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The map label for this gene is nadC [H]

Identifier: 116328857

GI number: 116328857

Start: 2640870

End: 2641784

Strand: Reverse

Name: nadC [H]

Synonym: LBL_2241

Alternate gene names: 116328857

Gene position: 2641784-2640870 (Counterclockwise)

Preceding gene: 116328858

Following gene: 116328856

Centisome position: 73.09

GC content: 42.08

Gene sequence:

>915_bases
TTGTGGTTTTCCGATCGTAAAACTCTCTTTTGGATTCAAATGAAACGTGCCTATACTGATCCGGTTTCGTCCGTAAGTTA
CCAAGACTATGAAACCTTGGTAAAACTCGCTTGGGAAGAGGATTGTCCGGAAGAAGATATCACATCCGTTTCTCTCTTTA
CTCCTGACCAGAAAGCTACGGCGAGTTTGAACGCGCGAGAGTCCGGAATCCTTTGTGGAATTGGTGTATTAGAAGTTCTG
AATGTTCTTTCGGAAAATCAAATCCATTCGGAACTTTTGAAACAAGATGCGGAGAGTTTTCAAAAAGGTGATACCCTTTT
GAGAATTCAAGGCAATCTCGTTCAAATTCTCAGAATAGAACGAATTTTATTGAACTTTCTTCAGTATCTTTCCGGAATCT
CTACTCGAACTGGAGAAGTCGTCCAAAAATACGGACGAAAAGGTCTGATGATTTTCGATACGCGTAAAACCCTTCCGGGG
TATCGCAAACTCGCAAAATATGCGGTTTATTGCGGGGGCGGGAATAATCATAGACTTAATCTTTCCGAGATGGCAATGAT
TAAAGATAATCATCTCGCGATGTATTCGTCTTCTCGTGAACCTGTGGAAAAAATCAAAGCTCGTTTTCCGGGTAAAATTG
TGGAAGTGGAAATCGATTCTCTCTTACAACTCGAAGAAGCGATAGGTTCAGGGGCCGAAGTGATCCTACTTGATAATTTT
TCTCTGGAAGATATGAAGACTGCGTATTCCATTCTCAAACAAAAGGCGCCTAACGTTCAAATTGAGTTCTCCGGGGGAAT
CACTCCCGAAAAATTAGAAGCGCTCTCGGAATTTTCGGGAGCCGGTGTTAGTATGGGTTATCTAACGCATACGACTCGTT
TTCTAGACCTCGGTTTGGATATAGAGCAACACTAA

Upstream 100 bases:

>100_bases
AGAAAGTAAGCGGACTTGATTATATCTGTGCTTCGGTAATATTCTTGCGAAAATATATAACGACCGTTTATTTTGAGATT
ATAACCGGAAATTCACTTGA

Downstream 100 bases:

>100_bases
CAACTATGGGATTTGTAAAAACTCCTGCAACTAAAGATATGCTACTAGAAGGAGTTCGTGAAACGCTTGGAGAGAGCGCC
TATGAATCTGTTCAGAAGGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: General stress protein 70; GSP70; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MWFSDRKTLFWIQMKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKATASLNARESGILCGIGVLEVL
NVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIERILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPG
YRKLAKYAVYCGGGNNHRLNLSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNF
SLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIEQH

Sequences:

>Translated_304_residues
MWFSDRKTLFWIQMKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKATASLNARESGILCGIGVLEVL
NVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIERILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPG
YRKLAKYAVYCGGGNNHRLNLSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNF
SLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIEQH
>Mature_304_residues
MWFSDRKTLFWIQMKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKATASLNARESGILCGIGVLEVL
NVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIERILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPG
YRKLAKYAVYCGGGNNHRLNLSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNF
SLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLDIEQH

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=276, Percent_Identity=32.9710144927536, Blast_Score=114, Evalue=8e-26,
Organism=Escherichia coli, GI1786299, Length=255, Percent_Identity=36.8627450980392, Blast_Score=137, Evalue=8e-34,
Organism=Saccharomyces cerevisiae, GI6321162, Length=267, Percent_Identity=33.7078651685393, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 34187; Mature: 34187

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFSDRKTLFWIQMKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKAT
CCCCCCCEEEEEEEEHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCHHH
ASLNARESGILCGIGVLEVLNVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIE
CCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
RILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPGYRKLAKYAVYCGGGNNHRLN
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHEEEEECCCCCCEEE
LSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNF
HHHHHEEECCCEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECC
SLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLD
CHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHEECCC
IEQH
CCCC
>Mature Secondary Structure
MWFSDRKTLFWIQMKRAYTDPVSSVSYQDYETLVKLAWEEDCPEEDITSVSLFTPDQKAT
CCCCCCCEEEEEEEEHHHCCCHHCCCHHHHHHHHHHHHHCCCCHHHCCEEEEECCCCHHH
ASLNARESGILCGIGVLEVLNVLSENQIHSELLKQDAESFQKGDTLLRIQGNLVQILRIE
CCCCCCCCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHH
RILLNFLQYLSGISTRTGEVVQKYGRKGLMIFDTRKTLPGYRKLAKYAVYCGGGNNHRLN
HHHHHHHHHHCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHEEEEECCCCCCEEE
LSEMAMIKDNHLAMYSSSREPVEKIKARFPGKIVEVEIDSLLQLEEAIGSGAEVILLDNF
HHHHHEEECCCEEEECCCCCHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCEEEEEECC
SLEDMKTAYSILKQKAPNVQIEFSGGITPEKLEALSEFSGAGVSMGYLTHTTRFLDLGLD
CHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEHHHHHHHHHHEECCC
IEQH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 8444804; 9298659 [H]