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The map label for this gene is nudH [H]

Identifier: 116329222

GI number: 116329222

Start: 3153290

End: 3153778

Strand: Direct

Name: nudH [H]

Synonym: LBL_2659

Alternate gene names: 116329222

Gene position: 3153290-3153778 (Clockwise)

Preceding gene: 116329220

Following gene: 116329223

Centisome position: 87.24

GC content: 39.67

Gene sequence:

>489_bases
ATGGAAAAGCCTTATAGAAAGAATGTCGGAATGGTCGTCTTCAACTCCCATGGAGAAGTTTTAGTGGGAGAAAGATCGAA
TTTTCCCGGTTCTTGGCAATTCCCCCAAGGTGGAATCGATGAAGCTGAAGACCCAACAACGGCGGCTCGGAGAGAATTGT
ATGAAGAGGTCGGAATCGATTCGGGAAAAATTGTGGCCGAATATCCGGATTGGATCCCCTATGATTTTCCGGAAAATCTT
CCGCTCAATCGACATCTTCAGAAATATAGAGGGCAAATTCAAAAATGGTTTCTCATTCATTGGGACGGAGAAATAAACGA
TTGCAAACTGGATATTTACGAAAGAGAATTCGAAACGGTTCGTTTTATTCCCATAAAAGACACTTTGGCAACAGCCGTTC
CTTTTAAAAAAGACGTATATTATAAAATTATAGAAGAATTCGGACCTAAGATTCATGCCTTTCTCCAAAAAACAAAAAAA
AAACTATGA

Upstream 100 bases:

>100_bases
TTCCTCTATATTCCGGAAACAGACTTTCAAGACCTCATGAAAGACCAAAACGGCTTTAAAACTTCTTGTCATACAAAAGC
TCGAACGGGAGCTTATTCGT

Downstream 100 bases:

>100_bases
CGGAAGAACGATTCATCTTCATCCCGCCGGAAGGGCCTCCCGGTCCGATTCCGGGTTTACAATAGGATGCGTGCAAGACA
TCTTCCGTTTCCGATCGATG

Product: NTP pyrophosphohydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MEKPYRKNVGMVVFNSHGEVLVGERSNFPGSWQFPQGGIDEAEDPTTAARRELYEEVGIDSGKIVAEYPDWIPYDFPENL
PLNRHLQKYRGQIQKWFLIHWDGEINDCKLDIYEREFETVRFIPIKDTLATAVPFKKDVYYKIIEEFGPKIHAFLQKTKK
KL

Sequences:

>Translated_162_residues
MEKPYRKNVGMVVFNSHGEVLVGERSNFPGSWQFPQGGIDEAEDPTTAARRELYEEVGIDSGKIVAEYPDWIPYDFPENL
PLNRHLQKYRGQIQKWFLIHWDGEINDCKLDIYEREFETVRFIPIKDTLATAVPFKKDVYYKIIEEFGPKIHAFLQKTKK
KL
>Mature_162_residues
MEKPYRKNVGMVVFNSHGEVLVGERSNFPGSWQFPQGGIDEAEDPTTAARRELYEEVGIDSGKIVAEYPDWIPYDFPENL
PLNRHLQKYRGQIQKWFLIHWDGEINDCKLDIYEREFETVRFIPIKDTLATAVPFKKDVYYKIIEEFGPKIHAFLQKTKK
KL

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=161, Percent_Identity=36.0248447204969, Blast_Score=90, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19039; Mature: 19039

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKPYRKNVGMVVFNSHGEVLVGERSNFPGSWQFPQGGIDEAEDPTTAARRELYEEVGID
CCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SGKIVAEYPDWIPYDFPENLPLNRHLQKYRGQIQKWFLIHWDGEINDCKLDIYEREFETV
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEECCCCEE
RFIPIKDTLATAVPFKKDVYYKIIEEFGPKIHAFLQKTKKKL
EEEECHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKPYRKNVGMVVFNSHGEVLVGERSNFPGSWQFPQGGIDEAEDPTTAARRELYEEVGID
CCCCCCCCCCEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCC
SGKIVAEYPDWIPYDFPENLPLNRHLQKYRGQIQKWFLIHWDGEINDCKLDIYEREFETV
CCCEEEECCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCEEEEEEECCCCEE
RFIPIKDTLATAVPFKKDVYYKIIEEFGPKIHAFLQKTKKKL
EEEECHHHHHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA