Click here to switch to the map view.

The map label for this gene is fur [H]

Identifier: 116328861

GI number: 116328861

Start: 2645955

End: 2646437

Strand: Reverse

Name: fur [H]

Synonym: LBL_2245

Alternate gene names: 116328861

Gene position: 2646437-2645955 (Counterclockwise)

Preceding gene: 116328862

Following gene: 116328860

Centisome position: 73.22

GC content: 39.54

Gene sequence:

>483_bases
ATGAATCGAGAAAAACAGGAAGCAATTCTAAACAAAGCGGAACCCGCGGTCCGTATGGAAATGCAGACCTTTTCGGAATA
TCTGCAGAAAGAAGGTCTAAAGATTACTAACCAGAGAATGCTAGTTGCTGAGAGAATTTTTTCCCTTCACAATCATTTCA
CAGCGGAAGGGCTTTTAGAGGAATTCAAGGATCAAAGGGATCAAATTTCCAAAGCTACAATTTATAGGATTCTTTCCATT
ATGGTTTCTGCGGGCTTATTGCAAGAGCATAATTTCGGAAAGGATTATAAATATTACGAATATATCATAGGACACAAACA
TCACGACCATATCATCTGTACGGTCTGCGGAAAAATCGTGGAATTTATGGATGAAAGAATCGAACAACTTCAAGAGCAGG
CCGCAAGAGAAAACGGTTTTAAAATCACGGGTCATAGTCTTAACATCTATGGAACTTGCAACGAACACACTGCCGGTAGA
TGA

Upstream 100 bases:

>100_bases
GGCGATTCGAATTGCGGAAGAGGTGGAACGAGCTTGGTATTTTTCTATTGCCGGAAAGATCGATCCCTGATAATCTTGAC
CCGTTCTTGGATAATCTAAT

Downstream 100 bases:

>100_bases
TTTTTCAAACCACTTCCGAAGATCTTCGAACTAGAGCCAGAACCGGAATTCTAAATCTCAACGGAGTGAAGCTGGAAACT
CCGGTGTTTATGCCCGTAGG

Product: FUR family transcriptional regulator

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 160; Mature: 160

Protein sequence:

>160_residues
MNREKQEAILNKAEPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEYIIGHKHHDHIICTVCGKIVEFMDERIEQLQEQAARENGFKITGHSLNIYGTCNEHTAGR

Sequences:

>Translated_160_residues
MNREKQEAILNKAEPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEYIIGHKHHDHIICTVCGKIVEFMDERIEQLQEQAARENGFKITGHSLNIYGTCNEHTAGR
>Mature_160_residues
MNREKQEAILNKAEPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLEEFKDQRDQISKATIYRILSI
MVSAGLLQEHNFGKDYKYYEYIIGHKHHDHIICTVCGKIVEFMDERIEQLQEQAARENGFKITGHSLNIYGTCNEHTAGR

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=136, Percent_Identity=38.9705882352941, Blast_Score=97, Evalue=4e-22,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 18692; Mature: 18692

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNREKQEAILNKAEPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EFKDQRDQISKATIYRILSIMVSAGLLQEHNFGKDYKYYEYIIGHKHHDHIICTVCGKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
EFMDERIEQLQEQAARENGFKITGHSLNIYGTCNEHTAGR
HHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCC
>Mature Secondary Structure
MNREKQEAILNKAEPAVRMEMQTFSEYLQKEGLKITNQRMLVAERIFSLHNHFTAEGLLE
CCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
EFKDQRDQISKATIYRILSIMVSAGLLQEHNFGKDYKYYEYIIGHKHHDHIICTVCGKIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHH
EFMDERIEQLQEQAARENGFKITGHSLNIYGTCNEHTAGR
HHHHHHHHHHHHHHHHHCCCEEECCEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8200525 [H]