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The map label for this gene is fusA [H]

Identifier: 116329257

GI number: 116329257

Start: 3195859

End: 3197979

Strand: Direct

Name: fusA [H]

Synonym: LBL_2696

Alternate gene names: 116329257

Gene position: 3195859-3197979 (Clockwise)

Preceding gene: 116329251

Following gene: 116329258

Centisome position: 88.42

GC content: 46.96

Gene sequence:

>2121_bases
ATGAGCACTGCTGTTGCCGAATTCAAACCGAGCGAAAAACTCCTAAAAACCAGAAATATCGGAATTTCTGCCCACATCGA
TTCCGGAAAAACGACCCTTACCGAAAGGATTCTATTTTATACGAATCGAATCCACGCCATTCATGAGGTTCGTGGAAAGG
ATGGAGTCGGCGCAAAGATGGACAGCATGGATCTCGAAAGAGAAAGAGGGATCACCATCCAGTCTGCCGCGACCTATTGC
CAGTGGAAGAACCACACGATCAACATCATCGATACCCCGGGTCACGTTGACTTTACCGTAGAGGTAGAACGTTCTCTCCG
CGTATTGGATTCCGCGATTCTTGTCCTTTGTGGAGTTGCCGGAGTTCAATCCCAGTCGATTACCGTGGATCGTCAGATGA
GACGTTACAACGTTCCTCGCGTCGCGTTCATCAATAAACTCGACAGAACGGGAGCAAACCCTTTTCGCGTAATCGAGCAA
CTCAAAGAAAAATTGAAACACAATGCCGTTCCGGTTCAAATTCCTATCGGTTTGGAAAACGACCTAAAAGGAGTCGTAGA
CCTCGTTACGATGAAAGCTTACTACTTTGAAGGAAAGGACGGAATGGACATCCAGGAAAAAGAAATTCCGGATGACCTCA
AAGAACTCGCGAACAAAAAGCACGAAGAACTTTTGGACGCAGCTTCTATGTTCTCCGACGAATTGACCGAGGCTCTTCTC
GAAGGAACTCCTACCGAAGAAATGATCAAAAAGGCGATCCGTACCGGAACGATCGAGCTCAAAATAACTCCTGTGTTCAT
GGGCTCCGCTTTCAAAAACAAAGGGGTTCAAAAACTTCTGGACGGAGTTTTGGATTATCTCGCAAGCCCTGTGGACGTTA
AGAACAAGGCTCTCGACCAAAACAACAACGAAGAAATGATCGTTCTTGAATCCAATTACGAGAAACCTCTGGTTTGTCTC
GCATTCAAACTCGAAGACGGTCGGTACGGTCAGCTCACCTACGTGCGTGTTTACCAAGGAAAACTTTCCAAAGGTATGAC
CATTTACAACATGTCGAATAACAAGAAGCATAACGTAGGTCGGCTCTGCCGAATGCATTCCGACGAGATGGAAGACATCG
ATTCGGCGGAAGCGGGTGATATCATCGCCCTTTTCGGTATCGATTGTGCTTCCGGAGATACGTTCACCGACGGAAAACTC
AAAGTTTCCATGGAATCCATGTTCGTTCCCGCTCCGGTGATTTCTCTTACCATCGAAGCGAAAGAATCCAAACATTTGAA
CAACCTTGCAAAAGCGTTAAACCGTTTTACCAAGGAAGATCCTACCTTCCAGACGCATGTGGATCCGGAATCCGGGCAAA
CCATCATCAAAGGGATGGGAGAACTTCATCTTGAAGTTTATATCGAGCGTATGAAACGAGAGTATGGAGTAGAACTCATC
ACCGGAGCTCCTCAGGTTGCGTATCGGGAAACGATCACGTCCAAAGCGGATTTCGATTATACTCACAAGAAACAAACCGG
CGGTCAAGGTCAGTTCGGTCGTGTTGCCGGTTACATGGAACCGATTCCTCTTGAAGAAACCTTGGATTATGATTTCGTAA
ACAAAGTCGTAGGTGGTGCAATCCCGAGAGAATATATCCAGTCGGTAGACAAAGGATTCAAAAGCTGTTTAGAACGTGGG
TCTCTCATCGGGTTCCCGATCATCGGAGTTCGCTGCGTGATCAACGACGGCGCTTATCATGACGTGGATTCTTCCGATAT
GGCATTCCAAATCGCAGGCCGCTATGCGTTTCGCCAGGGATTCAACAAAGCGAACCCTCAGATTCTCGAGCCGATCATGA
AAGTGGAAGTCGACGGACCTTCCGAGTTTCAAGGAGCGATCCTCGGATCGTTGAACCAAAGACGCGGTATGATTTTGAAC
ACAACCGAAGAGGATGCATACTGTAAAACGGAAGCAGAAGTTCCACTTGCGGACATGTTCGGATATTCCACCGTATTACG
TTCCTCAACTCAAGGAAAGGCGGAATTCTCTATGGAATTCTCCAGATACGCTCCGGTTCCAAGAAACGTTGCGGAAGAGT
TGATGAAAAAATACAAGGTCAACAACAAAGACGAAGATTGA

Upstream 100 bases:

>100_bases
ACTCTTTTTTGGAATTTGGTAAATTGAGGGATTTTCTTTAAAAACTCTCAACCGGTGTTTTTACCGAAAAGTATCTGCAA
TCTTTTATAAGAGGATGGCC

Downstream 100 bases:

>100_bases
TCTTAGAGCAAAATTCTTTTTTCTCCGAAAAAGGGAGCCAGAAGGCTCCCTTTTTTTGTCCTCCGAGCCTTTCCTGAAGC
AAGCTGATCAAGAAACCTGC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 706; Mature: 705

Protein sequence:

>706_residues
MSTAVAEFKPSEKLLKTRNIGISAHIDSGKTTLTERILFYTNRIHAIHEVRGKDGVGAKMDSMDLERERGITIQSAATYC
QWKNHTINIIDTPGHVDFTVEVERSLRVLDSAILVLCGVAGVQSQSITVDRQMRRYNVPRVAFINKLDRTGANPFRVIEQ
LKEKLKHNAVPVQIPIGLENDLKGVVDLVTMKAYYFEGKDGMDIQEKEIPDDLKELANKKHEELLDAASMFSDELTEALL
EGTPTEEMIKKAIRTGTIELKITPVFMGSAFKNKGVQKLLDGVLDYLASPVDVKNKALDQNNNEEMIVLESNYEKPLVCL
AFKLEDGRYGQLTYVRVYQGKLSKGMTIYNMSNNKKHNVGRLCRMHSDEMEDIDSAEAGDIIALFGIDCASGDTFTDGKL
KVSMESMFVPAPVISLTIEAKESKHLNNLAKALNRFTKEDPTFQTHVDPESGQTIIKGMGELHLEVYIERMKREYGVELI
TGAPQVAYRETITSKADFDYTHKKQTGGQGQFGRVAGYMEPIPLEETLDYDFVNKVVGGAIPREYIQSVDKGFKSCLERG
SLIGFPIIGVRCVINDGAYHDVDSSDMAFQIAGRYAFRQGFNKANPQILEPIMKVEVDGPSEFQGAILGSLNQRRGMILN
TTEEDAYCKTEAEVPLADMFGYSTVLRSSTQGKAEFSMEFSRYAPVPRNVAEELMKKYKVNNKDED

Sequences:

>Translated_706_residues
MSTAVAEFKPSEKLLKTRNIGISAHIDSGKTTLTERILFYTNRIHAIHEVRGKDGVGAKMDSMDLERERGITIQSAATYC
QWKNHTINIIDTPGHVDFTVEVERSLRVLDSAILVLCGVAGVQSQSITVDRQMRRYNVPRVAFINKLDRTGANPFRVIEQ
LKEKLKHNAVPVQIPIGLENDLKGVVDLVTMKAYYFEGKDGMDIQEKEIPDDLKELANKKHEELLDAASMFSDELTEALL
EGTPTEEMIKKAIRTGTIELKITPVFMGSAFKNKGVQKLLDGVLDYLASPVDVKNKALDQNNNEEMIVLESNYEKPLVCL
AFKLEDGRYGQLTYVRVYQGKLSKGMTIYNMSNNKKHNVGRLCRMHSDEMEDIDSAEAGDIIALFGIDCASGDTFTDGKL
KVSMESMFVPAPVISLTIEAKESKHLNNLAKALNRFTKEDPTFQTHVDPESGQTIIKGMGELHLEVYIERMKREYGVELI
TGAPQVAYRETITSKADFDYTHKKQTGGQGQFGRVAGYMEPIPLEETLDYDFVNKVVGGAIPREYIQSVDKGFKSCLERG
SLIGFPIIGVRCVINDGAYHDVDSSDMAFQIAGRYAFRQGFNKANPQILEPIMKVEVDGPSEFQGAILGSLNQRRGMILN
TTEEDAYCKTEAEVPLADMFGYSTVLRSSTQGKAEFSMEFSRYAPVPRNVAEELMKKYKVNNKDED
>Mature_705_residues
STAVAEFKPSEKLLKTRNIGISAHIDSGKTTLTERILFYTNRIHAIHEVRGKDGVGAKMDSMDLERERGITIQSAATYCQ
WKNHTINIIDTPGHVDFTVEVERSLRVLDSAILVLCGVAGVQSQSITVDRQMRRYNVPRVAFINKLDRTGANPFRVIEQL
KEKLKHNAVPVQIPIGLENDLKGVVDLVTMKAYYFEGKDGMDIQEKEIPDDLKELANKKHEELLDAASMFSDELTEALLE
GTPTEEMIKKAIRTGTIELKITPVFMGSAFKNKGVQKLLDGVLDYLASPVDVKNKALDQNNNEEMIVLESNYEKPLVCLA
FKLEDGRYGQLTYVRVYQGKLSKGMTIYNMSNNKKHNVGRLCRMHSDEMEDIDSAEAGDIIALFGIDCASGDTFTDGKLK
VSMESMFVPAPVISLTIEAKESKHLNNLAKALNRFTKEDPTFQTHVDPESGQTIIKGMGELHLEVYIERMKREYGVELIT
GAPQVAYRETITSKADFDYTHKKQTGGQGQFGRVAGYMEPIPLEETLDYDFVNKVVGGAIPREYIQSVDKGFKSCLERGS
LIGFPIIGVRCVINDGAYHDVDSSDMAFQIAGRYAFRQGFNKANPQILEPIMKVEVDGPSEFQGAILGSLNQRRGMILNT
TEEDAYCKTEAEVPLADMFGYSTVLRSSTQGKAEFSMEFSRYAPVPRNVAEELMKKYKVNNKDED

