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The map label for this gene is nuoH

Identifier: 116329148

GI number: 116329148

Start: 3051026

End: 3052066

Strand: Reverse

Name: nuoH

Synonym: LBL_2572

Alternate gene names: 116329148

Gene position: 3052066-3051026 (Counterclockwise)

Preceding gene: 116329149

Following gene: 116329147

Centisome position: 84.44

GC content: 45.82

Gene sequence:

>1041_bases
ATGAACTGGAACGAAATTCTATTTTGGCTTTTGAAAAGCGGGCTTTTCTTTTTTATTCTGATTACCGCCTGCGCGTATTA
TACGCTCGCAGAAAGAAAGGTGGCGGGTTTTATCCAGGATCGGAAAGGTCCAAACCGCGCTGGGATTTGGGGGCTTTTGC
AACCTCTTGCGGATGGAATTAAATTCTTAACTAAGGAAGAAGTGTTCCCGACCCAAGTGAACAAGATCATGTATTTGATT
GCTCCTGCGATTTCCATGACCTGTGCGATCATGGCCTGGTCTGTCGTCCCCTTGGGCGGTCGGATTCCTCTTCCACAATG
GCTTCAAGATAGGACCGGCCTGGTATTTTTGGACTTGCAGATCGCTAACCCGGATACCGGAATTTTATTTTTGTTTGCGA
TCTCTTCCCTTGCGGTTTACGGAATTATCATCGCGGGTTGGGCGAGTAACAACAAATATTCGTTGTTAGGCGCCATCCGT
TCCACGGCTCAGATGATCAGTTACGAACTTCCTCTTTCTATGAGTGTGGTTTCGATCGTGATCCTCACGGGTTCTTTGAA
ACTCACGGATATCAGCGCTTCTCAAGCCGGGCTTTGGAACATTTTTAAACTCCCGGGATTCATCGCGTTTTGTCTGTTCG
TCGTCGCGATGTTTGCGGAAACGAACCGTCTGCCTTTCGACTTGGCGGAAGCGGAGTCGGAACTCGTGGTCGGGTTTCAC
ACCGAATATGGAGCGTTTAAATTCGCATTATTTTTTATCGCGGAATATATGAACATGATCACGATGAGTTGTGTCGTGAC
ACTTCTGTTTTTCGGAGGATACCAGGTTCCGTTCGGAATTTTAGAAGGACACGTATTACAGTCTTTATTTGGGCTTTTTT
TCTTTTTGGGAAAGGTTTTGTTCTTCACTTTTTTATTCGTGTGGGTGAGATGGACTCTTCCCCGTTTCCGCTACGATCAG
CTCATGTCTCTCGGATGGAAAAAACTCATTCCTTGGGCGGTTTTGAATATTCTGATCGCGAGCCTCTATATACAATTTTA
A

Upstream 100 bases:

>100_bases
TTGACGCGAGATTGAAAGAAAAACCGGCGCCCGTACCCGATCATCCTCGAAGGAGAAAAGAGGATAGGATCGAGTCCGCA
ATAGGAGGAAGAGCTACTTC

Downstream 100 bases:

>100_bases
GAATATAGTAATATAAAAATTATGCCATTTGCAGATCAACCTCAGTTGCTTTTGTTCTTTCTGTTCGCTTCGGTGATGAT
ACTCAGTTCTCTCGGGGTGA

Product: NADH dehydrogenase (ubiquinone), H chain

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGIWGLLQPLADGIKFLTKEEVFPTQVNKIMYLI
APAISMTCAIMAWSVVPLGGRIPLPQWLQDRTGLVFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAIR
STAQMISYELPLSMSVVSIVILTGSLKLTDISASQAGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQSLFGLFFFLGKVLFFTFLFVWVRWTLPRFRYDQ
LMSLGWKKLIPWAVLNILIASLYIQF

Sequences:

>Translated_346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGIWGLLQPLADGIKFLTKEEVFPTQVNKIMYLI
APAISMTCAIMAWSVVPLGGRIPLPQWLQDRTGLVFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAIR
STAQMISYELPLSMSVVSIVILTGSLKLTDISASQAGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQSLFGLFFFLGKVLFFTFLFVWVRWTLPRFRYDQ
LMSLGWKKLIPWAVLNILIASLYIQF
>Mature_346_residues
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGIWGLLQPLADGIKFLTKEEVFPTQVNKIMYLI
APAISMTCAIMAWSVVPLGGRIPLPQWLQDRTGLVFLDLQIANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAIR
STAQMISYELPLSMSVVSIVILTGSLKLTDISASQAGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQSLFGLFFFLGKVLFFTFLFVWVRWTLPRFRYDQ
LMSLGWKKLIPWAVLNILIASLYIQF

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=309, Percent_Identity=42.3948220064725, Blast_Score=224, Evalue=1e-58,
Organism=Escherichia coli, GI1788618, Length=340, Percent_Identity=39.7058823529412, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1789077, Length=300, Percent_Identity=27, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_LEPBJ (Q04V66)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_799962.1
- STRING:   Q04V66
- GeneID:   4409406
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_0507
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   QLMNLGW
- PhylomeDB:   Q04V66
- ProtClustDB:   CLSK573689
- BioCyc:   LBOR355277:LBJ_0507-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39040; Mature: 39040

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x120bffb8)-; HASH(0xb7b4f74)-; HASH(0x1223072c)-; HASH(0x12230b58)-; HASH(0x1203b7d0)-; HASH(0x126761a4)-; HASH(0x122077c4)-; HASH(0x122344a4)-;

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGIWGLLQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KFLTKEEVFPTQVNKIMYLIAPAISMTCAIMAWSVVPLGGRIPLPQWLQDRTGLVFLDLQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEEE
IANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAIRSTAQMISYELPLSMSVVSIV
ECCCCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ILTGSLKLTDISASQAGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQSLFGLFFFLGKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFTFLFVWVRWTLPRFRYDQLMSLGWKKLIPWAVLNILIASLYIQF
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MNWNEILFWLLKSGLFFFILITACAYYTLAERKVAGFIQDRKGPNRAGIWGLLQPLADGI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
KFLTKEEVFPTQVNKIMYLIAPAISMTCAIMAWSVVPLGGRIPLPQWLQDRTGLVFLDLQ
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEEE
IANPDTGILFLFAISSLAVYGIIIAGWASNNKYSLLGAIRSTAQMISYELPLSMSVVSIV
ECCCCCCHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ILTGSLKLTDISASQAGLWNIFKLPGFIAFCLFVVAMFAETNRLPFDLAEAESELVVGFH
HHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCEEEEEE
TEYGAFKFALFFIAEYMNMITMSCVVTLLFFGGYQVPFGILEGHVLQSLFGLFFFLGKVL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FFTFLFVWVRWTLPRFRYDQLMSLGWKKLIPWAVLNILIASLYIQF
HHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA