Click here to switch to the map view.

The map label for this gene is rcsC [H]

Identifier: 116329368

GI number: 116329368

Start: 3368071

End: 3369189

Strand: Direct

Name: rcsC [H]

Synonym: LBL_2824

Alternate gene names: 116329368

Gene position: 3368071-3369189 (Clockwise)

Preceding gene: 116329367

Following gene: 116329369

Centisome position: 93.18

GC content: 37.53

Gene sequence:

>1119_bases
ATGGAAAATACGCAGGACGCGATCTTGTCCGTGGGCAAAGATTACAAAATTCTAACGATGAATCGCCTCTTTCAAGAATT
CGTATTCAATATATATAAAATAGATCTGAAAATAGGAAATAACGCCTTAGAACGGTTCGGGCTCGATACCTCCGCCACTT
GGAAGGATATTTACGATTCCACTTTCGACGGCATTCCGGTTCGAAAAGAATGGAAGATTTCGAATCAAGAAGGAAATTCA
AATTATTATGAAATTCTAACTTCTCCCATTTACAGTTCGACTGAAAACACTCGAATATCGTATCCGAAAGATCAGGCGTC
TTTTTCGGCTACTCTATGCAATGAAGAATCAAAAAGCGAGAGGGAAATTCTAGGAGCGACGCTTTATATTCGAGATATCA
CCGAAAAAAAGTTATTGGAACAAAAAACCGCCAGTCTTATCAAAAGTAAGAACCGGTTGTTGACGACGGTGGTGCATGAT
CTTAAAAATCCGATTAACGGAATTCTGGGCCTAATTGAACTTTTAAAAGAACAAACCGATAATCAAAACAGAACGGAACT
TCTTAATATGATGTTTCGAGCGGCGGATAAATCCTTAAATATCATCCAAGATCTGTTGCAGATTGCGGAAATGGAAAATG
AAAACTTCAAACTCAAAACGGAAAAAACGAATTTAAACTATCTTATTGAATCGCTCGTAAAACAAAATTACCCTGAAGCT
CAAAATAAAAAGATCAAACTTTACACAATACAGGAAATCGATCCACTTCCGGTAAAGATAGAGTTGTTGAAATTCCAAAG
AGTTTTGGAAAACCTAATTTCCAATTCATTAAAGTTCACGAAAGAAGGCGGAGAAATCCTCATTCATTCTTACGCTCAAA
ATAAAAAAGCGATGATGATAGTGAAAGACACCGGGATCGGAATTCCTTACGGCCTTCAGTCCTCGATTTTCGATCAGTTC
ACAAAAGCCAGAAGACAAGGACTAAAAGGGGAAGAAACTACAGGGCTCGGAATGTTCATCGTAAAAGTTATCGTGGAACT
TCACAAAGGAAAAATTAGTTTAGAAAGTGAAGAAGGGCTCGGAACTAAATTCATTGTAGAAATTCCATTGGATGCTTGA

Upstream 100 bases:

>100_bases
ATCCGACCAAAAAATAAAAAGATCACCGGAATCTTCCCACTTTCAAAACATCTGTATGCAAATCGAGTTATCCAAATAGC
GGGGAAATCTAAAGGTACCG

Downstream 100 bases:

>100_bases
ATCAATAATTTAAAGATAAAACCATTTATTTCTTTTTGCAGAAAGAATTAAATTTGATCTAAAGATATCAAACATCAATT
TTGGAAATCAAGAAAACCAA

Product: sensor histidine kinase of a two component response regulator

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MENTQDAILSVGKDYKILTMNRLFQEFVFNIYKIDLKIGNNALERFGLDTSATWKDIYDSTFDGIPVRKEWKISNQEGNS
NYYEILTSPIYSSTENTRISYPKDQASFSATLCNEESKSEREILGATLYIRDITEKKLLEQKTASLIKSKNRLLTTVVHD
LKNPINGILGLIELLKEQTDNQNRTELLNMMFRAADKSLNIIQDLLQIAEMENENFKLKTEKTNLNYLIESLVKQNYPEA
QNKKIKLYTIQEIDPLPVKIELLKFQRVLENLISNSLKFTKEGGEILIHSYAQNKKAMMIVKDTGIGIPYGLQSSIFDQF
TKARRQGLKGEETTGLGMFIVKVIVELHKGKISLESEEGLGTKFIVEIPLDA

Sequences:

>Translated_372_residues
MENTQDAILSVGKDYKILTMNRLFQEFVFNIYKIDLKIGNNALERFGLDTSATWKDIYDSTFDGIPVRKEWKISNQEGNS
NYYEILTSPIYSSTENTRISYPKDQASFSATLCNEESKSEREILGATLYIRDITEKKLLEQKTASLIKSKNRLLTTVVHD
LKNPINGILGLIELLKEQTDNQNRTELLNMMFRAADKSLNIIQDLLQIAEMENENFKLKTEKTNLNYLIESLVKQNYPEA
QNKKIKLYTIQEIDPLPVKIELLKFQRVLENLISNSLKFTKEGGEILIHSYAQNKKAMMIVKDTGIGIPYGLQSSIFDQF
TKARRQGLKGEETTGLGMFIVKVIVELHKGKISLESEEGLGTKFIVEIPLDA
>Mature_372_residues
MENTQDAILSVGKDYKILTMNRLFQEFVFNIYKIDLKIGNNALERFGLDTSATWKDIYDSTFDGIPVRKEWKISNQEGNS
NYYEILTSPIYSSTENTRISYPKDQASFSATLCNEESKSEREILGATLYIRDITEKKLLEQKTASLIKSKNRLLTTVVHD
LKNPINGILGLIELLKEQTDNQNRTELLNMMFRAADKSLNIIQDLLQIAEMENENFKLKTEKTNLNYLIESLVKQNYPEA
QNKKIKLYTIQEIDPLPVKIELLKFQRVLENLISNSLKFTKEGGEILIHSYAQNKKAMMIVKDTGIGIPYGLQSSIFDQF
TKARRQGLKGEETTGLGMFIVKVIVELHKGKISLESEEGLGTKFIVEIPLDA

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=233, Percent_Identity=30.4721030042918, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI1788713, Length=277, Percent_Identity=29.9638989169675, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788549, Length=303, Percent_Identity=26.4026402640264, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI48994928, Length=247, Percent_Identity=26.7206477732794, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789149, Length=248, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786912, Length=230, Percent_Identity=26.5217391304348, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=26.5486725663717, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790436, Length=248, Percent_Identity=26.2096774193548, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1786783, Length=216, Percent_Identity=26.3888888888889, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786600, Length=240, Percent_Identity=23.75, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790861, Length=206, Percent_Identity=26.6990291262136, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790300, Length=234, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI87082128, Length=244, Percent_Identity=22.9508196721311, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790346, Length=226, Percent_Identity=23.4513274336283, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42512; Mature: 42512

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENTQDAILSVGKDYKILTMNRLFQEFVFNIYKIDLKIGNNALERFGLDTSATWKDIYDS
CCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHEEEEEEECCHHHHHCCCCCCCHHHHHHHC
TFDGIPVRKEWKISNQEGNSNYYEILTSPIYSSTENTRISYPKDQASFSATLCNEESKSE
CCCCCCCCEECEECCCCCCCCHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCHHH
REILGATLYIRDITEKKLLEQKTASLIKSKNRLLTTVVHDLKNPINGILGLIELLKEQTD
HHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NQNRTELLNMMFRAADKSLNIIQDLLQIAEMENENFKLKTEKTNLNYLIESLVKQNYPEA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
QNKKIKLYTIQEIDPLPVKIELLKFQRVLENLISNSLKFTKEGGEILIHSYAQNKKAMMI
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCEEEE
VKDTGIGIPYGLQSSIFDQFTKARRQGLKGEETTGLGMFIVKVIVELHKGKISLESEEGL
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCC
GTKFIVEIPLDA
CEEEEEEECCCC
>Mature Secondary Structure
MENTQDAILSVGKDYKILTMNRLFQEFVFNIYKIDLKIGNNALERFGLDTSATWKDIYDS
CCCHHHHHHHCCCCCEEEHHHHHHHHHHHHHEEEEEEECCHHHHHCCCCCCCHHHHHHHC
TFDGIPVRKEWKISNQEGNSNYYEILTSPIYSSTENTRISYPKDQASFSATLCNEESKSE
CCCCCCCCEECEECCCCCCCCHHHHHCCCCCCCCCCCEECCCCCHHHHHHHHCCCCCHHH
REILGATLYIRDITEKKLLEQKTASLIKSKNRLLTTVVHDLKNPINGILGLIELLKEQTD
HHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NQNRTELLNMMFRAADKSLNIIQDLLQIAEMENENFKLKTEKTNLNYLIESLVKQNYPEA
CCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCC
QNKKIKLYTIQEIDPLPVKIELLKFQRVLENLISNSLKFTKEGGEILIHSYAQNKKAMMI
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCEEEE
VKDTGIGIPYGLQSSIFDQFTKARRQGLKGEETTGLGMFIVKVIVELHKGKISLESEEGL
EEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCC
GTKFIVEIPLDA
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]