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The map label for this gene is 116328827

Identifier: 116328827

GI number: 116328827

Start: 2598254

End: 2599207

Strand: Direct

Name: 116328827

Synonym: LBL_2206

Alternate gene names: NA

Gene position: 2598254-2599207 (Clockwise)

Preceding gene: 116328825

Following gene: 116328828

Centisome position: 71.89

GC content: 37.63

Gene sequence:

>954_bases
ATGAAAACAGGTTTCATCTACTCAAAAGATTTTCTTTATCACAACGCAGATCCAAAAATTCCACACTATGAAAACTCCGA
TAGATTACTTGCATGTCTTAATAAATTACATCAAACCAGTTATTTTAATTCCCTATTTTTTCCCGAAATGAAGAAGGTCC
CCAGTGAATTCTTCAATGAAATTCACTCTAGCGCTCATCTTCAAAAAATTGAACGTTCGAAAGGGAAAAGAGGCTACTTT
GATTCTGATACCCCTTTCACGGAAAAATCGTGGATTGCCGCTTATTCCGCCGCAAATTCCGGAATAACCCTAGCAGACGC
GTTAATTTCAGGAACAATCAAGAACGGTTTTTCACTTCTTAGGCCTCCGGGCCATCATGCGGAACACAATCGAATCATGG
GTTTTTGTATGTTAAATAACGTTGCCATTACCGCACGATATTTACAAAAGAATGGGTTCAAGAAAATCTTTATTATCGAC
TGGGATGTCCATCATGGAAATGGAACCCAAGAAATTTTTTACCAAGATCCAAATGTTTTCTATCTATCGATTCATCAATT
TCCATTTTATCCTATGACAGGCCTTTCCAGTGAAACCGGAAAAAACGAAGGTAGTGGAACTACAAAAAACATTCCAATGC
AAGCGAACTCCGACAACCAAGCTTACATTCAAAAATTCAAAGAAGTCGTAATTCCTACGATGGAACATTTCGAACCGGAT
ATCGTATTAATATCCGCAGGTTTTGACGCACATAAGGAAGATCCTCTGGGTGAAATGGATATCACAACCAAGGGGTTTGA
AGACTTAACTAAAATCGTTTTAGAAAGTGCTGATAAAATCTGCGAAGGTAAAGTATTATCCTTTTTAGAAGGCGGCTACA
ATTTAACGGCCTTATCAGAATCCGTAGAAGCTCAGCGGTTTTCAATTTTTTTTCTTAAAAGAACACGAATTTGA

Upstream 100 bases:

>100_bases
CGGCTTTTGGACTTTTTGTAATCGAAAATCCAAGATTTATTACAAGAAGTCGTAAATTTCTGGACAGTCCCTTAAATAAC
GTTCAAAAAGAGAAGTGAAA

Downstream 100 bases:

>100_bases
TACAAGAAAGTTTGGGCGGTCCAATTCCTTCGGAATTTAACTCAATGTTCCTTCATACATTCTGAATACAAAATTGATCA
AAACAAAAACGAGGTTTTGA

Product: histone deacetylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKTGFIYSKDFLYHNADPKIPHYENSDRLLACLNKLHQTSYFNSLFFPEMKKVPSEFFNEIHSSAHLQKIERSKGKRGYF
DSDTPFTEKSWIAAYSAANSGITLADALISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQKNGFKKIFIID
WDVHHGNGTQEIFYQDPNVFYLSIHQFPFYPMTGLSSETGKNEGSGTTKNIPMQANSDNQAYIQKFKEVVIPTMEHFEPD
IVLISAGFDAHKEDPLGEMDITTKGFEDLTKIVLESADKICEGKVLSFLEGGYNLTALSESVEAQRFSIFFLKRTRI

Sequences:

>Translated_317_residues
MKTGFIYSKDFLYHNADPKIPHYENSDRLLACLNKLHQTSYFNSLFFPEMKKVPSEFFNEIHSSAHLQKIERSKGKRGYF
DSDTPFTEKSWIAAYSAANSGITLADALISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQKNGFKKIFIID
WDVHHGNGTQEIFYQDPNVFYLSIHQFPFYPMTGLSSETGKNEGSGTTKNIPMQANSDNQAYIQKFKEVVIPTMEHFEPD
IVLISAGFDAHKEDPLGEMDITTKGFEDLTKIVLESADKICEGKVLSFLEGGYNLTALSESVEAQRFSIFFLKRTRI
>Mature_317_residues
MKTGFIYSKDFLYHNADPKIPHYENSDRLLACLNKLHQTSYFNSLFFPEMKKVPSEFFNEIHSSAHLQKIERSKGKRGYF
DSDTPFTEKSWIAAYSAANSGITLADALISGTIKNGFSLLRPPGHHAEHNRIMGFCMLNNVAITARYLQKNGFKKIFIID
WDVHHGNGTQEIFYQDPNVFYLSIHQFPFYPMTGLSSETGKNEGSGTTKNIPMQANSDNQAYIQKFKEVVIPTMEHFEPD
IVLISAGFDAHKEDPLGEMDITTKGFEDLTKIVLESADKICEGKVLSFLEGGYNLTALSESVEAQRFSIFFLKRTRI

Specific function: Putative deacetylase [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI13128864, Length=222, Percent_Identity=45.045045045045, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI20070354, Length=322, Percent_Identity=34.472049689441, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI30795202, Length=339, Percent_Identity=36.5781710914454, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI30795204, Length=339, Percent_Identity=36.5781710914454, Blast_Score=191, Evalue=6e-49,
Organism=Homo sapiens, GI17158039, Length=339, Percent_Identity=36.5781710914454, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI169234807, Length=339, Percent_Identity=35.3982300884956, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI148539870, Length=339, Percent_Identity=35.3982300884956, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI153085395, Length=339, Percent_Identity=34.8082595870207, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI62750349, Length=340, Percent_Identity=35, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI62750347, Length=340, Percent_Identity=35, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI226529806, Length=322, Percent_Identity=31.6770186335404, Blast_Score=160, Evalue=1e-39,
Organism=Homo sapiens, GI8923769, Length=246, Percent_Identity=28.8617886178862, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI293336691, Length=150, Percent_Identity=32, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI13128860, Length=150, Percent_Identity=32, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI13128862, Length=151, Percent_Identity=30.4635761589404, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI262073088, Length=174, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI262073092, Length=189, Percent_Identity=29.6296296296296, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI209862883, Length=268, Percent_Identity=20.1492537313433, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI217272877, Length=175, Percent_Identity=22.8571428571429, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI193209491, Length=234, Percent_Identity=44.4444444444444, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17540334, Length=199, Percent_Identity=44.7236180904523, Blast_Score=177, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17540332, Length=199, Percent_Identity=44.7236180904523, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI193206283, Length=199, Percent_Identity=44.7236180904523, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17537347, Length=300, Percent_Identity=31.3333333333333, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI25154020, Length=328, Percent_Identity=27.7439024390244, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25154022, Length=313, Percent_Identity=28.1150159744409, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17561978, Length=142, Percent_Identity=33.0985915492958, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17508561, Length=142, Percent_Identity=32.3943661971831, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=195, Percent_Identity=29.2307692307692, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324307, Length=345, Percent_Identity=33.6231884057971, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321244, Length=151, Percent_Identity=34.4370860927152, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323999, Length=150, Percent_Identity=30.6666666666667, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6325325, Length=178, Percent_Identity=28.6516853932584, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641720, Length=338, Percent_Identity=35.7988165680473, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI281360799, Length=338, Percent_Identity=35.7988165680473, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI281360801, Length=338, Percent_Identity=35.7988165680473, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI24642144, Length=315, Percent_Identity=32.0634920634921, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24642142, Length=315, Percent_Identity=32.0634920634921, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24642146, Length=315, Percent_Identity=32.0634920634921, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI281360899, Length=315, Percent_Identity=32.0634920634921, Blast_Score=165, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24644244, Length=153, Percent_Identity=34.640522875817, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24657891, Length=150, Percent_Identity=32.6666666666667, Blast_Score=91, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24649807, Length=212, Percent_Identity=23.5849056603774, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286
- InterPro:   IPR003084 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 35981; Mature: 35981

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTGFIYSKDFLYHNADPKIPHYENSDRLLACLNKLHQTSYFNSLFFPEMKKVPSEFFNE
CCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IHSSAHLQKIERSKGKRGYFDSDTPFTEKSWIAAYSAANSGITLADALISGTIKNGFSLL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCHHHC
RPPGHHAEHNRIMGFCMLNNVAITARYLQKNGFKKIFIIDWDVHHGNGTQEIFYQDPNVF
CCCCCCCCCCCEEEEEEECCCCEEHHHHHHCCCCEEEEEEEEEECCCCCCEEEEECCCEE
YLSIHQFPFYPMTGLSSETGKNEGSGTTKNIPMQANSDNQAYIQKFKEVVIPTMEHFEPD
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCHHHHCCCC
IVLISAGFDAHKEDPLGEMDITTKGFEDLTKIVLESADKICEGKVLSFLEGGYNLTALSE
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
SVEAQRFSIFFLKRTRI
HHHHHEEEEEEEEECCC
>Mature Secondary Structure
MKTGFIYSKDFLYHNADPKIPHYENSDRLLACLNKLHQTSYFNSLFFPEMKKVPSEFFNE
CCCCEEEECCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
IHSSAHLQKIERSKGKRGYFDSDTPFTEKSWIAAYSAANSGITLADALISGTIKNGFSLL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCHHHC
RPPGHHAEHNRIMGFCMLNNVAITARYLQKNGFKKIFIIDWDVHHGNGTQEIFYQDPNVF
CCCCCCCCCCCEEEEEEECCCCEEHHHHHHCCCCEEEEEEEEEECCCCCCEEEEECCCEE
YLSIHQFPFYPMTGLSSETGKNEGSGTTKNIPMQANSDNQAYIQKFKEVVIPTMEHFEPD
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCHHHHCCCC
IVLISAGFDAHKEDPLGEMDITTKGFEDLTKIVLESADKICEGKVLSFLEGGYNLTALSE
EEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHH
SVEAQRFSIFFLKRTRI
HHHHHEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]