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=697, Percent_Identity=53.5150645624103, Blast_Score=755, Evalue=0.0,
Organism=Homo sapiens, GI19923640, Length=710, Percent_Identity=35.9154929577465, Blast_Score=395, Evalue=1e-109,
Organism=Homo sapiens, GI25306287, Length=709, Percent_Identity=34.132581100141, Blast_Score=350, Evalue=4e-96,
Organism=Homo sapiens, GI25306283, Length=395, Percent_Identity=40.7594936708861, Blast_Score=258, Evalue=2e-68,
Organism=Homo sapiens, GI4503483, Length=482, Percent_Identity=24.6887966804979, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI157426893, Length=150, Percent_Identity=37.3333333333333, Blast_Score=97, Evalue=7e-20,
Organism=Homo sapiens, GI94966754, Length=136, Percent_Identity=41.1764705882353, Blast_Score=88, Evalue=3e-17,
Organism=Homo sapiens, GI310132016, Length=112, Percent_Identity=39.2857142857143, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI310110807, Length=112, Percent_Identity=39.2857142857143, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI310123363, Length=112, Percent_Identity=39.2857142857143, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1789738, Length=698, Percent_Identity=48.7106017191977, Blast_Score=629, Evalue=0.0,
Organism=Escherichia coli, GI1790835, Length=482, Percent_Identity=27.8008298755187, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI48994988, Length=146, Percent_Identity=41.7808219178082, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788922, Length=151, Percent_Identity=38.4105960264901, Blast_Score=101, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=705, Percent_Identity=49.9290780141844, Blast_Score=701, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17556745, Length=726, Percent_Identity=29.3388429752066, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI17506493, Length=815, Percent_Identity=25.2760736196319, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17557151, Length=166, Percent_Identity=38.5542168674699, Blast_Score=107, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71988819, Length=201, Percent_Identity=30.3482587064677, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71988811, Length=201, Percent_Identity=30.3482587064677, Blast_Score=79, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323098, Length=689, Percent_Identity=57.1843251088534, Blast_Score=803, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322359, Length=775, Percent_Identity=29.9354838709677, Blast_Score=299, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6324707, Length=819, Percent_Identity=25.5189255189255, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6320593, Length=819, Percent_Identity=25.5189255189255, Blast_Score=163, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6323320, Length=199, Percent_Identity=31.6582914572864, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324166, Length=146, Percent_Identity=34.2465753424658, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582462, Length=700, Percent_Identity=54.4285714285714, Blast_Score=781, Evalue=0.0,
Organism=Drosophila melanogaster, GI221458488, Length=726, Percent_Identity=30.7162534435262, Blast_Score=315, Evalue=5e-86,
Organism=Drosophila melanogaster, GI24585711, Length=817, Percent_Identity=25.703794369645, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585713, Length=817, Percent_Identity=25.703794369645, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24585709, Length=817, Percent_Identity=25.703794369645, Blast_Score=163, Evalue=5e-40,
Organism=Drosophila melanogaster, GI78706572, Length=151, Percent_Identity=39.0728476821192, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI28574573, Length=143, Percent_Identity=36.3636363636364, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 78957; Mature: 78826

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAVAEFKPSEKLLKTRNIGISAHIDSGKTTLTERILFYTNRIHAIHEVRGKDGVGAKM
CCCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DSMDLERERGITIQSAATYCQWKNHTINIIDTPGHVDFTVEVERSLRVLDSAILVLCGVA
CCCCCHHHCCCEEECCHHHEEECCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCC
GVQSQSITVDRQMRRYNVPRVAFINKLDRTGANPFRVIEQLKEKLKHNAVPVQIPIGLEN
CCCCCCEEHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
DLKGVVDLVTMKAYYFEGKDGMDIQEKEIPDDLKELANKKHEELLDAASMFSDELTEALL
HHHHHHHHHHHHHEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTPTEEMIKKAIRTGTIELKITPVFMGSAFKNKGVQKLLDGVLDYLASPVDVKNKALDQ
CCCCHHHHHHHHHHCCEEEEEEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCC
NNNEEMIVLESNYEKPLVCLAFKLEDGRYGQLTYVRVYQGKLSKGMTIYNMSNNKKHNVG
CCCCCEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCHH
RLCRMHSDEMEDIDSAEAGDIIALFGIDCASGDTFTDGKLKVSMESMFVPAPVISLTIEA
HHHHHCCCHHHHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEHHHEECCCCEEEEEEEC
KESKHLNNLAKALNRFTKEDPTFQTHVDPESGQTIIKGMGELHLEVYIERMKREYGVELI
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
TGAPQVAYRETITSKADFDYTHKKQTGGQGQFGRVAGYMEPIPLEETLDYDFVNKVVGGA
ECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHCCHHHHHHHHCCC
IPREYIQSVDKGFKSCLERGSLIGFPIIGVRCVINDGAYHDVDSSDMAFQIAGRYAFRQG
CCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHC
FNKANPQILEPIMKVEVDGPSEFQGAILGSLNQRRGMILNTTEEDAYCKTEAEVPLADMF
CCCCCHHHHHHHHEEECCCCCHHHHHHHHCCHHCCCEEEECCCCCCEECCCCCCCHHHHH
GYSTVLRSSTQGKAEFSMEFSRYAPVPRNVAEELMKKYKVNNKDED
HHHHHHHCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
STAVAEFKPSEKLLKTRNIGISAHIDSGKTTLTERILFYTNRIHAIHEVRGKDGVGAKM
CCCCCCCCCHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DSMDLERERGITIQSAATYCQWKNHTINIIDTPGHVDFTVEVERSLRVLDSAILVLCGVA
CCCCCHHHCCCEEECCHHHEEECCCEEEEEECCCCEEEEEEHHHHHHHHHHHHHHHHCCC
GVQSQSITVDRQMRRYNVPRVAFINKLDRTGANPFRVIEQLKEKLKHNAVPVQIPIGLEN
CCCCCCEEHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCC
DLKGVVDLVTMKAYYFEGKDGMDIQEKEIPDDLKELANKKHEELLDAASMFSDELTEALL
HHHHHHHHHHHHHEEEECCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGTPTEEMIKKAIRTGTIELKITPVFMGSAFKNKGVQKLLDGVLDYLASPVDVKNKALDQ
CCCCHHHHHHHHHHCCEEEEEEEEEEECCHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCC
NNNEEMIVLESNYEKPLVCLAFKLEDGRYGQLTYVRVYQGKLSKGMTIYNMSNNKKHNVG
CCCCCEEEEECCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCEEEEECCCCCCCCHH
RLCRMHSDEMEDIDSAEAGDIIALFGIDCASGDTFTDGKLKVSMESMFVPAPVISLTIEA
HHHHHCCCHHHHCCCCCCCCEEEEEEEEECCCCCCCCCEEEEEHHHEECCCCEEEEEEEC
KESKHLNNLAKALNRFTKEDPTFQTHVDPESGQTIIKGMGELHLEVYIERMKREYGVELI
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEE
TGAPQVAYRETITSKADFDYTHKKQTGGQGQFGRVAGYMEPIPLEETLDYDFVNKVVGGA
ECCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHCCHHHHHHHHCCC
IPREYIQSVDKGFKSCLERGSLIGFPIIGVRCVINDGAYHDVDSSDMAFQIAGRYAFRQG
CCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHC
FNKANPQILEPIMKVEVDGPSEFQGAILGSLNQRRGMILNTTEEDAYCKTEAEVPLADMF
CCCCCHHHHHHHHEEECCCCCHHHHHHHHCCHHCCCEEEECCCCCCEECCCCCCCHHHHH
GYSTVLRSSTQGKAEFSMEFSRYAPVPRNVAEELMKKYKVNNKDED
HHHHHHHCCCCCCEEEEEEHHHCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA