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The map label for this gene is pepB [H]

Identifier: 116328873

GI number: 116328873

Start: 2665732

End: 2667219

Strand: Direct

Name: pepB [H]

Synonym: LBL_2260

Alternate gene names: 116328873

Gene position: 2665732-2667219 (Clockwise)

Preceding gene: 116328872

Following gene: 116328875

Centisome position: 73.75

GC content: 46.24

Gene sequence:

>1488_bases
ATGAAACTGGATAAGAATAAAATCCAAACCTCGATCGGAAAAAATCCTTCTAAGGCCTTTTACAAATTACAACTTCTCTT
GAAGGATCATTTTCCCGAGAATTTCAAGACGAAATATCCGCTTCAAACCTCCTCCGGAATTTTTACGGGAGATAACGGAC
AAATATTCACGGACGAGACCGAAAAAATCATCTACTTAGGGTTAGGTGATTCTTCCAAAGTAAAAACGAGAGGGATCGCA
CAGCACTTTTTTCAATTCGGAGAAAAGCTCAGAAAATGGAACGGAGTGGGCCTTGAAATTCATCTTCCGAAAATTCTTAC
TACCACACTTCCCGCAAATTCGCTCGTATACCAAATCATAAACTCTCTAGAGCAAGGAGCTTATGCGATCAACGTTCTCG
CCAAGGAATTCAAAGAAAACTCCAAAAAAATCGGAAACGTTTCCTTTATTCTCCAAGACGCGGCAAAAATAAAAGAGGCC
GAACAAGGGCTCAAACGGGGAAAAGTGGTCAGCCGTTACGTCAACGGAGCCCGTTTTATCGCACATCTTCCCGCAAATCA
CTTCACACCGGAAGACTTCGTTTCCAGATCGAAAGAAATCGCAAAGGAAAACGGACTTAAAATCACCGTCTTTGACGAAC
CTCAATTGAAAAAAGAAAAGATGGGAGGAATTCTCTCCGTCTGCGAAGGTTCGGATAAAAAGGCAAAGATGATTCTTTTG
GAATATACTCCCGCAAAACCGAGCACCAAGAAAAAACTCGCGATCATCGGAAAAGGTCTTACCTTTGATTCCGGAGGAAT
CAGTATCAAACCCGCACAAGACATGCACGAAATGAAATACGATATGTGCGGAGCGGCCGCGGCCATTCACGCGATCGGTG
CAATCGCCGAATTAGGATTAGGTGTTCCGGTTATCGCAGCAATCGGAGTCGCGGAGAATATGCCGGATGCAGCCGCGATC
AAACCGGGGGACGTTTACACGGCTCACAACGGAATTACGGTAGAAGTTCAAAATACGGATGCGGAAGGCCGTCTGGTTTT
AGGGGATGTCCTCTCCTACGTCGGAAAAAAATTCAAACCGGACTACATGTTGGATCTTGCCACTCTAACGGGAGCGATCA
TCATCTCGCTTGGACACGAAGCCGCCGGAGTCATGAGTAATTCGGAACCTCTCACAAATCTACTCAAAGAAGCATCGGCT
TCTTCGGATGAAAGAATCTGGGAAATGCCTCTTTGGGAAGAATATTCCGAAGACCTAAAGAGCGATATCGCGGATATTCG
TAACGTTGCGGGACGGGCGGGCGGTTCTTTATCCGCCGCTAAATTCTTAGAAAGATTCGTGGATCCCCAAATCGCTTGGG
CACACATCGACATCGCAGGAGCGGCCTGGAGAAAAAAGGCGTCCGGAACTCAGATCGGAAACGGACCGACCGGATATGGG
GTTCGATTATTGGTAGATCTGGCCGAGAGAATCGGGAAAAAGAAATAG

Upstream 100 bases:

>100_bases
TTATCGGAACCGACGGAAAAATCCTTAAAGTATATCCCAAGGTAAGCGTAAAAGGACACGTTGATGAAATCCTTTCAGAC
ATCAAAGCACTGGAGAAAAA

Downstream 100 bases:

>100_bases
AAAGTCTAACTCGTACATTAGATTTATGTGTTAAATCCGTTTTCCGCCGAATAGTTTACGGTTTCTTAAAGAGCTCAAAC
CGCGCAAGTGATTCGCTTGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 495; Mature: 495

Protein sequence:

>495_residues
MKLDKNKIQTSIGKNPSKAFYKLQLLLKDHFPENFKTKYPLQTSSGIFTGDNGQIFTDETEKIIYLGLGDSSKVKTRGIA
QHFFQFGEKLRKWNGVGLEIHLPKILTTTLPANSLVYQIINSLEQGAYAINVLAKEFKENSKKIGNVSFILQDAAKIKEA
EQGLKRGKVVSRYVNGARFIAHLPANHFTPEDFVSRSKEIAKENGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPAKPSTKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAAAAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAHNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSEPLTNLLKEASA
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVDPQIAWAHIDIAGAAWRKKASGTQIGNGPTGYG
VRLLVDLAERIGKKK

Sequences:

>Translated_495_residues
MKLDKNKIQTSIGKNPSKAFYKLQLLLKDHFPENFKTKYPLQTSSGIFTGDNGQIFTDETEKIIYLGLGDSSKVKTRGIA
QHFFQFGEKLRKWNGVGLEIHLPKILTTTLPANSLVYQIINSLEQGAYAINVLAKEFKENSKKIGNVSFILQDAAKIKEA
EQGLKRGKVVSRYVNGARFIAHLPANHFTPEDFVSRSKEIAKENGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPAKPSTKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAAAAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAHNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSEPLTNLLKEASA
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVDPQIAWAHIDIAGAAWRKKASGTQIGNGPTGYG
VRLLVDLAERIGKKK
>Mature_495_residues
MKLDKNKIQTSIGKNPSKAFYKLQLLLKDHFPENFKTKYPLQTSSGIFTGDNGQIFTDETEKIIYLGLGDSSKVKTRGIA
QHFFQFGEKLRKWNGVGLEIHLPKILTTTLPANSLVYQIINSLEQGAYAINVLAKEFKENSKKIGNVSFILQDAAKIKEA
EQGLKRGKVVSRYVNGARFIAHLPANHFTPEDFVSRSKEIAKENGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EYTPAKPSTKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAAAAIHAIGAIAELGLGVPVIAAIGVAENMPDAAAI
KPGDVYTAHNGITVEVQNTDAEGRLVLGDVLSYVGKKFKPDYMLDLATLTGAIIISLGHEAAGVMSNSEPLTNLLKEASA
SSDERIWEMPLWEEYSEDLKSDIADIRNVAGRAGGSLSAAKFLERFVDPQIAWAHIDIAGAAWRKKASGTQIGNGPTGYG
VRLLVDLAERIGKKK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=337, Percent_Identity=38.8724035608309, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI47155554, Length=412, Percent_Identity=30.0970873786408, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1790710, Length=374, Percent_Identity=39.3048128342246, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=35.202492211838, Blast_Score=159, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI17556903, Length=319, Percent_Identity=33.8557993730408, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17565172, Length=284, Percent_Identity=23.943661971831, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24661038, Length=322, Percent_Identity=32.2981366459627, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI21355725, Length=322, Percent_Identity=31.9875776397516, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI20129969, Length=301, Percent_Identity=31.2292358803987, Blast_Score=162, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24662227, Length=300, Percent_Identity=30, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21357381, Length=358, Percent_Identity=30.1675977653631, Blast_Score=149, Evalue=5e-36,
Organism=Drosophila melanogaster, GI221379063, Length=358, Percent_Identity=30.1675977653631, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI221379062, Length=358, Percent_Identity=30.1675977653631, Blast_Score=149, Evalue=6e-36,
Organism=Drosophila melanogaster, GI20129963, Length=294, Percent_Identity=31.6326530612245, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI161077148, Length=351, Percent_Identity=26.4957264957265, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI20130057, Length=351, Percent_Identity=26.4957264957265, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI21355645, Length=296, Percent_Identity=29.0540540540541, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24662223, Length=296, Percent_Identity=29.0540540540541, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI19922386, Length=297, Percent_Identity=30.976430976431, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI24646701, Length=193, Percent_Identity=32.1243523316062, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24646703, Length=193, Percent_Identity=32.1243523316062, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21358201, Length=193, Percent_Identity=32.1243523316062, Blast_Score=90, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042 [H]

Pfam domain/function: PF00883 Peptidase_M17 [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53831; Mature: 53831

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDKNKIQTSIGKNPSKAFYKLQLLLKDHFPENFKTKYPLQTSSGIFTGDNGQIFTDET
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCEEECCC
EKIIYLGLGDSSKVKTRGIAQHFFQFGEKLRKWNGVGLEIHLPKILTTTLPANSLVYQII
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCHHHHHHHHH
NSLEQGAYAINVLAKEFKENSKKIGNVSFILQDAAKIKEAEQGLKRGKVVSRYVNGARFI
HHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
AHLPANHFTPEDFVSRSKEIAKENGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCEEEECCCCCCCEEEEEE
EYTPAKPSTKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAAAAIHAIGAIAELGL
EECCCCCCCCCEEEEEECCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPVIAAIGVAENMPDAAAIKPGDVYTAHNGITVEVQNTDAEGRLVLGDVLSYVGKKFKP
CHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEHHHHHHHHCCCCCC
DYMLDLATLTGAIIISLGHEAAGVMSNSEPLTNLLKEASASSDERIWEMPLWEEYSEDLK
CHHHHHHHHHCEEEEEECCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
SDIADIRNVAGRAGGSLSAAKFLERFVDPQIAWAHIDIAGAAWRKKASGTQIGNGPTGYG
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEECCHHHHHCCCCCCCCCCCCCCH
VRLLVDLAERIGKKK
HHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLDKNKIQTSIGKNPSKAFYKLQLLLKDHFPENFKTKYPLQTSSGIFTGDNGQIFTDET
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCCEEECCC
EKIIYLGLGDSSKVKTRGIAQHFFQFGEKLRKWNGVGLEIHLPKILTTTLPANSLVYQII
CEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCHHHHHHHHH
NSLEQGAYAINVLAKEFKENSKKIGNVSFILQDAAKIKEAEQGLKRGKVVSRYVNGARFI
HHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEE
AHLPANHFTPEDFVSRSKEIAKENGLKITVFDEPQLKKEKMGGILSVCEGSDKKAKMILL
EECCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCEEEECCCCCCCEEEEEE
EYTPAKPSTKKKLAIIGKGLTFDSGGISIKPAQDMHEMKYDMCGAAAAIHAIGAIAELGL
EECCCCCCCCCEEEEEECCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GVPVIAAIGVAENMPDAAAIKPGDVYTAHNGITVEVQNTDAEGRLVLGDVLSYVGKKFKP
CHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCCCCCCEEHHHHHHHHCCCCCC
DYMLDLATLTGAIIISLGHEAAGVMSNSEPLTNLLKEASASSDERIWEMPLWEEYSEDLK
CHHHHHHHHHCEEEEEECCHHHCCCCCCHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHH
SDIADIRNVAGRAGGSLSAAKFLERFVDPQIAWAHIDIAGAAWRKKASGTQIGNGPTGYG
HHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEEEEECCHHHHHCCCCCCCCCCCCCCH
VRLLVDLAERIGKKK
HHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA