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The map label for this gene is norM [H]

Identifier: 116329229

GI number: 116329229

Start: 3159535

End: 3160908

Strand: Direct

Name: norM [H]

Synonym: LBL_2666

Alternate gene names: 116329229

Gene position: 3159535-3160908 (Clockwise)

Preceding gene: 116329224

Following gene: 116329230

Centisome position: 87.41

GC content: 44.1

Gene sequence:

>1374_bases
GTGAGAACCTTACAGCATTTAGTCCATACCTTTTATAGGAACATTCGTCCGAGTATTTTGAATTCCATGATCTTGAAACT
CGCGGTGCCCGTCGTGTTCGGAATGTTCAGCCAAACCGTAGTTTGGGTAACCGACACGATGATGGTAGGAAGACTCGGTA
AAAATTCGATTGCCTCGATCGGAATCGGAGGAATTGCACATTTTACCGTGCTTGCGTTTCTCATGGGATTTGCGATGGGA
ATTCAGGTCATAGTAGCGAGAAGATTCGGAGAAAAAAACGATTCCGAAATTGGTAAGATCGGAGTGACTACCTTGTACAT
CATTGCTGTTTTTGGAGGTTTTTTATCGATCGGAGGAGCGGCAATCAGCGACTGGTTGATGAATCTTCTCAATAAAGACG
AAATTGTAAAAGAACTTTCAAGTAAATATTTATACTTTCGTTTTCTGGGAACCGTCTTTTTTTTTCTACTCTTTACGACG
AGAGCATTTACCGACGGATTAGGGATCACGACCGCCGGTCTTGCATCTATGATCATAACATGTTTTACGAATATATTTTT
AAACTGGGTTTTGATTTACGGGAACCTAGGTTTTAATGCGATGGGCGTTAAAGGAGCGGCGATCGCATCTTCTTTGGCGG
GGGCTGCGGGTTTGTTTGCGTTTCCATTCTACTTTTATTCAAGAGGTCTGGGGAAATATTTTTCCCACATATCTTGGGCT
TTCAGTTTTACTCATTTTCGGGAAATCTTAAAGACGAGTACCTCGCCGGCGCTTGCGGAACTTCTCAATAATATTTCTTT
TATGATTTTTACGGAGTTTGCAACAGTCGTGGGAACAACCGCATTAGCCGTAACCAATATGCTTTTTAGTACTCTCAGTC
TTTCTTTTTTACCCGGATACGCGTTCGGGATTGCGGCGACCACGATTCTCGGCCAGGCGTTGGGAGCGGGAAAACCAAAA
CTTGCATATCACGGCGCATTTCGATCCGCTTTTTTTGCGGCTTGTGTGATGGGAAGTATGGGCCTTGTATTTATACTTTG
GGGAAAGGAGATGTTGTCCTTTTACACAAAAGATCCGGAGCTGATTCAGGAAGCGTATTCTCCTTTAGTCATCTTGGGAG
TCATTCAGATCGTAGACGCATATCATATGGTGATCGCTTGTGCCCTTCGGGGCGCAGGACTTCAAAACTTCGTTTTCCGC
GCTTACACTGCGGCCTCTTATTTAGTGTTTCTTCCTTGCGCTTATTTTCTGGGAATTCACTTAAGAATGGGATCGACCGG
ATTGTGGTCCGGAATCGTGGCTTGGGTTCTGGTCCTTGCGTCTGTGTTTATCGTTCGATTTCGTAGAAAGGATTGGGTTC
ACAATCAAGTTTGA

Upstream 100 bases:

>100_bases
ATTTGGAATTTCTCAGAAATGGTAAACAAAGTAAATCCGGAAAAAAGTTTTTTTGAAAAGGGATGGTTTTATTGTTTCTT
CCTAAAAAGTTGGAAGAACC

Downstream 100 bases:

>100_bases
TCCCAAGTTAGGAATTACTATCCGGACGCATGAAAAGAATATTGTAGCAAGTTTGTTTCAAAAGTTAGAATGTTCAATCC
TCTTCAAAAAAACCGACAAT

Product: Na+-driven multidrug efflux pump

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MRTLQHLVHTFYRNIRPSILNSMILKLAVPVVFGMFSQTVVWVTDTMMVGRLGKNSIASIGIGGIAHFTVLAFLMGFAMG
IQVIVARRFGEKNDSEIGKIGVTTLYIIAVFGGFLSIGGAAISDWLMNLLNKDEIVKELSSKYLYFRFLGTVFFFLLFTT
RAFTDGLGITTAGLASMIITCFTNIFLNWVLIYGNLGFNAMGVKGAAIASSLAGAAGLFAFPFYFYSRGLGKYFSHISWA
FSFTHFREILKTSTSPALAELLNNISFMIFTEFATVVGTTALAVTNMLFSTLSLSFLPGYAFGIAATTILGQALGAGKPK
LAYHGAFRSAFFAACVMGSMGLVFILWGKEMLSFYTKDPELIQEAYSPLVILGVIQIVDAYHMVIACALRGAGLQNFVFR
AYTAASYLVFLPCAYFLGIHLRMGSTGLWSGIVAWVLVLASVFIVRFRRKDWVHNQV

Sequences:

>Translated_457_residues
MRTLQHLVHTFYRNIRPSILNSMILKLAVPVVFGMFSQTVVWVTDTMMVGRLGKNSIASIGIGGIAHFTVLAFLMGFAMG
IQVIVARRFGEKNDSEIGKIGVTTLYIIAVFGGFLSIGGAAISDWLMNLLNKDEIVKELSSKYLYFRFLGTVFFFLLFTT
RAFTDGLGITTAGLASMIITCFTNIFLNWVLIYGNLGFNAMGVKGAAIASSLAGAAGLFAFPFYFYSRGLGKYFSHISWA
FSFTHFREILKTSTSPALAELLNNISFMIFTEFATVVGTTALAVTNMLFSTLSLSFLPGYAFGIAATTILGQALGAGKPK
LAYHGAFRSAFFAACVMGSMGLVFILWGKEMLSFYTKDPELIQEAYSPLVILGVIQIVDAYHMVIACALRGAGLQNFVFR
AYTAASYLVFLPCAYFLGIHLRMGSTGLWSGIVAWVLVLASVFIVRFRRKDWVHNQV
>Mature_457_residues
MRTLQHLVHTFYRNIRPSILNSMILKLAVPVVFGMFSQTVVWVTDTMMVGRLGKNSIASIGIGGIAHFTVLAFLMGFAMG
IQVIVARRFGEKNDSEIGKIGVTTLYIIAVFGGFLSIGGAAISDWLMNLLNKDEIVKELSSKYLYFRFLGTVFFFLLFTT
RAFTDGLGITTAGLASMIITCFTNIFLNWVLIYGNLGFNAMGVKGAAIASSLAGAAGLFAFPFYFYSRGLGKYFSHISWA
FSFTHFREILKTSTSPALAELLNNISFMIFTEFATVVGTTALAVTNMLFSTLSLSFLPGYAFGIAATTILGQALGAGKPK
LAYHGAFRSAFFAACVMGSMGLVFILWGKEMLSFYTKDPELIQEAYSPLVILGVIQIVDAYHMVIACALRGAGLQNFVFR
AYTAASYLVFLPCAYFLGIHLRMGSTGLWSGIVAWVLVLASVFIVRFRRKDWVHNQV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=457, Percent_Identity=23.6323851203501, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI48994890, Length=456, Percent_Identity=22.3684210526316, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320545, Length=430, Percent_Identity=23.0232558139535, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321821, Length=431, Percent_Identity=20.8816705336427, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50110; Mature: 50110

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MRTLQHLVHTFYRNIRPSILNSMILKLAVPVVFGMFSQTVVWVTDTMMVGRLGKNSIASI
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
GIGGIAHFTVLAFLMGFAMGIQVIVARRFGEKNDSEIGKIGVTTLYIIAVFGGFLSIGGA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHH
AISDWLMNLLNKDEIVKELSSKYLYFRFLGTVFFFLLFTTRAFTDGLGITTAGLASMIIT
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
CFTNIFLNWVLIYGNLGFNAMGVKGAAIASSLAGAAGLFAFPFYFYSRGLGKYFSHISWA
HHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSFTHFREILKTSTSPALAELLNNISFMIFTEFATVVGTTALAVTNMLFSTLSLSFLPGY
HHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
AFGIAATTILGQALGAGKPKLAYHGAFRSAFFAACVMGSMGLVFILWGKEMLSFYTKDPE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCCHH
LIQEAYSPLVILGVIQIVDAYHMVIACALRGAGLQNFVFRAYTAASYLVFLPCAYFLGIH
HHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRMGSTGLWSGIVAWVLVLASVFIVRFRRKDWVHNQV
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]