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The map label for this gene is mtnC

Identifier: 116328821

GI number: 116328821

Start: 2590792

End: 2591487

Strand: Direct

Name: mtnC

Synonym: LBL_2200

Alternate gene names: 116328821

Gene position: 2590792-2591487 (Clockwise)

Preceding gene: 116328812

Following gene: 116328822

Centisome position: 71.68

GC content: 40.8

Gene sequence:

>696_bases
TTGGATTTCGAAATCTATCTATTCGACATCGAAGGGACCACAACTCCCATCGAATTCGTTCATAAAATTCTCTTTCCATA
TTCTGTCGGGAAGTTCGAAACTTTTTTTCGATCGAACTCTCTTGAGAGAAAATGGATCGAAAAATTACTCGAAGAAGGAA
AACGTGATTCCACGTATTCGAGACAACTAACGGATTCTCCTCAGAATTTGAGCGATTATTGCAAATATCTCGTTTCCGTG
GATCGCAAGAGCGGACCTTTGAAAGAAATTCAGGGAAGAATTTGGAAACACGGTTACGAAAATGGAGAACTGAAAAGCTC
CTTATTCGCGGATGTCCCTTCTTTTTTAAAAAGAATTCAATCCGCCAAAAAGAAATCGGCCGTATATTCCTCCGGAAGTA
TTGAGGCTCAGAAATTAATTTTTAAATATTCGGATTTTGGAGATTTGACCGAATATTTTTCCGCTTACTTCGATACGGGA
GTGGGAGGGAAAAGGGAATCTGCGAGTTATTCAAGAATCGCGGAGCAGCTGGGAATCGCACCGGAAAAAATCTTATTCTT
CACCGATATCAAGGAAGAGGCCGACGCCGCAAGAAATGCCGAATTCAAAACAACCTTATTAGAACGCCCCGGAAATGCTC
CACAACCGAAACATTCCCACCCTAAAATTTCTTCTTTCGAAAATTTCAATCCTTAG

Upstream 100 bases:

>100_bases
CTTATTCTGGTTGATTGTATTGAAAAATTTTGAAAAGGACGAAAAAAACGTGCATGATTATCTGACTTCCGAAGCCGAAA
AAATCAAAGGGGCGATCTAA

Downstream 100 bases:

>100_bases
AGTCTGTTTAAAAATACGAAAGTACTCAAAGAACTCCAATTTTCGAAGAGGAAGGCAGCGATGAGTGACTACTGAAACAC
GAGGTTTGTGATCCATTTTT

Product: enolase-phosphatase

Products: NA

Alternate protein names: 2,3-diketo-5-methylthio-1-phosphopentane phosphatase

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MDFEIYLFDIEGTTTPIEFVHKILFPYSVGKFETFFRSNSLERKWIEKLLEEGKRDSTYSRQLTDSPQNLSDYCKYLVSV
DRKSGPLKEIQGRIWKHGYENGELKSSLFADVPSFLKRIQSAKKKSAVYSSGSIEAQKLIFKYSDFGDLTEYFSAYFDTG
VGGKRESASYSRIAEQLGIAPEKILFFTDIKEEADAARNAEFKTTLLERPGNAPQPKHSHPKISSFENFNP

Sequences:

>Translated_231_residues
MDFEIYLFDIEGTTTPIEFVHKILFPYSVGKFETFFRSNSLERKWIEKLLEEGKRDSTYSRQLTDSPQNLSDYCKYLVSV
DRKSGPLKEIQGRIWKHGYENGELKSSLFADVPSFLKRIQSAKKKSAVYSSGSIEAQKLIFKYSDFGDLTEYFSAYFDTG
VGGKRESASYSRIAEQLGIAPEKILFFTDIKEEADAARNAEFKTTLLERPGNAPQPKHSHPKISSFENFNP
>Mature_231_residues
MDFEIYLFDIEGTTTPIEFVHKILFPYSVGKFETFFRSNSLERKWIEKLLEEGKRDSTYSRQLTDSPQNLSDYCKYLVSV
DRKSGPLKEIQGRIWKHGYENGELKSSLFADVPSFLKRIQSAKKKSAVYSSGSIEAQKLIFKYSDFGDLTEYFSAYFDTG
VGGKRESASYSRIAEQLGIAPEKILFFTDIKEEADAARNAEFKTTLLERPGNAPQPKHSHPKISSFENFNP

Specific function: Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone

COG id: COG4229

COG function: function code C; Predicted enolase-phosphatase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. MasA/mtnC family

Homologues:

Organism=Homo sapiens, GI10864017, Length=228, Percent_Identity=37.719298245614, Blast_Score=154, Evalue=9e-38,
Organism=Caenorhabditis elegans, GI115533232, Length=239, Percent_Identity=36.4016736401674, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320797, Length=241, Percent_Identity=37.344398340249, Blast_Score=148, Evalue=6e-37,
Organism=Drosophila melanogaster, GI281360080, Length=218, Percent_Identity=44.954128440367, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24644163, Length=218, Percent_Identity=44.954128440367, Blast_Score=182, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTNC_LEPBJ (Q04QY0)

Other databases:

- EMBL:   CP000350
- RefSeq:   YP_801448.1
- ProteinModelPortal:   Q04QY0
- SMR:   Q04QY0
- STRING:   Q04QY0
- GeneID:   4411643
- GenomeReviews:   CP000350_GR
- KEGG:   lbj:LBJ_2207
- eggNOG:   COG4229
- HOGENOM:   HBG294242
- OMA:   TTDLNFI
- PhylomeDB:   Q04QY0
- ProtClustDB:   CLSK866737
- BioCyc:   LBOR355277:LBJ_2207-MONOMER
- HAMAP:   MF_01681
- InterPro:   IPR010041
- InterPro:   IPR023214
- InterPro:   IPR005833
- Gene3D:   G3DSA:3.40.50.1000
- PANTHER:   PTHR20371
- PRINTS:   PR00413
- TIGRFAMs:   TIGR01691

Pfam domain/function: SSF56784 SSF56784

EC number: =3.1.3.77

Molecular weight: Translated: 26452; Mature: 26452

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEIYLFDIEGTTTPIEFVHKILFPYSVGKFETFFRSNSLERKWIEKLLEEGKRDSTYS
CCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHH
RQLTDSPQNLSDYCKYLVSVDRKSGPLKEIQGRIWKHGYENGELKSSLFADVPSFLKRIQ
HHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SAKKKSAVYSSGSIEAQKLIFKYSDFGDLTEYFSAYFDTGVGGKRESASYSRIAEQLGIA
HHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
PEKILFFTDIKEEADAARNAEFKTTLLERPGNAPQPKHSHPKISSFENFNP
HHHEEEEECCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFEIYLFDIEGTTTPIEFVHKILFPYSVGKFETFFRSNSLERKWIEKLLEEGKRDSTYS
CCEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHH
RQLTDSPQNLSDYCKYLVSVDRKSGPLKEIQGRIWKHGYENGELKSSLFADVPSFLKRIQ
HHHCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
SAKKKSAVYSSGSIEAQKLIFKYSDFGDLTEYFSAYFDTGVGGKRESASYSRIAEQLGIA
HHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
PEKILFFTDIKEEADAARNAEFKTTLLERPGNAPQPKHSHPKISSFENFNP
HHHEEEEECCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA