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The map label for this gene is hsaB [H]

Identifier: 116328701

GI number: 116328701

Start: 2430213

End: 2430692

Strand: Direct

Name: hsaB [H]

Synonym: LBL_2073

Alternate gene names: 116328701

Gene position: 2430213-2430692 (Clockwise)

Preceding gene: 116328700

Following gene: 116328707

Centisome position: 67.24

GC content: 40.62

Gene sequence:

>480_bases
ATGAAAATTACAGACGAAGTTTTTAAAAATGCACTTTCACACTTTCCTTCCGGCGTTACCGTCATTACATATTCTCATCT
TGGAAAGCACGGCGGTCTAACCGTTAGCAGTTTCAGCTCTCTTTCACTCAATCCTCCTCTTGTTTTATTTTGTCTTCAGA
AGAACATAACCAGCCACGATTCGATTTATGATTCCGGTAAATTTATCGTGAACATTTTGGCGCAGGGACAGGATTCTCTA
TCCAATCAATTTGCCTCGGGAAAAACCGACAAACACACTCTCATTCAGGAGCTTAAATGTAAAACGGGAGAGCTGGAAAT
TCCTATTTTACCCGGAATTCTTTCTTATATCGAATGTGAGGTGGAGCAATTTGTAAACGGAGGAGATCACTCTATCGTAA
TCGGAAAAGTGATTTCCGCCGGAGCGGAAGACAGTTTGAGGCCTTTGTTGTATTACAGAAGGAACTATTATTCCATTTAG

Upstream 100 bases:

>100_bases
AGAGCGAAATTATTACCCTCATCATGATCGAATTCAATACCATCTTTTCTTTTCACTTCGATCGGTTGACAAAGAGTCTT
TCGGTTTTAAGATCGACCTC

Downstream 100 bases:

>100_bases
AATCTGTCCCAAACGTAGGAACAATTGTAACGATCCACGGAGATTCTGATAAGATCGAATGGTTTTGGGACACGCTCTTA
GGTTAGAACTCCTTTTATTA

Product: flavin reductase related protein

Products: NAD(+); reduced flavin [C]

Alternate protein names: Flavin:NADH reductase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKITDEVFKNALSHFPSGVTVITYSHLGKHGGLTVSSFSSLSLNPPLVLFCLQKNITSHDSIYDSGKFIVNILAQGQDSL
SNQFASGKTDKHTLIQELKCKTGELEIPILPGILSYIECEVEQFVNGGDHSIVIGKVISAGAEDSLRPLLYYRRNYYSI

Sequences:

>Translated_159_residues
MKITDEVFKNALSHFPSGVTVITYSHLGKHGGLTVSSFSSLSLNPPLVLFCLQKNITSHDSIYDSGKFIVNILAQGQDSL
SNQFASGKTDKHTLIQELKCKTGELEIPILPGILSYIECEVEQFVNGGDHSIVIGKVISAGAEDSLRPLLYYRRNYYSI
>Mature_159_residues
MKITDEVFKNALSHFPSGVTVITYSHLGKHGGLTVSSFSSLSLNPPLVLFCLQKNITSHDSIYDSGKFIVNILAQGQDSL
SNQFASGKTDKHTLIQELKCKTGELEIPILPGILSYIECEVEQFVNGGDHSIVIGKVISAGAEDSLRPLLYYRRNYYSI

Specific function: Catalyzes the reduction of free flavins (FMN or FAD) by NADH. Subsequently, the reduced flavins diffuse to the HsaA oxygenase subunit [H]

COG id: COG1853

COG function: function code R; Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the non-flavoprotein flavin reductase family [H]

Homologues:

Organism=Escherichia coli, GI87081819, Length=160, Percent_Identity=27.5, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002563
- InterPro:   IPR012349
- InterPro:   IPR009002 [H]

Pfam domain/function: PF01613 Flavin_Reduct [H]

EC number: 1.6.8.- [C]

Molecular weight: Translated: 17479; Mature: 17479

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITDEVFKNALSHFPSGVTVITYSHLGKHGGLTVSSFSSLSLNPPLVLFCLQKNITSHD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCC
SIYDSGKFIVNILAQGQDSLSNQFASGKTDKHTLIQELKCKTGELEIPILPGILSYIECE
CHHCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHH
VEQFVNGGDHSIVIGKVISAGAEDSLRPLLYYRRNYYSI
HHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKITDEVFKNALSHFPSGVTVITYSHLGKHGGLTVSSFSSLSLNPPLVLFCLQKNITSHD
CCCHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCCCC
SIYDSGKFIVNILAQGQDSLSNQFASGKTDKHTLIQELKCKTGELEIPILPGILSYIECE
CHHCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHH
VEQFVNGGDHSIVIGKVISAGAEDSLRPLLYYRRNYYSI
HHHHHCCCCCEEEEEHHHHCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; flavin [C]

Specific reaction: NADH + flavin = NAD(+) + reduced flavin [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]