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The map label for this gene is paaJ-1 [H]

Identifier: 116329106

GI number: 116329106

Start: 2996020

End: 2997345

Strand: Reverse

Name: paaJ-1 [H]

Synonym: LBL_2528

Alternate gene names: 116329106

Gene position: 2997345-2996020 (Counterclockwise)

Preceding gene: 116329107

Following gene: 116329094

Centisome position: 82.93

GC content: 47.66

Gene sequence:

>1326_bases
ATGAAATTAACAAAACCTTTGGCGCTTTGTACGCCGAGAAGAACTCCTTTTGCTCAGATTGCGAAAGCTCTGGGACCATA
CCCTGGACATCATCTTGGGAAAATTGTCGCAGAAGACATTCTCGCTAAAAGCAAACTGAAGCCGTCTCAAATCGACGGAG
TTGTGGTTGGAGAGGGATTTAGTAATGCGCCTAACTCTGCAAGAGTGATCGCTAACTTGGTCGGAATGAGAGACGAAATC
GCTTGTATCACCGTTGCGAACAACTGCGTTTCCGGTATGGAAGCGGTTGCGGAGGCGGCCCGTAGAATCATACTCGGCGA
AGGGGAGGTATTCCTCGCAATCGGCGAGGAGTCCCAAACTTCCATGCCTTTTATCGTTAAAAATGCTCGTTTGAATAAGA
AAGCGGGGTCTCTTGATAAACTCAAAAAACTTCTTCCGGATAACCTTCCAGAAGGTGTCGAGCTAAGGGACACTTTGGAA
GACGGACTCGGAGACGGGGAAACCTCTTACGGAATGCAAGTAACCGCGGAAATTGTAGCTCAGAACTACTCTCTTTCCCG
AGAGATTCAAGACAAGCTCGCTTTCGAATCTTTTAAAAGGGCATTAGAAGCTTCTAAAGCGGGTAGATACGCTCCTTATA
TTATTCCAATGAAAGACGACGAAGGTAACGAACTTGCCATCGACGAAGCGGTGGGTTTGCGCGAAGGTTTGGTGGAAAAC
CCGACTCGTATGGGACGTGCTATGCTTATGTTCGACAATCCCGGAATGAAATTCGAAGAATTCAAAACAAAATACGCAAA
GGATCTTAAAAAATCTCACGGACCGACGGTTTCCATCTTTAACGCAAGTCCTCGTTCCGACGGCGCTGCGGGTGTGATCG
TTACAACCGTTGAAAAAGCGAAGGAACTCGGTCTTACGATCGAAGCCGTCATTTCCGGGTGGCACATGAAAGGAGTTCAT
CCTAATAACATGGGAATCGGACAGGCGGTTGCCACCAAAGCCCTATTAGACGATGTTGGAATCAAGATGCAAGACGTAGA
CTACGTTGAAATCCACGAAGCTTTCGCTGCGACTGCGGTTGGCGCTCTTGAACAAATCAAAATGGATACTGGTTGGGATT
GGGAAAAATCCTTCGACGCTAAAAAGGTAAATCCGAACGGCGGATCCATCGCGATCGGTCACCCATTCGGAGCGACCGGA
ATCCGTTTGATCGCAAATGCGATCATGGACTTAAAAGAGGATTCTTCCGCGAATAAGGTTCTGATCACCGCATGTGCGCA
CGGTGGAATCGCAGGATCCATGTTGATCGAAAGATTTAAAGGTTGA

Upstream 100 bases:

>100_bases
GAGTTTCAAAGGCTTGTAGGTGAATACGTAGAGCATTTTGAATGTTCTAAAATATGAATATTTTATTGGTTATTAAGAAT
TTGAAGTTTGGAGAAAAAAA

Downstream 100 bases:

>100_bases
TTAGAATTTTAAGTTTTTCTAAAATTCAGATTAATTTCCTGTTTTTCTAAAGTAGGAATAAAAATTCAAAAGCCCCGGTT
TGAGCCGTGGTTTTTGAATT

Product: Acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MKLTKPLALCTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIILGEGEVFLAIGEESQTSMPFIVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYSLSREIQDKLAFESFKRALEASKAGRYAPYIIPMKDDEGNELAIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVISGWHMKGVH
PNNMGIGQAVATKALLDDVGIKMQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKVNPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERFKG

Sequences:

>Translated_441_residues
MKLTKPLALCTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIILGEGEVFLAIGEESQTSMPFIVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYSLSREIQDKLAFESFKRALEASKAGRYAPYIIPMKDDEGNELAIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVISGWHMKGVH
PNNMGIGQAVATKALLDDVGIKMQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKVNPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERFKG
>Mature_441_residues
MKLTKPLALCTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGFSNAPNSARVIANLVGMRDEI
ACITVANNCVSGMEAVAEAARRIILGEGEVFLAIGEESQTSMPFIVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLE
DGLGDGETSYGMQVTAEIVAQNYSLSREIQDKLAFESFKRALEASKAGRYAPYIIPMKDDEGNELAIDEAVGLREGLVEN
PTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKAKELGLTIEAVISGWHMKGVH
PNNMGIGQAVATKALLDDVGIKMQDVDYVEIHEAFAATAVGALEQIKMDTGWDWEKSFDAKKVNPNGGSIAIGHPFGATG
IRLIANAIMDLKEDSSANKVLITACAHGGIAGSMLIERFKG

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=443, Percent_Identity=28.4424379232506, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI148539872, Length=437, Percent_Identity=29.2906178489703, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4501853, Length=404, Percent_Identity=29.2079207920792, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4557237, Length=440, Percent_Identity=27.5, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI4504327, Length=454, Percent_Identity=25.3303964757709, Blast_Score=115, Evalue=7e-26,
Organism=Escherichia coli, GI87082165, Length=434, Percent_Identity=30.4147465437788, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI1787663, Length=436, Percent_Identity=29.5871559633028, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788683, Length=437, Percent_Identity=30.2059496567506, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788554, Length=438, Percent_Identity=28.310502283105, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI48994986, Length=388, Percent_Identity=27.0618556701031, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551802, Length=449, Percent_Identity=29.6213808463252, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI133906874, Length=440, Percent_Identity=28.4090909090909, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI25147385, Length=431, Percent_Identity=26.4501160092807, Blast_Score=128, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI17535921, Length=432, Percent_Identity=24.3055555555556, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17535917, Length=440, Percent_Identity=23.4090909090909, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6325229, Length=445, Percent_Identity=28.0898876404494, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322031, Length=332, Percent_Identity=29.8192771084337, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24655093, Length=436, Percent_Identity=28.2110091743119, Blast_Score=161, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24640423, Length=432, Percent_Identity=28.7037037037037, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17648125, Length=444, Percent_Identity=28.1531531531532, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17137578, Length=451, Percent_Identity=30.1552106430155, Blast_Score=136, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 47291; Mature: 47291

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLTKPLALCTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGF
CCCCCCCHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
SNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIILGEGEVFLAIGEESQT
CCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCC
SMPFIVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVA
CCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
QNYSLSREIQDKLAFESFKRALEASKAGRYAPYIIPMKDDEGNELAIDEAVGLREGLVEN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCC
PTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKA
HHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEHHHH
KELGLTIEAVISGWHMKGVHPNNMGIGQAVATKALLDDVGIKMQDVDYVEIHEAFAATAV
HHHCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
GALEQIKMDTGWDWEKSFDAKKVNPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKV
HHHHHHHCCCCCCHHHCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
LITACAHGGIAGSMLIERFKG
EEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MKLTKPLALCTPRRTPFAQIAKALGPYPGHHLGKIVAEDILAKSKLKPSQIDGVVVGEGF
CCCCCCCHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCC
SNAPNSARVIANLVGMRDEIACITVANNCVSGMEAVAEAARRIILGEGEVFLAIGEESQT
CCCCCHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHEEEECCCEEEEECCCCCC
SMPFIVKNARLNKKAGSLDKLKKLLPDNLPEGVELRDTLEDGLGDGETSYGMQVTAEIVA
CCCEEEECCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHH
QNYSLSREIQDKLAFESFKRALEASKAGRYAPYIIPMKDDEGNELAIDEAVGLREGLVEN
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCC
PTRMGRAMLMFDNPGMKFEEFKTKYAKDLKKSHGPTVSIFNASPRSDGAAGVIVTTVEKA
HHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEEEHHHH
KELGLTIEAVISGWHMKGVHPNNMGIGQAVATKALLDDVGIKMQDVDYVEIHEAFAATAV
HHHCCCHHHHHCCCEECCCCCCCCCCHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHH
GALEQIKMDTGWDWEKSFDAKKVNPNGGSIAIGHPFGATGIRLIANAIMDLKEDSSANKV
HHHHHHHCCCCCCHHHCCCCCEECCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEE
LITACAHGGIAGSMLIERFKG
EEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8566717 [H]