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The map label for this gene is nhaC [H]

Identifier: 116328673

GI number: 116328673

Start: 2393932

End: 2395362

Strand: Reverse

Name: nhaC [H]

Synonym: LBL_2043

Alternate gene names: 116328673

Gene position: 2395362-2393932 (Counterclockwise)

Preceding gene: 116328674

Following gene: 116328672

Centisome position: 66.27

GC content: 44.1

Gene sequence:

>1431_bases
GTGAAAACGACAGAGTCTGAACCCGGATTATTTGAGTCTTTCATTCCGGTAATTGTTCTCGTGATGGGACTCGGTTACGC
TGGAGTTGTATTTGGTAATGGAACCGTAGACGGACCTGCACAAATGCTTTTAATCCTTTCGGGAACGGTCGCCAGTTTAC
TTGGAATTCGTCTCGGAGTGAAGTGGGAATTTTTAGAAGAACGAATTCTAGAATCTTTGAAGAATGTTTTAAAACCGGTG
CTTATTCTTTTATTGATCGGTTCTTTGATAGGAGTCTGGGTCTGGTCCGGAATCGTTCCATCCATGATCGTGTGGGGATT
GAAACTTCTCAAACCTTCTCTCTTTTTAAGAACCGCCTGTCTTTTATCTTCCGTCGTTTCTTTGATAACCGGAAGTTCCT
GGTCCACAGTCGGAACTGTGGGAGTTGCTCTTATGGGAATCGGTACCACGTTGGATGTTCCTCCTGGAATTGCGGCGGGT
GCGATCGTATCCGGCGCCTACTTCGGTGATAAACTTTCTCCGTTTTCAGAGACTACCAACCTTGCGTCTTCGATAGCTGG
AACACCACTTTCTACGCATATTCAGCATATGTTATATACTACTTTGCCCGCTTTTTGCATTGCAATCATATTTTTCACTT
GGATGGGTTTCGATTACTCCGGATCGGAAAGTGGGGGGCAGAAGGTAAACGAGGTAATTGATCTACTTGAAAAATCGTTT
CGAATTCATCCGGTTTTGTTGTTTCCTCCCGTTTTGACATTCGTATTAATTTATTTTAAAGTCCCTGCAATTCCTTCCAT
CCTCGCGGGAATTCTATCGGGGGTTTTGTCCGGAATTTTTCTACAACATTCCGATTTGGATTTTCCGGAAGTTTACAGAC
AGGTTTTAAACGCGGCTTCCAAAGGGAACATGGCGAATACCGAAAATCCTCTTACGGATGCGTTACTTTCGAGAGGGGGA
ATGGCTTCTATGCTTCCCACGGTTTGGTTGATTTTCTCTGCGATGTTTTTTGCGGGTGCGATGGAAGGAGCCGGATTGAT
TCAGGAAATCACTAAAGGAATATTAAAGTATGCAAATACGGATCGATCTCTTTTGATAGGGACGATACTTACGAGTATTT
CCGCGAATTTACTATCTTCGGACCAGTATCTTTCGATTTTGGTTCCTGGTAAAATGTTTAAGAAGTCCTATGAAGAACTA
GGTCTTGATTCTAAAAATCTTTCGAGAGCGTTGGAAGATTCCGGTACGATGACTTCCGCATTGGTGCCTTGGAACACCTG
CGGTTCTTTTATGGCGGCCGCACTCGGAGTTCCGGTAGTCGTATTTCTTCCTTATGCGGTATTGAATCTAAGCAGTCCTT
TTATCTCCCTGATTTGCGCTTGGACCGGATGGACGATCCGTAAGAATCAATCGGATCGTATCATTCCGTGA

Upstream 100 bases:

>100_bases
GAATGGAAAGACAGGCATTGCACGCATACGCGATCCGTTTCAATCATCCGATCACAAATCGGAAAATGAAGATCGTAGCC
TCCGTTCCAAAGGATTTTTG

Downstream 100 bases:

>100_bases
AAAAAATAAAAAGAAACAGCGCCTTACTCGCGGTCATAAGCGTCGTTGCGATCGGCTTTCTTTTACCCGAATCGTTTACC
ATGCCGGTCGAAGGAGCGGA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: Sodium/hydrogen antiporter; Sodium/proton antiporter [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKTTESEPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWEFLEERILESLKNVLKPV
LILLLIGSLIGVWVWSGIVPSMIVWGLKLLKPSLFLRTACLLSSVVSLITGSSWSTVGTVGVALMGIGTTLDVPPGIAAG
AIVSGAYFGDKLSPFSETTNLASSIAGTPLSTHIQHMLYTTLPAFCIAIIFFTWMGFDYSGSESGGQKVNEVIDLLEKSF
RIHPVLLFPPVLTFVLIYFKVPAIPSILAGILSGVLSGIFLQHSDLDFPEVYRQVLNAASKGNMANTENPLTDALLSRGG
MASMLPTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLIGTILTSISANLLSSDQYLSILVPGKMFKKSYEEL
GLDSKNLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAVLNLSSPFISLICAWTGWTIRKNQSDRIIP

Sequences:

>Translated_476_residues
MKTTESEPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWEFLEERILESLKNVLKPV
LILLLIGSLIGVWVWSGIVPSMIVWGLKLLKPSLFLRTACLLSSVVSLITGSSWSTVGTVGVALMGIGTTLDVPPGIAAG
AIVSGAYFGDKLSPFSETTNLASSIAGTPLSTHIQHMLYTTLPAFCIAIIFFTWMGFDYSGSESGGQKVNEVIDLLEKSF
RIHPVLLFPPVLTFVLIYFKVPAIPSILAGILSGVLSGIFLQHSDLDFPEVYRQVLNAASKGNMANTENPLTDALLSRGG
MASMLPTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLIGTILTSISANLLSSDQYLSILVPGKMFKKSYEEL
GLDSKNLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAVLNLSSPFISLICAWTGWTIRKNQSDRIIP
>Mature_476_residues
MKTTESEPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGVKWEFLEERILESLKNVLKPV
LILLLIGSLIGVWVWSGIVPSMIVWGLKLLKPSLFLRTACLLSSVVSLITGSSWSTVGTVGVALMGIGTTLDVPPGIAAG
AIVSGAYFGDKLSPFSETTNLASSIAGTPLSTHIQHMLYTTLPAFCIAIIFFTWMGFDYSGSESGGQKVNEVIDLLEKSF
RIHPVLLFPPVLTFVLIYFKVPAIPSILAGILSGVLSGIFLQHSDLDFPEVYRQVLNAASKGNMANTENPLTDALLSRGG
MASMLPTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANTDRSLLIGTILTSISANLLSSDQYLSILVPGKMFKKSYEEL
GLDSKNLSRALEDSGTMTSALVPWNTCGSFMAAALGVPVVVFLPYAVLNLSSPFISLICAWTGWTIRKNQSDRIIP

Specific function: Na(+)/H(+) antiporter. Involved in pH homeostasis and sodium extrusion [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 50915; Mature: 50915

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTESEPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGV
CCCCCCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KWEFLEERILESLKNVLKPVLILLLIGSLIGVWVWSGIVPSMIVWGLKLLKPSLFLRTAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSSVVSLITGSSWSTVGTVGVALMGIGTTLDVPPGIAAGAIVSGAYFGDKLSPFSETTN
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
LASSIAGTPLSTHIQHMLYTTLPAFCIAIIFFTWMGFDYSGSESGGQKVNEVIDLLEKSF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RIHPVLLFPPVLTFVLIYFKVPAIPSILAGILSGVLSGIFLQHSDLDFPEVYRQVLNAAS
CCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KGNMANTENPLTDALLSRGGMASMLPTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANT
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DRSLLIGTILTSISANLLSSDQYLSILVPGKMFKKSYEELGLDSKNLSRALEDSGTMTSA
CHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
LVPWNTCGSFMAAALGVPVVVFLPYAVLNLSSPFISLICAWTGWTIRKNQSDRIIP
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCC
>Mature Secondary Structure
MKTTESEPGLFESFIPVIVLVMGLGYAGVVFGNGTVDGPAQMLLILSGTVASLLGIRLGV
CCCCCCCCCHHHHHHHHHHHHHHCCHHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCC
KWEFLEERILESLKNVLKPVLILLLIGSLIGVWVWSGIVPSMIVWGLKLLKPSLFLRTAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSSVVSLITGSSWSTVGTVGVALMGIGTTLDVPPGIAAGAIVSGAYFGDKLSPFSETTN
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHH
LASSIAGTPLSTHIQHMLYTTLPAFCIAIIFFTWMGFDYSGSESGGQKVNEVIDLLEKSF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
RIHPVLLFPPVLTFVLIYFKVPAIPSILAGILSGVLSGIFLQHSDLDFPEVYRQVLNAAS
CCCEEHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
KGNMANTENPLTDALLSRGGMASMLPTVWLIFSAMFFAGAMEGAGLIQEITKGILKYANT
CCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
DRSLLIGTILTSISANLLSSDQYLSILVPGKMFKKSYEELGLDSKNLSRALEDSGTMTSA
CHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHH
LVPWNTCGSFMAAALGVPVVVFLPYAVLNLSSPFISLICAWTGWTIRKNQSDRIIP
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1660475; 9190799 [H]