Click here to switch to the map view.

The map label for this gene is ccmA [H]

Identifier: 116328983

GI number: 116328983

Start: 2827210

End: 2827857

Strand: Reverse

Name: ccmA [H]

Synonym: LBL_2385

Alternate gene names: 116328983

Gene position: 2827857-2827210 (Counterclockwise)

Preceding gene: 116328986

Following gene: 116328982

Centisome position: 78.24

GC content: 42.59

Gene sequence:

>648_bases
TTGACATTCAATGAACAAGCGCTTTTCGTTTGTAAAAACCTATCTTATTCTATCGGAAAAAAACGGATTCTCAAACAGAT
TTCATTTTCTCTTTTTCGAGGAGAACTTGTACTACTTCGGGGAGACAACGGAGCCGGAAAAACAACTCTTCTCAGAGCGA
TTCTCAATCACGAACGTCATAAGGATTCTTTTTCTTTTATGAACTCTGAATCGACAAAGCCCCGGATTTCTTACTTAGGT
CACGAACTCGGACTTTATACCTCTCTCAGTCTCGAGGAAAATCTTCGTTATTTCCTTTCCATCGCAAAAATGGAATATTC
AAAAGATAAAGTCGGCGCCCTTTTGAAGTCGTTCCAACTCTGGGCGAGAAAACAAGATCCGATCTTTACTTTCTCCAGAG
GAATGAGGCAAAAGGCCGCTTTAGTGAGGGCGCTTTTGACCGGAGGAGACTTGATCCTTTTGGATGAACCGTTTACGGCT
TTCGATCAATCCGGACTCGAAACCGCGGTTCGTGTTTTGGAGGAATATTCTCTAAATTCCGCGGTGTTACTTGTGACTCA
CGACCCCCATATTCCATTTTCTCGTGAAACGAAGTCGTTGACTCTAAAGGAGGGGAATCTTGAAACTTCTGTTCTTTCTG
CTCCATAA

Upstream 100 bases:

>100_bases
CGTTCGTTCCTAACCGTTGAAACCCTTCGGAAGCCGAGCGCAAAAAACGCATTGTAAATTCCGTTTCTGAAAAGACTCTG
GTTTCATAAGAGGAACCGTT

Downstream 100 bases:

>100_bases
GGAATTTCTGTTATTGGGAAGGGCGGTCAACGGAATATTGTCTATTCTCGTTCTCATCACTTCGATCGTATTCATTTTCA
ATTATGCGTTAGAGCAGACT

Product: ATP-binding protein of an ABC transporter complex

Products: NA

Alternate protein names: Heme exporter protein A [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTFNEQALFVCKNLSYSIGKKRILKQISFSLFRGELVLLRGDNGAGKTTLLRAILNHERHKDSFSFMNSESTKPRISYLG
HELGLYTSLSLEENLRYFLSIAKMEYSKDKVGALLKSFQLWARKQDPIFTFSRGMRQKAALVRALLTGGDLILLDEPFTA
FDQSGLETAVRVLEEYSLNSAVLLVTHDPHIPFSRETKSLTLKEGNLETSVLSAP

Sequences:

>Translated_215_residues
MTFNEQALFVCKNLSYSIGKKRILKQISFSLFRGELVLLRGDNGAGKTTLLRAILNHERHKDSFSFMNSESTKPRISYLG
HELGLYTSLSLEENLRYFLSIAKMEYSKDKVGALLKSFQLWARKQDPIFTFSRGMRQKAALVRALLTGGDLILLDEPFTA
FDQSGLETAVRVLEEYSLNSAVLLVTHDPHIPFSRETKSLTLKEGNLETSVLSAP
>Mature_214_residues
TFNEQALFVCKNLSYSIGKKRILKQISFSLFRGELVLLRGDNGAGKTTLLRAILNHERHKDSFSFMNSESTKPRISYLGH
ELGLYTSLSLEENLRYFLSIAKMEYSKDKVGALLKSFQLWARKQDPIFTFSRGMRQKAALVRALLTGGDLILLDEPFTAF
DQSGLETAVRVLEEYSLNSAVLLVTHDPHIPFSRETKSLTLKEGNLETSVLSAP

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system [H]

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI153792144, Length=190, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI27477115, Length=184, Percent_Identity=25.5434782608696, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI27436953, Length=183, Percent_Identity=27.3224043715847, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI6005701, Length=170, Percent_Identity=24.7058823529412, Blast_Score=64, Evalue=7e-11,
Organism=Escherichia coli, GI1788165, Length=200, Percent_Identity=32, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1788761, Length=215, Percent_Identity=28.8372093023256, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI87081709, Length=208, Percent_Identity=25.9615384615385, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789873, Length=215, Percent_Identity=29.7674418604651, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789593, Length=214, Percent_Identity=26.6355140186916, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082064, Length=179, Percent_Identity=29.608938547486, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI48994997, Length=234, Percent_Identity=28.6324786324786, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1787105, Length=210, Percent_Identity=26.1904761904762, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790467, Length=190, Percent_Identity=29.4736842105263, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87082267, Length=181, Percent_Identity=27.6243093922652, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI48995001, Length=203, Percent_Identity=26.1083743842365, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1786563, Length=178, Percent_Identity=29.2134831460674, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI87081791, Length=194, Percent_Identity=26.2886597938144, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI87081834, Length=232, Percent_Identity=28.8793103448276, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983523, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983510, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71983516, Length=204, Percent_Identity=25.9803921568627, Blast_Score=65, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6324314, Length=181, Percent_Identity=31.4917127071823, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6325030, Length=230, Percent_Identity=29.1304347826087, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221512771, Length=185, Percent_Identity=25.4054054054054, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24666092, Length=185, Percent_Identity=25.4054054054054, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.41 [H]

Molecular weight: Translated: 24252; Mature: 24121

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFNEQALFVCKNLSYSIGKKRILKQISFSLFRGELVLLRGDNGAGKTTLLRAILNHERH
CCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHC
KDSFSFMNSESTKPRISYLGHELGLYTSLSLEENLRYFLSIAKMEYSKDKVGALLKSFQL
CCHHHHCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WARKQDPIFTFSRGMRQKAALVRALLTGGDLILLDEPFTAFDQSGLETAVRVLEEYSLNS
HHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHHHHHHHHCCCCC
AVLLVTHDPHIPFSRETKSLTLKEGNLETSVLSAP
EEEEEEECCCCCCCCCCCEEEEECCCCCCEEECCC
>Mature Secondary Structure 
TFNEQALFVCKNLSYSIGKKRILKQISFSLFRGELVLLRGDNGAGKTTLLRAILNHERH
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHC
KDSFSFMNSESTKPRISYLGHELGLYTSLSLEENLRYFLSIAKMEYSKDKVGALLKSFQL
CCHHHHCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
WARKQDPIFTFSRGMRQKAALVRALLTGGDLILLDEPFTAFDQSGLETAVRVLEEYSLNS
HHCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCHHHHHHHHHHCCCCC
AVLLVTHDPHIPFSRETKSLTLKEGNLETSVLSAP
EEEEEEECCCCCCCCCCCEEEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA