCGGAGAACAACTCAAAAAAATCGCCTATAATAACGGAATTGCAGAGTATCATCGAATCCCGGCTCCC
GGAATTTATCCGAAATTCATCGAAGCAATGGCAAAAATCGGATTGGAATCCATTCAATCCTCAAAGAACGAATGTATCTG
TAAAAAGTTAGGAGGACACTTTCCGAATCTAAAATCGGGAGAATGTCCGATCAATTTCTAA

Upstream 100 bases:

>100_bases
CCAAAAAATTAATTTTCTATCGGTTTCTATTTCATAGAAACGGTTGATTGAAGTGGTTTTGTTAATTTGAACTATGAAAT
TCTATTAAAGGTATATTCTT

Downstream 100 bases:

>100_bases
GCGAAAATTCCTTTCCATTTCGCATAATATTCCAAATCCTTTCTAAAATCGAACTTAGACCGATCCCGTATCGAAAATTT
CCTTCCACAAAAATCCCCTG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 366; Mature: 366

Protein sequence:

>366_residues
MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQTYKSMGFGGGSPLVSETSKQA
NAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTKQNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAP
FHSSQVYLESIRDLILDFFQNRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYE
KGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGEQLKKIAYNNGIAEYHRIPAP
GIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSGECPINF

Sequences:

>Translated_366_residues
MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQTYKSMGFGGGSPLVSETSKQA
NAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTKQNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAP
FHSSQVYLESIRDLILDFFQNRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYE
KGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGEQLKKIAYNNGIAEYHRIPAP
GIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSGECPINF
>Mature_366_residues
MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQTYKSMGFGGGSPLVSETSKQA
NAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTKQNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAP
FHSSQVYLESIRDLILDFFQNRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYE
KGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGEQLKKIAYNNGIAEYHRIPAP
GIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSGECPINF

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=357, Percent_Identity=28.2913165266106, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI60499025, Length=357, Percent_Identity=28.2913165266106, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1786681, Length=341, Percent_Identity=29.9120234604106, Blast_Score=104, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324750, Length=348, Percent_Identity=27.5862068965517, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI17864156, Length=354, Percent_Identity=25.4237288135593, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24651774, Length=276, Percent_Identity=24.2753623188406, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45552018, Length=179, Percent_Identity=26.8156424581006, Blast_Score=85, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_LEPBJ (Q04NU7)

Other databases:

- EMBL:   CP000351
- RefSeq:   YP_802181.1
- STRING:   Q04NU7
- GeneID:   4412241
- GenomeReviews:   CP000351_GR
- KEGG:   lbj:LBJ_4018
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- PhylomeDB:   Q04NU7
- ProtClustDB:   CLSK764753
- BioCyc:   LBOR355277:LBJ_4018-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41566; Mature: 41566

Theoretical pI: Translated: 9.23; Mature: 9.23

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQT
CCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHH
YKSMGFGGGSPLVSETSKQANAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCCCCC
QNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAPFHSSQVYLESIRDLILDFFQ
CCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYE
HHHCHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHHH
KGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGE
CCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
QLKKIAYNNGIAEYHRIPAPGIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSG
HHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
ECPINF
CCCCCC
>Mature Secondary Structure
MKNRILLINLGGPRDTSEIEKFLIDLFEDPLVFDLPLPEWIRKPLGKWVAKKRAPKVAQT
CCCCEEEEECCCCCCHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHH
YKSMGFGGGSPLVSETSKQANAIAKALEKITGEKWEGNITMTCGYPDIRKLNRDFLVPTK
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHCCCCCCCCCC
QNILLPLYPHFSRSTVLSTAKLVEQTTKFCPVSYEGWVAPFHSSQVYLESIRDLILDFFQ
CCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
NRLNRKDFLHSDSFQGVSNWETIDLIFSAHGIPIRLIEKGDRYREEINSNVENLKRLLYE
HHHCHHHHCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHHH
KGFQGKCHTSFQSRVGPSKWTEPNTITMLEQLGKNGVKRVAVYPISFVSDHLETLEEIGE
CCCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
QLKKIAYNNGIAEYHRIPAPGIYPKFIEAMAKIGLESIQSSKNECICKKLGGHFPNLKSG
HHHHHHHCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCC
ECPINF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA